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Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)

 NEC2_HUMAN              Reviewed;         638 AA.
P16519; B1ANH9; B4DFQ3; Q14927; Q5JYQ1; Q8IWA8; Q9NQG3; Q9NUG1;
Q9UJC6;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
21-FEB-2001, sequence version 2.
22-NOV-2017, entry version 174.
RecName: Full=Neuroendocrine convertase 2;
Short=NEC 2;
EC=3.4.21.94;
AltName: Full=KEX2-like endoprotease 2;
AltName: Full=Prohormone convertase 2;
AltName: Full=Proprotein convertase 2;
Short=PC2;
Flags: Precursor;
Name=PCSK2; Synonyms=NEC2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Insulinoma;
PubMed=2154467;
Smeekens S.P., Steiner D.F.;
"Identification of a human insulinoma cDNA encoding a novel mammalian
protein structurally related to the yeast dibasic processing protease
Kex2.";
J. Biol. Chem. 265:2997-3000(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=1594602; DOI=10.1073/pnas.89.11.4977;
Ohagi S., Lamendola J., Lebeau M.M., Espinosa R., Takeda J.,
Smeekens S.P., Chan S.J., Steiner D.F.;
"Identification and analysis of the gene encoding human PC2, a
prohormone convertase expressed in neuroendocrine tissues.";
Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Amygdala, and Brain cortex;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND
VARIANTS GLN-244 AND GLU-484.
TISSUE=Brain, and Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
PubMed=7983775;
Ohagi S., Yoshida H., Nanjo K.;
"Analysis of the gene encoding human PC2, a prohormone processing
enzyme.";
Nippon Rinsho 52:2544-2549(1994).
[8]
FUNCTION.
PubMed=9287128; DOI=10.1016/S0014-5793(97)00892-2;
Rouille Y., Bianchi M., Irminger J.C., Halban P.A.;
"Role of the prohormone convertase PC2 in the processing of
proglucagon to glucagon.";
FEBS Lett. 413:119-123(1997).
[9]
VARIANT [LARGE SCALE ANALYSIS] ASN-424.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Involved in the processing of hormone and other protein
precursors at sites comprised of pairs of basic amino acid
residues. Responsible for the release of glucagon from proglucagon
in pancreatic A cells. {ECO:0000269|PubMed:9287128}.
-!- CATALYTIC ACTIVITY: Release of protein hormones and neuropeptides
from their precursors, generally by hydrolysis of -Lys-
Arg-|- bonds.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle.
Note=Localized in the secretion granules.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P16519-1; Sequence=Displayed;
Name=2;
IsoId=P16519-2; Sequence=VSP_043358;
Note=No experimental confirmation available.;
Name=3;
IsoId=P16519-3; Sequence=VSP_045873;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA21069.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAB89428.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAB96732.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; J05252; AAA60032.1; -; mRNA.
EMBL; M95971; AAA59919.1; -; Genomic_DNA.
EMBL; M95960; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95961; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95962; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95963; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95964; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95965; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95966; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95967; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95968; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95969; AAA59919.1; JOINED; Genomic_DNA.
EMBL; M95970; AAA59919.1; JOINED; Genomic_DNA.
EMBL; AK294200; BAG57514.1; -; mRNA.
EMBL; AK312341; BAG35262.1; -; mRNA.
EMBL; AL031675; CAA21069.2; ALT_INIT; Genomic_DNA.
EMBL; AL031664; CAA21069.2; JOINED; Genomic_DNA.
EMBL; AL121779; CAA21069.2; JOINED; Genomic_DNA.
EMBL; AL359511; CAA21069.2; JOINED; Genomic_DNA.
EMBL; AL031664; CAB89428.2; ALT_INIT; Genomic_DNA.
EMBL; AL031675; CAB89428.2; JOINED; Genomic_DNA.
EMBL; AL121779; CAB89428.2; JOINED; Genomic_DNA.
EMBL; AL359511; CAB89428.2; JOINED; Genomic_DNA.
EMBL; AL121779; CAB96732.2; ALT_INIT; Genomic_DNA.
EMBL; AL031664; CAB96732.2; JOINED; Genomic_DNA.
EMBL; AL031675; CAB96732.2; JOINED; Genomic_DNA.
