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Na( )/H( ) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na( )/H( ) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)

 NHRF3_HUMAN             Reviewed;         519 AA.
Q5T2W1; B4DPB9; E7EU02; O60450; Q5T5P6; Q9BQ41;
16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
16-AUG-2005, sequence version 2.
25-OCT-2017, entry version 132.
RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF3;
Short=NHERF-3;
AltName: Full=CFTR-associated protein of 70 kDa;
AltName: Full=Na(+)/H(+) exchanger regulatory factor 3;
AltName: Full=Na/Pi cotransporter C-terminal-associated protein 1;
Short=NaPi-Cap1;
AltName: Full=PDZ domain-containing protein 1;
AltName: Full=Sodium-hydrogen exchanger regulatory factor 3;
Name=PDZK1; Synonyms=CAP70, NHERF3, PDZD1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
INTERACTION WITH PDZK1IP1.
PubMed=9461128;
Kocher O., Comella N., Tognazzi K., Brown L.F.;
"Identification and partial characterization of PDZK1: a novel protein
containing PDZ interaction domains.";
Lab. Invest. 78:117-125(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Kidney;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY, AND INTERACTION WITH ABCC2.
PubMed=10496535;
Kocher O., Comella N., Gilchrist A., Pal R., Tognazzi K., Brown L.F.,
Knoll J.H.;
"PDZK1, a novel PDZ domain-containing protein up-regulated in
carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2),
the multidrug resistance-associated protein.";
Lab. Invest. 79:1161-1170(1999).
[6]
TISSUE SPECIFICITY.
PubMed=11051556; DOI=10.1016/S0092-8674(00)00096-9;
Wang S., Yue H., Derin R.B., Guggino W.B., Li M.;
"Accessory protein facilitated CFTR-CFTR interaction, a molecular
mechanism to potentiate the chloride channel activity.";
Cell 103:169-179(2000).
[7]
INTERACTION WITH BCR.
PubMed=15494376; DOI=10.1242/jcs.01472;
Malmberg E.K., Andersson C.X., Gentzsch M., Chen J.H., Mengos A.,
Cui L., Hansson G.C., Riordan J.R.;
"Bcr (breakpoint cluster region) protein binds to PDZ-domains of
scaffold protein PDZK1 and vesicle coat protein Mint3.";
J. Cell Sci. 117:5535-5541(2004).
[8]
INTERACTION WITH SLC26A3.
PubMed=15766278; DOI=10.1021/bi048828b;
Rossmann H., Jacob P., Baisch S., Hassoun R., Meier J., Natour D.,
Yahya K., Yun C., Biber J., Lackner K.J., Fiehn W., Gregor M.,
Seidler U., Lamprecht G.;
"The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3-
exchanger DRA in rabbit small intestinal mucosa.";
Biochemistry 44:4477-4487(2005).
[9]
INTERACTION WITH SLC9A3.
PubMed=16141316; DOI=10.1073/pnas.0506578102;
Thomson R.B., Wang T., Thomson B.R., Tarrats L., Girardi A.,
Mentone S., Soleimani M., Kocher O., Aronson P.S.;
"Role of PDZK1 in membrane expression of renal brush border ion
exchangers.";
Proc. Natl. Acad. Sci. U.S.A. 102:13331-13336(2005).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[11]
STRUCTURE BY NMR OF 132-224 AND 376-458.
RIKEN structural genomics initiative (RSGI);
"Solution structure of PDZ domains of PDZ domain containing protein
1.";
Submitted (FEB-2008) to the PDB data bank.
-!- FUNCTION: A scaffold protein that connects plasma membrane
proteins and regulatory components, regulating their surface
expression in epithelial cells apical domains. May be involved in
the coordination of a diverse range of regulatory processes for
ion transport and second messenger cascades. In complex with
SLC9A3R1, may cluster proteins that are functionally dependent in
a mutual fashion and modulate the trafficking and the activity of
the associated membrane proteins. May play a role in the cellular
mechanisms associated with multidrug resistance through its
interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR
chloride channel activity. Required for normal cell-surface
expression of SCARB1. Plays a role in maintaining normal plasma
cholesterol levels via its effects on SCARB1. Plays a role in the
normal localization and function of the chloride-anion exchanger
SLC26A6 to the plasma membrane in the brush border of the proximal
tubule of the kidney. May be involved in the regulation of
proximal tubular Na(+)-dependent inorganic phosphate cotransport
therefore playing an important role in tubule function (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with PDZK1IP1 and ABCC2. Interacts (via PDZ
domains 1 and 3) with SCARB1 (C-terminal domain). Forms a
heterodimeric complex with SLC9A3R1. Interacts with AKAP2, BCR,
CFTR, SLC22A12, SLC22A4, SLC22A5, SLC9A3R2 and SLC17A1. Component
of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA
receptors. Interacts (via PDZ1 domain) directly with KLHL17; the
interaction is important for integrity of actin cytoskeleton
structures in neurons. Interacts (via the first PDZ domain) with
PTGIR (via non-isoprenylated C-terminus) (By similarity).
