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N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)

 GALNS_HUMAN             Reviewed;         522 AA.
P34059; Q86VK3;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
30-AUG-2017, entry version 172.
RecName: Full=N-acetylgalactosamine-6-sulfatase;
EC=3.1.6.4;
AltName: Full=Chondroitinsulfatase;
Short=Chondroitinase;
AltName: Full=Galactose-6-sulfate sulfatase;
Short=GalN6S;
AltName: Full=N-acetylgalactosamine-6-sulfate sulfatase;
Short=GalNAc6S sulfatase;
Flags: Precursor;
Name=GALNS;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Placenta;
PubMed=1755850; DOI=10.1016/0006-291X(91)91244-7;
Tomatsu S., Fukuda S., Masue M., Sukegawa K., Fukao T., Yamagishi A.,
Hori T., Iwata H., Ogawa T., Nakashima Y., Hanyu Y., Hashimoto T.,
Titani K., Oyama R., Suzuki M., Yagi K., Hayashi Y., Orii T.;
"Morquio disease: isolation, characterization and expression of full-
length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase.";
Biochem. Biophys. Res. Commun. 181:677-683(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8001980; DOI=10.1006/geno.1994.1443;
Morris C.P., Guo X.H., Apostolou S., Hopwood J.J., Scott H.S.;
"Morquio A syndrome: cloning, sequence, and structure of the human N-
acetylgalactosamine 6-sulfatase (GALNS) gene.";
Genomics 22:652-654(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-423.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of
multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[6]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 27-522, GLYCOSYLATION AT
ASN-204 AND ASN-423, OXOALANINE AT CYS-79, SUBUNIT, COFACTOR,
CATALYTIC ACTIVITY, CALCIUM-BINDING SITES, AND DISULFIDE BONDS.
PubMed=22940367; DOI=10.1016/j.jmb.2012.08.020;
Rivera-Colon Y., Schutsky E.K., Kita A.Z., Garman S.C.;
"The structure of human GALNS reveals the molecular basis for
mucopolysaccharidosis IV A.";
J. Mol. Biol. 423:736-751(2012).
[7]
INVOLVEMENT IN MPS4A, AND VARIANT MPS4A LYS-204.
PubMed=1522213; DOI=10.1172/JCI115919;
Fukuda S., Tomatsu S., Masue M., Sukegawa K., Iwata H., Ogawa T.,
Nakashima Y., Hori T., Yamagishi A., Hanyu Y., Morooka K., Kiman T.,
Hashimoto T., Orii T.;
"Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate
sulfatase exonic point mutations in classical Morquio and mild
cases.";
J. Clin. Invest. 90:1049-1053(1992).
[8]
VARIANTS MPS4A ARG-77; TRP-90; VAL-96; PHE-113; LEU-151; GLY-230;
THR-291; CYS-386 AND SER-487.
PubMed=7668283;
Tomatsu S., Fukuda S., Cooper A., Wraith J.E., Maruf Rezvi G.,
Yamagishi A., Yamada N., Kato Z., Isogai K., Sukegawa K., Kondo N.,
Suzuki Y., Shimozawa N., Orii T.;
"Mucopolysaccharidosis IVA: identification of a common missense
mutation I113F in the N-Acetylgalactosamine-6-sulfate sulfatase
gene.";
Am. J. Hum. Genet. 57:556-563(1995).
[9]
VARIANTS MPS4A.
PubMed=7795586; DOI=10.1093/hmg/4.3.341;
Ogawa T., Tomatsu S., Fukuda S., Yamagishi A., Maruf Rezvi G.,
Sukegawa K., Kondo N., Suzuki Y., Shimozawa N., Orii T.;
"Mucopolysaccharidosis IVA: screening and identification of mutations
of the N-acetylgalactosamine-6-sulfate sulfatase gene.";
Hum. Mol. Genet. 4:341-349(1995).
[10]
VARIANTS MPS4A ARG-77; TRP-90; VAL-96; LEU-151; GLY-230 AND THR-291.
PubMed=7633425; DOI=10.1093/hmg/4.4.741;
Tomatsu S., Fukuda S., Cooper A., Wraith J.E., Maruf Rezvi G.,
Yamagishi A., Yamada N., Kato Z., Isogai K., Sukegawa K., Kondo N.,
Suzuki Y., Shimozawa N., Orii T.;
"Mucopolysaccharidosis type IVA: identification of six novel mutations
among non-Japanese patients.";
Hum. Mol. Genet. 4:741-743(1995).
[11]
VARIANT MPS4A SER-487.
PubMed=7581409; DOI=10.1002/humu.1380060218;
Tomatsu S., Fukuda S., Cooper A., Wraith J.E., Yamada N., Isogai K.,
Kato Z., Sukegawa K., Kondo N., Suzuki Y., Shimozawa N., Orii T.;
"Two new mutations, Q473X and N487S, in a Caucasian patient with
mucopolysaccharidosis IVA (Morquio disease).";
Hum. Mutat. 6:195-196(1995).
