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NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3) (NADH dehydrogenase subunit 6)

 NU6M_HUMAN              Reviewed;         174 AA.
P03923; Q34774; Q8HG30;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
27-SEP-2017, entry version 169.
RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
EC=1.6.5.3;
AltName: Full=NADH dehydrogenase subunit 6;
Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
Homo sapiens (Human).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=7219534; DOI=10.1038/290457a0;
Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L.,
Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A.,
Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.;
"Sequence and organization of the human mitochondrial genome.";
Nature 290:457-465(1981).
[2]
SEQUENCE REVISION TO 102; 134 AND 159.
Kogelnik A., Brown M.;
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=7530363; DOI=10.1073/pnas.92.2.532;
Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
"Recent African origin of modern humans revealed by complete sequences
of hominoid mitochondrial DNAs.";
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LHON VAL-64.
PubMed=9452107;
Sudoyo H., Sitepu M., Malik S., Poesponegoro H.D., Marzuki S.;
"Leber's hereditary optic neuropathy in Indonesia: two families with
the mtDNA 11778G>A and 14484T>C mutations.";
Hum. Mutat. Suppl. 1:S271-S274(1998).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12949126; DOI=10.1093/molbev/msg230;
Moilanen J.S., Finnila S., Majamaa K.;
"Lineage-specific selection in human mtDNA: lack of polymorphisms in a
segment of MTND5 gene in haplogroup J.";
Mol. Biol. Evol. 20:2132-2142(2003).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11130070; DOI=10.1038/35047064;
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
"Mitochondrial genome variation and the origin of modern humans.";
Nature 408:708-713(2000).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12840039; DOI=10.1101/gr.686603;
Ingman M., Gyllensten U.;
"Mitochondrial genome variation and evolutionary history of Australian
and New Guinean aborigines.";
Genome Res. 13:1600-1606(2003).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
Irwin J.A., Parsons T.J.;
"Single nucleotide polymorphisms over the entire mtDNA genome that
increase the power of forensic testing in Caucasians.";
Int. J. Legal Med. 118:137-146(2004).
[9]
VARIANT VAL-58.
PubMed=2043137; DOI=10.1016/0006-291X(91)92014-B;
Ozawa T., Tanaka M., Sugiyama S., Ino H., Ohno K., Hattori K.,
Ohbayashi T., Ito T., Deguchi H., Kawamura K., Nakane Y., Hashiba K.;
"Patients with idiopathic cardiomyopathy belong to the same
mitochondrial DNA gene family of Parkinson's disease and mitochondrial
encephalomyopathy.";
Biochem. Biophys. Res. Commun. 177:518-525(1991).
[10]
VARIANT CYS-165.
PubMed=1757091; DOI=10.1007/BF00206061;
Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
Utthanaphol P., Byrne E.;
"Normal variants of human mitochondrial DNA and translation products:
the building of a reference data base.";
Hum. Genet. 88:139-145(1991).
[11]
VARIANT LHON VAL-64.
PubMed=1417830; DOI=10.1016/0006-291X(92)90479-5;
Johns D.R., Neufeld M.J., Park R.D.;
"An ND-6 mitochondrial DNA mutation associated with Leber hereditary
optic neuropathy.";
Biochem. Biophys. Res. Commun. 187:1551-1557(1992).
[12]
VARIANT LDYT VAL-72.
PubMed=8016139; DOI=10.1073/pnas.91.13.6206;
Jun A.S., Brown M.D., Wallace D.C.;
"A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH
dehydrogenase subunit 6 gene associated with maternally inherited
Leber hereditary optic neuropathy and dystonia.";
Proc. Natl. Acad. Sci. U.S.A. 91:6206-6210(1994).
[13]
VARIANT LDYT MET-26.
PubMed=8644732;
de Vries D.D., Went L.N., Bruyn G.W., Scholte H.R., Hofstra R.M.W.,
Bolhuis P.A., van Oost B.A.;
"Genetic and biochemical impairment of mitochondrial complex I
activity in a family with Leber hereditary optic neuropathy and
hereditary spastic dystonia.";
Am. J. Hum. Genet. 58:703-711(1996).
[14]
VARIANT LHON CYS-59.
PubMed=8854108;
Leo-Kottler B., Christ-Adler M., Baumann B., Zrenner E., Wissinger B.;
"Leber's hereditary optic neuropathy: clinical and molecular genetic
results obtained in a family with a new point mutation at nucleotide
position 14498 in the ND 6 gene.";
Ger. J. Ophthalmol. 5:233-240(1996).
[15]
VARIANT LHON SER-36.
PubMed=10447650; DOI=10.1007/s004170050307;
Besch D., Leo-Kottler B., Zrenner E., Wissinger B.;
"Leber's hereditary optic neuropathy: clinical and molecular genetic
findings in a patient with a new mutation in the ND6 gene.";
Graefes Arch. Clin. Exp. Ophthalmol. 237:745-752(1999).
[16]
VARIANT LHON SER-60, AND VARIANTS ALA-31 AND VAL-33.
PubMed=11133798; DOI=10.1093/brain/124.1.209;
Chinnery P.F., Brown D.T., Andrews R.M., Singh-Kler R.,
Riordan-Eva P., Lindley J., Applegarth D.A., Turnbull D.M., Howell N.;
"The mitochondrial ND6 gene is a hot spot for mutations that cause
Leber's hereditary optic neuropathy.";
Brain 124:209-218(2001).
[17]
VARIANT MELAS VAL-74.
PubMed=11781695; DOI=10.1038/sj.ejhg.5200712;
Ravn K., Wibrand F., Hansen F.J., Horn N., Rosenberg T., Schwartz M.;
"An mtDNA mutation, 14453G-->A, in the NADH dehydrogenase subunit 6
associated with severe MELAS syndrome.";
Eur. J. Hum. Genet. 9:805-809(2001).
[18]
VARIANT MT-C1D VAL-63.
PubMed=14595656; DOI=10.1002/ana.10734;
Ugalde C., Triepels R.H., Coenen M.J., van den Heuvel L.P., Smeets R.,
Uusimaa J., Briones P., Campistol J., Majamaa K., Smeitink J.A.,
Nijtmans L.G.;
"Impaired complex I assembly in a Leigh syndrome patient with a novel
missense mutation in the ND6 gene.";
Ann. Neurol. 54:665-669(2003).
[19]
VARIANTS MT-C1D VAL-63 AND VAL-72.
