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MyoD family inhibitor (Myogenic repressor I-mf)

 MDFI_MOUSE              Reviewed;         251 AA.
P70331; P70330; P70332; Q5XK64; Q99JM9;
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-NOV-2018, entry version 117.
RecName: Full=MyoD family inhibitor;
AltName: Full=Myogenic repressor I-mf;
Name=Mdfi;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I-MFA; I-MFB AND I-MFC),
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
STRAIN=NIH Swiss; TISSUE=Embryo;
PubMed=8797820; DOI=10.1016/S0092-8674(00)80148-8;
Chen C.-M.A., Kraut N., Groudine M., Weintraub H.;
"I-mf, a novel myogenic repressor, interacts with members of the MyoD
family.";
Cell 86:731-741(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I-MFA).
STRAIN=129, and FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION.
PubMed=9799236; DOI=10.1093/emboj/17.21.6276;
Kraut N., Snider L., Chen C.-M.A., Tapscott S.J., Groudine M.;
"Requirement of the mouse I-mfa gene for placental development and
skeletal patterning.";
EMBO J. 17:6276-6288(1998).
[4]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11238923; DOI=10.1128/MCB.21.5.1866-1873.2001;
Snider L., Thirlwell H., Miller J.R., Moon R.T., Groudine M.,
Tapscott S.J.;
"Inhibition of Tcf3 binding by I-mfa domain proteins.";
Mol. Cell. Biol. 21:1866-1873(2001).
[5]
FUNCTION, AND INTERACTION WITH AXIN1 AND LEF1.
PubMed=12192039; DOI=10.1128/MCB.22.18.6393-6405.2002;
Kusano S., Raab-Traub N.;
"I-mfa domain proteins interact with Axin and affect its regulation of
the Wnt and c-Jun N-terminal kinase signaling pathways.";
Mol. Cell. Biol. 22:6393-6405(2002).
-!- FUNCTION: Inhibits the transactivation activity of the Myod family
of myogenic factors and represses myogenesis. Acts by associating
with Myod family members and retaining them in the cytoplasm by
masking their nuclear localization signals. Can also interfere
with the DNA-binding activity of Myod family members. Plays an
important role in trophoblast and chondrogenic differentiation.
Regulates the transcriptional activity of TCF7L1/TCF3 by
interacting directly with TCF7L1/TCF3 and preventing it from
binding DNA. Binds to the axin complex, resulting in an increase
in the level of free beta-catenin. Affects axin regulation of the
WNT and JNK signaling pathways. {ECO:0000269|PubMed:11238923,
ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:8797820,
ECO:0000269|PubMed:9799236}.
-!- SUBUNIT: The C-terminus interacts with AXIN1 and LEF1
(PubMed:12192039). Interacts with CCNT2 (By similarity).
{ECO:0000250|UniProtKB:Q99750, ECO:0000269|PubMed:12192039}.
-!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=I-mfB;
IsoId=P70331-1; Sequence=Displayed;
Name=I-mfA;
IsoId=P70331-2; Sequence=VSP_004056;
Name=I-mfC;
IsoId=P70331-3; Sequence=VSP_004055, VSP_004057;
-!- TISSUE SPECIFICITY: In the embryo, highly expressed in the
sclerotome. Also expressed in the notochord, neural tube, limb
buds, heart, branchial arches and head mesenchyme. In the adult,
highly expressed in skeletal muscle. Expressed at lower levels in
most other tissues. {ECO:0000269|PubMed:8797820}.
-!- SIMILARITY: Belongs to the MDFI family. {ECO:0000305}.
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EMBL; U57820; AAC52791.1; -; mRNA.
EMBL; U57821; AAC52792.1; -; mRNA.
EMBL; U57822; AAC52793.1; -; mRNA.
EMBL; BC006018; AAH06018.1; -; mRNA.
EMBL; BC010259; AAH10259.1; -; mRNA.
EMBL; BC083058; AAH83058.1; -; mRNA.
EMBL; BC085233; AAH85233.1; -; mRNA.
