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MyoD family inhibitor (Myogenic repressor I-mf)

 MDFI_HUMAN              Reviewed;         246 AA.
Q99750;
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
27-SEP-2017, entry version 138.
RecName: Full=MyoD family inhibitor;
AltName: Full=Myogenic repressor I-mf;
Name=MDFI;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal brain;
PubMed=9250874; DOI=10.1007/s003359900517;
Kraut N.;
"The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse
chromosome 17.";
Mamm. Genome 8:618-619(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH CCNT2.
PubMed=17289077; DOI=10.1016/j.jmb.2007.01.020;
Wang Q., Young T.M., Mathews M.B., Pe'ery T.;
"Developmental regulators containing the I-mfa domain interact with T
cyclins and Tat and modulate transcription.";
J. Mol. Biol. 367:630-646(2007).
-!- FUNCTION: Inhibits the transactivation activity of the Myod family
of myogenic factors and represses myogenesis. Acts by associating
with Myod family members and retaining them in the cytoplasm by
masking their nuclear localization signals. Can also interfere
with the DNA-binding activity of Myod family members. Plays an
important role in trophoblast and chondrogenic differentiation.
Regulates the transcriptional activity of TCF7L1/TCF3 by
interacting directly with TCF7L1/TCF3 and preventing it from
binding DNA. Binds to the axin complex, resulting in an increase
in the level of free beta-catenin. Affects axin regulation of the
WNT and JNK signaling pathways (By similarity). {ECO:0000250}.
-!- SUBUNIT: The C-terminus interacts with AXIN1 and LEF1 (By
similarity). Interacts with CCNT2 (PubMed:17289077).
{ECO:0000250|UniProtKB:P70331, ECO:0000269|PubMed:17289077}.
-!- INTERACTION:
Self; NbExp=4; IntAct=EBI-724076, EBI-724076;
Q03989-5:-; NbExp=3; IntAct=EBI-724076, EBI-15327952;
Q5BKY6:-; NbExp=3; IntAct=EBI-724076, EBI-10243533;
Q5W150:-; NbExp=5; IntAct=EBI-724076, EBI-10248148;
Q5XG85:-; NbExp=5; IntAct=EBI-724076, EBI-10248413;
Q16613:AANAT; NbExp=6; IntAct=EBI-724076, EBI-7451846;
P82987:ADAMTSL3; NbExp=5; IntAct=EBI-724076, EBI-10221726;
Q02040-3:AKAP17A; NbExp=3; IntAct=EBI-724076, EBI-10222656;
P29972:AQP1; NbExp=6; IntAct=EBI-724076, EBI-745213;
P55064:AQP5; NbExp=3; IntAct=EBI-724076, EBI-746103;
A7KAX9:ARHGAP32; NbExp=3; IntAct=EBI-724076, EBI-308663;
Q5T686:AVPI1; NbExp=6; IntAct=EBI-724076, EBI-8640233;
Q8TBE0:BAHD1; NbExp=6; IntAct=EBI-724076, EBI-742750;
Q9BXC9:BBS2; NbExp=5; IntAct=EBI-724076, EBI-748297;
Q9HBH7:BEX1; NbExp=5; IntAct=EBI-724076, EBI-7162175;
Q5T681:C10orf62; NbExp=7; IntAct=EBI-724076, EBI-744052;
Q9NVL8:C14orf105; NbExp=3; IntAct=EBI-724076, EBI-10238351;
Q96EN9:C19orf60; NbExp=5; IntAct=EBI-724076, EBI-745810;
Q6P5X5:C22orf39; NbExp=3; IntAct=EBI-724076, EBI-7317823;
Q17RF5:C4orf26; NbExp=5; IntAct=EBI-724076, EBI-10239029;
Q96LM5:C4orf45; NbExp=4; IntAct=EBI-724076, EBI-12020542;
Q9H7E9:C8orf33; NbExp=4; IntAct=EBI-724076, EBI-715389;
Q96LL4:C8orf48; NbExp=5; IntAct=EBI-724076, EBI-751596;
Q8NEC5:CATSPER1; NbExp=3; IntAct=EBI-724076, EBI-744545;
O43439:CBFA2T2; NbExp=4; IntAct=EBI-724076, EBI-748628;
Q14781:CBX2; NbExp=3; IntAct=EBI-724076, EBI-745934;
Q5T0F9:CC2D1B; NbExp=3; IntAct=EBI-724076, EBI-10245204;
Q8IYX3:CCDC116; NbExp=4; IntAct=EBI-724076, EBI-744311;
Q8N715:CCDC185; NbExp=5; IntAct=EBI-724076, EBI-740814;
Q96GN5:CDCA7L; NbExp=5; IntAct=EBI-724076, EBI-5278764;
Q8IVW4:CDKL3; NbExp=3; IntAct=EBI-724076, EBI-3919850;
Q8IYX8:CEP57L1; NbExp=5; IntAct=EBI-724076, EBI-1104570;
O43745:CHP2; NbExp=4; IntAct=EBI-724076, EBI-8525536;
P07510-2:CHRNG; NbExp=5; IntAct=EBI-724076, EBI-11979451;
Q8NE01:CNNM3; NbExp=5; IntAct=EBI-724076, EBI-741032;
Q02930-3:CREB5; NbExp=7; IntAct=EBI-724076, EBI-10192698;
Q6DCB0:DAAM2; NbExp=3; IntAct=EBI-724076, EBI-10249414;
Q5TAQ9:DCAF8; NbExp=6; IntAct=EBI-724076, EBI-740686;
Q8TF63:DCANP1; NbExp=5; IntAct=EBI-724076, EBI-10275670;
Q96LJ7:DHRS1; NbExp=3; IntAct=EBI-724076, EBI-746300;
O94907:DKK1; NbExp=3; IntAct=EBI-724076, EBI-742864;
Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-724076, EBI-9679045;
Q9Y6K1:DNMT3A; NbExp=4; IntAct=EBI-724076, EBI-923653;
Q92608:DOCK2; NbExp=5; IntAct=EBI-724076, EBI-448771;
Q14240-2:EIF4A2; NbExp=3; IntAct=EBI-724076, EBI-10232522;
Q14241:ELOA; NbExp=5; IntAct=EBI-724076, EBI-742350;
Q9H0I2:ENKD1; NbExp=7; IntAct=EBI-724076, EBI-744099;
Q92731-3:ESR2; NbExp=3; IntAct=EBI-724076, EBI-12259414;
Q0VG06-3:FAAP100; NbExp=3; IntAct=EBI-724076, EBI-10226932;
Q9H5Z6:FAM124B; NbExp=4; IntAct=EBI-724076, EBI-741626;
Q3B820:FAM161A; NbExp=5; IntAct=EBI-724076, EBI-719941;
Q08E93:FAM27E3; NbExp=5; IntAct=EBI-724076, EBI-2602739;
Q96D16:FBXL18; NbExp=5; IntAct=EBI-724076, EBI-744419;
Q9NWN3:FBXO34; NbExp=3; IntAct=EBI-724076, EBI-719816;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-724076, EBI-744935;
Q3SYB3:FOXD4L6; NbExp=5; IntAct=EBI-724076, EBI-6425864;
P15976-2:GATA1; NbExp=5; IntAct=EBI-724076, EBI-9090198;
P23769:GATA2; NbExp=3; IntAct=EBI-724076, EBI-2806671;
Q99988:GDF15; NbExp=6; IntAct=EBI-724076, EBI-2116863;
P04899:GNAI2; NbExp=5; IntAct=EBI-724076, EBI-353997;
P63218:GNG5; NbExp=3; IntAct=EBI-724076, EBI-10220734;
Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-724076, EBI-5666657;
Q9Y5Q8:GTF3C5; NbExp=3; IntAct=EBI-724076, EBI-1045409;
Q8N4W5:hCG_2008078; NbExp=4; IntAct=EBI-724076, EBI-11746188;
B4DNA4:hCG_20425; NbExp=5; IntAct=EBI-724076, EBI-7399002;
Q9NQ87:HEYL; NbExp=6; IntAct=EBI-724076, EBI-751092;
Q8WVV9:HNRNPLL; NbExp=4; IntAct=EBI-724076, EBI-535849;
P49639:HOXA1; NbExp=3; IntAct=EBI-724076, EBI-740785;
P09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-724076, EBI-3957603;
P17482:HOXB9; NbExp=5; IntAct=EBI-724076, EBI-745290;
Q12329:HSP42 (xeno); NbExp=3; IntAct=EBI-724076, EBI-8571;
P28222:HTR1B; NbExp=6; IntAct=EBI-724076, EBI-1056863;
Q92993:KAT5; NbExp=3; IntAct=EBI-724076, EBI-399080;
