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MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (XIC)

 MDFIC_XENLA             Reviewed;         246 AA.
Q98SK0;
20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-NOV-2018, entry version 47.
RecName: Full=MyoD family inhibitor domain-containing protein;
AltName: Full=I-mfa domain-containing protein;
AltName: Full=XIC;
Name=mdfic {ECO:0000250|UniProtKB:Q9P1T7};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAG54082.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
TISSUE=Oocyte {ECO:0000269|PubMed:11238923};
PubMed=11238923; DOI=10.1128/MCB.21.5.1866-1873.2001;
Snider L., Thirlwell H., Miller J.R., Moon R.T., Groudine M.,
Tapscott S.J.;
"Inhibition of Tcf3 binding by I-mfa domain proteins.";
Mol. Cell. Biol. 21:1866-1873(2001).
[2] {ECO:0000305}
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15923623; DOI=10.1128/MCB.25.12.5061-5072.2005;
Snider L., Tapscott S.J.;
"XIC is required for Siamois activity and dorsoanterior development.";
Mol. Cell. Biol. 25:5061-5072(2005).
-!- FUNCTION: May act as a transcriptional activator or repressor.
Inhibits the transcriptional activation of Zic family proteins.
Retains nuclear Zic proteins in the cytoplasm (By similarity).
Required for dorsoanterior development. Necessary for siamois to
activate downstream target genes, including gsc, during execution
of the dorsal organizer program. Also regulates the
transcriptional activity of TCF7L1/TCF3 by interacting directly
with TCF7L1/TCF3 and preventing it from binding DNA. {ECO:0000250,
ECO:0000269|PubMed:11238923, ECO:0000269|PubMed:15923623}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P1T7}.
Nucleus {ECO:0000250|UniProtKB:Q9P1T7}. Nucleus, nucleolus
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed broadly at a low level in the early
embryo. {ECO:0000269|PubMed:11238923,
ECO:0000269|PubMed:15923623}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically,
with expression persisting to at least tadpole stages.
{ECO:0000269|PubMed:11238923}.
-!- DOMAIN: The C2H2-type 3, 4 and 5 zinc finger domains are necessary
for transcription activation. The cysteine-rich C-terminus is
involved in its granular distribution in the cytoplasm (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the MDFI family. {ECO:0000255}.
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EMBL; AY017419; AAG54082.1; -; mRNA.
RefSeq; NP_001082078.1; NM_001088609.1.
UniGene; Xl.757; -.
SMR; Q98SK0; -.
BioGrid; 99548; 1.
GeneID; 398213; -.
KEGG; xla:398213; -.
CTD; 398213; -.
Xenbase; XB-GENE-866365; mdfic.
HOVERGEN; HBG068212; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.
GO; GO:0043392; P:negative regulation of DNA binding; IDA:UniProtKB.
GO; GO:0042308; P:negative regulation of protein import into nucleus; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:UniProtKB.
InterPro; IPR026134; MDFI/MDFIC.
PANTHER; PTHR15304; PTHR15304; 1.
Pfam; PF15316; MDFI; 1.
2: Evidence at transcript level;
Activator; Cytoplasm; Developmental protein; Nucleus; Repressor;
Transcription; Transcription regulation.
CHAIN 1 246 MyoD family inhibitor domain-containing
protein.
/FTId=PRO_0000280224.
DOMAIN 74 246 MDFI.
COMPBIAS 167 243 Cys-rich. {ECO:0000255}.
SEQUENCE 246 AA; 26766 MW; 377B9E79A70F765A CRC64;
MSQEREPFSP RPEGPEQVTS TEESLLVPLP HGKCEKENMD LEDTTLYRNK SIQTDIEDRS
ILEDNSNSQP IKAQPQRLPQ PNTSALEQSE EETGKIQNGH VGLSNINGIH NGVKHVPADH
RNISAPVSQK MHRKIQSSLS VSSDGSKKSK ESSAYSQKPS ASPEDGCVHC ILTCLFCEFL
TLCNIVVGQA SCGICTSEAC CCCCTEEMGD DCNCPCDMDC GIMDACCESS DCLEICMECC
GICFPS


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