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N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]

 OGG1_MOUSE              Reviewed;         345 AA.
O08760; O08733; O08910; O08991; O35617; O35915; Q9QXE8;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
05-DEC-2018, entry version 156.
RecName: Full=N-glycosylase/DNA lyase;
Includes:
RecName: Full=8-oxoguanine DNA glycosylase;
EC=3.2.2.-;
Includes:
RecName: Full=DNA-(apurinic or apyrimidinic site) lyase;
Short=AP lyase;
EC=4.2.99.18;
Name=Ogg1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9187114;
Aburatani H., Hippo Y., Ishida T., Takashima R., Matsuba C.,
Kodama T., Takao M., Yasui A., Yamamoto K., Asano M., Fukasawa K.,
Yoshinari T., Inoue H., Otsuka E., Nishimura S.;
"Cloning and characterization of mammalian 8-hydroxyguanine-specific
DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM
homologue.";
Cancer Res. 57:2151-2156(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9197244; DOI=10.1016/S0960-9822(06)00187-4;
Lu R., Nash H.M., Verdine G.L.;
"A mammalian DNA repair enzyme that excises oxidatively damaged
guanines maps to a locus frequently lost in lung cancer.";
Curr. Biol. 7:397-407(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=9321410; DOI=10.1093/emboj/16.20.6314;
Bjoras M., Luna L., Johnsen B.E., Hoff E., Haug T., Rognes T.,
Seeberg E.;
"Opposite base-dependent reactions of a human base excision repair
enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.";
EMBO J. 16:6314-6322(1997).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9207108; DOI=10.1073/pnas.94.14.7429;
Rosenquist T.A., Zharkov D.O., Grollman A.P.;
"Cloning and characterization of a mammalian 8-oxoguanine DNA
glycosylase.";
Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=C3H/HeN; TISSUE=Melanoma;
PubMed=9434942; DOI=10.1007/s003359900675;
Tani M., Shinmura K., Kohno T., Takenoshita S., Nagamachi Y.,
Yokota J.;
"Genomic structure and chromosomal localization of the mouse Ogg1 gene
that is involved in the repair of 8-hydroxyguanine in DNA damage.";
Mamm. Genome 9:32-37(1998).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
Radicella J.P., Reille F., Dherin C., Boiteux S.;
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv; TISSUE=Embryonic stem cell;
Johnsen B., Luna L., Rognes T., Seeberg E.;
"Complete genomic DNA sequence of the Mus musculus 8-oxoguanine DNA
glycosylase 1 gene (OGH1).";
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues.
Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-
methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-
lyase activity that nicks DNA 3' to the lesion.
-!- CATALYTIC ACTIVITY:
Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in
DNA is broken by a beta-elimination reaction, leaving a 3'-
terminal unsaturated sugar and a product with a terminal 5'-
phosphate.; EC=4.2.99.18;
-!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Together
with APEX1 is recruited to nuclear speckles in UVA-irradiated
cells. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Highest expression in testis.
-!- SIMILARITY: Belongs to the type-1 OGG1 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF003596; AAB61289.1; -; mRNA.
EMBL; Y11247; CAA72117.1; -; mRNA.
EMBL; U88621; AAB68616.1; -; mRNA.
EMBL; U96711; AAB81133.1; -; mRNA.
EMBL; AF000669; AAB63151.1; -; mRNA.
EMBL; AF012916; AAB94512.1; -; Genomic_DNA.
EMBL; AF012912; AAB94512.1; JOINED; Genomic_DNA.
EMBL; AF012913; AAB94512.1; JOINED; Genomic_DNA.
EMBL; AF012914; AAB94512.1; JOINED; Genomic_DNA.
EMBL; AF012915; AAB94512.1; JOINED; Genomic_DNA.
EMBL; Y13479; CAA73883.1; -; mRNA.
EMBL; AJ001307; CAB65240.1; -; Genomic_DNA.
CCDS; CCDS20414.1; -.
PIR; T46962; T46962.
RefSeq; NP_035087.3; NM_010957.4.
UniGene; Mm.43612; -.
ProteinModelPortal; O08760; -.
SMR; O08760; -.
BioGrid; 201906; 2.
IntAct; O08760; 2.
STRING; 10090.ENSMUSP00000032406; -.
PhosphoSitePlus; O08760; -.
EPD; O08760; -.
PaxDb; O08760; -.
PeptideAtlas; O08760; -.
PRIDE; O08760; -.
Ensembl; ENSMUST00000032406; ENSMUSP00000032406; ENSMUSG00000030271.
GeneID; 18294; -.
KEGG; mmu:18294; -.
UCSC; uc009dfh.2; mouse.
CTD; 4968; -.
MGI; MGI:1097693; Ogg1.
eggNOG; KOG2875; Eukaryota.
eggNOG; COG0122; LUCA.
GeneTree; ENSGT00640000091554; -.
HOVERGEN; HBG001047; -.
InParanoid; O08760; -.
KO; K03660; -.
OMA; EYAGYAQ; -.
OrthoDB; EOG091G0AU6; -.
PhylomeDB; O08760; -.
TreeFam; TF323702; -.
Reactome; R-MMU-110329; Cleavage of the damaged pyrimidine.
Reactome; R-MMU-110331; Cleavage of the damaged purine.
Reactome; R-MMU-110357; Displacement of DNA glycosylase by APEX1.
Reactome; R-MMU-5649702; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.
PRO; PR:O08760; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000030271; Expressed in 146 organ(s), highest expression level in brown adipose tissue.
CleanEx; MM_OGG1; -.
ExpressionAtlas; O08760; baseline and differential.
Genevisible; O08760; MM.
GO; GO:0005739; C:mitochondrion; IMP:MGI.
GO; GO:0016363; C:nuclear matrix; ISS:UniProtKB.
GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IMP:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0034039; F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; IMP:MGI.
GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
GO; GO:0003684; F:damaged DNA binding; ISO:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0019104; F:DNA N-glycosylase activity; ISO:MGI.
GO; GO:0008017; F:microtubule binding; IDA:MGI.
GO; GO:0000702; F:oxidized base lesion DNA N-glycosylase activity; TAS:MGI.
GO; GO:0032357; F:oxidized purine DNA binding; ISO:MGI.
GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IDA:MGI.
GO; GO:0002526; P:acute inflammatory response; IEA:Ensembl.
GO; GO:0007568; P:aging; ISO:MGI.
GO; GO:0006284; P:base-excision repair; IDA:MGI.
GO; GO:0006285; P:base-excision repair, AP site formation; IBA:GO_Central.
GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISO:MGI.
GO; GO:0006281; P:DNA repair; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:1901291; P:negative regulation of double-strand break repair via single-strand annealing; ISO:MGI.
GO; GO:0033683; P:nucleotide-excision repair, DNA incision; ISO:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032355; P:response to estradiol; ISO:MGI.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0051593; P:response to folic acid; IEA:Ensembl.
GO; GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; ISS:UniProtKB.
GO; GO:0009314; P:response to radiation; ISS:UniProtKB.
CDD; cd00056; ENDO3c; 1.
Gene3D; 1.10.1670.10; -; 1.
InterPro; IPR011257; DNA_glycosylase.
InterPro; IPR003265; HhH-GPD_domain.
InterPro; IPR023170; HTH_base_excis_C.
InterPro; IPR004577; Ogg1.
InterPro; IPR012904; OGG_N.
Pfam; PF00730; HhH-GPD; 1.
Pfam; PF07934; OGG_N; 1.
SMART; SM00478; ENDO3c; 1.
SUPFAM; SSF48150; SSF48150; 1.
TIGRFAMs; TIGR00588; ogg; 1.
2: Evidence at transcript level;
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase;
Lyase; Multifunctional enzyme; Nucleus; Reference proteome.
CHAIN 1 345 N-glycosylase/DNA lyase.
/FTId=PRO_0000058592.
ACT_SITE 249 249 Schiff-base intermediate with DNA.
{ECO:0000250}.
BINDING 149 149 DNA. {ECO:0000250}.
BINDING 154 154 DNA. {ECO:0000250}.
BINDING 204 204 DNA. {ECO:0000250}.
BINDING 266 266 8-oxoguanine; via carbonyl oxygen.
{ECO:0000250}.
BINDING 268 268 8-oxoguanine. {ECO:0000250}.
BINDING 270 270 DNA. {ECO:0000250}.
BINDING 287 287 DNA. {ECO:0000250}.
BINDING 315 315 8-oxoguanine. {ECO:0000250}.
BINDING 319 319 8-oxoguanine. {ECO:0000250}.
CONFLICT 10 10 S -> Q (in Ref. 1; AAB61289).
{ECO:0000305}.
CONFLICT 23 25 WAS -> SVA (in Ref. 1; AAB61289).
{ECO:0000305}.
CONFLICT 239 239 A -> G (in Ref. 1; AAB61289).
{ECO:0000305}.
CONFLICT 299 299 L -> S (in Ref. 6; CAA73883).
{ECO:0000305}.
CONFLICT 329 329 S -> F (in Ref. 4; AAB81133).
{ECO:0000305}.
CONFLICT 336 336 R -> H (in Ref. 6; CAA73883 and 7;
CAB65240). {ECO:0000305}.
SEQUENCE 345 AA; 38883 MW; 75BB0DDB084E4947 CRC64;
MLFRSWLPSS MRHRTLSSSP ALWASIPCPR SELRLDLVLA SGQSFRWKEQ SPAHWSGVLA
DQVWTLTQTE DQLYCTVYRG DDSQVSRPTL EELETLHKYF QLDVSLAQLY SHWASVDSHF
QRVAQKFQGV RLLRQDPTEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG
FPNLHALAGP EAETHLRKLG LGYRARYVRA SAKAILEEQG GPAWLQQLRV APYEEAHKAL
CTLPGVGAKV ADCICLMALD KPQAVPVDVH VWQIAHRDYG WHPKTSQAKG PSPLANKELG
NFFRNLWGPY AGWAQAVLFS ADLRQPSLSR EPPAKRKKGS KRPEG


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