Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)

 NEC2_MOUSE              Reviewed;         637 AA.
P21661; Q80WU1;
01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
01-MAY-1991, sequence version 1.
25-OCT-2017, entry version 162.
RecName: Full=Neuroendocrine convertase 2;
Short=NEC 2;
EC=3.4.21.94;
AltName: Full=KEX2-like endoprotease 2;
AltName: Full=Prohormone convertase 2;
AltName: Full=Proprotein convertase 2;
Short=PC2;
Flags: Precursor;
Name=Pcsk2; Synonyms=Nec-2, Nec2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
PubMed=2169760; DOI=10.1089/dna.1990.9.415;
Seidah N.G., Gaspar L., Mion P., Marcinkiewicz M., Mbikay M.,
Chretien M.;
"cDNA sequence of two distinct pituitary proteins homologous to Kex2
and furin gene products: tissue-specific mRNAs encoding candidates for
pro-hormone processing proteinases.";
DNA Cell Biol. 9:415-424(1990).
[2]
ERRATUM.
PubMed=2264933; DOI=10.1089/dna.1990.9.789;
Seidah N.G., Gaspar L., Mion P., Marcinkiewicz M., Mbikay M.,
Chretien M.;
DNA Cell Biol. 9:789-789(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Involved in the processing of hormone and other protein
precursors at sites comprised of pairs of basic amino acid
residues. Responsible for the release of glucagon from proglucagon
in pancreatic A cells (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Release of protein hormones and neuropeptides
from their precursors, generally by hydrolysis of -Lys-
Arg-|- bonds.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle.
Note=Localized in the secretion granules.
-!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M55669; AAA39376.1; -; mRNA.
EMBL; BC052013; AAH52013.2; -; mRNA.
EMBL; BC057348; AAH57348.1; -; mRNA.
CCDS; CCDS16810.1; -.
PIR; B35571; KXMSC2.
RefSeq; NP_032818.1; NM_008792.4.
UniGene; Mm.294493; -.
UniGene; Mm.447466; -.
ProteinModelPortal; P21661; -.
SMR; P21661; -.
IntAct; P21661; 1.
MINT; MINT-1508709; -.
STRING; 10090.ENSMUSP00000028905; -.
MEROPS; S08.073; -.
iPTMnet; P21661; -.
PhosphoSitePlus; P21661; -.
PaxDb; P21661; -.
PeptideAtlas; P21661; -.
PRIDE; P21661; -.
Ensembl; ENSMUST00000028905; ENSMUSP00000028905; ENSMUSG00000027419.
GeneID; 18549; -.
KEGG; mmu:18549; -.
UCSC; uc008mqf.2; mouse.
CTD; 5126; -.
MGI; MGI:97512; Pcsk2.
eggNOG; KOG3525; Eukaryota.
eggNOG; KOG3526; Eukaryota.
eggNOG; COG1404; LUCA.
eggNOG; COG4935; LUCA.
GeneTree; ENSGT00750000117358; -.
HOVERGEN; HBG008705; -.
InParanoid; P21661; -.
KO; K01360; -.
OMA; PQRGVLK; -.
OrthoDB; EOG091G05HI; -.
TreeFam; TF314277; -.
Reactome; R-MMU-167060; NGF processing.
Reactome; R-MMU-264876; Insulin processing.
PMAP-CutDB; P21661; -.
PRO; PR:P21661; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027419; -.
CleanEx; MM_PCSK2; -.
ExpressionAtlas; P21661; baseline and differential.
Genevisible; P21661; MM.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0034774; C:secretory granule lumen; TAS:Reactome.
GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO; GO:0004175; F:endopeptidase activity; IDA:BHF-UCL.
GO; GO:0032403; F:protein complex binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO; GO:0034230; P:enkephalin processing; IDA:BHF-UCL.
GO; GO:0030070; P:insulin processing; ISO:MGI.
GO; GO:0034231; P:islet amyloid polypeptide processing; IEA:Ensembl.
GO; GO:0032455; P:nerve growth factor processing; TAS:Reactome.
GO; GO:0007399; P:nervous system development; IEP:HGNC.
GO; GO:0016486; P:peptide hormone processing; IDA:BHF-UCL.
GO; GO:0016540; P:protein autoprocessing; IDA:HGNC.
GO; GO:0016485; P:protein processing; IDA:BHF-UCL.
GO; GO:0006508; P:proteolysis; IMP:MGI.
CDD; cd04059; Peptidases_S8_Protein_converta; 1.
Gene3D; 2.60.120.260; -; 1.
