Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

NGFI-A-binding protein 2 (EGR-1-binding protein 2)

 NAB2_MOUSE              Reviewed;         525 AA.
Q61127; Q80VR9;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
28-MAR-2018, entry version 135.
RecName: Full=NGFI-A-binding protein 2;
AltName: Full=EGR-1-binding protein 2;
Name=Nab2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain;
PubMed=8668170; DOI=10.1128/MCB.16.7.3545;
Svaren J., Sevetson B.R., Apel E.D., Zimonjic D.B., Popescu N.C.,
Milbrandt J.;
"NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
proliferative and differentiative stimuli.";
Mol. Cell. Biol. 16:3545-3553(1996).
[2]
PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 2).
PubMed=9126479; DOI=10.1006/geno.1997.4609;
Svaren J., Apel E.D., Simburger K.S., Jenkins N.A., Gilbert D.J.,
Copeland N.G., Milbrandt J.;
"The Nab2 and Stat6 genes share a common transcription termination
region.";
Genomics 41:33-39(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-159; SER-162;
SER-171 AND SER-479, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Acts as a transcriptional repressor for zinc finger
transcription factors EGR1 and EGR2. Isoform 2 lacks repression
ability.
-!- SUBUNIT: Homomultimers may associate with EGR1 bound to DNA.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus. Note=Isoform 2 is not localized to
the nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q61127-1; Sequence=Displayed;
Name=2;
IsoId=Q61127-2; Sequence=VSP_003388, VSP_003389;
-!- TISSUE SPECIFICITY: Highly expressed in brain and thymus, and at
lower levels in spleen, kidney, heart and testis. Isoform 1 is
predominantly expressed in testis, whereas isoform 3 is more
abundant in thymus.
-!- INDUCTION: By serum stimulation.
-!- DOMAIN: The NAB conserved domain 1 (NCD1) interacts with EGR1
inhibitory domain and mediates multimerization.
-!- DOMAIN: The NAB conserved domain 2 (NCD2) is necessary for
transcriptional repression.
-!- PTM: Sumoylation by EGR2 represses EGR2 transcriptional activity
in hindbrain. {ECO:0000250}.
-!- SIMILARITY: Belongs to the NAB family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U47543; AAC52650.1; -; mRNA.
EMBL; CH466578; EDL24515.1; -; Genomic_DNA.
EMBL; BC045139; AAH45139.1; -; mRNA.
CCDS; CCDS24247.1; -. [Q61127-1]
RefSeq; NP_001116367.1; NM_001122895.1.
RefSeq; NP_032694.2; NM_008668.2. [Q61127-1]
UniGene; Mm.336898; -.
UniGene; Mm.470656; -.
ProteinModelPortal; Q61127; -.
SMR; Q61127; -.
BioGrid; 201681; 3.
IntAct; Q61127; 4.
MINT; Q61127; -.
STRING; 10090.ENSMUSP00000026469; -.
iPTMnet; Q61127; -.
PhosphoSitePlus; Q61127; -.
EPD; Q61127; -.
PaxDb; Q61127; -.
PeptideAtlas; Q61127; -.
PRIDE; Q61127; -.
Ensembl; ENSMUST00000026469; ENSMUSP00000026469; ENSMUSG00000025402. [Q61127-1]
GeneID; 17937; -.
KEGG; mmu:17937; -.
UCSC; uc011xpt.1; mouse. [Q61127-1]
CTD; 4665; -.
MGI; MGI:107563; Nab2.
eggNOG; KOG3835; Eukaryota.
eggNOG; ENOG410YKFH; LUCA.
GeneTree; ENSGT00390000006330; -.
HOGENOM; HOG000026777; -.
HOVERGEN; HBG003127; -.
InParanoid; Q61127; -.
KO; K22388; -.
OMA; HARTNAD; -.
OrthoDB; EOG091G0NQE; -.
TreeFam; TF315501; -.
ChiTaRS; Nab2; mouse.
PRO; PR:Q61127; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000025402; -.
CleanEx; MM_NAB2; -.
ExpressionAtlas; Q61127; baseline and differential.
Genevisible; Q61127; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0008134; F:transcription factor binding; IDA:MGI.
GO; GO:0001958; P:endochondral ossification; IGI:MGI.
GO; GO:0042552; P:myelination; IGI:MGI.
GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; ISO:MGI.
GO; GO:1902949; P:positive regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0045682; P:regulation of epidermis development; IGI:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IGI:MGI.
GO; GO:0014037; P:Schwann cell differentiation; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.40.390.60; -; 1.
InterPro; IPR006989; NAB_co-repressor_dom.
InterPro; IPR006988; Nab_N.
InterPro; IPR038398; NCD2_sf.
Pfam; PF04904; NCD1; 1.
Pfam; PF04905; NCD2; 1.
ProDom; PD342192; Nab_N; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 525 NGFI-A-binding protein 2.
/FTId=PRO_0000077043.
REGION 35 113 NCD1.
REGION 267 356 NCD2.
REGION 353 384 Necessary for nuclear localization.
{ECO:0000250}.
MOD_RES 6 6 Phosphoserine.
{ECO:0000250|UniProtKB:Q15742}.
MOD_RES 157 157 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 159 159 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 162 162 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 171 171 Phosphoserine.
{ECO:0000244|PubMed:19131326,
ECO:0000244|PubMed:21183079}.
MOD_RES 479 479 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CROSSLNK 379 379 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000250|UniProtKB:Q15742}.
CROSSLNK 517 517 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1);
alternate.
{ECO:0000250|UniProtKB:Q15742}.
CROSSLNK 517 517 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:Q15742}.
VAR_SEQ 320 322 LTI -> ASL (in isoform 2).
{ECO:0000303|PubMed:8668170}.
/FTId=VSP_003388.
VAR_SEQ 323 525 Missing (in isoform 2).
{ECO:0000303|PubMed:8668170}.
/FTId=VSP_003389.
CONFLICT 233 233 G -> C (in Ref. 1; AAC52650).
{ECO:0000305}.
CONFLICT 465 465 R -> W (in Ref. 1; AAC52650).
{ECO:0000305}.
SEQUENCE 525 AA; 56577 MW; 4FFA510C8E39DF70 CRC64;
MHRAPSPTAE QPPGRGDNTR RTPQPRFKAS APAMALPRTL GELQLYRVLQ RANLLSYYET
FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV
PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG
DPRIWPGQST PESDVGAGGE EEAGSPPFSP PAGGGVSEGP GVGGVAAGGA GGGPDRLEPE
MVRMVVESVE RIFRSFPRGD TGEIASLLKL NKKLARSVGH IFEMDDHDAQ KEEEIRKYSV
IYGRLDSKRR EGKQLSLHEL TINEAAAQFC MRDNTLLLRR VELFSLSRQV ARESTYLSSL
KGSRLHSEEL GGPPLKKLKQ EVGEQSHNEI QQPPPGPESY APPYRPSLEE DSASLSGESL
DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP
CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ


Related products :

Catalog number Product name Quantity
18-003-43240 NGFI-A-binding protein 2 - EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER Polyclonal 0.1 mg Protein A
EIAAB26234 EGR-1-binding protein 1,Homo sapiens,Human,NAB1,NGFI-A-binding protein 1,Transcriptional regulatory protein p54
EIAAB26236 EGR-1-binding protein 2,Homo sapiens,Human,MADER,Melanoma-associated delayed early response protein,NAB2,NGFI-A-binding protein 2,Protein MADER
CSB-EL015401RA Rat NGFI-A binding protein 1 (EGR1 binding protein 1) (NAB1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GWB-6E98B6 Anti- NAB1 (NGFI-A binding protein 1 (EGR1 binding protein 1)) Antibody
GWB-2564A1 Anti- NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)) Antibody
18-003-43415 NGFI-A-binding protein 1 - EGR-1-binding protein 1; Transcriptional regulatory protein p54 Polyclonal 0.05 mg Aff Pur
EIAAB26235 EGR-1-binding protein 1,Nab1,NGFI-A-binding protein 1,Rat,Rattus norvegicus
EIAAB26237 EGR-1-binding protein 2,Mouse,Mus musculus,Nab2,NGFI-A-binding protein 2
EIAAB26233 EGR-1-binding protein 1,Mouse,Mus musculus,Nab1,NGFI-A-binding protein 1
NACA2 NAB2 Gene NGFI-A binding protein 2 (EGR1 binding protein 2)
NACA NAB1 Gene NGFI-A binding protein 1 (EGR1 binding protein 1)
201-20-3616 NAB2{NGFI-A binding protein 2 (EGR1 binding protein 2)}rabbit.pAb 0.2ml
CSB-EL015401MO Mouse NGFI-A binding protein 1 (EGR1 binding protein 1) (NAB1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL015402HU Human NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL015402MO Mouse NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL015401HU Human NGFI-A binding protein 1 (EGR1 binding protein 1) (NAB1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-PA015402GA01HU Rabbit anti-human NGFI-A binding protein 2 (EGR1 binding protein 2) polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
CSB-PA015402GA01HU Rabbit anti-human NGFI-A binding protein 2 (EGR1 binding protein 2) polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul
E0831m Rat ELISA Kit FOR NGFI-A-binding protein 1 96T
EIAAB26845 Amyloid beta A4 protein-binding family A member 2-binding protein,APBA2BP,Bos taurus,Bovine,NECAB3,N-terminal EF-hand calcium-binding protein 3,X11L-binding protein 51,XB51
EIAAB26846 Amyloid beta A4 protein-binding family A member 2-binding protein,Apba2bp,Mouse,Mus musculus,mXB51,Necab3,N-terminal EF-hand calcium-binding protein 3,X11L-binding protein 51,Xb51
U1772m CLIA Gbp3,GBP-3,Gbp4,GBP-4,GTP-binding protein 3,GTP-binding protein 4,Guanine nucleotide-binding protein 4,Guanylate-binding protein 3,Guanylate-binding protein 4,Mouse,Mus musculus 96T
E1772m ELISA Gbp3,GBP-3,Gbp4,GBP-4,GTP-binding protein 3,GTP-binding protein 4,Guanine nucleotide-binding protein 4,Guanylate-binding protein 3,Guanylate-binding protein 4,Mouse,Mus musculus 96T
E1772m ELISA kit Gbp3,GBP-3,Gbp4,GBP-4,GTP-binding protein 3,GTP-binding protein 4,Guanine nucleotide-binding protein 4,Guanylate-binding protein 3,Guanylate-binding protein 4,Mouse,Mus musculus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur