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Neuroendocrine protein 7B2 (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]

 7B2_PIG                 Reviewed;         207 AA.
P01165;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
06-JUL-2016, entry version 77.
RecName: Full=Neuroendocrine protein 7B2;
AltName: Full=Secretogranin V;
AltName: Full=Secretogranin-5;
AltName: Full=Secretory granule endocrine protein I;
Contains:
RecName: Full=N-terminal peptide;
Contains:
RecName: Full=C-terminal peptide;
Flags: Precursor;
Name=SCG5; Synonyms=SGNE1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3234177; DOI=10.1089/dna.1988.7.713;
Brayton K.A., Aimi J., Qiu H., Yazdanparast R., Ghatei M.A.,
Polak J.M., Bloom S.R., Dixon J.E.;
"Cloning, characterization, and sequence of a porcine cDNA encoding a
secreted neuronal and endocrine protein.";
DNA 7:713-719(1988).
[2]
PROTEIN SEQUENCE OF 23-171.
TISSUE=Pituitary;
PubMed=1797712;
Lazure C., Benjannet S., Seidah N.G., Chretien M.;
"Processed forms of neuroendocrine proteins 7B2 and secretogranin II
are found in porcine pituitary extracts.";
Int. J. Pept. Protein Res. 38:392-400(1991).
[3]
PROTEIN SEQUENCE OF 23-103.
PubMed=6625600; DOI=10.1016/0003-9861(83)90063-2;
Seidah N.G., Hsi K.L., de Serres G., Rochemont J., Hamelin J.,
Antakly T., Cantin M., Chretien M.;
"Isolation and NH2-terminal sequence of a highly conserved human and
porcine pituitary protein belonging to a new superfamily.
Immunocytochemical localization in pars distalis and pars nervosa of
the pituitary and in the supraoptic nucleus of the hypothalamus.";
Arch. Biochem. Biophys. 225:525-534(1983).
[4]
PROTEIN SEQUENCE OF 23-72.
PubMed=6816630; DOI=10.1016/0014-5793(82)81055-7;
Hsi K.L., Seidah N.G., de Serres G., Chretien M.;
"Isolation and NH2-terminal sequence of a novel porcine anterior
pituitary polypeptide. Homology to proinsulin, secretin and Rous
sarcoma virus transforming protein TVFV60.";
FEBS Lett. 147:261-266(1982).
[5]
SUBCELLULAR LOCATION.
PubMed=6514132;
Iguchi H., Chan J.S., Seidah N.G., Chretien M.;
"Tissue distribution and molecular forms of a novel pituitary protein
in the rat.";
Neuroendocrinology 39:453-458(1984).
[6]
REVIEW.
PubMed=11439082; DOI=10.1042/0264-6021:3570329;
Mbikay M., Seidah N.G., Chretien M.;
"Neuroendocrine secretory protein 7B2: structure, expression and
functions.";
Biochem. J. 357:329-342(2001).
-!- FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing
its premature activation in the regulated secretory pathway. Binds
to inactive PCSK2 in the endoplasmic reticulum and facilitates its
transport from there to later compartments of the secretory
pathway where it is proteolytically matured and activated. Also
required for cleavage of PCSK2 but does not appear to be involved
in its folding. Plays a role in regulating pituitary hormone
secretion. The C-terminal peptide inhibits PCSK2 in vitro.
-!- SUBUNIT: Interacts with PCSK2/PC2 early in the secretory pathway.
Dissociation occurs at later stages (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6514132}.
Note=Neuroendocrine and endocrine secretory granules.
-!- PTM: Proteolytically cleaved in the Golgi by a furin-like
convertase to generate bioactive peptides. {ECO:0000250}.
-!- PTM: Sulfated on tyrosine residues. {ECO:0000250}.
-!- SIMILARITY: Belongs to the 7B2 family. {ECO:0000305}.
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EMBL; M23654; AAA50416.1; -; mRNA.
PIR; A31600; PUPG.
UniGene; Ssc.155; -.
STRING; 9823.ENSSSCP00000005176; -.
MEROPS; I21.001; -.
PaxDb; P01165; -.
PeptideAtlas; P01165; -.
eggNOG; KOG4187; Eukaryota.
eggNOG; ENOG410ZRXV; LUCA.
HOVERGEN; HBG000031; -.
InParanoid; P01165; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030141; C:secretory granule; IDA:UniProtKB.
GO; GO:0004857; F:enzyme inhibitor activity; ISS:UniProtKB.
GO; GO:0051082; F:unfolded protein binding; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO; GO:0016486; P:peptide hormone processing; ISS:UniProtKB.
GO; GO:0046883; P:regulation of hormone secretion; ISS:UniProtKB.
InterPro; IPR007945; Secretogranin_V.
PANTHER; PTHR12738; PTHR12738; 1.
Pfam; PF05281; Secretogranin_V; 1.
1: Evidence at protein level;
Chaperone; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Neuropeptide;
Phosphoprotein; Reference proteome; Secreted; Signal; Sulfation;
Transport.
SIGNAL 1 22 {ECO:0000269|PubMed:1797712,
ECO:0000269|PubMed:6625600,
ECO:0000269|PubMed:6816630}.
CHAIN 23 207 Neuroendocrine protein 7B2.
/FTId=PRO_0000000047.
CHAIN 23 171 N-terminal peptide.
/FTId=PRO_0000000048.
PEPTIDE 195 207 C-terminal peptide.
/FTId=PRO_0000000049.
MOD_RES 136 136 Phosphoserine.
{ECO:0000250|UniProtKB:P12961}.
MOD_RES 200 200 Phosphoserine.
{ECO:0000250|UniProtKB:P12961}.
DISULFID 116 125 {ECO:0000250}.
SEQUENCE 207 AA; 23224 MW; 20077D0E1EB6D0AC CRC64;
MVSTMLSGLV LWLTFGWTPA LAYSPRTPDR VSETDIQRLL HGVMEQLGIA RPRVEYPAHQ
AMNLVGPQSI EGGAHEGLQH LGPFGNIPNI VAELTGDNTP KDFSEDQGYP DPPNPCPIGK
TDDGCLENTP DTAEFSREFQ LHQHLFDPEH DYPGLGKWNK KLLYEKMKGG QRRKRRSVNP
YLQGQRLDNV VAKKSVPHFS DEDKDPE


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