Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Myocyte-specific enhancer factor 2C

 MEF2C_PONAB             Reviewed;         473 AA.
Q5R444;
01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
12-SEP-2018, entry version 79.
RecName: Full=Myocyte-specific enhancer factor 2C {ECO:0000305};
Name=MEF2C {ECO:0000250|UniProtKB:Q06413};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription activator which binds specifically to the
MEF2 element present in the regulatory regions of many muscle-
specific genes. Controls cardiac morphogenesis and myogenesis, and
is also involved in vascular development. Plays an essential role
in hippocampal-dependent learning and memory by suppressing the
number of excitatory synapses and thus regulating basal and evoked
synaptic transmission. Crucial for normal neuronal development,
distribution, and electrical activity in the neocortex. Necessary
for proper development of megakaryocytes and platelets and for
bone marrow B-lymphopoiesis. Required for B-cell survival and
proliferation in response to BCR stimulation, efficient IgG1
antibody responses to T-cell-dependent antigens and for normal
induction of germinal center B-cells. May also be involved in
neurogenesis and in the development of cortical architecture (By
similarity). {ECO:0000250|UniProtKB:Q06413,
ECO:0000250|UniProtKB:Q8CFN5}.
-!- SUBUNIT: Forms a complex with class II HDACs in undifferentiating
cells. On myogenic differentiation, HDACs are released into the
cytoplasm allowing MEF2s to interact with other proteins for
activation. Interacts with EP300 in differentiating cells; the
interaction acetylates MEF2C leading to increased DNA binding and
activation. Interacts with HDAC7 and CARM1. Interacts with HDAC4
and HDAC9; the interaction with HDACs represses transcriptional
activity. Interacts with LPIN1. Interacts with MYOCD. Interacts
with AKAP13. Interacts with FOXK1; the interaction inhibits MEF2C
transactivation activity. Interacts (via N-terminus) with HABP4;
this interaction decreases DNA-binding activity of MEF2C in
myocardial cells in response to mechanical stress.
{ECO:0000250|UniProtKB:A0A096MJY4, ECO:0000250|UniProtKB:Q06413,
ECO:0000250|UniProtKB:Q8CFN5}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}.
Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}.
-!- DOMAIN: The beta domain is required for enhancement of
transcriptional activity. {ECO:0000250}.
-!- PTM: Phosphorylated on Ser-59; which enhances DNA binding
activity. Phosphorylated on Ser-396; which is required for Lys-391
sumoylation and inhibits transcriptional activity. {ECO:0000250}.
-!- PTM: Acetylated by p300 on several sites in diffentiating
myocytes. Acetylation on Lys-4 increases DNA binding and
transactivation (By similarity). {ECO:0000250}.
-!- PTM: Sumoylated on Lys-391 with SUMO2 but not SUMO1; which
represses transcriptional activity. {ECO:0000250}.
-!- PTM: Proteolytically cleaved in cerebellar granule neurons on
several sites by caspase 3 and caspase 7 following neurotoxicity.
Preferentially cleaves the CDK5-mediated hyperphosphorylated form
which leads to neuron apoptosis and transcriptional inactivation
(By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the MEF2 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; CR861416; CAH93472.1; -; mRNA.
RefSeq; NP_001127669.1; NM_001134197.1.
RefSeq; XP_009239150.1; XM_009240875.1.
UniGene; Pab.19580; -.
ProteinModelPortal; Q5R444; -.
SMR; Q5R444; -.
PRIDE; Q5R444; -.
GeneID; 100174751; -.
KEGG; pon:100174751; -.
CTD; 4208; -.
HOVERGEN; HBG053944; -.
InParanoid; Q5R444; -.
KO; K04454; -.
Proteomes; UP000001595; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
GO; GO:0016528; C:sarcoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0001782; P:B cell homeostasis; ISS:UniProtKB.
GO; GO:0042100; P:B cell proliferation; ISS:UniProtKB.
GO; GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
GO; GO:0001568; P:blood vessel development; ISS:UniProtKB.
GO; GO:0001974; P:blood vessel remodeling; ISS:UniProtKB.
GO; GO:0003211; P:cardiac ventricle formation; ISS:UniProtKB.