[12]
VARIANTS MPS4A ALA-138; SER-151 AND LEU-151.
PubMed=8651279;
Tomatsu S., Fukuda S., Yamagishi A., Cooper A., Wraith J.E., Hori T.,
Kato Z., Yamada N., Isogai K., Sukegawa K., Kondo N., Suzuki Y.,
Shimozawa N., Orii T.;
"Mucopolysaccharidosis IVA: four new exonic mutations in patients with
N-acetylgalactosamine-6-sulfate sulfatase deficiency.";
Am. J. Hum. Genet. 58:950-962(1996).
[13]
VARIANTS MPS4A CYS-94 AND VAL-97.
PubMed=8826435;
DOI=10.1002/(SICI)1096-8628(19960628)63:4<558::AID-AJMG9>3.3.CO;2-V;
Cole D.E.C., Fukuda S., Gordon B.A., Rip J.W., Lecouteur A.N.,
Rupar C.A., Tomatsu S., Ogawa T., Sukegawa K., Orii T.;
"Heteroallelic missense mutations of the galactosamine-6-sulfate
sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA).";
Am. J. Med. Genet. 63:558-565(1996).
[14]
VARIANTS MPS4A.
PubMed=9298823;
DOI=10.1002/(SICI)1098-1004(1997)10:3<223::AID-HUMU8>3.3.CO;2-M;
Bunge S., Kleijer W.J., Tylki-Szymanska A., Steglich C., Beck M.,
Tomatsu S., Fukuda S., Poorthuis B.J.H.M., Czartoryska B., Orii T.,
Gal A.;
"Identification of 31 novel mutations in the N-acetylgalactosamine-6-
sulfatase gene reveals excessive allelic heterogeneity among patients
with Morquio A syndrome.";
Hum. Mutat. 10:223-232(1997).
[15]
VARIANTS MPS4A LEU-80; CYS-94; VAL-97; LEU-125; SER-139; GLN-166;
GLY-185; SER-290; ARG-309; VAL-351; CYS-386; VAL-391 AND PRO-395.
PubMed=9375852;
DOI=10.1002/(SICI)1098-1004(1997)10:5<368::AID-HUMU6>3.0.CO;2-B;
Tomatsu S., Fukuda S., Cooper A., Wraith J.E., Ferreira P.,
di Natale P., Tortora P., Fujimoto A., Kato Z., Yamada N., Isogai K.,
Yamagishi A., Sukegawa K., Suzuki Y., Shimozawa N., Kondo N.,
Sly W.S., Orii T.;
"Fourteen novel mucopolysaccharidosis IVA producing mutations in GALNS
gene.";
Hum. Mutat. 10:368-375(1997).
[16]
VARIANTS MPS4A VAL-96; PHE-113; ARG-135; CYS-156; LEU-179; THR-257;
VAL-284; SER-312; GLN-376 AND VAL-395.
PubMed=9521421;
DOI=10.1002/(SICI)1098-1004(1998)11:3<202::AID-HUMU4>3.0.CO;2-J;
Yamada N., Fukuda S., Tomatsu S., Muller V., Hopwood J.J., Nelson J.,
Kato Z., Yamagishi A., Sukegawa K., Kondo N., Orii T.;
"Molecular heterogeneity in mucopolysaccharidosis IVA in Australia and
Northern Ireland: nine novel mutations including T312S, a common
allele that confers a mild phenotype.";
Hum. Mutat. 11:202-208(1998).
[17]
VARIANTS SER-393 AND MET-488.
PubMed=9452036;
Tomatsu S., Fukuda S., Cooper A., Wraith J.E., Yamagishi A., Kato Z.,
Yamada N., Isogai K., Sukegawa K., Suzuki Y., Shimozawa N., Kondo N.,
Orii T.;
"Fifteen polymorphisms in the N-acetylgalactosamine-6-sulfate
sulfatase (GALNS) gene: diagnostic implications in Morquio disease.";
Hum. Mutat. Suppl. 1:S42-S46(1998).
[18]
VARIANTS MPS4A MET-15; 17-LEU-SER-18 DEL; ARG-23; PRO-36; LEU-41;
GLU-42; 52-PRO--GLU-55 DEL; PHE-53; TRP-61; VAL-69; 71-ASN--SER-74
DELINS THR; TYR-79; LEU-94; THR-107; SER-116; CYS-141; TYR-150;
GLU-155; PHE-162; THR-164; VAL-167; ALA-171; SER-179; VAL-203;
ASN-233; PHE-239; TRP-253; ASP-260; PHE-285 DEL; PRO-307; ASN-310;
CYS-325; ASP-340; ARG-341; PRO-345; PRO-352; LEU-357; PRO-369;
THR-380; SER-380; HIS-386; ASN-388; VAL-392; ASP-398; TYR-401;
403-TRP-THR-404 DEL; ILE-452; PRO-470 AND SER-484, AND VARIANTS
MET-67; VAL-178; MET-200; GLY-231; SER-393; VAL-459 AND MET-488.
