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NGFI-A-binding protein 1 (EGR-1-binding protein 1)

 NAB1_MOUSE              Reviewed;         486 AA.
Q61122; Q99J24;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
30-AUG-2017, entry version 127.
RecName: Full=NGFI-A-binding protein 1;
AltName: Full=EGR-1-binding protein 1;
Name=Nab1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=7624335; DOI=10.1073/pnas.92.15.6873;
Russo M.W., Sevetson B.R., Milbrandt J.;
"Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated
transcription.";
Proc. Natl. Acad. Sci. U.S.A. 92:6873-6877(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8668170; DOI=10.1128/MCB.16.7.3545;
Svaren J., Sevetson B.R., Apel E.D., Zimonjic D.B., Popescu N.C.,
Milbrandt J.;
"NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
proliferative and differentiative stimuli.";
Mol. Cell. Biol. 16:3545-3553(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129, and FVB/N; TISSUE=Kidney, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND MUTAGENESIS.
PubMed=9774344; DOI=10.1093/emboj/17.20.6010;
Svaren J., Sevetson B.R., Golda T., Stanton J.J., Swirnoff A.H.,
Milbrandt J.;
"Novel mutants of NAB corepressors enhance activation by Egr
transactivators.";
EMBO J. 17:6010-6019(1998).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171; SER-182 AND
SER-405, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Kidney, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Acts as a transcriptional repressor for zinc finger
transcription factors EGR1 and EGR2. {ECO:0000250,
ECO:0000269|PubMed:9774344}.
-!- SUBUNIT: Homomultimers may associate with EGR1 bound to DNA.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Widely expressed in adult. In day 16 embryo
highest levels in forebrain, thymus, salivary gland and cartilage.
-!- DEVELOPMENTAL STAGE: In day 16 embryo highest levels in forebrain,
thymus, salivary gland and cartilage.
-!- DOMAIN: The NAB conserved domain 1 (NCD1) interacts with EGR1
inhibitory domain and mediates multimerization.
-!- DOMAIN: The NAB conserved domain 2 (NCD2) is necessary for
transcriptional repression.
-!- SIMILARITY: Belongs to the NAB family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U47008; AAC52649.1; -; mRNA.
EMBL; CH466548; EDK99971.1; -; Genomic_DNA.
EMBL; BC005627; AAH05627.1; -; mRNA.
EMBL; BC016886; AAH16886.1; -; mRNA.
CCDS; CCDS14944.1; -.
RefSeq; NP_032693.2; NM_008667.3.
RefSeq; XP_006495833.1; XM_006495770.2.
UniGene; Mm.25903; -.
ProteinModelPortal; Q61122; -.
SMR; Q61122; -.
IntAct; Q61122; 1.
MINT; MINT-2737045; -.
STRING; 10090.ENSMUSP00000066696; -.
iPTMnet; Q61122; -.
PhosphoSitePlus; Q61122; -.
EPD; Q61122; -.
MaxQB; Q61122; -.
PaxDb; Q61122; -.
PRIDE; Q61122; -.
Ensembl; ENSMUST00000069792; ENSMUSP00000066696; ENSMUSG00000002881.
GeneID; 17936; -.
KEGG; mmu:17936; -.
UCSC; uc007ayh.2; mouse.
CTD; 4664; -.
MGI; MGI:107564; Nab1.
eggNOG; KOG3835; Eukaryota.
eggNOG; ENOG410YKFH; LUCA.
GeneTree; ENSGT00390000006330; -.
HOGENOM; HOG000026777; -.
HOVERGEN; HBG003127; -.
InParanoid; Q61122; -.
OMA; AAAQLCM; -.
OrthoDB; EOG091G0NQE; -.
TreeFam; TF315501; -.
PRO; PR:Q61122; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000002881; -.
CleanEx; MM_NAB1; -.
ExpressionAtlas; Q61122; baseline and differential.
Genevisible; Q61122; MM.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0008134; F:transcription factor binding; IDA:MGI.
GO; GO:0001958; P:endochondral ossification; IGI:MGI.
GO; GO:0042552; P:myelination; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0045682; P:regulation of epidermis development; IGI:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IGI:MGI.
GO; GO:0014037; P:Schwann cell differentiation; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR006986; Nab1_C.
InterPro; IPR006989; NAB_co-repressor_dom.
InterPro; IPR006988; Nab_N.
Pfam; PF04902; Nab1; 1.
Pfam; PF04904; NCD1; 1.
Pfam; PF04905; NCD2; 1.
ProDom; PD342192; Nab_N; 1.
1: Evidence at protein level;
Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein;
Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 486 NGFI-A-binding protein 1.
/FTId=PRO_0000077040.
REGION 4 82 NCD1.
REGION 220 309 NCD2.
REGION 306 337 Necessary for nuclear localization.
{ECO:0000250}.
MOD_RES 171 171 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 182 182 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 327 327 Phosphoserine.
{ECO:0000250|UniProtKB:Q13506}.
MOD_RES 405 405 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CROSSLNK 126 126 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 129 129 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 143 143 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 211 211 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 332 332 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 332 332 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 354 354 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 368 368 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 372 372 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 453 453 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 464 464 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 476 476 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 479 479 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000250|UniProtKB:Q13506}.
CROSSLNK 479 479 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q13506}.
MUTAGEN 33 33 Q->R: Loss of transcriptional repression;
when associated with Q-64.
{ECO:0000269|PubMed:9774344}.
MUTAGEN 51 51 E->K: Loss of transcriptional repression.
{ECO:0000269|PubMed:9774344}.
MUTAGEN 64 64 H->Q: Loss of transcriptional repression;
when associated with R-33.
{ECO:0000269|PubMed:9774344}.
CONFLICT 181 181 A -> V (in Ref. 2; AAC52649).
{ECO:0000305}.
SEQUENCE 486 AA; 54010 MW; 535CC2ADD604219C CRC64;
MATALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS
KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP EGSPTWLGIS CNSYERSSSS
REPHLKIPKC AATTCVQSLG QGKSEVGSLA LQSVSDSRLW QGHHATESEH SLSPADLGSP
ASPKESSEAL DAAAALSVAE CVERMAPTLP KSDLSEVKEL LKNNKKLAKM IGHIFEMSDE
DPHKEEEIRK YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKIEDGFPDF QESVPTLFQQ ARAKSEELAG
LGSQQAEKGM AKQMELLCAQ AGYERLQQER RLTAGLYRQS SGEQSPDGGL PSDSSDGQGE
RPLNLRIPSV QNRQPHHFVV DGELSRLYSS EAKSHSSESL GILKDYPHSA FTLEKKVIKT
EPEDSR


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