Interacts (via C-terminal PDZ domain) with SLC26A6 (via C-terminal
domain) (By similarity). Interacts (via C-terminal PDZ domain)
with SLC9A3 (via C-terminal domain). {ECO:0000250,
ECO:0000269|PubMed:10496535, ECO:0000269|PubMed:15494376,
ECO:0000269|PubMed:15766278, ECO:0000269|PubMed:16141316,
ECO:0000269|PubMed:9461128}.
-!- INTERACTION:
P13569:CFTR; NbExp=2; IntAct=EBI-349819, EBI-349854;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JJ40};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell
membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with
peripheral membranes. Localizes to the apical compartment of
proximal tubular cells and to sinusoidal liver membranes.
{ECO:0000250|UniProtKB:Q9JJ40}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q5T2W1-1; Sequence=Displayed;
Name=2;
IsoId=Q5T2W1-2; Sequence=VSP_044637;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expression is limited to epithelial cells.
Expressed in the kidney (brush border of proximal tubule),
pancreas, liver, and small intestine. Expressed at a lower level
in the adrenal cortex, testis and stomach. Overexpressed in
breast, renal and lung carcinomas. {ECO:0000269|PubMed:10496535,
ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:9461128}.
-!- DOMAIN: The PDZ 2 and 3 domains seem to be involved in the
interaction with SLC26A3. {ECO:0000250}.
-!- DOMAIN: Interaction with the C-terminus of CFTR could be mediated
through independent binding of PDZ 1, 3 and 4 domains.
{ECO:0000250}.
-!- DOMAIN: The PDZ 1 and 3 domains seem to be involved in the
interaction with SLCO1A1. {ECO:0000250}.
-!- DOMAIN: The PDZ 1 domain interacts with BCR.
-!- DOMAIN: The PDZ 2 and 4 domains do not interact with the C-
terminal region of SCARB1. {ECO:0000250}.
-!- SIMILARITY: Belongs to the NHER family. {ECO:0000305}.
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EMBL; AF012281; AAC12264.1; -; mRNA.
EMBL; AK298269; BAG60531.1; -; mRNA.
EMBL; AL390725; CAI13715.1; -; Genomic_DNA.
EMBL; AL390725; CAI13716.1; -; Genomic_DNA.
EMBL; BC006496; AAH06496.1; -; mRNA.
EMBL; BC006518; AAH06518.1; -; mRNA.
CCDS; CCDS72859.1; -. [Q5T2W1-2]
CCDS; CCDS72860.1; -. [Q5T2W1-1]
RefSeq; NP_001188254.1; NM_001201325.1. [Q5T2W1-1]
RefSeq; NP_001188255.1; NM_001201326.1. [Q5T2W1-2]
RefSeq; NP_002605.2; NM_002614.4. [Q5T2W1-1]
RefSeq; XP_016856953.1; XM_017001464.1. [Q5T2W1-1]
UniGene; Hs.444751; -.
UniGene; Hs.732345; -.
PDB; 2EEI; NMR; -; A=132-224.
PDB; 2EEJ; NMR; -; A=376-458.
PDB; 2VSP; X-ray; 2.60 A; A/B/C/D=375-459.
PDB; 3TMH; X-ray; 3.80 A; A/E/I=375-459.
PDB; 4Q2P; X-ray; 2.05 A; A/B/C=132-215.
PDBsum; 2EEI; -.
PDBsum; 2EEJ; -.
PDBsum; 2VSP; -.
PDBsum; 3TMH; -.
PDBsum; 4Q2P; -.
ProteinModelPortal; Q5T2W1; -.
SMR; Q5T2W1; -.
BioGrid; 111200; 55.
CORUM; Q5T2W1; -.
IntAct; Q5T2W1; 11.
MINT; MINT-4999193; -.
STRING; 9606.ENSP00000342143; -.
iPTMnet; Q5T2W1; -.
PhosphoSitePlus; Q5T2W1; -.
BioMuta; PDZK1; -.
DMDM; 73621372; -.
EPD; Q5T2W1; -.
MaxQB; Q5T2W1; -.
PaxDb; Q5T2W1; -.
PeptideAtlas; Q5T2W1; -.
PRIDE; Q5T2W1; -.
DNASU; 5174; -.
Ensembl; ENST00000344770; ENSP00000342143; ENSG00000174827. [Q5T2W1-1]
Ensembl; ENST00000417171; ENSP00000394485; ENSG00000174827. [Q5T2W1-1]
Ensembl; ENST00000451928; ENSP00000403422; ENSG00000174827. [Q5T2W1-2]
GeneID; 5174; -.
KEGG; hsa:5174; -.
UCSC; uc001eoo.3; human. [Q5T2W1-1]
CTD; 5174; -.
DisGeNET; 5174; -.
EuPathDB; HostDB:ENSG00000174827.13; -.
GeneCards; PDZK1; -.
H-InvDB; HIX0056850; -.
H-InvDB; HIX0178034; -.
HGNC; HGNC:8821; PDZK1.
HPA; CAB008971; -.
HPA; HPA005755; -.
HPA; HPA006155; -.
MIM; 603831; gene.
neXtProt; NX_Q5T2W1; -.
OpenTargets; ENSG00000174827; -.
PharmGKB; PA33165; -.
eggNOG; ENOG410ITAE; Eukaryota.
eggNOG; ENOG410ZYGE; LUCA.
GeneTree; ENSGT00530000062999; -.
HOGENOM; HOG000113782; -.
HOVERGEN; HBG082115; -.
InParanoid; Q5T2W1; -.
OMA; DSHMAKE; -.
OrthoDB; EOG091G0KAL; -.
PhylomeDB; Q5T2W1; -.
TreeFam; TF350449; -.
ChiTaRS; PDZK1; human.
EvolutionaryTrace; Q5T2W1; -.
GeneWiki; PDZK1; -.
GenomeRNAi; 5174; -.
PRO; PR:Q5T2W1; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000174827; -.
CleanEx; HS_PDZK1; -.
ExpressionAtlas; Q5T2W1; baseline and differential.
Genevisible; Q5T2W1; HS.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0031526; C:brush border membrane; ISS:UniProtKB.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0031528; C:microvillus membrane; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO; GO:0032403; F:protein complex binding; IEA:Ensembl.
GO; GO:0005124; F:scavenger receptor binding; IEA:Ensembl.
GO; GO:0005215; F:transporter activity; TAS:UniProtKB.
GO; GO:0015879; P:carnitine transport; IDA:BHF-UCL.
GO; GO:0008283; P:cell proliferation; TAS:UniProtKB.
GO; GO:0015893; P:drug transport; NAS:UniProtKB.
GO; GO:0034767; P:positive regulation of ion transmembrane transport; IDA:BHF-UCL.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
GO; GO:0044070; P:regulation of anion transport; ISS:UniProtKB.
GO; GO:0006810; P:transport; IDA:BHF-UCL.
InterPro; IPR001478; PDZ.
InterPro; IPR036034; PDZ_sf.
Pfam; PF00595; PDZ; 4.
SMART; SM00228; PDZ; 4.
SUPFAM; SSF50156; SSF50156; 4.
PROSITE; PS50106; PDZ; 4.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane; Complete proteome;
Membrane; Phosphoprotein; Reference proteome; Repeat.
CHAIN 1 519 Na(+)/H(+) exchange regulatory cofactor
NHE-RF3.
/FTId=PRO_0000058287.
DOMAIN 9 90 PDZ 1. {ECO:0000255|PROSITE-
ProRule:PRU00143}.
DOMAIN 134 215 PDZ 2. {ECO:0000255|PROSITE-
ProRule:PRU00143}.
DOMAIN 243 323 PDZ 3. {ECO:0000255|PROSITE-
ProRule:PRU00143}.
DOMAIN 378 458 PDZ 4. {ECO:0000255|PROSITE-
ProRule:PRU00143}.
MOD_RES 108 108 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JJ40}.
MOD_RES 148 148 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 192 192 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 250 250 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 334 334 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 348 348 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 451 451 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 492 492 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 508 508 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 510 510 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 511 511 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 512 512 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
MOD_RES 514 514 Phosphoserine.
{ECO:0000250|UniProtKB:Q9JIL4}.
VAR_SEQ 154 264 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_044637.
CONFLICT 195 195 E -> K (in Ref. 1; AAC12264).
{ECO:0000305}.
CONFLICT 270 270 D -> G (in Ref. 2; BAG60531).
{ECO:0000305}.
STRAND 134 139 {ECO:0000244|PDB:4Q2P}.
STRAND 142 144 {ECO:0000244|PDB:2EEI}.
STRAND 148 150 {ECO:0000244|PDB:4Q2P}.
STRAND 159 161 {ECO:0000244|PDB:4Q2P}.
HELIX 168 172 {ECO:0000244|PDB:4Q2P}.
STRAND 179 183 {ECO:0000244|PDB:4Q2P}.
HELIX 193 202 {ECO:0000244|PDB:4Q2P}.
TURN 203 205 {ECO:0000244|PDB:4Q2P}.
STRAND 206 212 {ECO:0000244|PDB:4Q2P}.
TURN 214 216 {ECO:0000244|PDB:2EEI}.
STRAND 376 382 {ECO:0000244|PDB:2VSP}.
STRAND 385 387 {ECO:0000244|PDB:2EEJ}.
STRAND 389 392 {ECO:0000244|PDB:2EEJ}.
STRAND 398 405 {ECO:0000244|PDB:2EEJ}.
HELIX 411 414 {ECO:0000244|PDB:2VSP}.
STRAND 422 426 {ECO:0000244|PDB:2VSP}.
STRAND 432 434 {ECO:0000244|PDB:2EEJ}.
HELIX 436 443 {ECO:0000244|PDB:2VSP}.
STRAND 448 455 {ECO:0000244|PDB:2VSP}.
SEQUENCE 519 AA; 57129 MW; 98BF707F87CD77A6 CRC64;
MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ DGDRVLRING
VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAVKTRV DLKELGQSQK EQGLSDNILS
PVMNGGVQTW TQPRLCYLVK EGGSYGFSLK TVQGKKGVYM TDITPQGVAM RAGVLADDHL
IEVNGENVED ASHEEVVEKV KKSGSRVMFL LVDKETDKRH VEQKIQFKRE TASLKLLPHQ
PRIVEMKKGS NGYGFYLRAG SEQKGQIIKD IDSGSPAEEA GLKNNDLVVA VNGESVETLD
HDSVVEMIRK GGDQTSLLVV DKETDNMYRL AHFSPFLYYQ SQELPNGSVK EAPAPTPTSL
EVSSPPDTTE EVDHKPKLCR LAKGENGYGF HLNAIRGLPG SFIKEVQKGG PADLAGLEDE
DVIIEVNGVN VLDEPYEKVV DRIQSSGKNV TLLVCGKKAY DYFQAKKIPI VSSLADPLDT
PPDSKEGIVV ESNHDSHMAK ERAHSTASHS SSNSEDTEM


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EIAAB27172 Bos taurus,Bovine,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,NHERF3,NHERF-3,PDZ domain-containing protein 1,PDZD1,PDZK1,Sodium-hydrogen exchanger regulato
EIAAB27168 Na(+)_H(+) exchange regulatory cofactor NHE-RF2,NHE3 kinase A regulatory protein E3KARP,Nherf2,NHERF-2,Rat,Rattus norvegicus,SIP-1,Slc9a3r2,Sodium-hydrogen exchanger regulatory factor 2,Solute carrier
EIAAB27171 Mouse,Mus musculus,Na(+)_H(+) exchange regulatory cofactor NHE-RF2,NHE3 kinase A regulatory protein E3KARP,Nherf2,NHERF-2,Octs2,SIP-1,Slc9a3r2,Sodium-hydrogen exchanger regulatory factor 2,Solute carr
EIAAB27169 Homo sapiens,Human,Na(+)_H(+) exchange regulatory cofactor NHE-RF2,NHE3 kinase A regulatory protein E3KARP,NHERF2,NHERF-2,SIP-1,SLC9A3R2,Sodium-hydrogen exchanger regulatory factor 2,Solute carrier fa
EIAAB27174 CAP70,CFTR-associated protein of 70 kDa,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,NHERF3,NHERF-3,Oryctolagus cuniculus,PDZ domain-containing protein 1,PD
EIAAB27170 Na(+)_H(+) exchange regulatory cofactor NHE-RF2,NHERF2,Oryctolagus cuniculus,PDZ domain-containing protein NHERF-2,Rabbit,SLC9A3R2,Sodium-hydrogen exchanger regulatory factor 2,Solute carrier family 9
EIAAB27176 Cap70,CFTR-associated protein of 70 kDa,Mouse,Mus musculus,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,Na_Pi cotransporter C-terminal-associated protein 1,
EIAAB27173 CAP70,CFTR-associated protein of 70 kDa,Homo sapiens,Human,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,Na_Pi cotransporter C-terminal-associated protein 1,
10-288-21942F Ezrin-radixin-moesin-binding phosphoprotein 50 - EBP50; Na(+)_H(+) exchange regulatory cofactor NHE-RF; NHERF-1; Regulatory cofactor of Na(+)_H(+) exchanger; Sodium-hydrogen exchanger regulatory facto 0.1 mg
