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Myocyte enhancer factor 2C

 W5Q3K1_SHEEP            Unreviewed;       463 AA.
W5Q3K1;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
30-AUG-2017, entry version 22.
SubName: Full=Myocyte enhancer factor 2C {ECO:0000313|Ensembl:ENSOARP00000017290};
Name=MEF2C {ECO:0000313|Ensembl:ENSOARP00000017290};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017290, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000017290, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017290};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000017290}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
ProRule:PRU00251, ECO:0000256|SAAS:SAAS00579852}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOARP00000017290}.
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EMBL; AMGL01094474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01094475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSOART00000017535; ENSOARP00000017290; ENSOARG00000016099.
GeneTree; ENSGT00390000011828; -.
OMA; HLVMPNS; -.
OrthoDB; EOG091G05BY; -.
Proteomes; UP000002356; Chromosome 5.
ExpressionAtlas; W5Q3K1; baseline.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
GO; GO:0003680; F:AT DNA binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
GO; GO:0035198; F:miRNA binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
GO; GO:0003211; P:cardiac ventricle formation; IEA:Ensembl.
GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:Ensembl.
GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071374; P:cellular response to parathyroid hormone stimulus; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0035984; P:cellular response to trichostatin A; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; IEA:Ensembl.
GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO; GO:0002467; P:germinal center formation; IEA:Ensembl.
GO; GO:0072102; P:glomerulus morphogenesis; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0007611; P:learning or memory; IEA:Ensembl.
GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
GO; GO:0007521; P:muscle cell fate determination; IEA:Ensembl.
GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0072160; P:nephron tubule epithelial cell differentiation; IEA:Ensembl.
GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0030220; P:platelet formation; IEA:Ensembl.
GO; GO:0010694; P:positive regulation of alkaline phosphatase activity; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:2000987; P:positive regulation of behavioral fear response; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
GO; GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
GO; GO:2000111; P:positive regulation of macrophage apoptotic process; IEA:Ensembl.
GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0090073; P:positive regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:2001016; P:positive regulation of skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0003138; P:primary heart field specification; IEA:Ensembl.
GO; GO:2000311; P:regulation of AMPA receptor activity; IEA:Ensembl.
GO; GO:0060998; P:regulation of dendritic spine development; IEA:Ensembl.
GO; GO:0002634; P:regulation of germinal center formation; IEA:Ensembl.
GO; GO:0045652; P:regulation of megakaryocyte differentiation; IEA:Ensembl.
GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:Ensembl.
GO; GO:2000310; P:regulation of NMDA receptor activity; IEA:Ensembl.
GO; GO:0060297; P:regulation of sarcomere organization; IEA:Ensembl.
GO; GO:0051963; P:regulation of synapse assembly; IEA:Ensembl.
GO; GO:0060025; P:regulation of synaptic activity; IEA:Ensembl.
GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0009615; P:response to virus; IEA:Ensembl.
GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
GO; GO:0003185; P:sinoatrial valve morphogenesis; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; IEA:Ensembl.
CDD; cd00265; MADS_MEF2_like; 1.
Gene3D; 3.40.1810.10; -; 1.
InterPro; IPR022102; HJURP_C.
InterPro; IPR033896; MADS_MEF2-like.
InterPro; IPR002100; TF_MADSbox.
Pfam; PF12347; HJURP_C; 1.
Pfam; PF00319; SRF-TF; 1.
PRINTS; PR00404; MADSDOMAIN.
SMART; SM00432; MADS; 1.
SUPFAM; SSF55455; SSF55455; 1.
PROSITE; PS50066; MADS_BOX_2; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00251,
ECO:0000256|SAAS:SAAS00579830};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00251,
ECO:0000256|SAAS:SAAS00579820};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Transcription {ECO:0000256|PROSITE-ProRule:PRU00251,
ECO:0000256|SAAS:SAAS00579844};
Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00251,
ECO:0000256|SAAS:SAAS00579844}.
DOMAIN 1 50 MADS-box. {ECO:0000259|PROSITE:PS50066}.
SEQUENCE 463 AA; 49937 MW; 7F1EFC3CB4E6D9A5 CRC64;
MDERNRQVTF TKRKFGLMKK AYELSVLCDC EIALIIFNST NKLFQYASTD MDKVLLKYTE
YNEPHESRTN SDIVETLRKK GLNGCDSPDP DADDSVGHSP ESEDKYRKIN EDIDLMISRQ
RLCAVPPPNF EMPVSIPVSS HNSLVYSNPV SSLGNPNLLP LAHPSLQRNS MSPGVTHRPP
SAGNTGGLMG GDLASGAGTS AAGNGYGNPR NSPGLLVSPG NLNKNMQAKS PPPMNLGMNN
RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT PTLPGQGMGG
YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW QQQHLHNMPP SALSQLGACT
STHLSQSSNL SLPSTQSLNI KSEPVSPPRD RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS
YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT


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