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NADPH--cytochrome P450 reductase (CPR) (p450R) (EC 1.6.2.4)

 C0Z3X6_PLESU            Unreviewed;       711 AA.
C0Z3X6;
26-MAY-2009, integrated into UniProtKB/TrEMBL.
26-MAY-2009, sequence version 1.
27-SEP-2017, entry version 32.
RecName: Full=NADPH--cytochrome P450 reductase {ECO:0000256|HAMAP-Rule:MF_03212};
Short=CPR {ECO:0000256|HAMAP-Rule:MF_03212};
Short=p450R {ECO:0000256|HAMAP-Rule:MF_03212};
EC=1.6.2.4 {ECO:0000256|HAMAP-Rule:MF_03212};
Name=cpr {ECO:0000313|EMBL:CAQ37789.1};
Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae;
Ocimeae; Solenostemon.
NCBI_TaxID=4142 {ECO:0000313|EMBL:CAQ37789.1};
[1] {ECO:0000313|EMBL:CAQ37789.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Cell suspension culture {ECO:0000313|EMBL:CAQ37789.1};
PubMed=18982412; DOI=10.1007/s11103-008-9420-7;
Eberle D., Ullmann P., Werck-Reichhart D., Petersen M.;
"cDNA cloning and functional characterisation of CYP98A14 and
NADPH:cytochrome P450 reductase from Coleus blumei involved in
rosmarinic acid biosynthesis.";
Plant Mol. Biol. 69:239-253(2009).
-!- FUNCTION: This enzyme is required for electron transfer from NADP
to cytochrome P450 in microsomes. It can also provide electron
transfer to heme oxygenase and cytochrome B5. {ECO:0000256|HAMAP-
Rule:MF_03212}.
-!- CATALYTIC ACTIVITY: NADPH + n oxidized hemoprotein = NADP(+) + n
reduced hemoprotein. {ECO:0000256|HAMAP-Rule:MF_03212}.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000256|HAMAP-Rule:MF_03212};
Note=Binds 1 FAD per monomer. {ECO:0000256|HAMAP-Rule:MF_03212};
-!- COFACTOR:
Name=FMN; Xref=ChEBI:CHEBI:58210;
Evidence={ECO:0000256|HAMAP-Rule:MF_03212};
Note=Binds 1 FMN per monomer. {ECO:0000256|HAMAP-Rule:MF_03212};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000256|HAMAP-Rule:MF_03212}; Single-pass membrane protein
{ECO:0000256|HAMAP-Rule:MF_03212}; Cytoplasmic side
{ECO:0000256|HAMAP-Rule:MF_03212}.
-!- SIMILARITY: Belongs to the NADPH--cytochrome P450 reductase
family. {ECO:0000256|HAMAP-Rule:MF_03212}.
-!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
pyridine nucleotide cytochrome reductase family.
{ECO:0000256|HAMAP-Rule:MF_03212}.
-!- SIMILARITY: In the N-terminal section; belongs to the flavodoxin
family. {ECO:0000256|HAMAP-Rule:MF_03212}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03212}.
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EMBL; AM980997; CAQ37789.1; -; mRNA.
ProteinModelPortal; C0Z3X6; -.
BRENDA; 1.6.2.4; 1561.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
GO; GO:0010181; F:FMN binding; IEA:UniProtKB-UniRule.
GO; GO:0050661; F:NADP binding; IEA:UniProtKB-UniRule.
GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:UniProtKB-UniRule.
Gene3D; 3.40.50.360; -; 1.
HAMAP; MF_03212; NCPR; 1.
InterPro; IPR003097; FAD-binding_1.
InterPro; IPR017927; Fd_Rdtase_FAD-bd.
InterPro; IPR001094; Flavdoxin-like.
InterPro; IPR008254; Flavodoxin/NO_synth.
InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
InterPro; IPR029039; Flavoprotein-like_dom.
InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
InterPro; IPR023208; P450R.
InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
Pfam; PF00667; FAD_binding_1; 1.
Pfam; PF00258; Flavodoxin_1; 1.
Pfam; PF00175; NAD_binding_1; 1.
PRINTS; PR00369; FLAVODOXIN.
PRINTS; PR00371; FPNCR.
SUPFAM; SSF52218; SSF52218; 1.
SUPFAM; SSF63380; SSF63380; 1.
PROSITE; PS51384; FAD_FR; 1.
PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
2: Evidence at transcript level;
Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03212};
FAD {ECO:0000256|HAMAP-Rule:MF_03212};
Flavoprotein {ECO:0000256|HAMAP-Rule:MF_03212};
FMN {ECO:0000256|HAMAP-Rule:MF_03212};
Membrane {ECO:0000256|HAMAP-Rule:MF_03212};
NADP {ECO:0000256|HAMAP-Rule:MF_03212};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_03212,
ECO:0000313|EMBL:CAQ37789.1};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_03212};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_03212}.
TRANSMEM 47 67 Helical. {ECO:0000256|HAMAP-
Rule:MF_03212}.
DOMAIN 102 252 Flavodoxin-like.
{ECO:0000259|PROSITE:PS50902}.
DOMAIN 309 556 FAD-binding FR-type.
{ECO:0000259|PROSITE:PS51384}.
NP_BIND 108 113 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 163 166 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 201 210 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 489 492 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 507 509 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 523 526 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 631 632 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
NP_BIND 637 641 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 236 236 FMN. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 329 329 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 570 570 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 673 673 NADP. {ECO:0000256|HAMAP-Rule:MF_03212}.
BINDING 711 711 FAD. {ECO:0000256|HAMAP-Rule:MF_03212}.
SEQUENCE 711 AA; 78373 MW; CD47D33D82AFF9A4 CRC64;
MESTIEKLSP LDLMTAILKG VKLDNSNGSA GVEHPAVVAM LMENKDLMMM LTTSVAVLLG
LVVYLVWRRG AGSAKKVVEP QKLVVPKGPV EVEEVDDGKK KVTIFFGTQT GTAEGFAKAL
AEEAKARYPQ ANFKVVDMDD YAADDEEYEE KMKKETFAFF FLATYGDGEP TDNAARFYKW
FSEGKDRGDM FKNLHYGVFG LGNRQYEHFN KIAIVVDDLL FEQGGKRLVP VGLGDDDQCI
EDDFSARRDN VWPELDNLLR DEDYPPVSTP YTAAVLEYRV VFHDQSDELP SENTLANGRA
NGHASYDAQH PCKVNVAVKK ELHTPLSDRS CTHLEFDISG TGLEYETGDH VGVYCENLIE
TVEEAERLLG LSPQTFFSVH TDKEDGTPLG GSALPPPFPP CTLRTALTRY ADLLSAPKKA
ALIALAAYAS DPVEAERLTH LVSPAGKEEY AQYVVAGQRS LLEVMADFPS AKPPLGVFFA
GIAPRLQPRF YSISSSPKIA PSRIHVTCAL VYEKTPTGRI HKGVCSTWMK NAVPLEESPN
CSSAPVFVRT SNFRLPADPK VPVIMIGPGT GLAPFRGFLQ ERLALKESGA ELGPAVLFFG
CRNSKMDFIY QDELDNFVQA GVVSELVLAF SREGPAKEYV QHKMAQKAWD VWNMISEGGY
VYVCGDAKGM ARDVHRTLHT IVQEQGSLDS SKTESFVKNL QMTGAVLRDV W


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