PubMed=20818383; DOI=10.1038/ng.659;
Calvo S.E., Tucker E.J., Compton A.G., Kirby D.M., Crawford G.,
Burtt N.P., Rivas M., Guiducci C., Bruno D.L., Goldberger O.A.,
Redman M.C., Wiltshire E., Wilson C.J., Altshuler D., Gabriel S.B.,
Daly M.J., Thorburn D.R., Mootha V.K.;
"High-throughput, pooled sequencing identifies mutations in NUBPL and
FOXRED1 in human complex I deficiency.";
Nat. Genet. 42:851-858(2010).
-!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
chain NADH dehydrogenase (Complex I) that is believed to belong to
the minimal assembly required for catalysis. Complex I functions
in the transfer of electrons from NADH to the respiratory chain.
The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
ubiquinol + 4 H(+)(Out).
-!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-
pass membrane protein {ECO:0000305}.
-!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A
maternally inherited disease resulting in acute or subacute loss
of central vision, due to optic nerve dysfunction. Cardiac
conduction defects and neurological defects have also been
described in some patients. LHON results from primary
mitochondrial DNA mutations affecting the respiratory chain
complexes. {ECO:0000269|PubMed:10447650,
ECO:0000269|PubMed:11133798, ECO:0000269|PubMed:1417830,
ECO:0000269|PubMed:8854108, ECO:0000269|PubMed:9452107}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- DISEASE: Leber hereditary optic neuropathy with dystonia (LDYT)
[MIM:500001]: Part of a spectrum of Leber hereditary optic
neuropathy. It is characterized by the association of optic
atrophy and central vision loss with dystonia.
{ECO:0000269|PubMed:8016139, ECO:0000269|PubMed:8644732}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- DISEASE: Mitochondrial encephalomyopathy with lactic acidosis and
stroke-like episodes syndrome (MELAS) [MIM:540000]: Genetically
heterogeneous disorder, characterized by episodic vomiting,
seizures, and recurrent cerebral insults resembling strokes and
causing hemiparesis, hemianopsia, or cortical blindness.
{ECO:0000269|PubMed:11781695}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]:
A disorder of the mitochondrial respiratory chain that causes a
wide range of clinical manifestations from lethal neonatal disease
to adult-onset neurodegenerative disorders. Phenotypes include
macrocephaly with progressive leukodystrophy, non-specific
encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh
syndrome, Leber hereditary optic neuropathy, and some forms of
Parkinson disease. {ECO:0000269|PubMed:14595656,
ECO:0000269|PubMed:20818383}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the complex I subunit 6 family.
{ECO:0000305}.
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EMBL; J01415; AAB58954.1; -; Genomic_DNA.
EMBL; V00662; CAA24037.1; -; Genomic_DNA.
EMBL; D38112; BAA07298.1; -; Genomic_DNA.
EMBL; AY063322; AAL47640.1; -; Genomic_DNA.
EMBL; AY339402; AAP89047.1; -; Genomic_DNA.
EMBL; AY339403; AAP89060.1; -; Genomic_DNA.
EMBL; AY339404; AAP89073.1; -; Genomic_DNA.
EMBL; AY339405; AAP89086.1; -; Genomic_DNA.
EMBL; AY339406; AAP89099.1; -; Genomic_DNA.
EMBL; AY339407; AAP89112.1; -; Genomic_DNA.
EMBL; AY339408; AAP89125.1; -; Genomic_DNA.
EMBL; AY339409; AAP89138.1; -; Genomic_DNA.
EMBL; AY339410; AAP89151.1; -; Genomic_DNA.
EMBL; AY339411; AAP89164.1; -; Genomic_DNA.
EMBL; AY339413; AAP89190.1; -; Genomic_DNA.
EMBL; AY339414; AAP89203.1; -; Genomic_DNA.
EMBL; AY339415; AAP89216.1; -; Genomic_DNA.
EMBL; AY339416; AAP89229.1; -; Genomic_DNA.
EMBL; AY339417; AAP89242.1; -; Genomic_DNA.
EMBL; AY339418; AAP89255.1; -; Genomic_DNA.
EMBL; AY339419; AAP89268.1; -; Genomic_DNA.
EMBL; AY339420; AAP89281.1; -; Genomic_DNA.
EMBL; AY339421; AAP89294.1; -; Genomic_DNA.
EMBL; AY339422; AAP89307.1; -; Genomic_DNA.
EMBL; AY339423; AAP89320.1; -; Genomic_DNA.
EMBL; AY339424; AAP89333.1; -; Genomic_DNA.
EMBL; AY339425; AAP89346.1; -; Genomic_DNA.
EMBL; AY339426; AAP89359.1; -; Genomic_DNA.
EMBL; AY339427; AAP89372.1; -; Genomic_DNA.
EMBL; AY339428; AAP89385.1; -; Genomic_DNA.
EMBL; AY339429; AAP89398.1; -; Genomic_DNA.
EMBL; AY339430; AAP89411.1; -; Genomic_DNA.
EMBL; AY339431; AAP89424.1; -; Genomic_DNA.
EMBL; AY339432; AAP89437.1; -; Genomic_DNA.
EMBL; AY339433; AAP89450.1; -; Genomic_DNA.
EMBL; AY339434; AAP89463.1; -; Genomic_DNA.
EMBL; AY339435; AAP89476.1; -; Genomic_DNA.
EMBL; AY339436; AAP89489.1; -; Genomic_DNA.
EMBL; AY339437; AAP89502.1; -; Genomic_DNA.
EMBL; AY339438; AAP89515.1; -; Genomic_DNA.
EMBL; AY339439; AAP89528.1; -; Genomic_DNA.
EMBL; AY339440; AAP89541.1; -; Genomic_DNA.
EMBL; AY339441; AAP89554.1; -; Genomic_DNA.
EMBL; AY339442; AAP89567.1; -; Genomic_DNA.
EMBL; AY339443; AAP89580.1; -; Genomic_DNA.
EMBL; AY339444; AAP89593.1; -; Genomic_DNA.
EMBL; AY339445; AAP89606.1; -; Genomic_DNA.
EMBL; AY339446; AAP89619.1; -; Genomic_DNA.
EMBL; AY339447; AAP89632.1; -; Genomic_DNA.
EMBL; AY339448; AAP89645.1; -; Genomic_DNA.
EMBL; AY339449; AAP89658.1; -; Genomic_DNA.
EMBL; AY339450; AAP89671.1; -; Genomic_DNA.
EMBL; AY339455; AAP89736.1; -; Genomic_DNA.
EMBL; AY339456; AAP89749.1; -; Genomic_DNA.
EMBL; AY339457; AAP89762.1; -; Genomic_DNA.
EMBL; AY339458; AAP89775.1; -; Genomic_DNA.
