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NEDD8 (Neddylin) (Protein NED-8) (Ubiquitin-like protein Nedd8)

 NEDD8_CAEEL             Reviewed;          77 AA.
Q93725;
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
23-MAY-2018, entry version 121.
RecName: Full=NEDD8;
AltName: Full=Neddylin;
AltName: Full=Protein NED-8;
AltName: Full=Ubiquitin-like protein Nedd8;
Flags: Precursor;
Name=ned-8; ORFNames=F45H11.2;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2]
DEVELOPMENTAL STAGE, FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=10993680; DOI=10.1006/dbio.2000.9847;
Jones D., Candido E.P.M.;
"The NED-8 conjugating system in Caenorhabditis elegans is required
for embryogenesis and terminal differentiation of the hypodermis.";
Dev. Biol. 226:152-165(2000).
[3]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=11847342; DOI=10.1126/science.1067765;
Kurz T., Pintard L., Willis J.H., Hamill D.R., Goenczy P., Peter M.,
Bowerman B.;
"Cytoskeletal regulation by the Nedd8 ubiquitin-like protein
modification pathway.";
Science 295:1294-1298(2002).
[4]
FUNCTION, AND SUBUNIT.
PubMed=12781129; DOI=10.1016/S0960-9822(03)00336-1;
Pintard L., Kurz T., Glaser S., Willis J.H., Peter M., Bowerman B.;
"Neddylation and deneddylation of CUL-3 is required to target MEI-
1/katanin for degradation at the meiosis-to-mitosis transition in C.
elegans.";
Curr. Biol. 13:911-921(2003).
[5]
INTERACTION WITH DCN-1.
PubMed=15988528; DOI=10.1038/nature03662;
Kurz T., Oezlue N., Rudolf F., O'Rourke S.M., Luke B., Hofmann K.,
Hyman A.A., Bowerman B., Peter M.;
"The conserved protein DCN-1/Dcn1p is required for cullin neddylation
in C. elegans and S. cerevisiae.";
Nature 435:1257-1261(2005).
[6]
INTERACTION WITH ATX-3.
PubMed=17935801; DOI=10.1016/j.bbamcr.2007.07.012;
Ferro A., Carvalho A.L., Teixeira-Castro A., Almeida C., Tome R.J.,
Cortes L., Rodrigues A.J., Logarinho E., Sequeiros J.,
Macedo-Ribeiro S., Maciel P.;
"NEDD8: a new ataxin-3 interactor.";
Biochim. Biophys. Acta 1773:1619-1627(2007).
-!- FUNCTION: Ubiquitin-like protein which plays an important role in
cell cycle control and embryogenesis. Covalent attachment to its
substrates requires prior activation by the E1 complex uba-3-ula-1
and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to
cullins activates their associated E3 ubiquitin ligase activity,
and thus promotes polyubiquitination and proteasomal degradation
of cyclins and other regulatory proteins.
{ECO:0000269|PubMed:10993680, ECO:0000269|PubMed:11847342,
ECO:0000269|PubMed:12781129}.
-!- SUBUNIT: Interacts with dcn-1 (PubMed:15988528). Covalently
attached to cullins (PubMed:12781129). May interact with atx-3
(PubMed:17935801). {ECO:0000269|PubMed:12781129,
ECO:0000269|PubMed:15988528, ECO:0000269|PubMed:17935801}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11847342}.
Cytoplasm {ECO:0000269|PubMed:11847342}. Note=Mainly nuclear
during interphase, also cytoplasmic during interphase and mitosis.
-!- DEVELOPMENTAL STAGE: Expressed throughout development.
{ECO:0000269|PubMed:10993680}.
-!- PTM: Cleavage of precursor form is necessary for function.
{ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Worms either arrest during embryonic
development, or show vulval eversion at the L4 stage and burst at
the vulva during the L4-to-adult molt. Those who survive to the
adult stage display severe defects in terminal differentiation of
seam cells, vulva and male tail. {ECO:0000269|PubMed:10993680}.
-!- SIMILARITY: Belongs to the ubiquitin family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z78420; CAB01708.1; -; Genomic_DNA.
PIR; T22249; T22249.
RefSeq; NP_492717.1; NM_060316.3.
UniGene; Cel.18712; -.
ProteinModelPortal; Q93725; -.
SMR; Q93725; -.
BioGrid; 38327; 3.
IntAct; Q93725; 1.
STRING; 6239.F45H11.2; -.
EPD; Q93725; -.
PaxDb; Q93725; -.
PeptideAtlas; Q93725; -.
PRIDE; Q93725; -.
EnsemblMetazoa; F45H11.2; F45H11.2; WBGene00003587.
GeneID; 172910; -.
KEGG; cel:CELE_F45H11.2; -.
UCSC; F45H11.2; c. elegans.
CTD; 172910; -.
WormBase; F45H11.2; CE10552; WBGene00003587; ned-8.
eggNOG; KOG0005; Eukaryota.
eggNOG; COG5272; LUCA.
GeneTree; ENSGT00900000141147; -.
HOGENOM; HOG000233942; -.
InParanoid; Q93725; -.
KO; K12158; -.
OMA; GKQMTDD; -.
OrthoDB; EOG091G178I; -.
PhylomeDB; Q93725; -.
Reactome; R-CEL-5689603; UCH proteinases.
Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-CEL-8951664; Neddylation.
PRO; PR:Q93725; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00003587; -.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:UniProtKB.
GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; IGI:WormBase.
CDD; cd01806; Nedd8; 1.
InterPro; IPR038738; Nedd8-like.
InterPro; IPR019956; Ubiquitin.
InterPro; IPR029071; Ubiquitin-like_domsf.
InterPro; IPR019954; Ubiquitin_CS.
InterPro; IPR000626; Ubiquitin_dom.
Pfam; PF00240; ubiquitin; 1.
PRINTS; PR00348; UBIQUITIN.
SMART; SM00213; UBQ; 1.
SUPFAM; SSF54236; SSF54236; 1.
PROSITE; PS00299; UBIQUITIN_1; 1.
PROSITE; PS50053; UBIQUITIN_2; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Developmental protein; Isopeptide bond;
Nucleus; Reference proteome; Ubl conjugation pathway.
CHAIN 1 76 NEDD8.
/FTId=PRO_0000042777.
PROPEP 77 77 {ECO:0000250}.
/FTId=PRO_0000042778.
REGION 70 72 Interaction with uba-3. {ECO:0000250}.
SITE 8 8 Interaction with uba-3. {ECO:0000250}.
SITE 44 44 Interaction with uba-3. {ECO:0000250}.
CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys)
(interchain with K-? in acceptor
proteins).
SEQUENCE 77 AA; 8629 MW; F3387DE33C671C78 CRC64;
MLIKVKTLTG KEIELDIEPN DRVERIKEKV EEKEGIPPPQ QRLIFAGKQM NDDKTAADYK
VLGGSVLHLV LALRGGF


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