Gene3D; 3.40.50.200; -; 1.
InterPro; IPR008979; Galactose-bd-like.
InterPro; IPR034182; Kexin/furin.
InterPro; IPR009020; Peptidase/Inhibitor_I9.
InterPro; IPR000209; Peptidase_S8/S53_dom.
InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
InterPro; IPR023827; Peptidase_S8_Asp-AS.
InterPro; IPR022398; Peptidase_S8_His-AS.
InterPro; IPR023828; Peptidase_S8_Ser-AS.
InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
InterPro; IPR002884; PrprotnconvertsP.
InterPro; IPR032815; S8_pro-domain.
Pfam; PF01483; P_proprotein; 1.
Pfam; PF00082; Peptidase_S8; 1.
Pfam; PF16470; S8_pro-domain; 1.
PRINTS; PR00723; SUBTILISIN.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF52743; SSF52743; 1.
SUPFAM; SSF54897; SSF54897; 1.
PROSITE; PS51829; P_HOMO_B; 1.
PROSITE; PS00136; SUBTILASE_ASP; 1.
PROSITE; PS00137; SUBTILASE_HIS; 1.
PROSITE; PS00138; SUBTILASE_SER; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Hydrolase;
Protease; Reference proteome; Serine protease; Signal; Zymogen.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 108 {ECO:0000255}.
/FTId=PRO_0000027067.
CHAIN 109 637 Neuroendocrine convertase 2.
/FTId=PRO_0000027068.
DOMAIN 161 452 Peptidase S8.
DOMAIN 460 596 P/Homo B. {ECO:0000255|PROSITE-
ProRule:PRU01173}.
ACT_SITE 166 166 Charge relay system. {ECO:0000250}.
ACT_SITE 207 207 Charge relay system. {ECO:0000250}.
ACT_SITE 383 383 Charge relay system. {ECO:0000250}.
CARBOHYD 374 374 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 513 513 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 523 523 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 224 375 {ECO:0000250}.
DISULFID 316 346 {ECO:0000250}.
DISULFID 467 493 {ECO:0000250}.
SEQUENCE 637 AA; 70785 MW; B69F2DCCD00FB0E6 CRC64;
MEGGCGSQWK AAGFLFCVMV FASAERPVFT NHFLVELHKD GEEEARQVAA EHGFGVRKLP
FAEGLYHFYH NGLAKAKRRR SLHHKRQLER DPRIKMALQQ EGFDRKKRGY RDINEIDINM
NDPLFTKQWY LFNTGQADGT PGLDLNVAEA WELGYTGKGV TIGIMDDGID YLHPDLAYNY
NADASYDFSS NDPYPYPRYT DDWFNSHGTR CAGEVSAAAS NNICGVGVAY NSKVAGIRML
DQPFMTDIIE ASSISHMPQL IDIYSASWGP TDNGKTVDGP RELTLQAMAD GVNKGRGGKG
SIYVWASGDG GSYDDCNCDG YASSMWTISI NSAINDGRTA LYDESCSSTL ASTFSNGRKR
NPEAGVATTD LYGNCTLRHS GTSAAAPEAA GVFALALEAN LDLTWRDMQH LTVLTSKRNQ
LHDEVHQWRR NGVGLEFNHL FGYGVLDAGA MVKMAKDWKT VPERFHCVGG SVQNPEKIPP
TGKLVLTLKT NACEGKENFV RYLEHVQAVI TVNATRRGDL NINMTSPMGT KSILLSRRPR
DDDSKVGFDK WPFMTTHTWG EDARGTWTLE LGFVGSAPQK GLLKEWTLML HGTQSAPYID
QVVRDYQSKL AMSKKQELEE ELDEAVERSL QSILRKN


Related products :

Catalog number Product name Quantity
EIAAB26839 KEX2-like endoprotease 2,NEC 2,Neuroendocrine convertase 2,PC2,PC2,PCSK2,Pig,Prohormone convertase 2,Proprotein convertase 2,Sus scrofa
EIAAB26838 KEX2-like endoprotease 2,Mouse,Mus musculus,NEC 2,Nec2,Nec-2,Neuroendocrine convertase 2,PC2,Pcsk2,Prohormone convertase 2,Proprotein convertase 2
EIAAB26837 Homo sapiens,Human,KEX2-like endoprotease 2,NEC 2,NEC2,Neuroendocrine convertase 2,PC2,PCSK2,Prohormone convertase 2,Proprotein convertase 2
EIAAB26836 KEX2-like endoprotease 2,NEC 2,Nec2,Nec-2,Neuroendocrine convertase 2,PC2,Pcsk2,Prohormone convertase 2,Proprotein convertase 2,Rat,Rattus norvegicus,Rpc2
EIAAB30202 KEX2-like endoprotease 3,NEC 3,Nec3,Nec-3,Neuroendocrine convertase 3,PC4,Pcsk4,Prohormone convertase 3,Proprotein convertase subtilisin_kexin type 4,Rat,Rattus norvegicus