GO; GO:0035051; P:cardiocyte differentiation; ISS:UniProtKB.
GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
GO; GO:0035690; P:cellular response to drug; ISS:UniProtKB.
GO; GO:0071498; P:cellular response to fluid shear stress; ISS:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
GO; GO:0071374; P:cellular response to parathyroid hormone stimulus; ISS:UniProtKB.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISS:UniProtKB.
GO; GO:0035984; P:cellular response to trichostatin A; ISS:UniProtKB.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; ISS:UniProtKB.
GO; GO:0002467; P:germinal center formation; ISS:UniProtKB.
GO; GO:0072102; P:glomerulus morphogenesis; ISS:UniProtKB.
GO; GO:0007507; P:heart development; ISS:UniProtKB.
GO; GO:0001947; P:heart looping; ISS:UniProtKB.
GO; GO:0006959; P:humoral immune response; ISS:UniProtKB.
GO; GO:0007611; P:learning or memory; ISS:UniProtKB.
GO; GO:0000165; P:MAPK cascade; ISS:UniProtKB.
GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
GO; GO:0007521; P:muscle cell fate determination; ISS:UniProtKB.
GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0030279; P:negative regulation of ossification; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0072160; P:nephron tubule epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0014033; P:neural crest cell differentiation; ISS:UniProtKB.
GO; GO:0048666; P:neuron development; ISS:UniProtKB.
GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0003151; P:outflow tract morphogenesis; ISS:UniProtKB.
GO; GO:0030220; P:platelet formation; ISS:UniProtKB.
GO; GO:0010694; P:positive regulation of alkaline phosphatase activity; ISS:UniProtKB.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:2000987; P:positive regulation of behavioral fear response; ISS:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
GO; GO:2000727; P:positive regulation of cardiac muscle cell differentiation; ISS:UniProtKB.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.
GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0090073; P:positive regulation of protein homodimerization activity; ISS:UniProtKB.
GO; GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0003138; P:primary heart field specification; ISS:UniProtKB.
GO; GO:0002634; P:regulation of germinal center formation; ISS:UniProtKB.
GO; GO:0045652; P:regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0060025; P:regulation of synaptic activity; ISS:UniProtKB.
GO; GO:0061333; P:renal tubule morphogenesis; ISS:UniProtKB.
GO; GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
GO; GO:0003185; P:sinoatrial valve morphogenesis; ISS:UniProtKB.
GO; GO:0007519; P:skeletal muscle tissue development; ISS:UniProtKB.
GO; GO:0051145; P:smooth muscle cell differentiation; ISS:UniProtKB.
GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; ISS:UniProtKB.
CDD; cd00265; MADS_MEF2_like; 1.
Gene3D; 3.40.1810.10; -; 1.
InterPro; IPR022102; HJURP_C.
InterPro; IPR033896; MADS_MEF2-like.
InterPro; IPR002100; TF_MADSbox.
InterPro; IPR036879; TF_MADSbox_sf.
Pfam; PF12347; HJURP_C; 1.
Pfam; PF00319; SRF-TF; 1.
PRINTS; PR00404; MADSDOMAIN.
SMART; SM00432; MADS; 1.
SUPFAM; SSF55455; SSF55455; 1.
PROSITE; PS00350; MADS_BOX_1; 1.
PROSITE; PS50066; MADS_BOX_2; 1.
2: Evidence at transcript level;
Acetylation; Activator; Apoptosis; Complete proteome; Cytoplasm;
Developmental protein; Differentiation; DNA-binding; Isopeptide bond;
Neurogenesis; Nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1 473 Myocyte-specific enhancer factor 2C.
/FTId=PRO_0000285804.
DOMAIN 3 57 MADS-box. {ECO:0000255|PROSITE-
ProRule:PRU00251}.
DNA_BIND 58 86 Mef2-type. {ECO:0000255}.
REGION 271 278 Beta domain. {ECO:0000250}.
REGION 368 399 Transcription repressor. {ECO:0000250}.
COMPBIAS 4 31 Lys-rich (basic).
COMPBIAS 146 183 Ser-rich.
SITE 432 433 Cleavage. {ECO:0000305}.
MOD_RES 4 4 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8CFN5}.
MOD_RES 59 59 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:Q8CFN5}.
MOD_RES 98 98 Phosphoserine.
{ECO:0000250|UniProtKB:Q8CFN5}.
MOD_RES 106 106 Phosphoserine.
{ECO:0000250|UniProtKB:Q8CFN5}.
MOD_RES 110 110 Phosphoserine.
{ECO:0000250|UniProtKB:Q8CFN5}.
MOD_RES 116 116 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 119 119 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 222 222 Phosphoserine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 228 228 Phosphoserine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 234 234 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 239 239 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 240 240 Phosphoserine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 252 252 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 264 264 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 293 293 Phosphothreonine; by MAPK14.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 300 300 Phosphothreonine; by MAPK14.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 396 396 Phosphoserine; by CDK5.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 419 419 Phosphoserine; by MAPK7.
{ECO:0000250|UniProtKB:Q06413}.
MOD_RES 445 445 Phosphoserine.
{ECO:0000250|UniProtKB:Q06413}.
CROSSLNK 391 391 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 473 AA; 51221 MW; A7982020BB8C8949 CRC64;
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD PDADDSVGHS PESEDKYRKI
NEDIDLMISR QRLCAVPPPN FEMPVSIPVS SHNSLVYSNP VSSLGNPNLL PLAHPSLQRN
SMSPGVTHRP PSAGNTGGLM GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNMQAKS
PPPMNLGMNN RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT
PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW QQQHLHNMPP
SALSQLGACT STHLSQSSNL SLPSTQSLNI KSEPVSPPRD RTTTPSRYPQ HTRHEAGRSP
VDSLSSCSSS YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT


Related products :

Catalog number Product name Quantity
MEF2D_RAT Rat ELISA Kit FOR Myocyte-specific enhancer factor 2D 96T
ISK2_RAT Rat ELISA Kit FOR Myocyte-specific enhancer factor 2A 96T
18-003-43947 Myocyte-specific enhancer factor 2B - N_A Polyclonal 0.1 mg Protein A
18-003-43976 Myocyte-specific enhancer factor 2A - N_A Polyclonal 0.1 mg Protein A
E0559p Rat ELISA Kit FOR Myocyte-specific enhancer factor 2A 96T
CSB-EL013670RA Rat Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit 96T
MEF2A_HUMAN Human ELISA Kit FOR Myocyte-specific enhancer factor 2A 96T
E9776h Human Myocyte Specific Enhancer Factor 2A ELISA Ki 96T
E11975h Human Myocyte Specific Enhancer Factor 2D ELISA Ki 96T
E11974h Human Myocyte Specific Enhancer Factor 2B ELISA Ki 96T
CSB-EL013674RA Rat Myocyte-specific enhancer factor 2D(MEF2D) ELISA kit 96T
CSB-EL013670RA Rat Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit SpeciesRat 96T
CSB-EL013670BO Bovine Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit 96T
CSB-EL013673BO Bovine Myocyte-specific enhancer factor 2C(MEF2C) ELISA kit 96T
CSB-EL013672MO Mouse Myocyte-specific enhancer factor 2B(MEF2B) ELISA kit 96T
CSB-EL013673HU Human Myocyte-specific enhancer factor 2C(MEF2C) ELISA kit 96T
CSB-EL013670PI Pig Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit SpeciesPig 96T
CSB-EL013673PI Pig Myocyte-specific enhancer factor 2C(MEF2C) ELISA kit SpeciesPig 96T
CSB-EL013672HU Human Myocyte-specific enhancer factor 2B(MEF2B) ELISA kit 96T
CSB-EL013670HU Human Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit 96T
CSB-EL013674HU Human Myocyte-specific enhancer factor 2D(MEF2D) ELISA kit 96T
CSB-EL013674RA Rat Myocyte-specific enhancer factor 2D(MEF2D) ELISA kit SpeciesRat 96T
CSB-EL013670MO Mouse Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit 96T
CSB-EL013673MO Mouse Myocyte-specific enhancer factor 2C(MEF2C) ELISA kit 96T
CSB-EL013670CH Chicken Myocyte-specific enhancer factor 2A(MEF2A) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur