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Natriuretic peptides A (Prepronatriodilatin) [Cleaved into: Atrial natriuretic factor (ANF) (Atrial natriuretic peptide) (ANP)]

 ANF_BOVIN               Reviewed;         152 AA.
P07501; A6QNW0;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 2.
12-SEP-2018, entry version 124.
RecName: Full=Natriuretic peptides A;
AltName: Full=Prepronatriodilatin;
Contains:
RecName: Full=Atrial natriuretic factor;
Short=ANF;
AltName: Full=Atrial natriuretic peptide;
Short=ANP;
Flags: Precursor;
Name=NPPA;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2939830; DOI=10.1016/0006-291X(86)90924-1;
Vlasuk G.P., Miller J., Bencen G.H., Lewicki J.A.;
"Structure and analysis of the bovine atrial natriuretic peptide
precursor gene.";
Biochem. Biophys. Res. Commun. 136:396-403(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Heart ventricle;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
[3]
PROTEIN SEQUENCE OF 123-150.
PubMed=3007908; DOI=10.1016/0024-3205(86)90425-X;
Ong H., McNicoll N., Lazure C., Seidah N., Chretien M., Cantin M.,
de Lean A.;
"Purification and sequence determination of bovine atrial natriuretic
factor.";
Life Sci. 38:1309-1315(1986).
-!- FUNCTION: Hormone playing a key role in cardiovascular homeostasis
through regulation of natriuresis, diuresis, and vasodilation.
Also plays a role in female pregnancy by promoting trophoblast
invasion and spiral artery remodeling in uterus. Specifically
binds and stimulates the cGMP production of the NPR1 receptor.
Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Cleaved by CORIN upon secretion to produce the functional
hormone. {ECO:0000250}.
-!- PTM: Atrial natriuretic factor: Cleaved by MME. The cleavage
initiates degradation of the factor and thereby regulate its
activity. {ECO:0000250|UniProtKB:P01160}.
-!- SIMILARITY: Belongs to the natriuretic peptide family.
{ECO:0000305}.
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EMBL; M13145; AAA30375.1; -; Genomic_DNA.
EMBL; BC149029; AAI49030.1; -; mRNA.
PIR; A90124; AWBO.
RefSeq; NP_776549.1; NM_174124.1.
UniGene; Bt.29967; -.
SMR; P07501; -.
STRING; 9913.ENSBTAP00000008819; -.
PaxDb; P07501; -.
Ensembl; ENSBTAT00000008819; ENSBTAP00000008819; ENSBTAG00000006709.
GeneID; 281355; -.
KEGG; bta:281355; -.
CTD; 4878; -.
VGNC; VGNC:32210; NPPA.
eggNOG; ENOG410IW5F; Eukaryota.
eggNOG; ENOG410ZUY6; LUCA.
GeneTree; ENSGT00510000048659; -.
HOGENOM; HOG000033937; -.
HOVERGEN; HBG004227; -.
InParanoid; P07501; -.
KO; K12334; -.
OMA; CNSFRYR; -.
OrthoDB; EOG091G0SV3; -.
TreeFam; TF106304; -.
Reactome; R-BTA-5578768; Physiological factors.
Proteomes; UP000009136; Chromosome 16.
Bgee; ENSBTAG00000006709; Expressed in 2 organ(s), highest expression level in heart.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0051427; F:hormone receptor binding; IEA:Ensembl.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0071855; F:neuropeptide receptor binding; IEA:Ensembl.
GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
GO; GO:0007565; P:female pregnancy; ISS:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IEA:Ensembl.
GO; GO:1902261; P:positive regulation of delayed rectifier potassium channel activity; IEA:Ensembl.
GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
GO; GO:1903766; P:positive regulation of potassium ion export across plasma membrane; IEA:Ensembl.
GO; GO:0006457; P:protein folding; IEA:Ensembl.
GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO; GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
InterPro; IPR000663; Natr_peptide.
InterPro; IPR030480; Natr_peptide_CS.
InterPro; IPR002407; Natriuretic_peptide_atrial.
Pfam; PF00212; ANP; 1.
PRINTS; PR00711; ANATPEPTIDE.
PRINTS; PR00710; NATPEPTIDES.
SMART; SM00183; NAT_PEP; 1.
PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal; Vasoactive.
SIGNAL 1 24 {ECO:0000250|UniProtKB:P24259}.
PROPEP 25 122 {ECO:0000305}.
/FTId=PRO_0000001482.
PEPTIDE 123 150 Atrial natriuretic factor.
{ECO:0000269|PubMed:3007908}.
/FTId=PRO_0000001483.
SITE 122 123 Cleavage; by CORIN.
{ECO:0000305|PubMed:3007908}.
SITE 129 130 Cleavage; by MME.
{ECO:0000250|UniProtKB:P01160}.
DISULFID 129 145 {ECO:0000250|UniProtKB:P01160}.
SEQUENCE 152 AA; 16518 MW; 48D040FAE01DFD15 CRC64;
MGSSAITVSF LLFLAFQLPG QTGANPVYGS VSNADLMDFK NLLDRLEDKM PLEDEAVPSQ
VLSEQNEEAG APLSPLSEMP PWMGEVNPAQ REGGVLGRGP WESSDRSALL KSKLRALLTA
PRSLRRSSCF GGRMDRIGAQ SGLGCNSFRY RR


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