EMBL; AL359511; CAB96732.2; JOINED; Genomic_DNA.
EMBL; AL359511; CAC34957.2; -; Genomic_DNA.
EMBL; AL031664; CAC34957.2; JOINED; Genomic_DNA.
EMBL; AL031675; CAC34957.2; JOINED; Genomic_DNA.
EMBL; AL121779; CAC34957.2; JOINED; Genomic_DNA.
EMBL; AL121779; CAI19155.1; -; Genomic_DNA.
EMBL; AL031664; CAI19155.1; JOINED; Genomic_DNA.
EMBL; AL031675; CAI19155.1; JOINED; Genomic_DNA.
EMBL; AL359511; CAI19155.1; JOINED; Genomic_DNA.
EMBL; AL359511; CAI20085.1; -; Genomic_DNA.
EMBL; AL031664; CAI20085.1; JOINED; Genomic_DNA.
EMBL; AL031675; CAI20085.1; JOINED; Genomic_DNA.
EMBL; AL121779; CAI20085.1; JOINED; Genomic_DNA.
EMBL; AL031664; CAI21690.1; -; Genomic_DNA.
EMBL; AL031675; CAI21690.1; JOINED; Genomic_DNA.
EMBL; AL121779; CAI21690.1; JOINED; Genomic_DNA.
EMBL; AL359511; CAI21690.1; JOINED; Genomic_DNA.
EMBL; AL031675; CAI22648.1; -; Genomic_DNA.
EMBL; AL031664; CAI22648.1; JOINED; Genomic_DNA.
EMBL; AL121779; CAI22648.1; JOINED; Genomic_DNA.
EMBL; AL359511; CAI22648.1; JOINED; Genomic_DNA.
EMBL; CH471133; EAX10279.1; -; Genomic_DNA.
EMBL; CH471133; EAX10280.1; -; Genomic_DNA.
EMBL; CH471133; EAX10281.1; -; Genomic_DNA.
EMBL; BC005815; AAH05815.1; -; mRNA.
EMBL; BC040546; AAH40546.1; -; mRNA.
EMBL; S75955; AAD14202.1; -; Genomic_DNA.
CCDS; CCDS13125.1; -. [P16519-1]
CCDS; CCDS56179.1; -. [P16519-2]
CCDS; CCDS56180.1; -. [P16519-3]
PIR; A45382; KXHUC2.
RefSeq; NP_001188457.1; NM_001201528.1. [P16519-3]
RefSeq; NP_001188458.1; NM_001201529.2. [P16519-2]
RefSeq; NP_002585.2; NM_002594.4. [P16519-1]
UniGene; Hs.315186; -.
ProteinModelPortal; P16519; -.
SMR; P16519; -.
STRING; 9606.ENSP00000262545; -.
BindingDB; P16519; -.
ChEMBL; CHEMBL2433; -.
DrugBank; DB00030; Insulin Human.
DrugBank; DB00071; Insulin Pork.
GuidetoPHARMACOLOGY; 2383; -.
MEROPS; S08.073; -.
iPTMnet; P16519; -.
PhosphoSitePlus; P16519; -.
BioMuta; PCSK2; -.
DMDM; 13124785; -.
PaxDb; P16519; -.
PeptideAtlas; P16519; -.
PRIDE; P16519; -.
DNASU; 5126; -.
Ensembl; ENST00000262545; ENSP00000262545; ENSG00000125851. [P16519-1]
Ensembl; ENST00000377899; ENSP00000367131; ENSG00000125851. [P16519-3]
Ensembl; ENST00000536609; ENSP00000437458; ENSG00000125851. [P16519-2]
GeneID; 5126; -.
KEGG; hsa:5126; -.
UCSC; uc002wpl.4; human. [P16519-1]
CTD; 5126; -.
DisGeNET; 5126; -.
EuPathDB; HostDB:ENSG00000125851.9; -.
GeneCards; PCSK2; -.
HGNC; HGNC:8744; PCSK2.
HPA; HPA049627; -.
MIM; 162151; gene.
neXtProt; NX_P16519; -.
OpenTargets; ENSG00000125851; -.
PharmGKB; PA33091; -.
eggNOG; KOG3525; Eukaryota.
eggNOG; KOG3526; Eukaryota.
eggNOG; COG1404; LUCA.
eggNOG; COG4935; LUCA.