Q96MP8-2:KCTD7; NbExp=4; IntAct=EBI-724076, EBI-11954971;
Q15053:KIAA0040; NbExp=5; IntAct=EBI-724076, EBI-2805673;
P52292:KPNA2; NbExp=3; IntAct=EBI-724076, EBI-349938;
Q7Z794:KRT77; NbExp=4; IntAct=EBI-724076, EBI-3045529;
Q14847:LASP1; NbExp=3; IntAct=EBI-724076, EBI-742828;
Q5T7P3:LCE1B; NbExp=3; IntAct=EBI-724076, EBI-10245913;
Q5T5B0:LCE3E; NbExp=5; IntAct=EBI-724076, EBI-10245456;
Q5TA78:LCE4A; NbExp=5; IntAct=EBI-724076, EBI-10246358;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-724076, EBI-10257651;
O75427:LRCH4; NbExp=3; IntAct=EBI-724076, EBI-718707;
Q9Y5V3:MAGED1; NbExp=5; IntAct=EBI-724076, EBI-716006;
Q9HAY2:MAGEF1; NbExp=3; IntAct=EBI-724076, EBI-5525855;
O60336:MAPKBP1; NbExp=7; IntAct=EBI-724076, EBI-947402;
Q92692:NECTIN2; NbExp=4; IntAct=EBI-724076, EBI-718419;
Q8WWR8:NEU4; NbExp=4; IntAct=EBI-724076, EBI-746964;
Q9NQX5:NPDC1; NbExp=7; IntAct=EBI-724076, EBI-748927;
F1D8P7:NR1H2; NbExp=5; IntAct=EBI-724076, EBI-10177172;
P55055:NR1H2; NbExp=3; IntAct=EBI-724076, EBI-745354;
Q13133:NR1H3; NbExp=3; IntAct=EBI-724076, EBI-781356;
Q13133-2:NR1H3; NbExp=3; IntAct=EBI-724076, EBI-12699353;
Q7RTU3:OLIG3; NbExp=5; IntAct=EBI-724076, EBI-10225049;
P32242:OTX1; NbExp=7; IntAct=EBI-724076, EBI-740446;
F8WBZ7:PARP11; NbExp=3; IntAct=EBI-724076, EBI-10177820;
Q92824-2:PCSK5; NbExp=4; IntAct=EBI-724076, EBI-11956269;
Q14554:PDIA5; NbExp=3; IntAct=EBI-724076, EBI-953879;
Q8WV24:PHLDA1; NbExp=3; IntAct=EBI-724076, EBI-738731;
Q7Z2X4:PID1; NbExp=3; IntAct=EBI-724076, EBI-10256685;
Q9HB75:PIDD1; NbExp=3; IntAct=EBI-724076, EBI-520427;
Q8WWB5:PIH1D2; NbExp=5; IntAct=EBI-724076, EBI-10232538;
Q13526:PIN1; NbExp=6; IntAct=EBI-724076, EBI-714158;
P78337:PITX1; NbExp=3; IntAct=EBI-724076, EBI-748265;
Q58EX7:PLEKHG4; NbExp=3; IntAct=EBI-724076, EBI-949255;
O43741:PRKAB2; NbExp=7; IntAct=EBI-724076, EBI-1053424;
Q8WWY3:PRPF31; NbExp=5; IntAct=EBI-724076, EBI-1567797;
Q8WUK0:PTPMT1; NbExp=6; IntAct=EBI-724076, EBI-7199479;
Q3YEC7:RABL6; NbExp=2; IntAct=EBI-724076, EBI-742029;
Q06141:REG3A; NbExp=3; IntAct=EBI-724076, EBI-10223932;
Q0D2K3:RIPPLY1; NbExp=5; IntAct=EBI-724076, EBI-10226430;
Q14D33:RTP5; NbExp=5; IntAct=EBI-724076, EBI-10217913;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-724076, EBI-10313866;
P34896:SHMT1; NbExp=4; IntAct=EBI-724076, EBI-715117;
P34164:SIP2 (xeno); NbExp=3; IntAct=EBI-724076, EBI-17187;
Q15475:SIX1; NbExp=2; IntAct=EBI-724076, EBI-743675;
Q9UBX3:SLC25A10; NbExp=7; IntAct=EBI-724076, EBI-750394;
P06782:SNF1 (xeno); NbExp=3; IntAct=EBI-724076, EBI-17516;
Q6RVD6:SPATA8; NbExp=5; IntAct=EBI-724076, EBI-8635958;
Q9UQ90:SPG7; NbExp=8; IntAct=EBI-724076, EBI-717201;
O43609:SPRY1; NbExp=5; IntAct=EBI-724076, EBI-3866665;
O43597:SPRY2; NbExp=3; IntAct=EBI-724076, EBI-742487;
P35184:SQT1 (xeno); NbExp=3; IntAct=EBI-724076, EBI-17971;
P32589:SSE1 (xeno); NbExp=3; IntAct=EBI-724076, EBI-8648;
Q15583:TGIF1; NbExp=4; IntAct=EBI-724076, EBI-714215;