PubMed=16287098; DOI=10.1002/humu.20257;
Tomatsu S., Montano A.M., Nishioka T., Gutierrez M.A., Pena O.M.,
Tranda Firescu G.G., Lopez P., Yamaguchi S., Noguchi A., Orii T.;
"Mutation and polymorphism spectrum of the GALNS gene in
mucopolysaccharidosis IVA (Morquio A).";
Hum. Mutat. 26:500-512(2005).
[19]
VARIANTS [LARGE SCALE ANALYSIS] TRP-61 AND THR-510.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
[20]
VARIANTS MPS4A GLU-16; ARG-36; ASN-40; GLY-48; LYS-51; ARG-77; LEU-80;
LEU-81; GLU-84; TRP-90; PRO-91; CYS-94; LEU-94; PHE-113; VAL-116;
SER-116; SER-139; ARG-141; TYR-145; LEU-151; ARG-155; LEU-156;
ARG-166; SER-179; GLU-201; PRO-214; SER-216; GLY-230; ASN-233;
LYS-235; THR-264; LEU-287; THR-291; CYS-301; SER-312; ARG-318;
LEU-357; GLY-380; THR-380; CYS-386; HIS-386; VAL-391; VAL-392;
HIS-407; VAL-415; THR-416; ARG-420; THR-492; VAL-494; SER-500 AND
PHE-507, VARIANTS PHE-74; ASP-121; CYS-159; TYR-165; GLN-251; CYS-254;
LYS-260 AND LYS-495, AND CHARACTERIZATION OF VARIANTS MPS4A GLU-16;
ARG-36; LYS-51; LEU-81; GLU-84; PRO-91; VAL-116; TYR-145; LEU-156;
ARG-166; GLU-201; PRO-214; SER-216; THR-264; GLY-380; VAL-415;
THR-416; ARG-420; THR-492 AND SER-500.
PubMed=24726177; DOI=10.1016/j.ymgme.2014.03.004;
Morrone A., Tylee K.L., Al-Sayed M., Brusius-Facchin A.C.,
Caciotti A., Church H.J., Coll M.J., Davidson K., Fietz M.J., Gort L.,
Hegde M., Kubaski F., Lacerda L., Laranjeira F., Leistner-Segal S.,
Mooney S., Pajares S., Pollard L., Ribeiro I., Wang R.Y., Miller N.;
"Molecular testing of 163 patients with Morquio A
(Mucopolysaccharidosis IVA) identifies 39 novel GALNS mutations.";
Mol. Genet. Metab. 112:160-170(2014).
-!- CATALYTIC ACTIVITY: Hydrolysis of the 6-sulfate groups of the N-
acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and
of the D-galactose 6-sulfate units of keratan sulfate.
{ECO:0000269|PubMed:22940367}.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Evidence={ECO:0000269|PubMed:22940367};
Note=Binds 1 Ca(2+) ion per subunit.
{ECO:0000269|PubMed:22940367};
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:22940367}.
-!- SUBCELLULAR LOCATION: Lysosome.
-!- PTM: The conversion to 3-oxoalanine (also known as C-
formylglycine, FGly), of a serine or cysteine residue in
prokaryotes and of a cysteine residue in eukaryotes, is critical
for catalytic activity. {ECO:0000269|PubMed:22940367}.
-!- DISEASE: Mucopolysaccharidosis 4A (MPS4A) [MIM:253000]: A form of
mucopolysaccharidosis type 4, an autosomal recessive lysosomal
storage disease characterized by intracellular accumulation of
keratan sulfate and chondroitin-6-sulfate. Key clinical features
include short stature, skeletal dysplasia, dental anomalies, and
corneal clouding. Intelligence is normal and there is no direct
central nervous system involvement, although the skeletal changes
may result in neurologic complications. There is variable
severity, but patients with the severe phenotype usually do not
survive past the second or third decade of life.
{ECO:0000269|PubMed:1522213, ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177, ECO:0000269|PubMed:7581409,
ECO:0000269|PubMed:7633425, ECO:0000269|PubMed:7668283,
ECO:0000269|PubMed:7795586, ECO:0000269|PubMed:8651279,
ECO:0000269|PubMed:8826435, ECO:0000269|PubMed:9298823,
ECO:0000269|PubMed:9375852, ECO:0000269|PubMed:9521421}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- SIMILARITY: Belongs to the sulfatase family. {ECO:0000305}.
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EMBL; D17629; BAA04535.1; -; Genomic_DNA.
EMBL; U06088; AAC51350.1; -; Genomic_DNA.
EMBL; U06078; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06079; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06080; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06081; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06082; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06083; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06084; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06085; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06086; AAC51350.1; JOINED; Genomic_DNA.
