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NADPH-dependent 7-cyano-7-deazaguanine reductase (EC 1.7.1.13) (7-cyano-7-carbaguanine reductase) (NADPH-dependent nitrile oxidoreductase) (PreQ(0) reductase)

 F4ARX3_GLAS4            Unreviewed;       279 AA.
F4ARX3;
28-JUN-2011, integrated into UniProtKB/TrEMBL.
28-JUN-2011, sequence version 1.
22-NOV-2017, entry version 44.
RecName: Full=NADPH-dependent 7-cyano-7-deazaguanine reductase {ECO:0000256|HAMAP-Rule:MF_00817, ECO:0000256|SAAS:SAAS00210972};
EC=1.7.1.13 {ECO:0000256|HAMAP-Rule:MF_00817, ECO:0000256|SAAS:SAAS00356735};
AltName: Full=7-cyano-7-carbaguanine reductase {ECO:0000256|HAMAP-Rule:MF_00817};
AltName: Full=NADPH-dependent nitrile oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00817};
AltName: Full=PreQ(0) reductase {ECO:0000256|HAMAP-Rule:MF_00817};
Name=queF {ECO:0000256|HAMAP-Rule:MF_00817};
OrderedLocusNames=Glaag_1139 {ECO:0000313|EMBL:AEE22100.1};
Glaciecola sp. (strain 4H-3-7+YE-5).
Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
Alteromonadaceae; Glaciecola.
NCBI_TaxID=983545 {ECO:0000313|EMBL:AEE22100.1, ECO:0000313|Proteomes:UP000006544};
[1] {ECO:0000313|EMBL:AEE22100.1, ECO:0000313|Proteomes:UP000006544}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=4H-3-7+YE-5 {ECO:0000313|EMBL:AEE22100.1,
ECO:0000313|Proteomes:UP000006544};
PubMed=21705587; DOI=10.1128/JB.05468-11;
US DOE Joint Genome Institute;
Klippel B., Lochner A., Bruce D.C., Davenport K.W., Detter C.,
Goodwin L.A., Han J., Han S., Land M.L., Mikhailova N., Nolan M.,
Pennacchio L., Pitluck S., Tapia R., Woyke T., Wiebusch S., Basner A.,
Abe F., Horikoshi K., Keller M., Antranikian G.;
"Complete genome sequence of the marine, cellulose and xylan degrading
bacterium Glaciecola sp. 4H-3-7+YE-5.";
J. Bacteriol. 193:4547-4548(2011).
[2]
NUCLEOTIDE SEQUENCE.
STRAIN=4H-3-7+YE-5;
US DOE Joint Genome Institute;
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I.,
Piela B., Lochner A., Antranikian F.I., Woyke T.;
"Complete sequence of chromosome of Glaciecola sp. 4H-3-7+YE-5.";
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the NADPH-dependent reduction of 7-cyano-7-
deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
{ECO:0000256|HAMAP-Rule:MF_00817, ECO:0000256|SAAS:SAAS00210964}.
-!- CATALYTIC ACTIVITY: 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-
cyano-7-carbaguanine + 2 NADPH. {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00356786}.
-!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
{ECO:0000256|HAMAP-Rule:MF_00817, ECO:0000256|SAAS:SAAS00356797}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00210971}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00356791}.
-!- SIMILARITY: Belongs to the GTP cyclohydrolase I family. QueF type
2 subfamily. {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00534868}.
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EMBL; CP002526; AEE22100.1; -; Genomic_DNA.
RefSeq; WP_013753161.1; NC_015497.1.
STRING; 983545.Glaag_1139; -.
EnsemblBacteria; AEE22100; AEE22100; Glaag_1139.
KEGG; gag:Glaag_1139; -.
eggNOG; ENOG4107R1K; Bacteria.
eggNOG; COG0780; LUCA.
eggNOG; COG2904; LUCA.
KO; K06879; -.
OrthoDB; POG091H01A3; -.
UniPathway; UPA00392; -.
Proteomes; UP000006544; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0046857; F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor; IEA:InterPro.
GO; GO:0033739; F:preQ1 synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniRule.
HAMAP; MF_00817; QueF_type2; 1.
InterPro; IPR029500; QueF.
InterPro; IPR029139; QueF_N.
InterPro; IPR016428; QueF_type2.
Pfam; PF14489; QueF; 1.
Pfam; PF14819; QueF_N; 1.
PIRSF; PIRSF004750; Nitrile_oxidored_YqcD_prd; 1.
TIGRFAMs; TIGR03138; QueF; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000006544};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00037298};
NADP {ECO:0000256|HAMAP-Rule:MF_00817, ECO:0000256|SAAS:SAAS00037302};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00037297, ECO:0000313|EMBL:AEE22100.1};
Queuosine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00817,
ECO:0000256|SAAS:SAAS00037293}.
DOMAIN 22 131 QueF_N. {ECO:0000259|Pfam:PF14819}.
NP_BIND 90 91 NADPH. {ECO:0000256|HAMAP-Rule:MF_00817}.
NP_BIND 255 256 NADPH. {ECO:0000256|HAMAP-Rule:MF_00817}.
REGION 88 90 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00817}.
REGION 226 227 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00817}.
ACT_SITE 187 187 Thioimide intermediate.
{ECO:0000256|HAMAP-Rule:MF_00817}.
ACT_SITE 194 194 Proton donor. {ECO:0000256|HAMAP-
Rule:MF_00817}.
SEQUENCE 279 AA; 32181 MW; FED943B9C3DDF809 CRC64;
MQDKTLPSDI LSSLTLGKTT QYKEHYSPDL LQGVPRSLNR DELNLGDTLP FKGVDRWNGY
ELSWLDLKGK PQVAILRCEV PCESVNLIES KSFKLYLNSF NQSKVESILH VQKMISKDLS
ACAGLPVNVQ LYAREAFPGL HLGTLEAQCI DDLDITIDNY ELEPSILRVE ESEVQETLCS
HLLKSNCLIT NQPDWGSVLI RYHGRKIDHE SVLRYLISFR QHNEFHEQCV ERIFSDIMKF
CKPQKLTVYA RYTRRGGLDI NPFRSNFESI YPELRLARQ


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