Q9P2T0:THEG; NbExp=3; IntAct=EBI-724076, EBI-751020;
P19237:TNNI1; NbExp=3; IntAct=EBI-724076, EBI-746692;
Q4VB56:TNP2; NbExp=3; IntAct=EBI-724076, EBI-10241829;
Q96RU7:TRIB3; NbExp=3; IntAct=EBI-724076, EBI-492476;
Q9Y260:TRPV6; NbExp=4; IntAct=EBI-724076, EBI-750052;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-724076, EBI-6447954;
Q6ZVT0:TTLL10; NbExp=3; IntAct=EBI-724076, EBI-7844656;
O75896:TUSC2; NbExp=7; IntAct=EBI-724076, EBI-1052725;
Q8TAI1:TYMSOS; NbExp=6; IntAct=EBI-724076, EBI-742060;
Q06418:TYRO3; NbExp=3; IntAct=EBI-724076, EBI-3951628;
Q9Y2K6:USP20; NbExp=3; IntAct=EBI-724076, EBI-2511991;
P40337:VHL; NbExp=3; IntAct=EBI-724076, EBI-301246;
P40337-2:VHL; NbExp=3; IntAct=EBI-724076, EBI-12157263;
Q15906:VPS72; NbExp=4; IntAct=EBI-724076, EBI-399189;
O96014:WNT11; NbExp=5; IntAct=EBI-724076, EBI-8058160;
P42947:YJL107C (xeno); NbExp=3; IntAct=EBI-724076, EBI-26023;
Q12259:YLR108C (xeno); NbExp=3; IntAct=EBI-724076, EBI-30776;
O43167:ZBTB24; NbExp=8; IntAct=EBI-724076, EBI-744471;
P24278:ZBTB25; NbExp=2; IntAct=EBI-724076, EBI-739899;
Q96C00:ZBTB9; NbExp=5; IntAct=EBI-724076, EBI-395708;
Q68DK2-5:ZFYVE26; NbExp=5; IntAct=EBI-724076, EBI-8656416;
Q8IZC7:ZNF101; NbExp=5; IntAct=EBI-724076, EBI-5278328;
P17014:ZNF12; NbExp=4; IntAct=EBI-724076, EBI-11278550;
Q15973:ZNF124; NbExp=5; IntAct=EBI-724076, EBI-2555767;
P52737:ZNF136; NbExp=9; IntAct=EBI-724076, EBI-749129;
P52744-2:ZNF138; NbExp=3; IntAct=EBI-724076, EBI-10213071;
Q12901-2:ZNF155; NbExp=3; IntAct=EBI-724076, EBI-10227379;
Q9UK11:ZNF223; NbExp=5; IntAct=EBI-724076, EBI-10322867;
Q9UIE0:ZNF230; NbExp=3; IntAct=EBI-724076, EBI-1105361;
Q14C61:ZNF264; NbExp=3; IntAct=EBI-724076, EBI-2826570;
Q14584:ZNF266; NbExp=5; IntAct=EBI-724076, EBI-7115319;
Q9H9D4:ZNF408; NbExp=5; IntAct=EBI-724076, EBI-347633;
Q8TAU3:ZNF417; NbExp=8; IntAct=EBI-724076, EBI-740727;
Q8N7K0:ZNF433; NbExp=3; IntAct=EBI-724076, EBI-10267553;
Q8NDP4:ZNF439; NbExp=9; IntAct=EBI-724076, EBI-747580;
Q8IYI8:ZNF440; NbExp=9; IntAct=EBI-724076, EBI-726439;
Q9ULM2:ZNF490; NbExp=6; IntAct=EBI-724076, EBI-1105370;
Q9BR84:ZNF559; NbExp=6; IntAct=EBI-724076, EBI-746605;
Q8TBZ8:ZNF564; NbExp=5; IntAct=EBI-724076, EBI-10273713;
Q3MI94:ZNF578; NbExp=3; IntAct=EBI-724076, EBI-10241108;
Q9P0T4:ZNF581; NbExp=6; IntAct=EBI-724076, EBI-745520;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-724076, EBI-6427977;
Q96SK3:ZNF607; NbExp=4; IntAct=EBI-724076, EBI-747175;
O15015:ZNF646; NbExp=3; IntAct=EBI-724076, EBI-745608;
Q9BS34:ZNF670; NbExp=4; IntAct=EBI-724076, EBI-745276;
Q8IYX0:ZNF679; NbExp=3; IntAct=EBI-724076, EBI-745567;
Q9H7X3:ZNF696; NbExp=4; IntAct=EBI-724076, EBI-11090299;
Q96C28:ZNF707; NbExp=4; IntAct=EBI-724076, EBI-748111;
Q96H86:ZNF764; NbExp=3; IntAct=EBI-724076, EBI-745775;
Q15937:ZNF79; NbExp=3; IntAct=EBI-724076, EBI-10237274;
Q08AG5:ZNF844; NbExp=5; IntAct=EBI-724076, EBI-10225757;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}.
