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NADPH--cytochrome P450 reductase (CPR) (p450R) (EC 1.6.2.4)

 A0A161I4M3_9ROSI        Unreviewed;       712 AA.
A0A161I4M3;
06-JUL-2016, integrated into UniProtKB/TrEMBL.
06-JUL-2016, sequence version 1.
28-MAR-2018, entry version 11.
RecName: Full=NADPH--cytochrome P450 reductase {ECO:0000256|HAMAP-Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208};
Short=CPR {ECO:0000256|HAMAP-Rule:MF_03212};
Short=P450R {ECO:0000256|HAMAP-Rule:MF_03212};
EC=1.6.2.4 {ECO:0000256|HAMAP-Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208};
Hypericum calycinum.
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; fabids; Malpighiales; Hypericaceae; Hypericeae;
Hypericum.
NCBI_TaxID=55963 {ECO:0000313|EMBL:ANC33513.1};
[1] {ECO:0000313|EMBL:ANC33513.1}
NUCLEOTIDE SEQUENCE.
PubMed=27145837; DOI=10.1038/ncomms11472;
El-Awaad I., Bocola M., Beuerle T., Liu B., Beerhues L.;
"Bifunctional CYP81AA proteins catalyse identical hydroxylations but
alternative regioselective phenol couplings in plant xanthone
biosynthesis.";
Nat. Commun. 7:11472-11472(2016).
-!- CATALYTIC ACTIVITY: NADPH + n oxidized hemoprotein = NADP(+) + n
reduced hemoprotein. {ECO:0000256|HAMAP-Rule:MF_03212,
ECO:0000256|PIRNR:PIRNR000208}.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000256|HAMAP-Rule:MF_03212};
Note=Binds 1 FAD per monomer. {ECO:0000256|HAMAP-Rule:MF_03212};
-!- COFACTOR:
Name=FMN; Xref=ChEBI:CHEBI:58210;
Evidence={ECO:0000256|HAMAP-Rule:MF_03212};
Note=Binds 1 FMN per monomer. {ECO:0000256|HAMAP-Rule:MF_03212};
-!- SIMILARITY: Belongs to the NADPH--cytochrome P450 reductase
family. {ECO:0000256|HAMAP-Rule:MF_03212}.
-!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
pyridine nucleotide cytochrome reductase family.
{ECO:0000256|HAMAP-Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208}.
-!- SIMILARITY: In the N-terminal section; belongs to the flavodoxin
family. {ECO:0000256|HAMAP-Rule:MF_03212}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03212}.
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EMBL; KT777456; ANC33513.1; -; mRNA.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-UniRule.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
GO; GO:0010181; F:FMN binding; IEA:UniProtKB-UniRule.
GO; GO:0050661; F:NADP binding; IEA:UniProtKB-UniRule.
GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:UniProtKB-UniRule.
Gene3D; 1.20.990.10; -; 1.
Gene3D; 3.40.50.360; -; 1.
HAMAP; MF_03212; NCPR; 1.
InterPro; IPR003097; FAD-binding_1.
InterPro; IPR017927; Fd_Rdtase_FAD-bd.
InterPro; IPR001094; Flavdoxin-like.
InterPro; IPR008254; Flavodoxin/NO_synth.
InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
InterPro; IPR029039; Flavoprotein-like_sf.
InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
InterPro; IPR023208; P450R.
InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
Pfam; PF00667; FAD_binding_1; 1.
Pfam; PF00258; Flavodoxin_1; 1.
Pfam; PF00175; NAD_binding_1; 1.
PIRSF; PIRSF000208; P450R; 1.
PRINTS; PR00369; FLAVODOXIN.
PRINTS; PR00371; FPNCR.
SUPFAM; SSF52218; SSF52218; 1.
SUPFAM; SSF63380; SSF63380; 1.
PROSITE; PS51384; FAD_FR; 1.
PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
2: Evidence at transcript level;
Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03212,
ECO:0000256|PIRNR:PIRNR000208}; FAD {ECO:0000256|HAMAP-Rule:MF_03212};
Flavoprotein {ECO:0000256|HAMAP-Rule:MF_03212};
FMN {ECO:0000256|HAMAP-Rule:MF_03212};
Membrane {ECO:0000256|HAMAP-Rule:MF_03212};
NADP {ECO:0000256|HAMAP-Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_03212,
ECO:0000256|PIRNR:PIRNR000208};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_03212};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_03212}.
TRANSMEM 50 70 Helical. {ECO:0000256|HAMAP-
Rule:MF_03212}.
DOMAIN 105 255 Flavodoxin-like.
{ECO:0000259|PROSITE:PS50902}.
DOMAIN 311 557 FAD-binding FR-type.
{ECO:0000259|PROSITE:PS51384}.
NP_BIND 111 116 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 166 169 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 204 213 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 490 493 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 508 510 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 632 633 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 638 642 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 239 239 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 331 331 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 571 571 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 674 674 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 712 712 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
SEQUENCE 712 AA; 78617 MW; 1AAF3B1A415DEC9C CRC64;
MEPTGSSTAM KVSPLDLMAA ILKGGRVDPA NASSAGPEVV SMILGNRETV VMVVATSIAV
IIGCAVFLFW RRSSSSRVKP KPHPLRPIAM RDLDLDEAVD GKKKVTILFG TQTGTAEGFA
KALAEEAKAR YDKAVFKVVD LDDYAADDEE YEEKLKKEDL VVLFLATYGD GEPTDNAARF
YKWLTEGNER SEWLKHLQFA VFGLGNRQYE HFNKVAIVVD EILAKEGAKR LAPVGLGDDD
QCIEDDFNAW REALWPEMDQ LLHDEDDVTT VATPYTAAVP EYRVVFNDSV DPNVEDKNWS
NANGHAVYDA QHPCRANVAV RKELHSPASD RSCTHLEFDI AGTGLSYETG DHVGVYCENL
EETVEEALQL LGLSPDTYFS LHSNKEDGTP LGGSLSPPFP PCTLRTALAR YADLLSSPKK
SALLALAAHA TDPTEVDRLR HLASLAGKDD YAQWMVANQR SLLEVMAEFP SAKPPLGVFF
AAVAPRLQPR YYSISSSPKI APTRIHVTCA LVLEKTPTGR IHKGICSTWM KNAIPMEKSN
DCSWAPVFVR QSNFKLPADP KVPVIMIGPG TGLAPFRGFL QERLALKESG AELGPAVLFF
GCRNRRMDFI YEDELNNFLE CGALSELVIA FSREGPTKEY VQHKMAEKAS DIWNMISQGG
YLYVCGDAKG MAKDVHRTLH TIVQEQGSLD SSKTESMVKN LQMNGRYLRD VW


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