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Natriuretic peptides B (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: Brain natriuretic peptide 45 (5 kDa cardiac natriuretic peptide) (BNP-34)]

 ANFB_RAT                Reviewed;         121 AA.
P13205;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 3.
18-JUL-2018, entry version 129.
RecName: Full=Natriuretic peptides B;
AltName: Full=Gamma-brain natriuretic peptide;
AltName: Full=Iso-ANP;
Contains:
RecName: Full=Brain natriuretic peptide 45;
AltName: Full=5 kDa cardiac natriuretic peptide;
AltName: Full=BNP-34;
Flags: Precursor;
Name=Nppb;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2522776; DOI=10.1016/0006-291X(89)92268-7;
Kojima M., Minamino N., Kangawa K., Matsuo H.;
"Cloning and sequence analysis of cDNA encoding a precursor for rat
brain natriuretic peptide.";
Biochem. Biophys. Res. Commun. 159:1420-1426(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2144113; DOI=10.1016/0006-291X(90)91409-L;
Roy R.N., Flynn T.G.;
"Organization of the gene for iso-rANP, a rat B-type natriuretic
peptide.";
Biochem. Biophys. Res. Commun. 171:416-423(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1837590; DOI=10.1210/mend-5-9-1292;
Dagnino L., Drouin J., Nemer M.;
"Differential expression of natriuretic peptide genes in cardiac and
extracardiac tissues.";
Mol. Endocrinol. 5:1292-1300(1991).
[4]
PROTEIN SEQUENCE OF 27-121.
PubMed=2673236; DOI=10.1016/0006-291X(89)92125-6;
Abuyara M., Hino J., Minamino N., Kangawa K., Matsuo H.;
"Isolation and identification of rat brain natriuretic peptides in
cardiac atrium.";
Biochem. Biophys. Res. Commun. 163:226-232(1989).
[5]
PROTEIN SEQUENCE OF 77-121.
TISSUE=Heart;
PubMed=2528349; DOI=10.1016/0006-291X(89)92126-8;
Kambayashi Y., Nakao K., Itoh H., Hosoda K., Saito Y., Yamada T.,
Mukoyama M., Arai H., Shirikami G., Suga S., Ogawa Y., Jougasaki M.,
Minamino N., Kangawa K., Matsuo H., Inouye K., Imura H.;
"Isolation and sequence determination of rat cardiac natriuretic
peptide.";
Biochem. Biophys. Res. Commun. 163:233-240(1989).
[6]
PROTEIN SEQUENCE OF 77-121.
PubMed=2525380; DOI=10.1016/0006-291X(89)92675-2;
Flynn T.G., Brar A., Tremblay L., Sarda I., Lyons C., Jennings D.B.;
"Isolation and characterization of iso-rANP, a new natriuretic peptide
from rat atria.";
Biochem. Biophys. Res. Commun. 161:830-837(1989).
[7]
PROTEIN SEQUENCE OF 99-115.
PubMed=2525379; DOI=10.1016/0006-291X(89)92661-2;
Itoh H., Nakao K., Kambayashi Y., Hosoda K., Saito Y., Yamada T.,
Mukoyama M., Arai H., Shirakami G., Suga S., Yoshida I., Inouye K.,
Imura H.;
"Occurrence of a novel cardiac natriuretic peptide in rats.";
Biochem. Biophys. Res. Commun. 161:732-739(1989).
-!- FUNCTION: Cardiac hormone which may function as a paracrine
antifibrotic factor in the heart. Also plays a key role in
cardiovascular homeostasis through natriuresis, diuresis,
vasorelaxation, and inhibition of renin and aldosterone secretion.
Specifically binds and stimulates the cGMP production of the NPR1
receptor. Binds the clearance receptor NPR3 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Brain and also in atria, but at much lower
levels than ANP.
-!- PTM: The brain natriuretic peptide 32 form is cleaved at Ser-91 by
the prolyl endopeptidase FAP (seprase) activity (in vitro).
{ECO:0000250|UniProtKB:P16860}.
-!- SIMILARITY: Belongs to the natriuretic peptide family.
{ECO:0000305}.
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EMBL; M25297; AAA57269.1; -; mRNA.
EMBL; M60731; AAA41456.1; -; Genomic_DNA.
EMBL; M60266; AAA41455.1; -; Genomic_DNA.
PIR; A30162; A30162.
RefSeq; NP_113733.1; NM_031545.1.
UniGene; Rn.3835; -.
SMR; P13205; -.
STRING; 10116.ENSRNOP00000010778; -.
PaxDb; P13205; -.
PRIDE; P13205; -.
Ensembl; ENSRNOT00000010779; ENSRNOP00000010778; ENSRNOG00000008141.
GeneID; 25105; -.
KEGG; rno:25105; -.
CTD; 4879; -.
RGD; 3194; Nppb.
eggNOG; ENOG410J2F8; Eukaryota.
eggNOG; ENOG410ZE1B; LUCA.
GeneTree; ENSGT00510000049822; -.
HOGENOM; HOG000033937; -.
HOVERGEN; HBG004227; -.
InParanoid; P13205; -.
KO; K12335; -.
OMA; SGCFGRK; -.
OrthoDB; EOG091G0T3N; -.
PhylomeDB; P13205; -.
TreeFam; TF106304; -.
PRO; PR:P13205; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000008141; -.
Genevisible; P13205; RN.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0005179; F:hormone activity; IDA:RGD.
GO; GO:0061049; P:cell growth involved in cardiac muscle cell development; IEP:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0007507; P:heart development; IEP:RGD.
GO; GO:0006954; P:inflammatory response; IEP:RGD.
GO; GO:0030308; P:negative regulation of cell growth; IDA:RGD.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IDA:RGD.
GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; IDA:RGD.
GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IDA:RGD.
GO; GO:1903816; P:positive regulation of collecting lymphatic vessel constriction; IDA:RGD.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IDA:RGD.
GO; GO:0035810; P:positive regulation of urine volume; IDA:RGD.
GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
GO; GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
GO; GO:0051592; P:response to calcium ion; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
InterPro; IPR000663; Natr_peptide.
InterPro; IPR030480; Natr_peptide_CS.
InterPro; IPR002408; Natriuretic_peptide_brain.
Pfam; PF00212; ANP; 1.
PRINTS; PR00712; BNATPEPTIDE.
SMART; SM00183; NAT_PEP; 1.
PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal; Vasoactive.
SIGNAL 1 26 {ECO:0000269|PubMed:2673236}.
PEPTIDE 27 121 Natriuretic peptides B.
/FTId=PRO_0000001538.
PEPTIDE 77 121 Brain natriuretic peptide 45.
/FTId=PRO_0000001539.
SITE 91 92 Cleavage; by FAP.
{ECO:0000250|UniProtKB:P16860}.
DISULFID 99 115
CONFLICT 15 15 L -> V (in Ref. 2; AAA41456).
{ECO:0000305}.
CONFLICT 120 120 L -> Q (in Ref. 6; AA sequence).
{ECO:0000305}.
SEQUENCE 121 AA; 13656 MW; B5D4151ED18C7294 CRC64;
MDLQKVLPQM ILLLLFLNLS PLGGHSHPLG SPSQSPEQST MQKLLELIRE KSEEMAQRQL
SKDQGPTKEL LKRVLRSQDS AFRIQERLRN SKMAHSSSCF GQKIDRIGAV SRLGCDGLRL
F


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