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N-acetylaspartate synthetase (NAA synthetase) (N-acetyltransferase 8-like protein) (EC 2.3.1.17)

 NAT8L_RAT               Reviewed;         299 AA.
D3ZVU9;
05-APR-2011, integrated into UniProtKB/Swiss-Prot.
20-APR-2010, sequence version 1.
12-SEP-2018, entry version 47.
RecName: Full=N-acetylaspartate synthetase;
Short=NAA synthetase;
AltName: Full=N-acetyltransferase 8-like protein;
EC=2.3.1.17;
Name=Nat8l;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
SUBCELLULAR LOCATION.
PubMed=18621030; DOI=10.1016/j.brainres.2008.06.040;
Ariyannur P.S., Madhavarao C.N., Namboodiri A.M.;
"N-acetylaspartate synthesis in the brain: mitochondria vs.
microsomes.";
Brain Res. 1227:34-41(2008).
[3]
TISSUE SPECIFICITY.
PubMed=20385109; DOI=10.1016/j.brainres.2010.04.008;
Ariyannur P.S., Moffett J.R., Manickam P., Pattabiraman N., Arun P.,
Nitta A., Nabeshima T., Madhavarao C.N., Namboodiri A.M.;
"Methamphetamine-induced neuronal protein NAT8L is the NAA
biosynthetic enzyme: implications for specialized acetyl coenzyme A
metabolism in the CNS.";
Brain Res. 1335:1-13(2010).
-!- FUNCTION: Plays a role in the regulation of lipogenesis by
producing N-acetylaspartate acid (NAA), a brain-specific
metabolite. NAA occurs in high concentration in brain and its
hydrolysis plays a significant part in the maintenance of intact
white matter. Promotes dopamine uptake by regulating TNF-alpha
expression. Attenuates methamphetamine-induced inhibition of
dopamine uptake (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Acetyl-CoA + L-aspartate = CoA + N-acetyl-L-
aspartate.
-!- ACTIVITY REGULATION: Aminooxyacetic acid (AOAA) blocks its
activity in both cytoplasm and mitochondria. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
{ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Microsome membrane {ECO:0000269|PubMed:18621030}; Single-pass type
I membrane protein {ECO:0000269|PubMed:18621030}. Mitochondrion
membrane {ECO:0000269|PubMed:18621030}; Single-pass membrane
protein {ECO:0000269|PubMed:18621030}. Rough endoplasmic reticulum
membrane {ECO:0000250}; Single-pass membrane protein
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in brain, including in mesencephalic
dopaminergic neurons of the substantia nigra and ventral tegmental
area and oligodendrocytes. Expressed in cortical pyramidal neurons
and granule cells of the hippocampus (at protein level).
{ECO:0000269|PubMed:20385109}.
-!- SIMILARITY: Belongs to the camello family. {ECO:0000305}.
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EMBL; CH473963; EDM00108.1; -; Genomic_DNA.
RefSeq; NP_001178610.1; NM_001191681.1.
UniGene; Rn.76732; -.
ProteinModelPortal; D3ZVU9; -.
SMR; D3ZVU9; -.
STRING; 10116.ENSRNOP00000066413; -.
PaxDb; D3ZVU9; -.
PRIDE; D3ZVU9; -.
Ensembl; ENSRNOT00000074734; ENSRNOP00000066413; ENSRNOG00000049351.
GeneID; 289727; -.
KEGG; rno:289727; -.
CTD; 339983; -.
RGD; 1305719; Nat8l.
eggNOG; KOG3139; Eukaryota.
eggNOG; COG0456; LUCA.
GeneTree; ENSGT00390000009559; -.
InParanoid; D3ZVU9; -.
KO; K18309; -.
OMA; YMKPTGS; -.
OrthoDB; EOG091G0JGW; -.
PhylomeDB; D3ZVU9; -.
TreeFam; TF324687; -.
Reactome; R-RNO-70614; Amino acid synthesis and interconversion (transamination).
PRO; PR:D3ZVU9; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000049351; Expressed in 9 organ(s), highest expression level in brain.
Genevisible; D3ZVU9; RN.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0017188; F:aspartate N-acetyltransferase activity; IDA:UniProtKB.
InterPro; IPR016181; Acyl_CoA_acyltransferase.
InterPro; IPR000182; GNAT_dom.
Pfam; PF00583; Acetyltransf_1; 1.
SUPFAM; SSF55729; SSF55729; 1.
PROSITE; PS51186; GNAT; 1.
1: Evidence at protein level;
Acyltransferase; Complete proteome; Cytoplasm; Endoplasmic reticulum;
Membrane; Microsome; Mitochondrion; Reference proteome; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 299 N-acetylaspartate synthetase.
/FTId=PRO_0000406989.
TRANSMEM 118 138 Helical. {ECO:0000255}.
DOMAIN 143 280 N-acetyltransferase.
{ECO:0000255|PROSITE-ProRule:PRU00532}.
SEQUENCE 299 AA; 32719 MW; 4F971F8FFBE65780 CRC64;
MHCGPPDMVC ETKIVATEDH EALPGAKKDA LLAAAGAMWP PLPAAPGPAA APPPAAGPQP
HGGTGGAGPP EGRGVCIREF RAAEQEAARR IFYDGILERI PNTAFRGLRQ HPRTQLLYAL
LAALCFAVTR SLLLTCLVPA GLLALRYYYS RKVILAYLEC ALHTDMADIE QYYMKPPGSC
FWVAVLDGNV VGIVAARAHE EDNTVELLRM SVDSRFRGKG IAKALGRRVL EFAMLHNYSA
VVLGTTAVKV AAHKLYESLG FRHMGASDHY VLPGMTLSLA ERLFFQVRYH RYRLQLREE


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