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NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (Fragment)

 B0JCW0_HAECO            Unreviewed;       133 AA.
B0JCW0;
18-MAR-2008, integrated into UniProtKB/TrEMBL.
18-MAR-2008, sequence version 1.
15-MAR-2017, entry version 28.
RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297};
EC=1.6.5.3 {ECO:0000256|RuleBase:RU003297};
Flags: Fragment;
Name=ND4 {ECO:0000313|EMBL:CAD22484.1};
Haemonchus contortus (Barber pole worm).
Mitochondrion {ECO:0000313|EMBL:CAD22484.1}.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
Haemonchus.
NCBI_TaxID=6289 {ECO:0000313|EMBL:CAD22484.1};
[1] {ECO:0000313|EMBL:CAD22484.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Hc chamois05 {ECO:0000313|EMBL:CAD22484.1},
Hc chamois06 {ECO:0000313|EMBL:CAD22485.1},
Hc chamois09 {ECO:0000313|EMBL:CAD22488.1},
Hc chamois13 {ECO:0000313|EMBL:CAD22492.1},
Hc chamois14 {ECO:0000313|EMBL:CAD22493.1},
Hc chamois16 {ECO:0000313|EMBL:CAD22495.1},
Hc chamois18 {ECO:0000313|EMBL:CAD22497.1},
Hc chamois20 {ECO:0000313|EMBL:CAD22499.1},
Hc chamois22 {ECO:0000313|EMBL:CAD22500.1},
Hc chamois23 {ECO:0000313|EMBL:CAD22501.1},
Hc chamois25 {ECO:0000313|EMBL:CAD22502.1},
Hc chamois27 {ECO:0000313|EMBL:CAD22504.1},
Hc chamois28 {ECO:0000313|EMBL:CAD22505.1},
Hc chamois29 {ECO:0000313|EMBL:CAD22506.1},
Hc goat04 {ECO:0000313|EMBL:CAD22511.1},
Hc goat11 {ECO:0000313|EMBL:CAD22512.1},
Hc goat12 {ECO:0000313|EMBL:CAD22513.1},
Hc goat14 {ECO:0000313|EMBL:CAD22515.1},
Hc goat17 {ECO:0000313|EMBL:CAD22517.1},
Hc goat20 {ECO:0000313|EMBL:CAD22520.1},
Hc goat21 {ECO:0000313|EMBL:CAD22521.1},
Hc goat23 {ECO:0000313|EMBL:CAD22523.1}, and
Hc goatB {ECO:0000313|EMBL:CAD22509.1};
Citterio C.V.;
"Il parassitismo abomasale nel monitoraggio sanitario di popolazioni
di ruminanti selvatici alpini: aspetti epidemiologici, fisiopatologici
e molecolari.";
Thesis (2001), Department of Facolta di Medicina Veterinaria,
Universita degli Studi di Milano, Milano, Italy.
[2] {ECO:0000313|EMBL:CAD22484.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Hc chamois05 {ECO:0000313|EMBL:CAD22484.1},
Hc chamois06 {ECO:0000313|EMBL:CAD22485.1},
Hc chamois09 {ECO:0000313|EMBL:CAD22488.1},
Hc chamois13 {ECO:0000313|EMBL:CAD22492.1},
Hc chamois14 {ECO:0000313|EMBL:CAD22493.1},
Hc chamois16 {ECO:0000313|EMBL:CAD22495.1},
Hc chamois18 {ECO:0000313|EMBL:CAD22497.1},
Hc chamois20 {ECO:0000313|EMBL:CAD22499.1},
Hc chamois22 {ECO:0000313|EMBL:CAD22500.1},
Hc chamois23 {ECO:0000313|EMBL:CAD22501.1},
Hc chamois25 {ECO:0000313|EMBL:CAD22502.1},
Hc chamois27 {ECO:0000313|EMBL:CAD22504.1},
Hc chamois28 {ECO:0000313|EMBL:CAD22505.1},
Hc chamois29 {ECO:0000313|EMBL:CAD22506.1},
Hc goat04 {ECO:0000313|EMBL:CAD22511.1},
Hc goat11 {ECO:0000313|EMBL:CAD22512.1},
Hc goat12 {ECO:0000313|EMBL:CAD22513.1},
Hc goat14 {ECO:0000313|EMBL:CAD22515.1},
Hc goat17 {ECO:0000313|EMBL:CAD22517.1},
Hc goat20 {ECO:0000313|EMBL:CAD22520.1},
Hc goat21 {ECO:0000313|EMBL:CAD22521.1},
Hc goat23 {ECO:0000313|EMBL:CAD22523.1}, and
Hc goatB {ECO:0000313|EMBL:CAD22509.1};
Citterio C.V.;
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003297}.
-!- SIMILARITY: Belongs to the complex I subunit 4 family.
{ECO:0000256|RuleBase:RU003297}.
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EMBL; AJ429770; CAD22484.1; -; Genomic_DNA.
EMBL; AJ429771; CAD22485.1; -; Genomic_DNA.
EMBL; AJ429774; CAD22488.1; -; Genomic_DNA.
EMBL; AJ429778; CAD22492.1; -; Genomic_DNA.
EMBL; AJ429779; CAD22493.1; -; Genomic_DNA.
EMBL; AJ429781; CAD22495.1; -; Genomic_DNA.
EMBL; AJ429783; CAD22497.1; -; Genomic_DNA.
EMBL; AJ429785; CAD22499.1; -; Genomic_DNA.
EMBL; AJ429786; CAD22500.1; -; Genomic_DNA.
EMBL; AJ429787; CAD22501.1; -; Genomic_DNA.
EMBL; AJ429788; CAD22502.1; -; Genomic_DNA.
EMBL; AJ429790; CAD22504.1; -; Genomic_DNA.
EMBL; AJ429791; CAD22505.1; -; Genomic_DNA.
EMBL; AJ429792; CAD22506.1; -; Genomic_DNA.
EMBL; AJ429795; CAD22509.1; -; Genomic_DNA.
EMBL; AJ429797; CAD22511.1; -; Genomic_DNA.
EMBL; AJ429798; CAD22512.1; -; Genomic_DNA.
EMBL; AJ429799; CAD22513.1; -; Genomic_DNA.
EMBL; AJ429801; CAD22515.1; -; Genomic_DNA.
EMBL; AJ429803; CAD22517.1; -; Genomic_DNA.
EMBL; AJ429806; CAD22520.1; -; Genomic_DNA.
EMBL; AJ429807; CAD22521.1; -; Genomic_DNA.
EMBL; AJ429809; CAD22523.1; -; Genomic_DNA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
InterPro; IPR003918; NADH_UbQ_OxRdtase.
InterPro; IPR001750; ND/Mrp_mem.
PANTHER; PTHR43507; PTHR43507; 1.
Pfam; PF00361; Proton_antipo_M; 1.
PRINTS; PR01437; NUOXDRDTASE4.
3: Inferred from homology;
Membrane {ECO:0000256|SAM:Phobius};
Mitochondrion {ECO:0000256|RuleBase:RU003297,
ECO:0000313|EMBL:CAD22484.1}; NAD {ECO:0000256|RuleBase:RU003297};
Oxidoreductase {ECO:0000256|RuleBase:RU003297};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius};
Ubiquinone {ECO:0000256|RuleBase:RU003297}.
TRANSMEM 6 24 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 36 57 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 84 105 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 112 132 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 3 93 Proton_antipo_M.
{ECO:0000259|Pfam:PF00361}.
NON_TER 1 1 {ECO:0000313|EMBL:CAD22484.1}.
NON_TER 133 133 {ECO:0000313|EMBL:CAD22484.1}.
SEQUENCE 133 AA; 15643 MW; 262E0C50AE3341E5 CRC64;
SKNSALMMML AHGYTSTLMF YVIGEFYHTS STRMIYFMNS FMNSSMIFSI MFAMIFLSNS
GMPPSLSFLS EFIIITNSMM LNKILFFFVF VYFMISFYYS LFLIVNSFAG KVYINYNNNN
FGIMMFLMVM MYN


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