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NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1)

 NU1M_MURSU              Reviewed;         318 AA.
Q8M867;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
15-MAR-2017, entry version 52.
RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
EC=1.6.5.3;
AltName: Full=NADH dehydrogenase subunit 1;
Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
Murina suilla (Brown tube-nosed bat) (Lesser tube-nosed bat).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
Vespertilionidae; Murina.
NCBI_TaxID=59489;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12187382; DOI=10.1007/s00239-002-2326-0;
Kawai K., Nikaido M., Harada M., Matsumura S., Lin L.K., Wu Y.,
Hasegawa M., Okada N.;
"Intra- and interfamily relationships of Vespertilionidae inferred by
various molecular markers including SINE insertion data.";
J. Mol. Evol. 55:284-301(2002).
-!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
chain NADH dehydrogenase (Complex I) that is believed to belong to
the minimal assembly required for catalysis. Complex I functions
in the transfer of electrons from NADH to the respiratory chain.
The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
ubiquinol + 4 H(+)(Out).
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the complex I subunit 1 family.
{ECO:0000305}.
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EMBL; AB079835; BAB92060.1; -; Genomic_DNA.
HOVERGEN; HBG016682; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
HAMAP; MF_01350; NDH1_NuoH; 1.
InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
PANTHER; PTHR11432; PTHR11432; 1.
Pfam; PF00146; NADHdh; 1.
PROSITE; PS00667; COMPLEX1_ND1_1; 1.
PROSITE; PS00668; COMPLEX1_ND1_2; 1.
3: Inferred from homology;
Electron transport; Membrane; Mitochondrion;
Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain;
Transmembrane; Transmembrane helix; Transport; Ubiquinone.
CHAIN 1 318 NADH-ubiquinone oxidoreductase chain 1.
/FTId=PRO_0000117432.
TRANSMEM 3 23 Helical. {ECO:0000255}.
TRANSMEM 69 89 Helical. {ECO:0000255}.
TRANSMEM 102 122 Helical. {ECO:0000255}.
TRANSMEM 144 164 Helical. {ECO:0000255}.
TRANSMEM 171 191 Helical. {ECO:0000255}.
TRANSMEM 222 242 Helical. {ECO:0000255}.
TRANSMEM 253 273 Helical. {ECO:0000255}.
TRANSMEM 294 314 Helical. {ECO:0000255}.
SEQUENCE 318 AA; 35860 MW; FE93F9D119543389 CRC64;
MYLINLLAMI VPVLLAVAFL TLLERKVLGY MQLRKGPNIV GPYGLLQPIA DAVKLFTKEP
LQPLTSSPML FIIAPTLALT LALTMWTPLP MPYPLMNMNL SMLFILALSS LAVYTIMWSG
WASNSKYALI GALRAVAQTI SYEVTLAIII LSLLLMNGSF TLLSMTTTQE YIWLLIPSWP
LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAGGPF ALFFLAEYAN IIMMNALTII
LFLGAYHNSM VPELYTINFT IKTLLFTAFF LWIRASYPRF RYDQLMHLLW KNFLPLTLVM
CMWHVALPIM LAGIPPQT


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