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Neuroendocrine protein 7B2 (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]

 7B2_RAT                 Reviewed;         210 AA.
P27682;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
22-NOV-2017, entry version 105.
RecName: Full=Neuroendocrine protein 7B2;
AltName: Full=Secretogranin V;
AltName: Full=Secretogranin-5;
AltName: Full=Secretory granule endocrine protein I;
Contains:
RecName: Full=N-terminal peptide;
Contains:
RecName: Full=C-terminal peptide;
Flags: Precursor;
Name=Scg5; Synonyms=Sgne1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1709861; DOI=10.1210/endo-128-6-3228;
Waldbieser G.C., Aimi J., Dixon J.E.;
"Cloning and characterization of the rat complementary
deoxyribonucleic acid and gene encoding the neuroendocrine peptide
7B2.";
Endocrinology 128:3228-3236(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary anterior lobe;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
REVIEW.
PubMed=11439082; DOI=10.1042/0264-6021:3570329;
Mbikay M., Seidah N.G., Chretien M.;
"Neuroendocrine secretory protein 7B2: structure, expression and
functions.";
Biochem. J. 357:329-342(2001).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing
its premature activation in the regulated secretory pathway. Binds
to inactive PCSK2 in the endoplasmic reticulum and facilitates its
transport from there to later compartments of the secretory
pathway where it is proteolytically matured and activated. Also
required for cleavage of PCSK2 but does not appear to be involved
in its folding. Plays a role in regulating pituitary hormone
secretion. The C-terminal peptide inhibits PCSK2 in vitro.
-!- SUBUNIT: Interacts with PCSK2/PC2 early in the secretory pathway.
Dissociation occurs at later stages (By similarity).
{ECO:0000250}.
-!- INTERACTION:
P28841:Pcsk2; NbExp=4; IntAct=EBI-988232, EBI-988244;
-!- SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine
secretory granules.
-!- PTM: Proteolytically cleaved in the Golgi by a furin-like
convertase to generate bioactive peptides. {ECO:0000250}.
-!- PTM: Sulfated on tyrosine residues. {ECO:0000250}.
-!- SIMILARITY: Belongs to the 7B2 family. {ECO:0000305}.
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EMBL; M63901; AAA40626.1; -; mRNA.
EMBL; BC061560; AAH61560.1; -; mRNA.
PIR; A49745; A49745.
RefSeq; NP_037307.1; NM_013175.3.
UniGene; Rn.6173; -.
BioGrid; 247748; 1.
IntAct; P27682; 1.
STRING; 10116.ENSRNOP00000010679; -.
MEROPS; I21.001; -.
iPTMnet; P27682; -.
PhosphoSitePlus; P27682; -.
PaxDb; P27682; -.
PRIDE; P27682; -.
GeneID; 25719; -.
KEGG; rno:25719; -.
UCSC; RGD:3669; rat.
CTD; 6447; -.
RGD; 3669; Scg5.
eggNOG; KOG4187; Eukaryota.
eggNOG; ENOG410ZRXV; LUCA.
HOGENOM; HOG000259690; -.
HOVERGEN; HBG000031; -.
InParanoid; P27682; -.
PhylomeDB; P27682; -.
PRO; PR:P27682; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISO:RGD.
GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
GO; GO:0004857; F:enzyme inhibitor activity; ISS:UniProtKB.
GO; GO:0051082; F:unfolded protein binding; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO; GO:0016486; P:peptide hormone processing; ISS:UniProtKB.
GO; GO:0046883; P:regulation of hormone secretion; ISS:UniProtKB.
InterPro; IPR007945; Secretogranin_V.
PANTHER; PTHR12738; PTHR12738; 1.
Pfam; PF05281; Secretogranin_V; 1.
1: Evidence at protein level;
Chaperone; Cleavage on pair of basic residues; Complete proteome;
Disulfide bond; Neuropeptide; Phosphoprotein; Reference proteome;
Secreted; Signal; Sulfation; Transport.
SIGNAL 1 24 {ECO:0000250}.
CHAIN 25 210 Neuroendocrine protein 7B2.
/FTId=PRO_0000000050.
CHAIN 25 176 N-terminal peptide. {ECO:0000250}.
/FTId=PRO_0000000051.
PEPTIDE 198 210 C-terminal peptide. {ECO:0000250}.
/FTId=PRO_0000000052.
MOD_RES 139 139 Phosphoserine.
{ECO:0000250|UniProtKB:P12961}.
MOD_RES 203 203 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
DISULFID 118 128 {ECO:0000250}.
SEQUENCE 210 AA; 23684 MW; 14FBA7D070E79992 CRC64;
MTSRMAILSG LLFWLLLEWN PAFAYSPRTP DRVSETDIQR LLHGVMEQLG IARPRVEYPA
HQAMNLVGPQ SIEGGAHEGL QHLGPFGNIP NIVAELTGDN IPKDFSEDQG YPDPPNPCPL
GKTADDGCLE NAPDTAEFSR EFQLDQHLFD PEHDYPGLGK WNKKLLYEKM KGGQRRKRRS
VNPYLQGKRL DNVVAKKSVP HFSEEEKEPE


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