GeneTree; ENSGT00750000117358; -.
HOGENOM; HOG000192536; -.
HOVERGEN; HBG008705; -.
InParanoid; P16519; -.
KO; K01360; -.
OMA; PQRGVLK; -.
OrthoDB; EOG091G05HI; -.
PhylomeDB; P16519; -.
TreeFam; TF314277; -.
Reactome; R-HSA-264876; Insulin processing.
SignaLink; P16519; -.
SIGNOR; P16519; -.
ChiTaRS; PCSK2; human.
GeneWiki; Proprotein_convertase_2; -.
GenomeRNAi; 5126; -.
PRO; PR:P16519; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000125851; -.
CleanEx; HS_PCSK2; -.
Genevisible; P16519; HS.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0016020; C:membrane; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0034774; C:secretory granule lumen; TAS:Reactome.
GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO; GO:0032403; F:protein complex binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO; GO:0034230; P:enkephalin processing; ISS:BHF-UCL.
GO; GO:0030070; P:insulin processing; IDA:BHF-UCL.
GO; GO:0034231; P:islet amyloid polypeptide processing; ISS:BHF-UCL.
GO; GO:0007399; P:nervous system development; IEA:Ensembl.
GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
GO; GO:0006508; P:proteolysis; IDA:BHF-UCL.
CDD; cd04059; Peptidases_S8_Protein_converta; 1.
Gene3D; 2.60.120.260; -; 1.
Gene3D; 3.40.50.200; -; 1.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR034182; Kexin/furin.
InterPro; IPR009020; Peptidase/Inhibitor_I9.
InterPro; IPR000209; Peptidase_S8/S53_dom.
InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
InterPro; IPR023827; Peptidase_S8_Asp-AS.
InterPro; IPR022398; Peptidase_S8_His-AS.
InterPro; IPR023828; Peptidase_S8_Ser-AS.
InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
InterPro; IPR002884; PrprotnconvertsP.
InterPro; IPR032815; S8_pro-domain.
Pfam; PF01483; P_proprotein; 1.
Pfam; PF00082; Peptidase_S8; 1.
Pfam; PF16470; S8_pro-domain; 1.
PRINTS; PR00723; SUBTILISIN.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF52743; SSF52743; 1.
SUPFAM; SSF54897; SSF54897; 1.
PROSITE; PS51829; P_HOMO_B; 1.
PROSITE; PS00136; SUBTILASE_ASP; 1.
PROSITE; PS00137; SUBTILASE_HIS; 1.
PROSITE; PS00138; SUBTILASE_SER; 1.
2: Evidence at transcript level;
Alternative splicing; Cleavage on pair of basic residues;
Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein;
Hydrolase; Polymorphism; Protease; Reference proteome;
Serine protease; Signal; Zymogen.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 109 {ECO:0000255}.
/FTId=PRO_0000027065.
CHAIN 110 638 Neuroendocrine convertase 2.
/FTId=PRO_0000027066.
DOMAIN 162 453 Peptidase S8.
DOMAIN 461 597 P/Homo B. {ECO:0000255|PROSITE-
ProRule:PRU01173}.
ACT_SITE 167 167 Charge relay system. {ECO:0000250}.
ACT_SITE 208 208 Charge relay system. {ECO:0000250}.
ACT_SITE 384 384 Charge relay system. {ECO:0000250}.
CARBOHYD 375 375 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 514 514 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 524 524 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 225 376 {ECO:0000250}.
DISULFID 317 347 {ECO:0000250}.
DISULFID 468 494 {ECO:0000250}.
VAR_SEQ 1 19 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_045873.
VAR_SEQ 60 94 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_043358.
VARIANT 244 244 P -> Q (in dbSNP:rs17854040).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_069075.
VARIANT 424 424 D -> N (in a colorectal cancer sample;
somatic mutation; dbSNP:rs780820865).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036548.
VARIANT 484 484 K -> E (in dbSNP:rs17857236).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_069076.
CONFLICT 283 284 EL -> DV (in Ref. 1; AAA60032).
{ECO:0000305}.
