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Neurogenic differentiation factor 4 (NeuroD4) (Helix-loop-helix protein mATH-3) (mATH3) (Protein atonal homolog 3)

 NDF4_MOUSE              Reviewed;         330 AA.
O09105;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
05-DEC-2018, entry version 142.
RecName: Full=Neurogenic differentiation factor 4;
Short=NeuroD4;
AltName: Full=Helix-loop-helix protein mATH-3;
Short=mATH3;
AltName: Full=Protein atonal homolog 3;
Name=Neurod4; Synonyms=Ath3, Atoh3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
TISSUE=Retina;
PubMed=9029157; DOI=10.1093/emboj/16.2.384;
Takebayashi K., Takahashi S., Yokota C., Tsuda H., Nakanishi S.,
Asashima M., Kageyama R.;
"Conversion of ectoderm into a neural fate by ATH-3, a vertebrate
basic helix-loop-helix gene homologous to Drosophila proneural gene
atonal.";
EMBO J. 16:384-395(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=129/J;
PubMed=9497361; DOI=10.1074/jbc.273.11.6327;
Tsuda H., Takebayashi K., Nakanishi S., Kageyama R.;
"Structure and promoter analysis of Math3 gene, a mouse homolog of
Drosophila proneural gene atonal. Neural-specific expression by dual
promoter elements.";
J. Biol. Chem. 273:6327-6333(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Retina;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11861467;
Inoue T., Hojo M., Bessho Y., Tano Y., Lee J.E., Kageyama R.;
"Math3 and NeuroD regulate amacrine cell fate specification in the
retina.";
Development 129:831-842(2002).
-!- FUNCTION: Probably acts as a transcriptional activator. Mediates
neuronal differentiation. Required for the regulation of amacrine
cell fate specification in the retina.
{ECO:0000269|PubMed:11861467}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
-!- TISSUE SPECIFICITY: Expressed in retinal interneurons amacrine
cells (at protein level). Expressed in neurons of ventricular zone
of the retina at postnatal day 1 (P1). Expressed transiently in
amacrine and horizontal cells of the inner nuclear layer (INL) of
the retina at P7 until P14. {ECO:0000269|PubMed:11861467,
ECO:0000269|PubMed:9029157, ECO:0000269|PubMed:9497361}.
-!- DEVELOPMENTAL STAGE: Weakly expressed in the neural tube around
E8.5. By E9.5, expression is prominent in the ventral brain and
spinal cord, and weak expression begins in the retina. At E10.5,
highly expressed in the trigeminal and dorsal root ganglions, and
the ventral midbrain and hindbrain. At E12.5, expressed in the
mantle layer of the brain and spinal cord, trigeminal ganglion,
Rathke's pouch, dorsal root ganglion and the ventricular zone of
the neural retina. At E16.5, expression becomes restricted to the
anterior region, persisting in the diencephalon and neural retina
but decreasing in other regions. {ECO:0000269|PubMed:9029157,
ECO:0000269|PubMed:9497361}.
-!- PTM: Serine or threonine phosphorylation within the basic region
may regulate neurogenic activity. {ECO:0000250}.
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EMBL; D85845; BAA12880.1; -; mRNA.
EMBL; AF036257; AAC15969.1; -; Genomic_DNA.
EMBL; BC054391; AAH54391.1; -; mRNA.
CCDS; CCDS24353.1; -.
RefSeq; NP_001316418.1; NM_001329489.1.
RefSeq; NP_001316419.1; NM_001329490.1.
RefSeq; NP_031527.1; NM_007501.5.
UniGene; Mm.10695; -.
ProteinModelPortal; O09105; -.
SMR; O09105; -.
BioGrid; 198239; 1.
STRING; 10090.ENSMUSP00000051379; -.
PhosphoSitePlus; O09105; -.
PaxDb; O09105; -.
PRIDE; O09105; -.
Ensembl; ENSMUST00000061571; ENSMUSP00000051379; ENSMUSG00000048015.
GeneID; 11923; -.
KEGG; mmu:11923; -.
UCSC; uc007hri.2; mouse.
CTD; 58158; -.
MGI; MGI:108055; Neurod4.
eggNOG; ENOG410KD2S; Eukaryota.
eggNOG; ENOG410Z6FG; LUCA.
GeneTree; ENSGT00940000160217; -.
HOGENOM; HOG000049256; -.
HOVERGEN; HBG000250; -.
InParanoid; O09105; -.
KO; K09079; -.
OMA; PPYGHME; -.
OrthoDB; EOG091G15AI; -.
PhylomeDB; O09105; -.
TreeFam; TF315153; -.
PRO; PR:O09105; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000048015; Expressed in 112 organ(s), highest expression level in pineal body.
CleanEx; MM_NEUROD4; -.
ExpressionAtlas; O09105; baseline and differential.
Genevisible; O09105; MM.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0035881; P:amacrine cell differentiation; IDA:UniProtKB.
GO; GO:0043010; P:camera-type eye development; IGI:MGI.
GO; GO:0045165; P:cell fate commitment; IGI:MGI.
GO; GO:0010001; P:glial cell differentiation; IGI:MGI.
GO; GO:0007405; P:neuroblast proliferation; IGI:MGI.
GO; GO:0048666; P:neuron development; IMP:MGI.
GO; GO:0001764; P:neuron migration; IMP:MGI.
GO; GO:0007219; P:Notch signaling pathway; IGI:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; IDA:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR032651; Neurod4.
InterPro; IPR022575; Neurogenic_DUF.
InterPro; IPR016637; TF_bHLH_NeuroD.
PANTHER; PTHR19290:SF86; PTHR19290:SF86; 1.
Pfam; PF00010; HLH; 1.
Pfam; PF12533; Neuro_bHLH; 1.
PIRSF; PIRSF015618; bHLH_NeuroD; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; Differentiation;
DNA-binding; Neurogenesis; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 330 Neurogenic differentiation factor 4.
/FTId=PRO_0000127391.
DOMAIN 87 139 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 49 65 Asp/Glu-rich (acidic).
SEQUENCE 330 AA; 37133 MW; F8EC228F4EE0FF88 CRC64;
MAKMYMKSKD MVELVNTQSW MDKGLSSQNE MKEQERRPGS YGMLGTLTEE HDSIEEDEEE
EEDGDKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM HGLNDALDNL RRVMPCYSKT
QKLSKIETLR LARNYIWALS EVLETGQTLE GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS
TLLEKHEEKS SICDSTISVH SFNYQSPGLP SPPYGHMETH SLHLKPQPFK SLGDSFGSHP
PDCSTPPYEG PLTPPLSISG NFSLKQDGSP DLEKSYNFMP HYTSASLSSG HVHSTPFQTG
TPRYDVPVDL SYDSYSHHSI GTQLNTIFSD


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