EMBL; U06087; AAC51350.1; JOINED; Genomic_DNA.
EMBL; BC050684; AAH50684.2; -; mRNA.
EMBL; BC056151; AAH56151.1; -; mRNA.
CCDS; CCDS10970.1; -.
PIR; JQ1299; KJHUG6.
RefSeq; NP_000503.1; NM_000512.4.
UniGene; Hs.271383; -.
PDB; 4FDI; X-ray; 2.20 A; A/B=27-522.
PDB; 4FDJ; X-ray; 2.81 A; A/B=27-522.
PDBsum; 4FDI; -.
PDBsum; 4FDJ; -.
ProteinModelPortal; P34059; -.
SMR; P34059; -.
BioGrid; 108860; 38.
IntAct; P34059; 1.
STRING; 9606.ENSP00000268695; -.
DrugBank; DB09051; Elosulfase alfa.
iPTMnet; P34059; -.
PhosphoSitePlus; P34059; -.
BioMuta; GALNS; -.
DMDM; 462148; -.
EPD; P34059; -.
MaxQB; P34059; -.
PaxDb; P34059; -.
PeptideAtlas; P34059; -.
PRIDE; P34059; -.
DNASU; 2588; -.
Ensembl; ENST00000268695; ENSP00000268695; ENSG00000141012.
GeneID; 2588; -.
KEGG; hsa:2588; -.
UCSC; uc002fly.4; human.
CTD; 2588; -.
DisGeNET; 2588; -.
GeneCards; GALNS; -.
GeneReviews; GALNS; -.
H-InvDB; HIX0134371; -.
HGNC; HGNC:4122; GALNS.
HPA; CAB026404; -.
MalaCards; GALNS; -.
MIM; 253000; phenotype.
MIM; 612222; gene.
neXtProt; NX_P34059; -.
OpenTargets; ENSG00000141012; -.
Orphanet; 309297; Mucopolysaccharidosis type 4A.
PharmGKB; PA28535; -.
eggNOG; KOG3867; Eukaryota.
eggNOG; COG3119; LUCA.
GeneTree; ENSGT00760000119062; -.
HOGENOM; HOG000135352; -.
HOVERGEN; HBG004283; -.
InParanoid; P34059; -.
KO; K01132; -.
OMA; WEEFRQG; -.
OrthoDB; EOG091G07AL; -.
PhylomeDB; P34059; -.
TreeFam; TF314186; -.
BioCyc; MetaCyc:HS06790-MONOMER; -.
BRENDA; 3.1.6.4; 2681.
Reactome; R-HSA-2022857; Keratan sulfate degradation.
Reactome; R-HSA-6798695; Neutrophil degranulation.
ChiTaRS; GALNS; human.
GeneWiki; Galactosamine-6_sulfatase; -.
GenomeRNAi; 2588; -.
PRO; PR:P34059; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000141012; -.
CleanEx; HS_GALNS; -.
ExpressionAtlas; P34059; baseline and differential.
Genevisible; P34059; HS.
GO; GO:0035578; C:azurophil granule lumen; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003943; F:N-acetylgalactosamine-4-sulfatase activity; TAS:ProtInc.
GO; GO:0043890; F:N-acetylgalactosamine-6-sulfatase activity; IEA:UniProtKB-EC.
GO; GO:0008484; F:sulfuric ester hydrolase activity; IDA:MGI.
GO; GO:0042340; P:keratan sulfate catabolic process; TAS:Reactome.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
CDD; cd16157; GALNS; 1.
Gene3D; 3.40.720.10; -; 2.
InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
InterPro; IPR017850; Alkaline_phosphatase_core.
InterPro; IPR035626; GALNS.
InterPro; IPR024607; Sulfatase_CS.
InterPro; IPR000917; Sulfatase_N.
Pfam; PF00884; Sulfatase; 1.
SUPFAM; SSF53649; SSF53649; 1.
PROSITE; PS00523; SULFATASE_1; 1.
PROSITE; PS00149; SULFATASE_2; 1.
1: Evidence at protein level;
3D-structure; Calcium; Complete proteome; Direct protein sequencing;
Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; Hydrolase;
Lysosome; Metal-binding; Mucopolysaccharidosis; Polymorphism;
Reference proteome; Signal.
SIGNAL 1 26
CHAIN 27 522 N-acetylgalactosamine-6-sulfatase.
/FTId=PRO_0000033411.
REGION 27 379 Catalytic domain.
METAL 39 39 Calcium. {ECO:0000269|PubMed:22940367}.
METAL 40 40 Calcium. {ECO:0000269|PubMed:22940367}.
METAL 79 79 Calcium; via 3-oxoalanine.
{ECO:0000269|PubMed:22940367}.
METAL 288 288 Calcium. {ECO:0000269|PubMed:22940367}.
METAL 289 289 Calcium. {ECO:0000269|PubMed:22940367}.
MOD_RES 79 79 3-oxoalanine (Cys).