EIAAB30201 KEX2-like endoprotease 3,Mouse,Mus musculus,NEC 3,Nec3,Nec-3,Neuroendocrine convertase 3,Pcsk4,Prohormone convertase 3,Proprotein convertase subtilisin_kexin type 4
EIAAB30210 Homo sapiens,hPC8,Human,LPC,Lymphoma proprotein convertase,PC7,PC7,PC8,PC8,PCSK7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase 8,Proprotein convertase subtilisin_kexin type 7,S
EIAAB26832 Homo sapiens,Human,NEC 1,NEC1,Neuroendocrine convertase 1,PC1,PCSK1,Prohormone convertase 1,Proprotein convertase 1
EIAAB26831 Bdp,NEC 1,Nec1,Nec-1,Neuroendocrine convertase 1,PC1,Pcsk1,Prohormone convertase 1,Proprotein convertase 1,Rat,Rattus norvegicus
EIAAB26835 Bos taurus,Bovine,NEC 2,Neuroendocrine convertase 2,PC2,PCSK2,Prohormone convertase 2,Proprotein convertase 2
EIAAB26833 Bos taurus,Bovine,NEC 1,Neuroendocrine convertase 1,PC1,PCSK1,Prohormone convertase 1,Proprotein convertase 1
EIAAB26834 Att-1,Furin homolog,Mouse,Mus musculus,NEC 1,Nec1,Nec-1,Neuroendocrine convertase 1,PC1,PC3,Pcsk1,Prohormone convertase 1,Propeptide-processing protease,Proprotein convertase 1
18-272-195521 NEC2 - Rabbit polyclonal to NEC2; EC 3.4.21.94; NEC 2; PC2; Prohormone convertase 2; Proprotein convertase 2; KEX2-like endoprotease 2 Polyclonal 0.05 ml
EIAAB30209 Mouse,Mus musculus,PC7,Pc7,Pcsk7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase subtilisin_kexin type 7,SPC7,Subtilisin_kexin-like protease PC7,Subtilisin-like proprotein conver
EIAAB30211 PC7,Pc7,Pcsk7,Prohormone convertase 7,Proprotein convertase 7,Proprotein convertase subtilisin_kexin type 7,Rat,Rattus norvegicus,rPC7,Subtilisin_kexin-like protease PC7
EIAAB30205 Mouse,Mus musculus,PC5,PC6,Pcsk5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,SPC6,Subtilisin_kexin-like protease PC5,Subtilisin-like proprotein conver
EIAAB30204 Homo sapiens,hPC6,Human,PC5,PC5,PC6,PC6,PCSK5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,Subtilisin_kexin-like protease PC5
EIAAB30206 PC5,PC6,Pcsk5,Proprotein convertase 5,Proprotein convertase 6,Proprotein convertase subtilisin_kexin type 5,Rat,Rattus norvegicus,rPC5,Subtilisin_kexin-like protease PC5
EIAAB30213 Mouse,Mus musculus,Narc1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,Pcsk9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,Subtilisin_kexin-like protease PC9
EIAAB30212 Narc1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,Pcsk9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,Rat,Rattus norvegicus,Subtilisin_kexin-like protease PC9
EIAAB30214 Homo sapiens,Human,NARC1,NARC-1,Neural apoptosis-regulated convertase 1,PC9,PCSK9,Proprotein convertase 9,Proprotein convertase subtilisin_kexin type 9,PSEC0052,Subtilisin_kexin-like protease PC9
EIAAB30203 Homo sapiens,Human,PC4,PC4,PCSK4,Proprotein convertase 4,Proprotein convertase subtilisin_kexin type 4,UNQ2757_PRO6496
EIAAB30199 Homo sapiens,Human,PCSK1N,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
EIAAB30198 IA-4,Mouse,Mus musculus,Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS
EIAAB30200 Pcsk1n,Proprotein convertase 1 inhibitor,Proprotein convertase subtilisin_kexin type 1 inhibitor,ProSAAS,pro-SAAS,Rat,Rattus norvegicus


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur