Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK)

 MYLK3_RAT               Reviewed;         786 AA.
E9PT87; A8WE96;
03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 1.
23-MAY-2018, entry version 49.
RecName: Full=Myosin light chain kinase 3;
EC=2.7.11.18;
AltName: Full=Cardiac-MyBP-C-associated Ca/CaM kinase;
Short=Cardiac-MLCK;
Name=Mylk3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND TISSUE
SPECIFICITY.
STRAIN=Wistar;
PubMed=20615916; DOI=10.1093/cvr/cvq223;
Gu X., Liu X., Xu D., Li X., Yan M., Qi Y., Yan W., Wang W., Pan J.,
Xu Y., Xi B., Cheng L., Jia J., Wang K., Ge J., Zhou M.;
"Cardiac functional improvement in rats with myocardial infarction by
up-regulating cardiac myosin light chain kinase with neuregulin.";
Cardiovasc. Res. 88:334-343(2010).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
PubMed=17885681; DOI=10.1172/JCI30804;
Seguchi O., Takashima S., Yamazaki S., Asakura M., Asano Y.,
Shintani Y., Wakeno M., Minamino T., Kondo H., Furukawa H.,
Nakamaru K., Naito A., Takahashi T., Ohtsuka T., Kawakami K.,
Isomura T., Kitamura S., Tomoike H., Mochizuki N., Kitakaze M.;
"A cardiac myosin light chain kinase regulates sarcomere assembly in
the vertebrate heart.";
J. Clin. Invest. 117:2812-2824(2007).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155; SER-341 AND
SER-422, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Calmodulin-dependent kinase that phosphorylates MYL2 in
vitro. Promotes sarcomere formation in cardiomyocytes. Increases
cardiomyocyte contractility. {ECO:0000269|PubMed:17885681,
ECO:0000269|PubMed:20615916}.
-!- CATALYTIC ACTIVITY: ATP + [myosin light-chain] = ADP + [myosin
light-chain] phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17885681}.
-!- TISSUE SPECIFICITY: Expressed in cardiomyocytes (at protein
level). Up-regulated in heart after experimental myocardial
infarction at the mRNA level. {ECO:0000269|PubMed:17885681,
ECO:0000269|PubMed:20615916}.
-!- DEVELOPMENTAL STAGE: Up-regulated in the heart from 1 week after
birth through adulthood. {ECO:0000269|PubMed:17885681}.
-!- INDUCTION: by NRG1 (at protein level).
{ECO:0000269|PubMed:20615916}.
-!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
Ser/Thr protein kinase family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; EU236721; ABW96144.1; -; mRNA.
RefSeq; NP_001104280.1; NM_001110810.1.
UniGene; Rn.204358; -.
SMR; E9PT87; -.
STRING; 10116.ENSRNOP00000023657; -.
iPTMnet; E9PT87; -.
PhosphoSitePlus; E9PT87; -.
PaxDb; E9PT87; -.
PeptideAtlas; E9PT87; -.
PRIDE; E9PT87; -.
Ensembl; ENSRNOT00000023657; ENSRNOP00000023657; ENSRNOG00000017546.
GeneID; 291926; -.
KEGG; rno:291926; -.
CTD; 91807; -.
RGD; 1305801; Mylk3.
eggNOG; KOG0032; Eukaryota.
eggNOG; ENOG410XRMJ; LUCA.
GeneTree; ENSGT00760000118877; -.
HOGENOM; HOG000233016; -.
InParanoid; E9PT87; -.
KO; K00907; -.
OMA; CLTTMDK; -.
OrthoDB; EOG091G005W; -.
TreeFam; TF314166; -.
PRO; PR:E9PT87; -.
Proteomes; UP000002494; Chromosome 19.
Bgee; ENSRNOG00000017546; -.
Genevisible; E9PT87; RN.
GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IDA:BHF-UCL.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:BHF-UCL.
GO; GO:0004687; F:myosin light chain kinase activity; IMP:BHF-UCL.
GO; GO:0055003; P:cardiac myofibril assembly; IMP:BHF-UCL.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IBA:GO_Central.
GO; GO:0060298; P:positive regulation of sarcomere organization; IDA:BHF-UCL.
GO; GO:0006468; P:protein phosphorylation; IDA:BHF-UCL.
GO; GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; IEA:Ensembl.
GO; GO:0045214; P:sarcomere organization; IMP:BHF-UCL.
GO; GO:0048769; P:sarcomerogenesis; IMP:BHF-UCL.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium;
Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 786 Myosin light chain kinase 3.
/FTId=PRO_0000419665.
DOMAIN 482 737 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 488 496 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 603 603 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 511 511 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 155 155 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 341 341 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 422 422 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 244 244 T -> A (in Ref. 1; ABW96144).
{ECO:0000305}.
SEQUENCE 786 AA; 85541 MW; 3355DA69E4FCBB26 CRC64;
MSGVSEEDPE GLGPQGLPAL GGACLVTVDK KLNVLTEKVD RLLHFQEDVT EKLQCVCQGM
DHLEQGLHRL EASQELGLAG PGSTSPAAAQ AAWPEVLELV RAVRQEGAQH GARLEALFKM
VVAVDRAITL VGSTIQNSKV DDFILQGTVP WRKGSLADGP EENKEQAEVA GVKPKHVLNT
GSVQAATSRA LWEESQKQDT PVGTVEGLPL IIDTSLKGAD LTQAGASLRQ GVEALDPGQE
PPPTEAESRL PALASEDTGT TLELSVAIDR ISEVLTSLRM SQSAGEGTSS SKPDCSEPGP
QPLGPLTTDS DIHSDEGLPR ISVRMREMTT PEELFETQGG SPIGSAEAPG PGTVLEDQIP
KGARPFPPLP KRSCNNGGAS AEEATGPGAE PIRGPSLVTR DWRDEPVGTT DLQQGRDPGA
VSPEPGKDHA AQGPGRTEAG RRVSSAAEAA IVVLDDSAAP PAPFEHRVVS IKDTLISTSY
TVSQHEVLGG GRFGQVHRCT ERSTGLALAA KIIKVKNIKD REDVKNEINI MNQLSHVNLI
QLYDAFESKN SFTLIMEYVD GGELFDRITD EKYHLTELDV VLFTRQICEG VHYLHQHYIL
HLDLKPENIL CVSQTGHQIK IIDFGLARRY KPREKLKVNF GTPEFLAPEV VNYEFVSFPT
DMWSVGVITY MLLSGLSPFL GETDAETMNF IVNCSWDFDA DTFKGLSEEA KDFVSRLLVK
EKSCRMSATQ CLKHEWLNHL IAKASGSNVR LRSQLLLQKY MAQRKWKKHF HVVTAVNRLR
KFPTCP


Related products :

Catalog number Product name Quantity
EIAAB26028 Cardiac-MyBP-C-associated Ca_CaM kinase,Homo sapiens,Human,MLCK,MYLK3,Putative myosin light chain kinase 3
18-272-196023 cardiac Myosin light chain 1 - Rabbit polyclonal to cardiac Myosin light chain 1; Myosin light chain 1. slow-twitch muscle B_ventricular isoform; MLC1SB; Ventricular_slow twitch myosin alkali light ch 0.05 mg
E1106h ELISA Homo sapiens,Human,Kinase-related protein,KRP,MLCK,MLCK,MYLK,Myosin light chain kinase, smooth muscle,Telokin 96T
U1106h CLIA Homo sapiens,Human,Kinase-related protein,KRP,MLCK,MLCK,MYLK,Myosin light chain kinase, smooth muscle,Telokin 96T
E1106h ELISA kit Homo sapiens,Human,Kinase-related protein,KRP,MLCK,MLCK,MYLK,Myosin light chain kinase, smooth muscle,Telokin 96T
E1530b Rat ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
EIAAB26144 Cardiac MyBP-C,C-protein, cardiac muscle isoform,Mouse,Mus musculus,Mybpc3,Myosin-binding protein C, cardiac-type
EIAAB26138 Cardiac MyBP-C,C-protein, cardiac muscle isoform,Mybpc3,Myosin-binding protein C, cardiac-type,Rat,Rattus norvegicus
EIAAB26146 Cardiac MyBP-C,C-protein, cardiac muscle isoform,Homo sapiens,Human,MYBPC3,Myosin-binding protein C, cardiac-type
E0668m Mouse ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
MYLK2_BOVIN Bovine ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
E0097p Human ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
S39AC_BOVIN Mouse ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
FEZ2_HUMAN Human ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
STEA3_MOUSE Human ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle 96T
E1391h ELISA Cardiac myosin light chain 1,CMLC1,Homo sapiens,Human,MLC1SB,MYL3,Myosin light chain 1, slow-twitch muscle B_ventricular isoform,Myosin light chain 3,Ventricular_slow twitch myosin alkali light 96T
U1391h CLIA Cardiac myosin light chain 1,CMLC1,Homo sapiens,Human,MLC1SB,MYL3,Myosin light chain 1, slow-twitch muscle B_ventricular isoform,Myosin light chain 3,Ventricular_slow twitch myosin alkali light c 96T
MYLK2_RAT ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle; organism: Rat; gene name: Mylk2 96T
E1391h ELISA kit Cardiac myosin light chain 1,CMLC1,Homo sapiens,Human,MLC1SB,MYL3,Myosin light chain 1, slow-twitch muscle B_ventricular isoform,Myosin light chain 3,Ventricular_slow twitch myosin alkali l 96T
U1106m CLIA Kinase-related protein,KRP,MLCK,Mouse,Mus musculus,Mylk,Myosin light chain kinase, smooth muscle,Telokin 96T
E1106m ELISA kit Kinase-related protein,KRP,MLCK,Mouse,Mus musculus,Mylk,Myosin light chain kinase, smooth muscle,Telokin 96T
E1106m ELISA Kinase-related protein,KRP,MLCK,Mouse,Mus musculus,Mylk,Myosin light chain kinase, smooth muscle,Telokin 96T
MYLK2_MOUSE ELISA Kit FOR Myosin light chain kinase 2, skeletal per cardiac muscle; organism: Mouse; gene name: Mylk2 96T
EIAAB26145 Cardiac MyBP-C,Chicken,C-protein, cardiac muscle isoform,Gallus gallus,MYBPC3,Myosin-binding protein C, cardiac-type
YHB0756Ra Rat myosin light chain kinase,MLCK ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur