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NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase)
NDOR1_YEAST Reviewed; 623 AA.
Q12181; D6W456;
22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
13-FEB-2019, entry version 149.
RecName: Full=NADPH-dependent diflavin oxidoreductase 1 {ECO:0000255|HAMAP-Rule:MF_03178};
EC=1.18.1.- {ECO:0000255|HAMAP-Rule:MF_03178};
AltName: Full=NADPH-dependent FMN and FAD-containing oxidoreductase {ECO:0000255|HAMAP-Rule:MF_03178};
Name=TAH18 {ECO:0000255|HAMAP-Rule:MF_03178};
OrderedLocusNames=YPR048W; ORFNames=YP9499.06;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169875;
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V.,
Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M.,
Chung E., Churcher C.M., Coster F., Davis K., Davis R.W.,
Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A.,
Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A.,
Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W.,
Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K.,
Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J.,
Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D.,
Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V.,
Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W.,
Zollner A., Vo D.H., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
Nature 387:103-105(1997).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
FUNCTION.
PubMed=12759774; DOI=10.1007/s00294-003-0407-2;
Chanet R., Heude M.;
"Characterization of mutations that are synthetic lethal with pol3-13,
a mutated allele of DNA polymerase delta in Saccharomyces
cerevisiae.";
Curr. Genet. 43:337-350(2003).
[4]
FUNCTION IN APOPTOSIS, INTERACTION WITH DRE2, AND SUBCELLULAR
LOCATION.
PubMed=19194512; DOI=10.1371/journal.pone.0004376;
Vernis L., Facca C., Delagoutte E., Soler N., Chanet R., Guiard B.,
Faye G., Baldacci G.;
"A newly identified essential complex, Dre2-Tah18, controls
mitochondria integrity and cell death after oxidative stress in
yeast.";
PLoS ONE 4:E4376-E4376(2009).
[5]
FUNCTION, AND COFACTOR.
PubMed=20802492; DOI=10.1038/nchembio.432;
Netz D.J., Stumpfig M., Dore C., Muhlenhoff U., Pierik A.J., Lill R.;
"Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein
biogenesis.";
Nat. Chem. Biol. 6:758-765(2010).
[6]
FUNCTION, AND INTERACTION WITH DRE2.
PubMed=21902732; DOI=10.1111/j.1365-2958.2011.07788.x;
Soler N., Delagoutte E., Miron S., Facca C., Baille D., d'Autreaux B.,
Craescu G., Frapart Y.M., Mansuy D., Baldacci G., Huang M.E.,
Vernis L.;
"Interaction between the reductase Tah18 and highly conserved Fe-S
containing Dre2 C-terminus is essential for yeast viability.";
Mol. Microbiol. 82:54-67(2011).
-!- FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein
assembly (CIA) machinery. Required for the maturation of
extramitochondrial Fe-S proteins. Part of an electron transfer
chain functioning in an early step of cytosolic Fe-S biogenesis.
Transfers electrons from NADPH to the Fe-S cluster of DRE2.
Positively controls H(2)O(2)-induced cell death.
{ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:12759774,
ECO:0000269|PubMed:19194512, ECO:0000269|PubMed:20802492,
ECO:0000269|PubMed:21902732}.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000255|HAMAP-Rule:MF_03178,
ECO:0000269|PubMed:20802492};
-!- COFACTOR:
Name=FMN; Xref=ChEBI:CHEBI:58210;
Evidence={ECO:0000255|HAMAP-Rule:MF_03178,
ECO:0000269|PubMed:20802492};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=26 uM for NADPH;
KM=12 uM for cytochrome c;
Note=kcat is 0.14 sec(-1) for cytochrome c reduction.;
-!- SUBUNIT: Interacts with DRE2. {ECO:0000255|HAMAP-Rule:MF_03178,
ECO:0000269|PubMed:19194512, ECO:0000269|PubMed:21902732}.
-!- INTERACTION:
P36152:DRE2; NbExp=3; IntAct=EBI-37624, EBI-26482;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03178,
ECO:0000269|PubMed:19194512}. Mitochondrion {ECO:0000255|HAMAP-
Rule:MF_03178, ECO:0000269|PubMed:19194512}. Note=Relocalizes to
mitochondria after H(2)O(2) exposure. {ECO:0000255|HAMAP-
Rule:MF_03178, ECO:0000269|PubMed:19194512}.
-!- SIMILARITY: Belongs to the NADPH-dependent diflavin oxidoreductase
NDOR1 family. {ECO:0000255|HAMAP-Rule:MF_03178}.
-!- SIMILARITY: In the N-terminal section; belongs to the flavodoxin
family. {ECO:0000255|HAMAP-Rule:MF_03178}.
-!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
pyridine nucleotide cytochrome reductase family.
{ECO:0000255|HAMAP-Rule:MF_03178}.
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EMBL; Z71255; CAA94995.1; -; Genomic_DNA.
EMBL; Z49219; CAA89168.1; -; Genomic_DNA.
EMBL; BK006949; DAA11472.1; -; Genomic_DNA.
PIR; S54072; S54072.
RefSeq; NP_015373.1; NM_001184145.1.
ProteinModelPortal; Q12181; -.
SMR; Q12181; -.
BioGrid; 36224; 149.
ComplexPortal; CPX-386; TAH18-DRE2 complex.
DIP; DIP-1688N; -.
IntAct; Q12181; 7.
MINT; Q12181; -.
STRING; 4932.YPR048W; -.
MaxQB; Q12181; -.
PaxDb; Q12181; -.
PRIDE; Q12181; -.
EnsemblFungi; YPR048W_mRNA; YPR048W_mRNA; YPR048W.
GeneID; 856161; -.
KEGG; sce:YPR048W; -.
EuPathDB; FungiDB:YPR048W; -.
SGD; S000006252; TAH18.
GeneTree; ENSGT00930000151050; -.
HOGENOM; HOG000173033; -.
InParanoid; Q12181; -.
OMA; FEMMPLI; -.
BioCyc; YEAST:G3O-34203-MONOMER; -.
Reactome; R-SCE-2564818; Cytosolic iron-sulfur cluster assembly (yeast).
PRO; PR:Q12181; -.
Proteomes; UP000002311; Chromosome XVI.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IDA:SGD.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
GO; GO:0010181; F:FMN binding; IBA:GO_Central.
GO; GO:0050661; F:NADP binding; IEA:UniProtKB-UniRule.
GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IBA:GO_Central.
GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IDA:SGD.
GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:SGD.
GO; GO:0006809; P:nitric oxide biosynthetic process; IMP:SGD.
GO; GO:0055114; P:oxidation-reduction process; IDA:SGD.
GO; GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IMP:SGD.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:SGD.
Gene3D; 1.20.990.10; -; 1.
Gene3D; 3.40.50.360; -; 1.
Gene3D; 3.40.50.80; -; 1.
HAMAP; MF_03178; NDOR1; 1.
InterPro; IPR003097; CysJ-like_FAD-binding.
InterPro; IPR017927; FAD-bd_FR_type.
InterPro; IPR001094; Flavdoxin-like.
InterPro; IPR008254; Flavodoxin/NO_synth.
InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
InterPro; IPR029039; Flavoprotein-like_sf.
InterPro; IPR039261; FNR_nucleotide-bd.
InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
InterPro; IPR028879; NDOR1.
InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
Pfam; PF00667; FAD_binding_1; 1.
Pfam; PF00258; Flavodoxin_1; 1.
Pfam; PF00175; NAD_binding_1; 1.
PRINTS; PR00369; FLAVODOXIN.
PRINTS; PR00371; FPNCR.
SUPFAM; SSF52218; SSF52218; 1.
SUPFAM; SSF52343; SSF52343; 1.
SUPFAM; SSF63380; SSF63380; 1.
PROSITE; PS51384; FAD_FR; 1.
PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; FAD; Flavoprotein; FMN; Mitochondrion;
NADP; Oxidoreductase; Reference proteome.
CHAIN 1 623 NADPH-dependent diflavin oxidoreductase
1.
/FTId=PRO_0000167624.
DOMAIN 7 168 Flavodoxin-like. {ECO:0000255|HAMAP-
Rule:MF_03178}.
DOMAIN 224 491 FAD-binding FR-type. {ECO:0000255|HAMAP-
Rule:MF_03178}.
NP_BIND 13 18 FMN. {ECO:0000255|HAMAP-Rule:MF_03178}.
NP_BIND 60 63 FMN. {ECO:0000255|HAMAP-Rule:MF_03178}.
NP_BIND 106 115 FMN. {ECO:0000255|HAMAP-Rule:MF_03178}.
NP_BIND 413 416 FAD. {ECO:0000255|HAMAP-Rule:MF_03178}.
NP_BIND 445 448 FAD. {ECO:0000255|HAMAP-Rule:MF_03178}.
NP_BIND 538 539 NADP. {ECO:0000255|HAMAP-Rule:MF_03178}.
BINDING 142 142 FMN. {ECO:0000255|HAMAP-Rule:MF_03178}.
BINDING 383 383 FAD. {ECO:0000255|HAMAP-Rule:MF_03178}.
BINDING 623 623 FAD. {ECO:0000255|HAMAP-Rule:MF_03178}.
SEQUENCE 623 AA; 72328 MW; 5248B9512F77D628 CRC64;
MSSSKKIVIL YGSETGNAHD FATILSHRLH RWHFSHTFCS IGDYDPQDIL KCRYLFIICS
TTGQGELPRN VNALKGERPV TFWSFLKRKN LPSNLLNHIQ TAMLGLGDSS YPKFNYGIRK
LHQRIVTQLG ANELFDRLEA DDQAMAGSNK GTGLGIESVY FEYEKKVLSF LLSKYPNRKV
NGQIIKREEL DPEVYLEPAS YLQLSDEHAN EKFTSTKVIF EGDESLKVGR VNINKRITSE
GHFQDVRQFK FSNVDKIQEN YEPGDTVTIY PCNTDEDVSR FLANQSHWLE IADKPLNFTS
GVPNDLKDGG LVRPMTLRNL LKYHCDFMSI PRTSFFLKIW TFATDVTKME RGQEQLNDQR
EKLRQFATDQ DMQDLYDYCN RPRRSILEVL EDFISVKLPW KYVLDYLPII KPRYYSISSG
PGDPNIELTV AIVKYKTILR KIRRGICTNY IARLQEGEQI RYKLQNNHII KKEFLNKPMI
LVGPGVGLAP LLSVVKAEIS KDIKLLFGCR YKDKDYIYKD MLEDWFRKGK IALHSSFSRD
EENSPGVKYV QDYLWRLGEE ITNLVVNKDA VFFLCGSSGK MPIQVRLTFI EMLKKWGNFS
DEETAKKYLK EMEKSDRYIQ ETW
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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1566: Citrate cycle (TCA cycle)
WP1567: Glycolysis and Gluconeogenesis
WP1611: 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT
WP1619: Amino sugar and nucleotide sugar metabolism
WP1625: Base excision repair
WP1627: Benzoate degradation via hydroxylation
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair
WP1689: Porphyrin and chlorophyll metabolism
WP1695: Pyruvate metabolism
WP1717: Valine, leucine and isoleucine degradation
WP2199: Seed Development
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP710: DNA damage response (only ATM dependent)
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