SEQUENCE 638 AA; 70565 MW; 323623FBDA6086B2 CRC64;
MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA AEHGFGVRKL
PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ QEGFDRKKRG YRDINEIDIN
MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN
YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM
LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK
RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN
QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQDPEKIP
STGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP
RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN


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EIAAB26836 KEX2-like endoprotease 2,NEC 2,Nec2,Nec-2,Neuroendocrine convertase 2,PC2,Pcsk2,Prohormone convertase 2,Proprotein convertase 2,Rat,Rattus norvegicus,Rpc2
EIAAB30202 KEX2-like endoprotease 3,NEC 3,Nec3,Nec-3,Neuroendocrine convertase 3,PC4,Pcsk4,Prohormone convertase 3,Proprotein convertase subtilisin_kexin type 4,Rat,Rattus norvegicus
EIAAB30201 KEX2-like endoprotease 3,Mouse,Mus musculus,NEC 3,Nec3,Nec-3,Neuroendocrine convertase 3,Pcsk4,Prohormone convertase 3,Proprotein convertase subtilisin_kexin type 4
EIAAB30210 Homo sapiens,hPC8,Human,LPC,Lymphoma proprotein convertase,PC7,PC7,PC8,PC8,PCSK7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase 8,Proprotein convertase subtilisin_kexin type 7,S
EIAAB26832 Homo sapiens,Human,NEC 1,NEC1,Neuroendocrine convertase 1,PC1,PCSK1,Prohormone convertase 1,Proprotein convertase 1
EIAAB26831 Bdp,NEC 1,Nec1,Nec-1,Neuroendocrine convertase 1,PC1,Pcsk1,Prohormone convertase 1,Proprotein convertase 1,Rat,Rattus norvegicus
EIAAB26835 Bos taurus,Bovine,NEC 2,Neuroendocrine convertase 2,PC2,PCSK2,Prohormone convertase 2,Proprotein convertase 2
EIAAB26833 Bos taurus,Bovine,NEC 1,Neuroendocrine convertase 1,PC1,PCSK1,Prohormone convertase 1,Proprotein convertase 1
EIAAB26834 Att-1,Furin homolog,Mouse,Mus musculus,NEC 1,Nec1,Nec-1,Neuroendocrine convertase 1,PC1,PC3,Pcsk1,Prohormone convertase 1,Propeptide-processing protease,Proprotein convertase 1
18-272-195521 NEC2 - Rabbit polyclonal to NEC2; EC 3.4.21.94; NEC 2; PC2; Prohormone convertase 2; Proprotein convertase 2; KEX2-like endoprotease 2 Polyclonal 0.05 ml
EIAAB30209 Mouse,Mus musculus,PC7,Pc7,Pcsk7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase subtilisin_kexin type 7,SPC7,Subtilisin_kexin-like protease PC7,Subtilisin-like proprotein conver
EIAAB30211 PC7,Pc7,Pcsk7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase subtilisin_kexin type 7,Rat,Rattus norvegicus,rPC7,Subtilisin_kexin-like protease PC7
EIAAB30205 Mouse,Mus musculus,PC5,PC6,Pcsk5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,SPC6,Subtilisin_kexin-like protease PC5,Subtilisin-like proprotein conver
EIAAB30204 Homo sapiens,hPC6,Human,PC5,PC5,PC6,PC6,PCSK5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,Subtilisin_kexin-like protease PC5
EIAAB30206 PC5,PC6,Pcsk5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,Rat,Rattus norvegicus,rPC5,Subtilisin_kexin-like protease PC5
EIAAB30213 Mouse,Mus musculus,Narc1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,Pcsk9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,Subtilisin_kexin-like protease PC9
EIAAB30212 Narc1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,Pcsk9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,Rat,Rattus norvegicus,Subtilisin_kexin-like protease PC9
EIAAB30214 Homo sapiens,Human,NARC1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,PCSK9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,PSEC0052,Subtilisin_kexin-like protease PC9
EIAAB30203 Homo sapiens,Human,PC4,PC4,PCSK4,Proprotein convertase 4,Proprotein convertase subtilisin_kexin type 4,UNQ2757_PRO6496
EIAAB30199 Homo sapiens,Human,PCSK1N,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
EIAAB30198 IA-4,Mouse,Mus musculus,Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
EIAAB30200 Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS,Rat,Rattus norvegicus


 

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