EMBL; AY339459; AAP89788.1; -; Genomic_DNA.
EMBL; AY339460; AAP89801.1; -; Genomic_DNA.
EMBL; AY339461; AAP89814.1; -; Genomic_DNA.
EMBL; AY339462; AAP89827.1; -; Genomic_DNA.
EMBL; AY339463; AAP89840.1; -; Genomic_DNA.
EMBL; AY339464; AAP89853.1; -; Genomic_DNA.
EMBL; AY339465; AAP89866.1; -; Genomic_DNA.
EMBL; AY339466; AAP89879.1; -; Genomic_DNA.
EMBL; AY339467; AAP89892.1; -; Genomic_DNA.
EMBL; AY339468; AAP89905.1; -; Genomic_DNA.
EMBL; AY339469; AAP89918.1; -; Genomic_DNA.
EMBL; AY339470; AAP89931.1; -; Genomic_DNA.
EMBL; AY339471; AAP89944.1; -; Genomic_DNA.
EMBL; AY339472; AAP89957.1; -; Genomic_DNA.
EMBL; AY339473; AAP89970.1; -; Genomic_DNA.
EMBL; AY339474; AAP89983.1; -; Genomic_DNA.
EMBL; AY339475; AAP89996.1; -; Genomic_DNA.
EMBL; AY339476; AAP90009.1; -; Genomic_DNA.
EMBL; AY339477; AAP90022.1; -; Genomic_DNA.
EMBL; AY339478; AAP90035.1; -; Genomic_DNA.
EMBL; AY339479; AAP90048.1; -; Genomic_DNA.
EMBL; AY339480; AAP90061.1; -; Genomic_DNA.
EMBL; AY339481; AAP90074.1; -; Genomic_DNA.
EMBL; AY339482; AAP90087.1; -; Genomic_DNA.
EMBL; AY339483; AAP90100.1; -; Genomic_DNA.
EMBL; AY339484; AAP90113.1; -; Genomic_DNA.
EMBL; AY339485; AAP90126.1; -; Genomic_DNA.
EMBL; AY339486; AAP90139.1; -; Genomic_DNA.
EMBL; AY339487; AAP90152.1; -; Genomic_DNA.
EMBL; AY339488; AAP90165.1; -; Genomic_DNA.
EMBL; AY339489; AAP90178.1; -; Genomic_DNA.
EMBL; AY339490; AAP90191.1; -; Genomic_DNA.
EMBL; AY339491; AAP90204.1; -; Genomic_DNA.
EMBL; AY339492; AAP90217.1; -; Genomic_DNA.
EMBL; AY339493; AAP90230.1; -; Genomic_DNA.
EMBL; AY339494; AAP90243.1; -; Genomic_DNA.
EMBL; AY339495; AAP90256.1; -; Genomic_DNA.
EMBL; AY339496; AAP90269.1; -; Genomic_DNA.
EMBL; AY339497; AAP90282.1; -; Genomic_DNA.
EMBL; AY339498; AAP90295.1; -; Genomic_DNA.
EMBL; AY339499; AAP90308.1; -; Genomic_DNA.
EMBL; AY339500; AAP90321.1; -; Genomic_DNA.
EMBL; AY339501; AAP90334.1; -; Genomic_DNA.
EMBL; AY339502; AAP90347.1; -; Genomic_DNA.
EMBL; AY339503; AAP90360.1; -; Genomic_DNA.
EMBL; AY339504; AAP90373.1; -; Genomic_DNA.
EMBL; AY339505; AAP90386.1; -; Genomic_DNA.
EMBL; AY339506; AAP90399.1; -; Genomic_DNA.
EMBL; AY339507; AAP90412.1; -; Genomic_DNA.
EMBL; AY339508; AAP90425.1; -; Genomic_DNA.
EMBL; AY339509; AAP90438.1; -; Genomic_DNA.
EMBL; AY339510; AAP90451.1; -; Genomic_DNA.
EMBL; AY339511; AAP90464.1; -; Genomic_DNA.
EMBL; AY339512; AAP90477.1; -; Genomic_DNA.
EMBL; AY339513; AAP90490.1; -; Genomic_DNA.
EMBL; AY339514; AAP90503.1; -; Genomic_DNA.
EMBL; AY339515; AAP90516.1; -; Genomic_DNA.
EMBL; AY339516; AAP90529.1; -; Genomic_DNA.
EMBL; AY339517; AAP90542.1; -; Genomic_DNA.
EMBL; AY339518; AAP90555.1; -; Genomic_DNA.
EMBL; AY339519; AAP90568.1; -; Genomic_DNA.
EMBL; AY339520; AAP90581.1; -; Genomic_DNA.
EMBL; AY339521; AAP90594.1; -; Genomic_DNA.
EMBL; AY339522; AAP90607.1; -; Genomic_DNA.
EMBL; AY339523; AAP90620.1; -; Genomic_DNA.
EMBL; AY339524; AAP90633.1; -; Genomic_DNA.
EMBL; AY339525; AAP90646.1; -; Genomic_DNA.
EMBL; AY339526; AAP90659.1; -; Genomic_DNA.
EMBL; AY339528; AAP90685.1; -; Genomic_DNA.
EMBL; AY339529; AAP90698.1; -; Genomic_DNA.
EMBL; AY339530; AAP90711.1; -; Genomic_DNA.
EMBL; AY339531; AAP90724.1; -; Genomic_DNA.
EMBL; AY339532; AAP90737.1; -; Genomic_DNA.
EMBL; AY339533; AAP90750.1; -; Genomic_DNA.
EMBL; AY339534; AAP90763.1; -; Genomic_DNA.
EMBL; AY339535; AAP90776.1; -; Genomic_DNA.
EMBL; AY339536; AAP90789.1; -; Genomic_DNA.
EMBL; AY339537; AAP90802.1; -; Genomic_DNA.
EMBL; AY339538; AAP90815.1; -; Genomic_DNA.
EMBL; AY339539; AAP90828.1; -; Genomic_DNA.
EMBL; AY339540; AAP90841.1; -; Genomic_DNA.
EMBL; AY339541; AAP90854.1; -; Genomic_DNA.
EMBL; AY339542; AAP90867.1; -; Genomic_DNA.
EMBL; AY339543; AAP90880.1; -; Genomic_DNA.
EMBL; AY339544; AAP90893.1; -; Genomic_DNA.
EMBL; AY339545; AAP90906.1; -; Genomic_DNA.
EMBL; AY339546; AAP90919.1; -; Genomic_DNA.
EMBL; AY339547; AAP90932.1; -; Genomic_DNA.
