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Myoblast determination protein 1

 MYOD1_PIG               Reviewed;         319 AA.
P49811;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
25-OCT-2017, entry version 115.
RecName: Full=Myoblast determination protein 1;
Name=MYOD1; Synonyms=MYOD;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Large white X Landrace;
PubMed=7559997; DOI=10.1007/BF00121133;
Chang K.C., Fernandes K., Chantler P.D.;
"Cloning and in vivo expression of the pig MyoD gene.";
J. Muscle Res. Cell Motil. 16:243-247(1995).
-!- FUNCTION: Acts as a transcriptional activator that promotes
transcription of muscle-specific target genes and plays a role in
muscle differentiation. Together with MYF5 and MYOG, co-occupies
muscle-specific gene promoter core region during myogenesis.
Induces fibroblasts to differentiate into myoblasts. Interacts
with and is inhibited by the twist protein. This interaction
probably involves the basic domains of both proteins (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein. Seems to form active heterodimers with ITF-2.
Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2.
Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By
similarity). Interacts with P-TEFB complex; promotes the
transcriptional activity of MYOD1 through its CDK9-mediated
phosphorylation (By similarity). Interacts with CSRP3 (By
similarity). {ECO:0000250|UniProtKB:P10085,
ECO:0000250|UniProtKB:Q02346}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- PTM: Phosphorylated by CDK9. This phosphorylation promotes its
function in muscle differentiation (By similarity). {ECO:0000250}.
-!- PTM: Acetylated by a complex containing EP300 and PCAF. The
acetylation is essential to activate target genes. Conversely, its
deacetylation by SIRT1 inhibits its function (By similarity).
{ECO:0000250}.
-!- PTM: Ubiquitinated on the N-terminus; which is required for
proteasomal degradation. {ECO:0000250}.
-!- PTM: Methylation at Lys-104 by EHMT2/G9a inhibits myogenic
activity. {ECO:0000250}.
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EMBL; U12574; AAA87061.1; -; Genomic_DNA.
RefSeq; NP_001002824.1; NM_001002824.1.
UniGene; Ssc.22906; -.
ProteinModelPortal; P49811; -.
SMR; P49811; -.
STRING; 9823.ENSSSCP00000014214; -.
PaxDb; P49811; -.
GeneID; 407604; -.
KEGG; ssc:407604; -.
CTD; 4654; -.
eggNOG; KOG3960; Eukaryota.
eggNOG; ENOG4111SED; LUCA.
HOGENOM; HOG000234800; -.
HOVERGEN; HBG006429; -.
InParanoid; P49811; -.
KO; K09064; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005667; C:transcription factor complex; ISS:AgBase.
GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
GO; GO:0001047; F:core promoter binding; ISS:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:AgBase.
GO; GO:0008134; F:transcription factor binding; ISS:AgBase.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IBA:GO_Central.
GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
GO; GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
GO; GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
GO; GO:0007517; P:muscle organ development; ISS:AgBase.
GO; GO:0045445; P:myoblast differentiation; ISS:UniProtKB.
GO; GO:0007518; P:myoblast fate determination; ISS:UniProtKB.
GO; GO:0051149; P:positive regulation of muscle cell differentiation; ISS:UniProtKB.
GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
GO; GO:0007519; P:skeletal muscle tissue development; ISS:UniProtKB.
GO; GO:0051146; P:striated muscle cell differentiation; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR002546; Basic.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR022032; Myf5.
Pfam; PF01586; Basic; 1.
Pfam; PF00010; HLH; 1.
Pfam; PF12232; Myf5; 1.
SMART; SM00520; BASIC; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
3: Inferred from homology;
Acetylation; Activator; Complete proteome; Developmental protein;
Differentiation; DNA-binding; Methylation; Myogenesis; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 319 Myoblast determination protein 1.
/FTId=PRO_0000127362.
DOMAIN 109 160 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
MOD_RES 104 104 N6-methyllysine; by EHMT2.
{ECO:0000250|UniProtKB:P15172}.
CROSSLNK 1 1 Peptide (Met-Gly) (interchain with G-Cter
in ubiquitin). {ECO:0000250}.
SEQUENCE 319 AA; 34243 MW; B84E5A5C8CF9B288 CRC64;
MELLSPPLRD VDLTGPDGSL CNFATADDFY DDPCFDSPDL RFFEDLDPRL VHVGALLKPE
EHSHFPAAAH PAPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR
RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAAFYA
PGPLPPGRGG EHYSGDSDAS SPRSNCSDGM MDYSGPPSGA RRRNCYDGTY YSEAPSEPRP
GKNAAVSSLD CLSSIVESIS TESPAAPALL LADTPRESSP GPQEAAAGSE VERGTPTPSP
DAAPQCPASA NPNPIYQVL


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