CCDS; CCDS50134.1; -. [P70331-2]
RefSeq; NP_001103443.1; NM_001109973.2. [P70331-2]
RefSeq; NP_001263319.1; NM_001276390.1. [P70331-2]
RefSeq; NP_034913.2; NM_010783.3. [P70331-2]
RefSeq; XP_006523806.1; XM_006523743.3. [P70331-1]
RefSeq; XP_006523807.1; XM_006523744.3. [P70331-1]
RefSeq; XP_006523808.1; XM_006523745.3. [P70331-1]
UniGene; Mm.329100; -.
ProteinModelPortal; P70331; -.
SMR; P70331; -.
BioGrid; 201368; 2.
STRING; 10090.ENSMUSP00000037888; -.
iPTMnet; P70331; -.
PhosphoSitePlus; P70331; -.
PaxDb; P70331; -.
PRIDE; P70331; -.
Ensembl; ENSMUST00000035375; ENSMUSP00000037888; ENSMUSG00000032717. [P70331-2]
Ensembl; ENSMUST00000066368; ENSMUSP00000069915; ENSMUSG00000032717. [P70331-2]
GeneID; 17240; -.
KEGG; mmu:17240; -.
UCSC; uc008cwh.3; mouse. [P70331-2]
UCSC; uc008cwj.3; mouse. [P70331-1]
CTD; 4188; -.
MGI; MGI:107687; Mdfi.
eggNOG; ENOG410IYH9; Eukaryota.
eggNOG; ENOG410YK34; LUCA.
GeneTree; ENSGT00390000010600; -.
HOGENOM; HOG000001577; -.
InParanoid; P70331; -.
OrthoDB; EOG091G0RJH; -.
PhylomeDB; P70331; -.
TreeFam; TF332113; -.
PRO; PR:P70331; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000032717; Expressed in 160 organ(s), highest expression level in cardiac ventricle.
CleanEx; MM_MDFI; -.
ExpressionAtlas; P70331; baseline and differential.
Genevisible; P70331; MM.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0007257; P:activation of JUN kinase activity; IDA:UniProtKB.
GO; GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
GO; GO:0043392; P:negative regulation of DNA binding; IDA:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IGI:UniProtKB.
GO; GO:0030111; P:regulation of Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
InterPro; IPR026134; MDFI/MDFIC.
PANTHER; PTHR15304; PTHR15304; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasm;
Developmental protein; Differentiation; Nucleus; Reference proteome.
CHAIN 1 251 MyoD family inhibitor.
/FTId=PRO_0000096325.
VAR_SEQ 136 163 SLGSQAGRKSRGSARSASQVPLQAQEGK -> PQPPNRSAF
RRVAWSPPRVTRNTASRAW (in isoform I-mfC).
{ECO:0000303|PubMed:8797820}.
/FTId=VSP_004055.
VAR_SEQ 162 251 GKAPAVRIHRQTASPTCCLRNAQLSGTALRSLRLESQGHRE
LNNKTLSQSNNKKPGVAAHAAIIPALTRPKQNCHDPSLLPG
THGVGKEF -> DCCVHCILSCLFCEFLTLCNILLDCATCG
SCSSEDSCLCCCCCGSGECADCDLPCDLDCGIVDACCESAD
CLEICMECCGLCFSS (in isoform I-mfA).
{ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:8797820}.
/FTId=VSP_004056.
VAR_SEQ 164 251 Missing (in isoform I-mfC).
{ECO:0000303|PubMed:8797820}.
/FTId=VSP_004057.
SEQUENCE 251 AA; 26013 MW; E77D693D935F1B83 CRC64;
MSQVSGQCPS RCDAPHGVPS AALDPAQTMS LLPGLEVARS THPVEASSEE GFPEEAAPSM
PHDSGLRAQQ ALNSIDLDVP TEAVTCQPQG NPQGCTPLLP NGSSHDHLSE PGSAGHAGNG
ALGGSKAHRK LQTHPSLGSQ AGRKSRGSAR SASQVPLQAQ EGKAPAVRIH RQTASPTCCL
RNAQLSGTAL RSLRLESQGH RELNNKTLSQ SNNKKPGVAA HAAIIPALTR PKQNCHDPSL
LPGTHGVGKE F


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