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Natriuretic peptides B (Gamma-brain natriuretic peptide) [Cleaved into: Brain natriuretic peptide (BNP)]

 ANFB_MOUSE              Reviewed;         121 AA.
P40753;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
05-DEC-2018, entry version 134.
RecName: Full=Natriuretic peptides B;
AltName: Full=Gamma-brain natriuretic peptide;
Contains:
RecName: Full=Brain natriuretic peptide;
Short=BNP;
Flags: Precursor;
Name=Nppb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ; TISSUE=Heart;
PubMed=8182124; DOI=10.1172/JCI117182;
Ogawa Y., Itoh H., Tamura N., Suga S., Yoshimasa T., Uehira M.,
Matsuda S., Shiono S., Nishimoto H., Nakao K.;
"Molecular cloning of the complementary DNA and gene that encode mouse
brain natriuretic peptide and generation of transgenic mice that
overexpress the brain natriuretic peptide gene.";
J. Clin. Invest. 93:1911-1921(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ;
PubMed=8097440; DOI=10.1161/01.RES.72.5.984;
Steinhelper M.E.;
"Structure, expression, and genomic mapping of the mouse natriuretic
peptide type-B gene.";
Circ. Res. 72:984-992(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
DISRUPTION PHENOTYPE.
PubMed=10737768; DOI=10.1073/pnas.070371497;
Tamura N., Ogawa Y., Chusho H., Nakamura K., Nakao K., Suda M.,
Kasahara M., Hashimoto R., Katsuura G., Mukoyama M., Itoh H.,
Saito Y., Tanaka I., Otani H., Katsuki M.;
"Cardiac fibrosis in mice lacking brain natriuretic peptide.";
Proc. Natl. Acad. Sci. U.S.A. 97:4239-4244(2000).
-!- FUNCTION: Cardiac hormone which may function as a paracrine
antifibrotic factor in the heart. Also plays a key role in
cardiovascular homeostasis through natriuresis, diuresis,
vasorelaxation, and inhibition of renin and aldosterone secretion.
Specifically binds and stimulates the cGMP production of the NPR1
receptor. Binds the clearance receptor NPR3.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=P40753-1; Sequence=Displayed;
Name=Short;
IsoId=P40753-2; Sequence=VSP_000263;
-!- TISSUE SPECIFICITY: Expressed abundantly in the ventricle, and in
a lesser extent in the atrium.
-!- PTM: The brain natriuretic peptide 32 form is cleaved at Ser-91 by
the prolyl endopeptidase FAP (seprase) activity (in vitro).
{ECO:0000250|UniProtKB:P16860}.
-!- DISRUPTION PHENOTYPE: Mice are viable and fertile and do not
display gross skeletal abnormalities. Fluid-electrolyte balance
and blood pressure remain normal although an increased rate of
focal fibrotic lesions is observed within the cardiac ventricles.
{ECO:0000269|PubMed:10737768}.
-!- SIMILARITY: Belongs to the natriuretic peptide family.
{ECO:0000305}.
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EMBL; D16497; BAA03948.1; -; Genomic_DNA.
EMBL; S58667; AAB26344.2; -; Genomic_DNA.
EMBL; BC061165; AAH61165.1; -; mRNA.
CCDS; CCDS18926.1; -. [P40753-1]
PIR; A49144; A49144.
PIR; I49548; I49548.
RefSeq; NP_001274277.1; NM_001287348.1. [P40753-2]
RefSeq; NP_032752.1; NM_008726.5. [P40753-1]
UniGene; Mm.2740; -.
ProteinModelPortal; P40753; -.
SMR; P40753; -.
STRING; 10090.ENSMUSP00000099521; -.
PhosphoSitePlus; P40753; -.
PaxDb; P40753; -.
PeptideAtlas; P40753; -.
PRIDE; P40753; -.
Ensembl; ENSMUST00000103231; ENSMUSP00000099521; ENSMUSG00000029019. [P40753-1]
GeneID; 18158; -.
KEGG; mmu:18158; -.
UCSC; uc008vto.3; mouse. [P40753-1]
UCSC; uc008vtp.3; mouse. [P40753-2]
CTD; 4879; -.
MGI; MGI:97368; Nppb.
eggNOG; ENOG410J2F8; Eukaryota.
eggNOG; ENOG410ZE1B; LUCA.
GeneTree; ENSGT00940000154513; -.
HOGENOM; HOG000033937; -.
HOVERGEN; HBG004227; -.
InParanoid; P40753; -.
KO; K12335; -.
OMA; GCNVLRR; -.
OrthoDB; EOG091G0T3N; -.
PhylomeDB; P40753; -.
TreeFam; TF106304; -.
PRO; PR:P40753; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000029019; Expressed in 43 organ(s), highest expression level in cardiac ventricle.
CleanEx; MM_NPPB; -.
ExpressionAtlas; P40753; baseline and differential.
Genevisible; P40753; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0005179; F:hormone activity; ISO:MGI.
GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IDA:MGI.
GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; ISO:MGI.
GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; ISO:MGI.
GO; GO:1903816; P:positive regulation of collecting lymphatic vessel constriction; ISO:MGI.
GO; GO:0035815; P:positive regulation of renal sodium excretion; ISO:MGI.
GO; GO:0035810; P:positive regulation of urine volume; ISO:MGI.
GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
GO; GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
InterPro; IPR000663; Natr_peptide.
InterPro; IPR030480; Natr_peptide_CS.
InterPro; IPR002408; Natriuretic_peptide_brain.
Pfam; PF00212; ANP; 1.
PRINTS; PR00712; BNATPEPTIDE.
SMART; SM00183; NAT_PEP; 1.
PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal; Vasoactive.
SIGNAL 1 26 {ECO:0000250}.
PEPTIDE 27 121 Natriuretic peptides B.
/FTId=PRO_0000001533.
PEPTIDE 77 121 Brain natriuretic peptide.
/FTId=PRO_0000001534.
SITE 91 92 Cleavage; by FAP.
{ECO:0000250|UniProtKB:P16860}.
DISULFID 99 115 {ECO:0000250}.
VAR_SEQ 43 43 Missing (in isoform Short).
{ECO:0000305}.
/FTId=VSP_000263.
CONFLICT 27 27 Y -> H (in Ref. 2; AAB26344).
{ECO:0000305}.
CONFLICT 71 71 P -> L (in Ref. 2; AAB26344).
{ECO:0000305}.
SEQUENCE 121 AA; 13756 MW; 4F62AC9445E293B9 CRC64;
MDLLKVLSQM ILFLLFLYLS PLGGHSYPLG SPSQSPEQFK MQKLLELIRE KSEEMAQRQL
LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF GHKIDRIGSV SRLGCNALKL
L


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