{ECO:0000269|PubMed:22940367}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:22940367}.
CARBOHYD 423 423 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19159218,
ECO:0000269|PubMed:22940367}.
DISULFID 308 419 {ECO:0000269|PubMed:22940367}.
DISULFID 489 518 {ECO:0000269|PubMed:22940367}.
DISULFID 501 507 {ECO:0000269|PubMed:22940367}.
VARIANT 15 15 L -> M (in MPS4A; dbSNP:rs866745731).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024873.
VARIANT 16 16 V -> E (in MPS4A; reduced enzymatic
activity; dbSNP:rs794729202).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071569.
VARIANT 17 18 Missing (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024874.
VARIANT 23 23 G -> R (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024875.
VARIANT 36 36 L -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024876.
VARIANT 36 36 L -> R (in MPS4A; reduced enzymatic
activity; dbSNP:rs755832705).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071570.
VARIANT 40 40 D -> N (in MPS4A).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071571.
VARIANT 41 41 M -> L (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024877.
VARIANT 42 42 G -> E (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024878.
VARIANT 47 47 G -> R (in MPS4A; severe form;
dbSNP:rs199638097).
/FTId=VAR_007172.
VARIANT 48 48 V -> G (in MPS4A; dbSNP:rs191519947).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071572.
VARIANT 51 51 E -> K (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071573.
VARIANT 52 55 Missing (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024879.
VARIANT 53 53 S -> F (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024880.
VARIANT 60 60 D -> N (in MPS4A; mild form;
dbSNP:rs118204447).
/FTId=VAR_007173.
VARIANT 61 61 R -> W (in MPS4A; dbSNP:rs145798311).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:16959974}.
/FTId=VAR_024881.
VARIANT 67 67 L -> M (associated with S-409 in a MPS4A
patient; dbSNP:rs11862754).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_007174.
VARIANT 69 69 F -> V (in MPS4A; dbSNP:rs118204445).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024882.
VARIANT 71 74 NFYS -> T (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024883.
VARIANT 74 74 S -> F. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071574.
VARIANT 77 77 P -> R (in MPS4A; severe form).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283}.
/FTId=VAR_007175.
VARIANT 79 79 C -> Y (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024884.
VARIANT 80 80 S -> L (in MPS4A; intermediate form).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007177.
VARIANT 81 81 P -> L (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071575.
VARIANT 84 84 A -> E (in MPS4A; loss of enzymatic
activity; dbSNP:rs141340188).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071576.
VARIANT 90 90 R -> W (in MPS4A; severe form).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283}.
/FTId=VAR_007178.
VARIANT 91 91 L -> P (in MPS4A; loss of enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071577.
VARIANT 94 94 R -> C (in MPS4A; mild/intermediate
form). {ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:8826435,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007179.
VARIANT 94 94 R -> G (in MPS4A; mild/intermediate form;
dbSNP:rs118204441).
/FTId=VAR_007180.
VARIANT 94 94 R -> L (in MPS4A).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024885.
VARIANT 96 96 G -> C (in MPS4A).
/FTId=VAR_007181.
VARIANT 96 96 G -> V (in MPS4A; severe form).
{ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283,
ECO:0000269|PubMed:9521421}.
/FTId=VAR_007182.
VARIANT 97 97 F -> V (in MPS4A; mild form).
{ECO:0000269|PubMed:8826435,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007183.
VARIANT 107 107 A -> T (in MPS4A; dbSNP:rs763184657).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024886.
VARIANT 111 111 Q -> R (in MPS4A; intermediate form).
/FTId=VAR_007184.
VARIANT 113 113 I -> F (in MPS4A; severe form; common
mutation; found in patients with Irish-
British ancestry; dbSNP:rs118204438).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7668283,
ECO:0000269|PubMed:9521421}.
/FTId=VAR_007185.
VARIANT 116 116 G -> S (in MPS4A).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024887.
VARIANT 116 116 G -> V (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071578.
VARIANT 121 121 E -> D. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071579.
VARIANT 125 125 P -> L (in MPS4A; severe form;
dbSNP:rs746949976).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007186.
VARIANT 135 135 S -> R (in MPS4A; severe form).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007187.
VARIANT 138 138 V -> A (in MPS4A; mild/severe/
intermediate form; dbSNP:rs118204436).
{ECO:0000269|PubMed:8651279}.
/FTId=VAR_007188.
VARIANT 139 139 G -> S (in MPS4A; severe form;
dbSNP:rs146093755).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007189.
VARIANT 141 141 W -> C (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024888.
VARIANT 141 141 W -> R (in MPS4A; severe form;
dbSNP:rs794727625).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007190.
VARIANT 145 145 H -> Y (in MPS4A; reduced enzymatic
activity; dbSNP:rs577334837).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071580.
VARIANT 150 150 H -> Y (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024889.
VARIANT 151 151 P -> L (in MPS4A; severe form;
dbSNP:rs559063128).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283,
ECO:0000269|PubMed:8651279}.
/FTId=VAR_007191.
VARIANT 151 151 P -> S (in MPS4A; severe form).
{ECO:0000269|PubMed:8651279}.
/FTId=VAR_007192.
VARIANT 155 155 G -> E (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024890.
VARIANT 155 155 G -> R (in MPS4A; severe form;
dbSNP:rs398123438).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007193.
VARIANT 156 156 F -> C (in MPS4A; severe form).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007194.
VARIANT 156 156 F -> L (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071581.
VARIANT 156 156 F -> S (in MPS4A; mild form).
/FTId=VAR_007195.
VARIANT 159 159 W -> C. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071582.
VARIANT 162 162 S -> F (in MPS4A; dbSNP:rs118204444).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024891.
VARIANT 164 164 N -> T (in MPS4A; dbSNP:rs761725425).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024892.
VARIANT 165 165 C -> Y (in dbSNP:rs768757999).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071583.
VARIANT 166 166 H -> Q (in MPS4A; severe form).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007196.
VARIANT 166 166 H -> R (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071584.
VARIANT 167 167 F -> V (in MPS4A; dbSNP:rs148565559).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024893.
VARIANT 168 168 G -> R (in MPS4A; dbSNP:rs775732598).
/FTId=VAR_007197.
VARIANT 171 171 D -> A (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024894.
VARIANT 178 178 I -> V. {ECO:0000269|PubMed:16287098}.
/FTId=VAR_007198.
VARIANT 179 179 P -> H (in MPS4A; severe form).
/FTId=VAR_007199.
VARIANT 179 179 P -> L (in MPS4A; severe form).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007200.
VARIANT 179 179 P -> S (in MPS4A).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024895.
VARIANT 185 185 E -> G (in MPS4A; severe form).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007201.
VARIANT 200 200 T -> M (in dbSNP:rs7187889).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_007202.
VARIANT 201 201 G -> E (in MPS4A; reduced enzymatic
activity; dbSNP:rs772413313).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071585.
VARIANT 203 203 A -> V (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024896.
VARIANT 204 204 N -> K (in MPS4A; mild form;
dbSNP:rs118204435).
{ECO:0000269|PubMed:1522213}.
/FTId=VAR_007203.
VARIANT 214 214 L -> P (in MPS4A; reduced enzymatic
activity; dbSNP:rs771810111).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071586.
VARIANT 216 216 F -> S (in MPS4A; reduced enzymatic
activity; dbSNP:rs747805226).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071587.
VARIANT 230 230 W -> G (in MPS4A; severe form).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283}.
/FTId=VAR_007204.
VARIANT 231 231 A -> G (in dbSNP:rs34745339).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_007205.
VARIANT 233 233 D -> N (in MPS4A; dbSNP:rs753051547).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024897.
VARIANT 235 235 T -> K (in MPS4A; dbSNP:rs398123440).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071588.
VARIANT 239 239 V -> F (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024898.
VARIANT 247 247 G -> D (in MPS4A; dbSNP:rs761385192).
/FTId=VAR_007206.
VARIANT 251 251 R -> Q. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071589.
VARIANT 253 253 R -> W (in MPS4A; dbSNP:rs775300515).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024899.
VARIANT 254 254 Y -> C. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071590.
VARIANT 257 257 A -> T (in MPS4A; severe form;
dbSNP:rs773283163).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007207.
VARIANT 259 259 R -> Q (in MPS4A; mild form;
dbSNP:rs118204442).
/FTId=VAR_007208.
VARIANT 260 260 E -> D (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024900.
VARIANT 260 260 E -> K. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071591.
VARIANT 264 264 S -> T (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071592.
VARIANT 279 287 Missing (in MPS4A; mild form).
/FTId=VAR_007209.
VARIANT 284 284 F -> V (in MPS4A; severe form;
dbSNP:rs144067930).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007210.
VARIANT 285 285 Missing (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024901.
VARIANT 287 287 S -> L (in MPS4A; severe form;
dbSNP:rs770053354).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007211.
VARIANT 290 290 G -> S (in MPS4A; severe form).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007212.
VARIANT 291 291 A -> D (in MPS4A; mild form).
/FTId=VAR_007213.
VARIANT 291 291 A -> T (in MPS4A; severe form;
dbSNP:rs118204448).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7633425,
ECO:0000269|PubMed:7668283}.
/FTId=VAR_007214.
VARIANT 295 295 S -> F (in MPS4A; mild form;
dbSNP:rs149239881).
/FTId=VAR_007215.
VARIANT 301 301 G -> C (in MPS4A; severe form;
dbSNP:rs118204443).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007216.
VARIANT 307 307 L -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024902.
VARIANT 309 309 G -> R (in MPS4A; severe form).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007217.
VARIANT 310 310 K -> N (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024903.
VARIANT 312 312 T -> S (in MPS4A; mild/intermediate/
severe form; dbSNP:rs118204446).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:9521421}.
/FTId=VAR_007218.
VARIANT 318 318 M -> R (in MPS4A; severe form;
dbSNP:rs746756997).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007219.
VARIANT 325 325 W -> C (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024904.
VARIANT 325 325 Missing (in MPS4A).
/FTId=VAR_007220.
VARIANT 340 340 G -> D (in MPS4A; dbSNP:rs267606838).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024905.
VARIANT 341 341 S -> R (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024906.
VARIANT 343 343 M -> R (in MPS4A; severe form).
/FTId=VAR_007221.
VARIANT 344 344 D -> E (in MPS4A).
/FTId=VAR_007222.
VARIANT 344 344 D -> N (in MPS4A; severe form).
/FTId=VAR_007223.
VARIANT 345 345 L -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024907.
VARIANT 346 346 F -> L (in MPS4A; severe form).
/FTId=VAR_007224.
VARIANT 351 351 A -> V (in MPS4A; severe form;
dbSNP:rs761386453).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007225.
VARIANT 352 352 L -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024908.
VARIANT 357 357 P -> L (in MPS4A; dbSNP:rs769748679).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024909.
VARIANT 361 361 R -> G (in MPS4A; dbSNP:rs778120439).
/FTId=VAR_007226.
VARIANT 369 369 L -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024910.
VARIANT 376 376 R -> Q (in MPS4A; severe form;
dbSNP:rs150734270).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007227.
VARIANT 380 380 R -> G (in MPS4A; loss of enzymatic
activity; dbSNP:rs770908172).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071593.
VARIANT 380 380 R -> S (in MPS4A; dbSNP:rs200763834).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024911.
VARIANT 380 380 R -> T (in MPS4A).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024912.
VARIANT 386 386 R -> C (in MPS4A; severe form;
dbSNP:rs118204437).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:7668283,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007228.
VARIANT 386 386 R -> H (in MPS4A).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024913.
VARIANT 388 388 D -> N (in MPS4A; dbSNP:rs373739301).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024914.
VARIANT 391 391 M -> V (in MPS4A; severe form;
dbSNP:rs398123429).
{ECO:0000269|PubMed:24726177,
ECO:0000269|PubMed:9375852}.
/FTId=VAR_007229.
VARIANT 392 392 A -> V (in MPS4A; dbSNP:rs398123430).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:24726177}.
/FTId=VAR_024915.
VARIANT 393 393 A -> S (in dbSNP:rs2303269).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:9452036}.
/FTId=VAR_007230.
VARIANT 395 395 L -> P (in MPS4A).
{ECO:0000269|PubMed:9375852}.
/FTId=VAR_007231.
VARIANT 395 395 L -> V (in MPS4A; severe form).
{ECO:0000269|PubMed:9521421}.
/FTId=VAR_007232.
VARIANT 398 398 H -> D (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024916.
VARIANT 401 401 H -> Y (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024917.
VARIANT 403 404 Missing (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024918.
VARIANT 407 407 N -> H (in MPS4A; dbSNP:rs749578474).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007233.
VARIANT 409 409 W -> S (in MPS4A; associated with M-67 in
a patient).
/FTId=VAR_007234.
VARIANT 415 415 G -> V (in MPS4A; loss of enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071594.
VARIANT 416 416 I -> T (in MPS4A; reduced enzymatic
activity; dbSNP:rs142822371).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071595.
VARIANT 420 420 P -> R (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071596.
VARIANT 450 450 E -> V (in MPS4A; severe form).
/FTId=VAR_007235.
VARIANT 452 452 F -> I (in MPS4A; dbSNP:rs398123432).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024919.
VARIANT 459 459 A -> V (in dbSNP:rs114703967).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_007236.
VARIANT 470 470 S -> P (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024920.
VARIANT 484 484 P -> S (in MPS4A).
{ECO:0000269|PubMed:16287098}.
/FTId=VAR_024921.
VARIANT 487 487 N -> S (in MPS4A; dbSNP:rs118204440).
{ECO:0000269|PubMed:7581409,
ECO:0000269|PubMed:7668283}.
/FTId=VAR_007237.
VARIANT 488 488 V -> M (in dbSNP:rs78127134).
{ECO:0000269|PubMed:16287098,
ECO:0000269|PubMed:9452036}.
/FTId=VAR_007238.
VARIANT 492 492 A -> T (in MPS4A; reduced enzymatic
activity; dbSNP:rs760300454).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071597.
VARIANT 494 494 M -> V (in MPS4A; severe form).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_007239.
VARIANT 495 495 N -> K. {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071598.
VARIANT 500 500 G -> S (in MPS4A; reduced enzymatic
activity). {ECO:0000269|PubMed:24726177}.
/FTId=VAR_071599.
VARIANT 507 507 C -> F (in MPS4A; dbSNP:rs398123433).
{ECO:0000269|PubMed:24726177}.
/FTId=VAR_071600.