EMBL; AY339548; AAP90945.1; -; Genomic_DNA.
EMBL; AY339549; AAP90958.1; -; Genomic_DNA.
EMBL; AY339550; AAP90971.1; -; Genomic_DNA.
EMBL; AY339551; AAP90984.1; -; Genomic_DNA.
EMBL; AY339552; AAP90997.1; -; Genomic_DNA.
EMBL; AY339553; AAP91010.1; -; Genomic_DNA.
EMBL; AY339554; AAP91023.1; -; Genomic_DNA.
EMBL; AY339555; AAP91036.1; -; Genomic_DNA.
EMBL; AY339556; AAP91049.1; -; Genomic_DNA.
EMBL; AY339557; AAP91062.1; -; Genomic_DNA.
EMBL; AY339558; AAP91075.1; -; Genomic_DNA.
EMBL; AY339559; AAP91088.1; -; Genomic_DNA.
EMBL; AY339560; AAP91101.1; -; Genomic_DNA.
EMBL; AY339561; AAP91114.1; -; Genomic_DNA.
EMBL; AY339562; AAP91127.1; -; Genomic_DNA.
EMBL; AY339563; AAP91140.1; -; Genomic_DNA.
EMBL; AY339564; AAP91153.1; -; Genomic_DNA.
EMBL; AY339565; AAP91166.1; -; Genomic_DNA.
EMBL; AY339566; AAP91179.1; -; Genomic_DNA.
EMBL; AY339567; AAP91192.1; -; Genomic_DNA.
EMBL; AY339568; AAP91205.1; -; Genomic_DNA.
EMBL; AY339569; AAP91218.1; -; Genomic_DNA.
EMBL; AY339570; AAP91231.1; -; Genomic_DNA.
EMBL; AY339571; AAP91244.1; -; Genomic_DNA.
EMBL; AY339572; AAP91257.1; -; Genomic_DNA.
EMBL; AY339573; AAP91270.1; -; Genomic_DNA.
EMBL; AY339574; AAP91283.1; -; Genomic_DNA.
EMBL; AY339575; AAP91296.1; -; Genomic_DNA.
EMBL; AY339576; AAP91309.1; -; Genomic_DNA.
EMBL; AY339577; AAP91322.1; -; Genomic_DNA.
EMBL; AY339578; AAP91335.1; -; Genomic_DNA.
EMBL; AY339579; AAP91348.1; -; Genomic_DNA.
EMBL; AY339580; AAP91361.1; -; Genomic_DNA.
EMBL; AY339581; AAP91374.1; -; Genomic_DNA.
EMBL; AY339582; AAP91387.1; -; Genomic_DNA.
EMBL; AY339583; AAP91400.1; -; Genomic_DNA.
EMBL; AY339584; AAP91413.1; -; Genomic_DNA.
EMBL; AY339585; AAP91426.1; -; Genomic_DNA.
EMBL; AY339586; AAP91439.1; -; Genomic_DNA.
EMBL; AY339587; AAP91452.1; -; Genomic_DNA.
EMBL; AY339588; AAP91465.1; -; Genomic_DNA.
EMBL; AY339589; AAP91478.1; -; Genomic_DNA.
EMBL; AY339590; AAP91491.1; -; Genomic_DNA.
EMBL; AY339591; AAP91504.1; -; Genomic_DNA.
EMBL; AY339592; AAP91517.1; -; Genomic_DNA.
EMBL; AY339593; AAP91530.1; -; Genomic_DNA.
EMBL; AF346964; AAK17231.1; -; Genomic_DNA.
EMBL; AF346965; AAK17244.1; -; Genomic_DNA.
EMBL; AF346966; AAK17257.1; -; Genomic_DNA.
EMBL; AF346967; AAK17270.1; -; Genomic_DNA.
EMBL; AF346971; AAK17322.1; -; Genomic_DNA.
EMBL; AF346972; AAK17335.1; -; Genomic_DNA.
EMBL; AF346973; AAK17348.1; -; Genomic_DNA.
EMBL; AF346974; AAK17361.1; -; Genomic_DNA.
EMBL; AF346975; AAK17374.1; -; Genomic_DNA.
EMBL; AF346976; AAK17387.1; -; Genomic_DNA.
EMBL; AF346977; AAK17400.1; -; Genomic_DNA.
EMBL; AF346978; AAK17413.1; -; Genomic_DNA.
EMBL; AF346981; AAK17452.1; -; Genomic_DNA.
EMBL; AF346982; AAK17465.1; -; Genomic_DNA.
EMBL; AF346983; AAK17478.1; -; Genomic_DNA.
EMBL; AF346984; AAK17491.1; -; Genomic_DNA.
EMBL; AF346985; AAK17504.1; -; Genomic_DNA.
EMBL; AF346988; AAK17543.1; -; Genomic_DNA.
EMBL; AF346989; AAK17556.1; -; Genomic_DNA.
EMBL; AF346990; AAK17569.1; -; Genomic_DNA.
EMBL; AF346993; AAK17608.1; -; Genomic_DNA.
EMBL; AF346994; AAK17621.1; -; Genomic_DNA.
EMBL; AF346995; AAK17634.1; -; Genomic_DNA.
EMBL; AF346998; AAK17673.1; -; Genomic_DNA.
EMBL; AF346999; AAK17686.1; -; Genomic_DNA.
EMBL; AF347000; AAK17699.1; -; Genomic_DNA.
EMBL; AF347001; AAK17712.1; -; Genomic_DNA.
EMBL; AF347002; AAK17725.1; -; Genomic_DNA.
EMBL; AF347003; AAK17738.1; -; Genomic_DNA.
EMBL; AF347004; AAK17751.1; -; Genomic_DNA.
EMBL; AF347005; AAK17764.1; -; Genomic_DNA.
EMBL; AF347006; AAK17777.1; -; Genomic_DNA.
EMBL; AF347007; AAK17790.1; -; Genomic_DNA.
EMBL; AF347008; AAK17803.1; -; Genomic_DNA.
EMBL; AF347009; AAK17816.1; -; Genomic_DNA.
EMBL; AF347010; AAK17829.1; -; Genomic_DNA.
EMBL; AF347014; AAK17881.1; -; Genomic_DNA.
EMBL; AF347015; AAK17894.1; -; Genomic_DNA.
EMBL; AY289052; AAP47904.1; -; Genomic_DNA.
EMBL; AY289053; AAP47917.1; -; Genomic_DNA.
EMBL; AY289056; AAP47956.1; -; Genomic_DNA.
EMBL; AY289057; AAP47969.1; -; Genomic_DNA.
EMBL; AY289058; AAP47982.1; -; Genomic_DNA.
EMBL; AY289059; AAP47995.1; -; Genomic_DNA.
EMBL; AY289060; AAP48008.1; -; Genomic_DNA.
EMBL; AY289062; AAP48034.1; -; Genomic_DNA.
EMBL; AY289063; AAP48047.1; -; Genomic_DNA.
EMBL; AY289064; AAP48060.1; -; Genomic_DNA.
EMBL; AY289065; AAP48073.1; -; Genomic_DNA.
EMBL; AY289066; AAP48086.1; -; Genomic_DNA.
EMBL; AY289067; AAP48099.1; -; Genomic_DNA.
EMBL; AY289068; AAP48112.1; -; Genomic_DNA.
EMBL; AY289069; AAP48125.1; -; Genomic_DNA.
EMBL; AY289070; AAP48138.1; -; Genomic_DNA.
EMBL; AY289071; AAP48151.1; -; Genomic_DNA.
EMBL; AY289072; AAP48164.1; -; Genomic_DNA.
EMBL; AY289073; AAP48177.1; -; Genomic_DNA.
EMBL; AY289074; AAP48190.1; -; Genomic_DNA.
EMBL; AY289075; AAP48203.1; -; Genomic_DNA.
EMBL; AY289076; AAP48216.1; -; Genomic_DNA.
EMBL; AY289077; AAP48229.1; -; Genomic_DNA.
EMBL; AY289078; AAP48242.1; -; Genomic_DNA.
EMBL; AY289079; AAP48255.1; -; Genomic_DNA.
EMBL; AY289080; AAP48268.1; -; Genomic_DNA.
EMBL; AY289081; AAP48281.1; -; Genomic_DNA.
EMBL; AY289082; AAP48294.1; -; Genomic_DNA.
EMBL; AY289083; AAP48307.1; -; Genomic_DNA.
EMBL; AY289084; AAP48320.1; -; Genomic_DNA.
EMBL; AY289085; AAP48333.1; -; Genomic_DNA.
EMBL; AY289086; AAP48346.1; -; Genomic_DNA.
EMBL; AY289088; AAP48372.1; -; Genomic_DNA.
EMBL; AY289089; AAP48385.1; -; Genomic_DNA.
EMBL; AY289090; AAP48398.1; -; Genomic_DNA.
EMBL; AY289091; AAP48411.1; -; Genomic_DNA.
EMBL; AY289092; AAP48423.1; -; Genomic_DNA.
EMBL; AY289093; AAP48436.1; -; Genomic_DNA.
EMBL; AY289094; AAP48449.1; -; Genomic_DNA.
EMBL; AY289095; AAP48462.1; -; Genomic_DNA.
EMBL; AY289096; AAP48475.1; -; Genomic_DNA.
EMBL; AY289097; AAP48488.1; -; Genomic_DNA.
EMBL; AY289098; AAP48501.1; -; Genomic_DNA.
EMBL; AY289099; AAP48514.1; -; Genomic_DNA.
EMBL; AY289100; AAP48527.1; -; Genomic_DNA.
EMBL; AY289101; AAP48540.1; -; Genomic_DNA.
EMBL; AY289102; AAP48553.1; -; Genomic_DNA.
EMBL; AY495090; AAR92507.1; -; Genomic_DNA.
EMBL; AY495091; AAR92520.1; -; Genomic_DNA.
EMBL; AY495092; AAR92533.1; -; Genomic_DNA.
EMBL; AY495093; AAR92546.1; -; Genomic_DNA.
EMBL; AY495094; AAR92559.1; -; Genomic_DNA.
EMBL; AY495096; AAR92585.1; -; Genomic_DNA.
EMBL; AY495097; AAR92598.1; -; Genomic_DNA.
EMBL; AY495098; AAR92611.1; -; Genomic_DNA.
EMBL; AY495099; AAR92624.1; -; Genomic_DNA.
EMBL; AY495100; AAR92637.1; -; Genomic_DNA.
EMBL; AY495101; AAR92650.1; -; Genomic_DNA.
EMBL; AY495102; AAR92663.1; -; Genomic_DNA.
EMBL; AY495103; AAR92676.1; -; Genomic_DNA.
EMBL; AY495104; AAR92689.1; -; Genomic_DNA.
EMBL; AY495105; AAR92702.1; -; Genomic_DNA.
EMBL; AY495106; AAR92715.1; -; Genomic_DNA.
EMBL; AY495107; AAR92728.1; -; Genomic_DNA.
EMBL; AY495109; AAR92754.1; -; Genomic_DNA.
EMBL; AY495110; AAR92767.1; -; Genomic_DNA.
EMBL; AY495112; AAR92793.1; -; Genomic_DNA.
EMBL; AY495113; AAR92806.1; -; Genomic_DNA.
EMBL; AY495114; AAR92819.1; -; Genomic_DNA.
EMBL; AY495115; AAR92832.1; -; Genomic_DNA.
EMBL; AY495116; AAR92845.1; -; Genomic_DNA.
EMBL; AY495117; AAR92858.1; -; Genomic_DNA.
EMBL; AY495118; AAR92871.1; -; Genomic_DNA.
EMBL; AY495119; AAR92884.1; -; Genomic_DNA.
EMBL; AY495120; AAR92897.1; -; Genomic_DNA.
EMBL; AY495121; AAR92910.1; -; Genomic_DNA.
EMBL; AY495122; AAR92923.1; -; Genomic_DNA.
EMBL; AY495124; AAR92949.1; -; Genomic_DNA.
EMBL; AY495125; AAR92962.1; -; Genomic_DNA.
EMBL; AY495126; AAR92975.1; -; Genomic_DNA.
EMBL; AY495128; AAR93001.1; -; Genomic_DNA.
EMBL; AY495129; AAR93014.1; -; Genomic_DNA.
EMBL; AY495130; AAR93027.1; -; Genomic_DNA.
EMBL; AY495131; AAR93040.1; -; Genomic_DNA.
EMBL; AY495132; AAR93053.1; -; Genomic_DNA.
EMBL; AY495133; AAR93066.1; -; Genomic_DNA.
EMBL; AY495134; AAR93079.1; -; Genomic_DNA.
EMBL; AY495135; AAR93092.1; -; Genomic_DNA.
EMBL; AY495136; AAR93105.1; -; Genomic_DNA.
EMBL; AY495137; AAR93118.1; -; Genomic_DNA.
EMBL; AY495138; AAR93131.1; -; Genomic_DNA.
EMBL; AY495139; AAR93144.1; -; Genomic_DNA.
EMBL; AY495140; AAR93157.1; -; Genomic_DNA.
EMBL; AY495141; AAR93170.1; -; Genomic_DNA.
EMBL; AY495142; AAR93183.1; -; Genomic_DNA.
EMBL; AY495143; AAR93196.1; -; Genomic_DNA.
EMBL; AY495144; AAR93209.1; -; Genomic_DNA.
EMBL; AY495145; AAR93222.1; -; Genomic_DNA.
EMBL; AY495146; AAR93235.1; -; Genomic_DNA.
EMBL; AY495147; AAR93248.1; -; Genomic_DNA.
EMBL; AY495148; AAR93261.1; -; Genomic_DNA.
EMBL; AY495149; AAR93274.1; -; Genomic_DNA.
EMBL; AY495150; AAR93287.1; -; Genomic_DNA.
EMBL; AY495151; AAR93300.1; -; Genomic_DNA.
EMBL; AY495152; AAR93313.1; -; Genomic_DNA.
EMBL; AY495153; AAR93326.1; -; Genomic_DNA.
EMBL; AY495154; AAR93339.1; -; Genomic_DNA.
EMBL; AY495155; AAR93352.1; -; Genomic_DNA.
EMBL; AY495156; AAR93365.1; -; Genomic_DNA.
EMBL; AY495157; AAR93378.1; -; Genomic_DNA.
EMBL; AY495158; AAR93391.1; -; Genomic_DNA.
EMBL; AY495159; AAR93404.1; -; Genomic_DNA.
EMBL; AY495160; AAR93417.1; -; Genomic_DNA.
EMBL; AY495161; AAR93430.1; -; Genomic_DNA.
EMBL; AY495162; AAR93443.1; -; Genomic_DNA.
EMBL; AY495163; AAR93456.1; -; Genomic_DNA.
EMBL; AY495164; AAR93469.1; -; Genomic_DNA.
EMBL; AY495165; AAR93482.1; -; Genomic_DNA.
EMBL; AY495166; AAR93495.1; -; Genomic_DNA.
EMBL; AY495167; AAR93508.1; -; Genomic_DNA.
EMBL; AY495168; AAR93521.1; -; Genomic_DNA.
EMBL; AY495169; AAR93534.1; -; Genomic_DNA.
EMBL; AY495170; AAR93547.1; -; Genomic_DNA.
EMBL; AY495171; AAR93560.1; -; Genomic_DNA.
EMBL; AY495172; AAR93573.1; -; Genomic_DNA.
EMBL; AY495173; AAR93586.1; -; Genomic_DNA.
EMBL; AY495174; AAR93599.1; -; Genomic_DNA.
EMBL; AY495175; AAR93612.1; -; Genomic_DNA.
EMBL; AY495176; AAR93625.1; -; Genomic_DNA.
EMBL; AY495177; AAR93638.1; -; Genomic_DNA.
EMBL; AY495180; AAR93677.1; -; Genomic_DNA.
EMBL; AY495185; AAR93742.1; -; Genomic_DNA.
EMBL; AY495187; AAR93768.1; -; Genomic_DNA.
EMBL; AY495188; AAR93781.1; -; Genomic_DNA.
EMBL; AY495189; AAR93794.1; -; Genomic_DNA.
EMBL; AY495190; AAR93807.1; -; Genomic_DNA.
EMBL; AY495191; AAR93820.1; -; Genomic_DNA.
EMBL; AY495192; AAR93833.1; -; Genomic_DNA.
EMBL; AY495193; AAR93846.1; -; Genomic_DNA.
EMBL; AY495194; AAR93859.1; -; Genomic_DNA.
EMBL; AY495195; AAR93872.1; -; Genomic_DNA.
EMBL; AY495196; AAR93885.1; -; Genomic_DNA.
EMBL; AY495197; AAR93898.1; -; Genomic_DNA.
EMBL; AY495198; AAR93911.1; -; Genomic_DNA.
EMBL; AY495199; AAR93924.1; -; Genomic_DNA.
EMBL; AY495200; AAR93937.1; -; Genomic_DNA.
EMBL; AY495201; AAR93950.1; -; Genomic_DNA.
EMBL; AY495202; AAR93963.1; -; Genomic_DNA.
EMBL; AY495203; AAR93976.1; -; Genomic_DNA.
EMBL; AY495204; AAR93989.1; -; Genomic_DNA.
EMBL; AY495205; AAR94002.1; -; Genomic_DNA.
EMBL; AY495206; AAR94015.1; -; Genomic_DNA.
EMBL; AY495207; AAR94028.1; -; Genomic_DNA.
EMBL; AY495208; AAR94041.1; -; Genomic_DNA.
EMBL; AY495210; AAR94067.1; -; Genomic_DNA.
EMBL; AY495211; AAR94080.1; -; Genomic_DNA.
EMBL; AY495212; AAR94093.1; -; Genomic_DNA.
EMBL; AY495213; AAR94106.1; -; Genomic_DNA.
EMBL; AY495214; AAR94119.1; -; Genomic_DNA.
EMBL; AY495216; AAR94145.1; -; Genomic_DNA.
EMBL; AY495217; AAR94158.1; -; Genomic_DNA.
EMBL; AY495218; AAR94171.1; -; Genomic_DNA.
EMBL; AY495219; AAR94184.1; -; Genomic_DNA.
EMBL; AY495220; AAR94197.1; -; Genomic_DNA.
EMBL; AY495221; AAR94210.1; -; Genomic_DNA.
EMBL; AY495222; AAR94223.1; -; Genomic_DNA.
EMBL; AY495223; AAR94236.1; -; Genomic_DNA.
EMBL; AY495224; AAR94249.1; -; Genomic_DNA.
EMBL; AY495225; AAR94262.1; -; Genomic_DNA.
EMBL; AY495226; AAR94275.1; -; Genomic_DNA.
EMBL; AY495227; AAR94288.1; -; Genomic_DNA.
EMBL; AY495228; AAR94301.1; -; Genomic_DNA.
EMBL; AY495229; AAR94314.1; -; Genomic_DNA.
EMBL; AY495230; AAR94327.1; -; Genomic_DNA.
EMBL; AY495231; AAR94340.1; -; Genomic_DNA.
EMBL; AY495232; AAR94353.1; -; Genomic_DNA.
EMBL; AY495233; AAR94366.1; -; Genomic_DNA.
EMBL; AY495234; AAR94379.1; -; Genomic_DNA.
EMBL; AY495235; AAR94392.1; -; Genomic_DNA.
EMBL; AY495236; AAR94405.1; -; Genomic_DNA.
EMBL; AY495237; AAR94418.1; -; Genomic_DNA.
EMBL; AY495238; AAR94431.1; -; Genomic_DNA.
EMBL; AY495239; AAR94444.1; -; Genomic_DNA.
EMBL; AY495240; AAR94457.1; -; Genomic_DNA.
EMBL; AY495241; AAR94470.1; -; Genomic_DNA.
EMBL; AY495242; AAR94483.1; -; Genomic_DNA.
EMBL; AY495243; AAR94496.1; -; Genomic_DNA.
EMBL; AY495244; AAR94509.1; -; Genomic_DNA.
EMBL; AY495245; AAR94522.1; -; Genomic_DNA.
EMBL; AY495246; AAR94535.1; -; Genomic_DNA.
EMBL; AY495247; AAR94548.1; -; Genomic_DNA.
EMBL; AY495248; AAR94561.1; -; Genomic_DNA.
EMBL; AY495249; AAR94574.1; -; Genomic_DNA.
EMBL; AY495250; AAR94587.1; -; Genomic_DNA.
EMBL; AY495251; AAR94600.1; -; Genomic_DNA.
EMBL; AY495252; AAR94613.1; -; Genomic_DNA.
EMBL; AY495253; AAR94626.1; -; Genomic_DNA.
EMBL; AY495254; AAR94639.1; -; Genomic_DNA.
EMBL; AY495255; AAR94652.1; -; Genomic_DNA.
EMBL; AY495256; AAR94665.1; -; Genomic_DNA.
EMBL; AY495257; AAR94678.1; -; Genomic_DNA.
EMBL; AY495258; AAR94691.1; -; Genomic_DNA.
EMBL; AY495259; AAR94704.1; -; Genomic_DNA.
EMBL; AY495261; AAR94730.1; -; Genomic_DNA.
EMBL; AY495262; AAR94743.1; -; Genomic_DNA.
EMBL; AY495263; AAR94756.1; -; Genomic_DNA.
EMBL; AY495264; AAR94769.1; -; Genomic_DNA.
EMBL; AY495266; AAR94795.1; -; Genomic_DNA.
EMBL; AY495267; AAR94808.1; -; Genomic_DNA.
EMBL; AY495268; AAR94821.1; -; Genomic_DNA.
EMBL; AY495269; AAR94834.1; -; Genomic_DNA.
EMBL; AY495270; AAR94847.1; -; Genomic_DNA.
EMBL; AY495271; AAR94860.1; -; Genomic_DNA.
EMBL; AY495272; AAR94873.1; -; Genomic_DNA.
EMBL; AY495273; AAR94886.1; -; Genomic_DNA.
EMBL; AY495274; AAR94899.1; -; Genomic_DNA.
EMBL; AY495275; AAR94912.1; -; Genomic_DNA.
EMBL; AY495276; AAR94925.1; -; Genomic_DNA.
EMBL; AY495277; AAR94938.1; -; Genomic_DNA.
EMBL; AY495278; AAR94951.1; -; Genomic_DNA.
EMBL; AY495279; AAR94964.1; -; Genomic_DNA.
EMBL; AY495280; AAR94977.1; -; Genomic_DNA.
EMBL; AY495281; AAR94990.1; -; Genomic_DNA.
EMBL; AY495282; AAR95003.1; -; Genomic_DNA.
EMBL; AY495283; AAR95016.1; -; Genomic_DNA.
EMBL; AY495284; AAR95029.1; -; Genomic_DNA.
EMBL; AY495285; AAR95042.1; -; Genomic_DNA.
EMBL; AY495286; AAR95055.1; -; Genomic_DNA.
EMBL; AY495287; AAR95068.1; -; Genomic_DNA.
EMBL; AY495288; AAR95081.1; -; Genomic_DNA.
EMBL; AY495289; AAR95094.1; -; Genomic_DNA.
EMBL; AY495290; AAR95107.1; -; Genomic_DNA.
EMBL; AY495291; AAR95120.1; -; Genomic_DNA.
EMBL; AY495292; AAR95133.1; -; Genomic_DNA.
EMBL; AY495293; AAR95146.1; -; Genomic_DNA.
EMBL; AY495294; AAR95159.1; -; Genomic_DNA.
EMBL; AY495295; AAR95172.1; -; Genomic_DNA.
EMBL; AY495296; AAR95185.1; -; Genomic_DNA.
EMBL; AY495297; AAR95198.1; -; Genomic_DNA.
EMBL; AY495298; AAR95211.1; -; Genomic_DNA.
EMBL; AY495299; AAR95224.1; -; Genomic_DNA.
EMBL; AY495300; AAR95237.1; -; Genomic_DNA.
EMBL; AY495301; AAR95250.1; -; Genomic_DNA.
EMBL; AY495302; AAR95263.1; -; Genomic_DNA.
EMBL; AY495303; AAR95276.1; -; Genomic_DNA.
EMBL; AY495304; AAR95289.1; -; Genomic_DNA.
EMBL; AY495305; AAR95302.1; -; Genomic_DNA.
EMBL; AY495306; AAR95315.1; -; Genomic_DNA.
EMBL; AY495307; AAR95328.1; -; Genomic_DNA.
EMBL; AY495308; AAR95341.1; -; Genomic_DNA.
EMBL; AY495310; AAR95367.1; -; Genomic_DNA.
EMBL; AY495311; AAR95380.1; -; Genomic_DNA.
EMBL; AY495312; AAR95393.1; -; Genomic_DNA.
EMBL; AY495313; AAR95406.1; -; Genomic_DNA.
EMBL; AY495314; AAR95419.1; -; Genomic_DNA.
EMBL; AY495315; AAR95432.1; -; Genomic_DNA.
EMBL; AY495316; AAR95445.1; -; Genomic_DNA.
EMBL; AY495317; AAR95458.1; -; Genomic_DNA.
EMBL; AY495318; AAR95471.1; -; Genomic_DNA.
EMBL; AY495319; AAR95484.1; -; Genomic_DNA.
EMBL; AY495320; AAR95497.1; -; Genomic_DNA.
EMBL; AY495321; AAR95510.1; -; Genomic_DNA.
EMBL; AY495322; AAR95523.1; -; Genomic_DNA.
EMBL; AY495323; AAR95536.1; -; Genomic_DNA.
EMBL; AY495324; AAR95549.1; -; Genomic_DNA.
EMBL; AY495325; AAR95562.1; -; Genomic_DNA.
EMBL; AY495326; AAR95575.1; -; Genomic_DNA.
EMBL; AY495327; AAR95588.1; -; Genomic_DNA.
EMBL; AY495328; AAR95601.1; -; Genomic_DNA.
EMBL; AY495329; AAR95614.1; -; Genomic_DNA.
EMBL; AY495330; AAR95627.1; -; Genomic_DNA.
PIR; A00455; DEHUN6.
RefSeq; YP_003024037.1; NC_012920.1.
ProteinModelPortal; P03923; -.
BioGrid; 110637; 6.
CORUM; P03923; -.
IntAct; P03923; 4.
STRING; 9606.ENSP00000354665; -.
ChEMBL; CHEMBL2363065; -.
DrugBank; DB00157; NADH.
DMDM; 6648060; -.
EPD; P03923; -.
PaxDb; P03923; -.
PeptideAtlas; P03923; -.
PRIDE; P03923; -.
TopDownProteomics; P03923; -.
Ensembl; ENST00000361681; ENSP00000354665; ENSG00000198695.
GeneID; 4541; -.
KEGG; hsa:4541; -.
CTD; 4541; -.
DisGeNET; 4541; -.
EuPathDB; HostDB:ENSG00000198695.2; -.
GeneCards; MT-ND6; -.
GeneReviews; MT-ND6; -.
HGNC; HGNC:7462; MT-ND6.
MalaCards; MT-ND6; -.
MIM; 252010; phenotype.
MIM; 500001; phenotype.
MIM; 516006; gene.
MIM; 535000; phenotype.
MIM; 540000; phenotype.
neXtProt; NX_P03923; -.
OpenTargets; ENSG00000198695; -.
Orphanet; 104; Leber hereditary optic neuropathy.
Orphanet; 99718; Leber plus disease.
Orphanet; 255210; Maternally-inherited Leigh syndrome.
Orphanet; 550; MELAS.
PharmGKB; PA31266; -.
eggNOG; ENOG410IYM9; Eukaryota.
eggNOG; ENOG410YP23; LUCA.
GeneTree; ENSGT00390000003988; -.
HOVERGEN; HBG007487; -.
InParanoid; P03923; -.
KO; K03884; -.
OMA; YLGGMMV; -.
OrthoDB; EOG091G111J; -.
PhylomeDB; P03923; -.
TreeFam; TF343324; -.
Reactome; R-HSA-611105; Respiratory electron transport.
Reactome; R-HSA-6799198; Complex I biogenesis.
GeneWiki; MT-ND6; -.
GenomeRNAi; 4541; -.
PRO; PR:P03923; -.
Proteomes; UP000005640; Mitochondrion.
Bgee; ENSG00000198695; -.
ExpressionAtlas; P03923; baseline and differential.
Genevisible; P03923; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
Pfam; PF00499; Oxidored_q3; 1.
1: Evidence at protein level;
Complete proteome; Disease mutation; Dystonia; Electron transport;
Leber hereditary optic neuropathy; MELAS syndrome; Membrane;
Mitochondrion; NAD; Oxidoreductase; Polymorphism;
Primary mitochondrial disease; Reference proteome; Respiratory chain;
Transmembrane; Transmembrane helix; Transport; Ubiquinone.
CHAIN 1 174 NADH-ubiquinone oxidoreductase chain 6.
/FTId=PRO_0000118291.
TRANSMEM 1 21 Helical. {ECO:0000255}.
TRANSMEM 26 46 Helical. {ECO:0000255}.
TRANSMEM 47 67 Helical. {ECO:0000255}.
TRANSMEM 86 106 Helical. {ECO:0000255}.
TRANSMEM 111 131 Helical. {ECO:0000255}.
TRANSMEM 151 171 Helical. {ECO:0000255}.
VARIANT 26 26 I -> M (in LDYT; possible rare primary
mutation; dbSNP:rs387906424).
{ECO:0000269|PubMed:8644732}.
/FTId=VAR_008394.
VARIANT 31 31 V -> A (in dbSNP:rs41354845).
{ECO:0000269|PubMed:11133798}.
/FTId=VAR_014393.
VARIANT 33 33 I -> V (in dbSNP:rs386829219).
{ECO:0000269|PubMed:11133798}.
/FTId=VAR_014394.
VARIANT 36 36 G -> S (in LHON; possible rare primary
mutation; dbSNP:rs397515506).
{ECO:0000269|PubMed:10447650}.
/FTId=VAR_008395.
VARIANT 58 58 I -> V (in dbSNP:rs201327354).
{ECO:0000269|PubMed:2043137}.
/FTId=VAR_014395.
VARIANT 59 59 Y -> C (in LHON; possible rare primary
mutation; dbSNP:rs869025186).
{ECO:0000269|PubMed:8854108}.
/FTId=VAR_008396.
VARIANT 60 60 L -> S (in LHON; possible rare primary
mutation; dbSNP:rs199476106).
{ECO:0000269|PubMed:11133798}.
/FTId=VAR_014396.
VARIANT 63 63 M -> V (in MT-C1D; dbSNP:rs199476109).
{ECO:0000269|PubMed:14595656,
ECO:0000269|PubMed:20818383}.
/FTId=VAR_064568.
VARIANT 64 64 M -> I (in LHON; possible rare primary
mutation; dbSNP:rs199476108).
/FTId=VAR_008512.
VARIANT 64 64 M -> V (in LHON; primary mutation; low
severity; up to 50% of vision recovery;
dbSNP:rs199476104).
{ECO:0000269|PubMed:1417830,
ECO:0000269|PubMed:9452107}.
/FTId=VAR_004763.
VARIANT 72 72 A -> V (in MT-C1D and LDYT; most severe
mutation with no vision recovery;
dbSNP:rs199476105).
{ECO:0000269|PubMed:20818383,
ECO:0000269|PubMed:8016139}.
/FTId=VAR_004764.
VARIANT 74 74 A -> V (in MELAS; dbSNP:rs199476107).
{ECO:0000269|PubMed:11781695}.
/FTId=VAR_014397.
VARIANT 165 165 Y -> C (in dbSNP:rs200933339).
{ECO:0000269|PubMed:1757091}.
/FTId=VAR_008604.
CONFLICT 102 102 L -> F (in Ref. 1; CAA24037).
{ECO:0000305}.
CONFLICT 134 134 L -> F (in Ref. 1; CAA24037).
{ECO:0000305}.
CONFLICT 159 159 T -> P (in Ref. 1; CAA24037).
{ECO:0000305}.
SEQUENCE 174 AA; 18622 MW; E50CD9F3FAFC600D CRC64;
MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY MGLMVFLIYL
GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV GLVLWVKEYD GVVVVVNFNS
VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYIVIEI ARGN


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