15-288-21942B Ezrin-radixin-moesin-binding phosphoprotein 50 - EBP50; Na(+)_H(+) exchange regulatory cofactor NHE-RF; NHERF-1; Regulatory cofactor of Na(+)_H(+) exchanger; Sodium-hydrogen exchanger regulatory facto 0.05 mg
10-288-21942F Ezrin-radixin-moesin-binding phosphoprotein 50 - EBP50; Na(+)_H(+) exchange regulatory cofactor NHE-RF; NHERF-1; Regulatory cofactor of Na(+)_H(+) exchanger; Sodium-hydrogen exchanger regulatory facto 0.05 mg
15-288-21942B Ezrin-radixin-moesin-binding phosphoprotein 50 - EBP50; Na(+)_H(+) exchange regulatory cofactor NHE-RF; NHERF-1; Regulatory cofactor of Na(+)_H(+) exchanger; Sodium-hydrogen exchanger regulatory facto 0.1 mg
EIAAB27175 Clamp,C-terminal-linking and modulating protein,Dietary Pi-regulated RNA-1,Diphor1,Diphor-1,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,Na_Pi cotransporter
EIAAB27167 Bos taurus,Bovine,EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,NHERF,NHERF1,NHERF-1,Regulatory cofactor of Na(+)_H(+) exchanger,SLC9A3R1,Sodium-
EIAAB27166 EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Mouse,Mus musculus,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,Nherf,Nherf1,NHERF-1,Regulatory cofactor of Na(+)_H(+) exchanger,Slc9a3r1,Sodium
EIAAB27164 EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Homo sapiens,Human,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,NHERF,NHERF1,NHERF-1,Regulatory cofactor of Na(+)_H(+) exchanger,SLC9A3R1,Sodium
EIAAB27165 EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,Nherf,Nherf1,NHERF-1,Rat,Rattus norvegicus,Regulatory cofactor of Na(+)_H(+) exchanger,Slc9a3r1,Sod
EIAAB27163 EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,NHERF,NHERF1,NHERF-1,Oryctolagus cuniculus,Rabbit,Regulatory cofactor of Na(+)_H(+) exchanger,SLC9A
EIAAB27162 Chicken,EBP50,Ezrin-radixin-moesin-binding phosphoprotein 50,Gallus gallus,Na(+)_H(+) exchange regulatory cofactor NHE-RF1,NHERF,NHERF1,NHERF-1,RCJMB04_3g21,Regulatory cofactor of Na(+)_H(+) exchanger
EIAAB27177 Mouse,Mus musculus,Na(+)_H(+) exchange regulatory cofactor NHE-RF4,Na_Pi cotransporter C-terminal-associated protein 2,NaPi-Cap2,Natrium-phosphate cotransporter IIa C-terminal-associated protein 2,Nhe
EIAAB27178 DLNB27,Homo sapiens,Human,IKEPP,Intestinal and kidney-enriched PDZ protein,Na(+)_H(+) exchange regulatory cofactor NHE-RF4,Na_Pi cotransporter C-terminal-associated protein 2,NaPi-Cap2,Natrium-phospha
EIAAB34440 DNA-binding protein RFX7,Homo sapiens,Human,Regulatory factor X 7,Regulatory factor X domain-containing protein 2,RFX7,RFXDC2
EIAAB34439 DNA-binding protein RFX6,Homo sapiens,Human,Regulatory factor X 6,Regulatory factor X domain-containing protein 1,RFX6,RFXDC1
EIAAB34438 DNA-binding protein RFX6,Mouse,Mus musculus,Regulatory factor X 6,Regulatory factor X domain-containing protein 1,Rfx6,Rfxdc1
EIAAB47434 HD gene regulatory region-binding protein 2,HDBP2,HDBP-2,HD-regulating factor 2,HDRF-2,Homo sapiens,Human,Huntington disease gene regulatory region-binding protein 2,Papillomavirus regulatory factor 1


 

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