VARIANT 510 510 P -> T (in a colorectal cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036493.
STRAND 32 40 {ECO:0000244|PDB:4FDI}.
HELIX 47 49 {ECO:0000244|PDB:4FDI}.
HELIX 57 64 {ECO:0000244|PDB:4FDI}.
STRAND 66 68 {ECO:0000244|PDB:4FDI}.
STRAND 70 73 {ECO:0000244|PDB:4FDI}.
STRAND 75 78 {ECO:0000244|PDB:4FDI}.
HELIX 79 88 {ECO:0000244|PDB:4FDI}.
HELIX 92 95 {ECO:0000244|PDB:4FDI}.
HELIX 124 128 {ECO:0000244|PDB:4FDI}.
HELIX 129 131 {ECO:0000244|PDB:4FDI}.
STRAND 134 139 {ECO:0000244|PDB:4FDI}.
HELIX 147 149 {ECO:0000244|PDB:4FDI}.
HELIX 151 153 {ECO:0000244|PDB:4FDI}.
STRAND 157 161 {ECO:0000244|PDB:4FDI}.
STRAND 172 175 {ECO:0000244|PDB:4FDI}.
STRAND 179 182 {ECO:0000244|PDB:4FDI}.
STRAND 185 190 {ECO:0000244|PDB:4FDI}.
TURN 191 193 {ECO:0000244|PDB:4FDI}.
TURN 198 200 {ECO:0000244|PDB:4FDI}.
HELIX 205 220 {ECO:0000244|PDB:4FDI}.
TURN 221 223 {ECO:0000244|PDB:4FDI}.
STRAND 226 231 {ECO:0000244|PDB:4FDI}.
STRAND 236 238 {ECO:0000244|PDB:4FDI}.
HELIX 243 245 {ECO:0000244|PDB:4FDI}.
HELIX 252 274 {ECO:0000244|PDB:4FDI}.
HELIX 278 280 {ECO:0000244|PDB:4FDI}.
STRAND 281 289 {ECO:0000244|PDB:4FDI}.
TURN 296 298 {ECO:0000244|PDB:4FDI}.
STRAND 312 314 {ECO:0000244|PDB:4FDI}.
HELIX 315 318 {ECO:0000244|PDB:4FDI}.
STRAND 322 325 {ECO:0000244|PDB:4FDI}.
TURN 327 329 {ECO:0000244|PDB:4FDI}.
HELIX 344 353 {ECO:0000244|PDB:4FDI}.
STRAND 359 361 {ECO:0000244|PDB:4FDI}.
HELIX 369 374 {ECO:0000244|PDB:4FDI}.
STRAND 382 386 {ECO:0000244|PDB:4FDI}.
STRAND 389 395 {ECO:0000244|PDB:4FDI}.
STRAND 398 404 {ECO:0000244|PDB:4FDI}.
HELIX 409 413 {ECO:0000244|PDB:4FDI}.
TURN 425 427 {ECO:0000244|PDB:4FDI}.
STRAND 436 438 {ECO:0000244|PDB:4FDI}.
STRAND 440 443 {ECO:0000244|PDB:4FDI}.
TURN 444 446 {ECO:0000244|PDB:4FDI}.
HELIX 459 477 {ECO:0000244|PDB:4FDI}.
STRAND 485 489 {ECO:0000244|PDB:4FDI}.
HELIX 491 493 {ECO:0000244|PDB:4FDI}.
STRAND 494 497 {ECO:0000244|PDB:4FDI}.
HELIX 501 504 {ECO:0000244|PDB:4FDI}.
SEQUENCE 522 AA; 58026 MW; 1D086E528AAAE949 CRC64;
MAAVVAATRW WQLLLVLSAA GMGASGAPQP PNILLLLMDD MGWGDLGVYG EPSRETPNLD
RMAAEGLLFP NFYSANPLCS PSRAALLTGR LPIRNGFYTT NAHARNAYTP QEIVGGIPDS
EQLLPELLKK AGYVSKIVGK WHLGHRPQFH PLKHGFDEWF GSPNCHFGPY DNKARPNIPV
YRDWEMVGRY YEEFPINLKT GEANLTQIYL QEALDFIKRQ ARHHPFFLYW AVDATHAPVY
ASKPFLGTSQ RGRYGDAVRE IDDSIGKILE LLQDLHVADN TFVFFTSDNG AALISAPEQG
GSNGPFLCGK QTTFEGGMRE PALAWWPGHV TAGQVSHQLG SIMDLFTTSL ALAGLTPPSD
RAIDGLNLLP TLLQGRLMDR PIFYYRGDTL MAATLGQHKA HFWTWTNSWE NFRQGIDFCP
GQNVSGVTTH NLEDHTKLPL IFHLGRDPGE RFPLSFASAE YQEALSRITS VVQQHQEALV
PAQPQLNVCN WAVMNWAPPG CEKLGKCLTP PESIPKKCLW SH


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