-!- SIMILARITY: Belongs to the MDFI family. {ECO:0000305}.
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EMBL; U78313; AAB39748.1; -; mRNA.
EMBL; AL035588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC007836; AAH07836.1; -; mRNA.
CCDS; CCDS4857.1; -.
RefSeq; NP_001287733.1; NM_001300804.1.
RefSeq; NP_001287734.1; NM_001300805.1.
RefSeq; NP_001287735.1; NM_001300806.1.
RefSeq; NP_005577.1; NM_005586.3.
UniGene; Hs.520119; -.
ProteinModelPortal; Q99750; -.
SMR; Q99750; -.
BioGrid; 110353; 231.
IntAct; Q99750; 408.
MINT; MINT-190174; -.
STRING; 9606.ENSP00000230321; -.
iPTMnet; Q99750; -.
PhosphoSitePlus; Q99750; -.
BioMuta; MDFI; -.
DMDM; 25090674; -.
MaxQB; Q99750; -.
PaxDb; Q99750; -.
PeptideAtlas; Q99750; -.
PRIDE; Q99750; -.
DNASU; 4188; -.
Ensembl; ENST00000230321; ENSP00000230321; ENSG00000112559.
Ensembl; ENST00000373051; ENSP00000362142; ENSG00000112559.
GeneID; 4188; -.
KEGG; hsa:4188; -.
UCSC; uc003oqq.5; human.
CTD; 4188; -.
EuPathDB; HostDB:ENSG00000112559.13; -.
GeneCards; MDFI; -.
HGNC; HGNC:6967; MDFI.
HPA; HPA049973; -.
MIM; 604971; gene.
neXtProt; NX_Q99750; -.
OpenTargets; ENSG00000112559; -.
PharmGKB; PA30713; -.
eggNOG; ENOG410IYH9; Eukaryota.
eggNOG; ENOG410YK34; LUCA.
GeneTree; ENSGT00390000010600; -.
HOGENOM; HOG000001577; -.
HOVERGEN; HBG031704; -.
InParanoid; Q99750; -.
OMA; HCDAPHG; -.
OrthoDB; EOG091G0RJH; -.
PhylomeDB; Q99750; -.
TreeFam; TF332113; -.
SIGNOR; Q99750; -.
ChiTaRS; MDFI; human.
GeneWiki; MDFI; -.
GenomeRNAi; 4188; -.
PRO; PR:Q99750; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000112559; -.
CleanEx; HS_MDFI; -.
ExpressionAtlas; Q99750; baseline and differential.
Genevisible; Q99750; HS.
GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
GO; GO:0042994; P:cytoplasmic sequestering of transcription factor; TAS:ProtInc.
GO; GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.
GO; GO:0009790; P:embryo development; TAS:ProtInc.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0043392; P:negative regulation of DNA binding; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0060707; P:trophoblast giant cell differentiation; IEA:Ensembl.
InterPro; IPR026134; MDFI/MDFIC.
PANTHER; PTHR15304; PTHR15304; 1.
Pfam; PF15316; MDFI; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Developmental protein; Differentiation;
Nucleus; Reference proteome.
CHAIN 1 246 MyoD family inhibitor.
/FTId=PRO_0000096324.
DOMAIN 99 246 MDFI.
COMPBIAS 163 243 Cys-rich.
SEQUENCE 246 AA; 25029 MW; 9330E52141B79E5A CRC64;
MYQVSGQRPS GCDAPYGAPS AAPGPAQTLS LLPGLEVVTG STHPAEAAPE EGSLEEAATP
MPQGNGPGIP QGLDSTDLDV PTEAVTCQPQ GNPLGCTPLL PNDSGHPSEL GGTRRAGNGA
LGGPKAHRKL QTHPSLASQG SKKSKSSSKS TTSQIPLQAQ EDCCVHCILS CLFCEFLTLC
NIVLDCATCG SCSSEDSCLC CCCCGSGECA DCDLPCDLDC GILDACCESA DCLEICMECC
GLCFSS


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