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Neurogenin-1 (NGN-1) (Helix-loop-helix protein mATH-4C) (mATH4C) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3)

 NGN1_MOUSE              Reviewed;         244 AA.
P70660;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
12-SEP-2018, entry version 130.
RecName: Full=Neurogenin-1;
Short=NGN-1;
AltName: Full=Helix-loop-helix protein mATH-4C;
Short=mATH4C;
AltName: Full=Neurogenic basic-helix-loop-helix protein;
AltName: Full=Neurogenic differentiation factor 3;
Short=NeuroD3;
Name=Neurog1; Synonyms=Ath4c, Neurod3, Ngn, Ngn1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=8816493; DOI=10.1128/MCB.16.10.5792;
McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D.,
Tapscott S.J.;
"NeuroD2 and neuroD3: distinct expression patterns and transcriptional
activation potentials within the neuroD gene family.";
Mol. Cell. Biol. 16:5792-5800(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=8858147; DOI=10.1016/S0092-8674(00)81321-5;
Ma Q., Kintner C., Anderson D.J.;
"Identification of neurogenin, a vertebrate neuronal determination
gene.";
Cell 87:43-52(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=9108377;
Cau E., Gradwohl G., Fode C., Guillemot F.;
"Mash1 activates a cascade of bHLH regulators in olfactory neuron
progenitors.";
Development 124:1611-1621(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND DNA-BINDING.
PubMed=10648228;
Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J.,
Turner D.L.;
"Generation of neurons by transient expression of neural bHLH proteins
in mammalian cells.";
Development 127:693-702(2000).
[6]
FUNCTION, AND DNA-BINDING.
PubMed=14697366; DOI=10.1016/j.ydbio.2003.08.027;
Lin C.H., Stoeck J., Ravanpay A.C., Guillemot F., Tapscott S.J.,
Olson J.M.;
"Regulation of neuroD2 expression in mouse brain.";
Dev. Biol. 265:234-245(2004).
[7]
FUNCTION, AND ASSOCIATION WITH CHROMATIN.
PubMed=18007592; DOI=10.1038/sj.emboj.7601923;
Seo S., Lim J.W., Yellajoshyula D., Chang L.W., Kroll K.L.;
"Neurogenin and NeuroD direct transcriptional targets and their
regulatory enhancers.";
EMBO J. 26:5093-5108(2007).
-!- FUNCTION: Acts as a transcriptional regulator. Involved in the
initiation of neuronal differentiation. Activates transcription by
binding to the E box (5'-CANNTG-3'). Associates with chromatin to
enhancer regulatory elements in genes encoding key transcriptional
regulators of neurogenesis. {ECO:0000269|PubMed:10648228,
ECO:0000269|PubMed:14697366, ECO:0000269|PubMed:18007592}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expression restricted to the embryonic nervous
system.
-!- DEVELOPMENTAL STAGE: Highest expression in the embryo between days
10 and 12. Declines to undetectable levels by embryonic day 16.
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EMBL; U63841; AAB37576.1; -; Genomic_DNA.
EMBL; U67776; AAC52856.1; -; Genomic_DNA.
EMBL; Y09166; CAA70365.1; -; Genomic_DNA.
EMBL; BC062148; AAH62148.1; -; mRNA.
CCDS; CCDS26559.1; -.
RefSeq; NP_035026.1; NM_010896.2.
UniGene; Mm.266665; -.
ProteinModelPortal; P70660; -.
SMR; P70660; -.
BioGrid; 201735; 3.
STRING; 10090.ENSMUSP00000050484; -.
iPTMnet; P70660; -.
PhosphoSitePlus; P70660; -.
PaxDb; P70660; -.
PRIDE; P70660; -.
Ensembl; ENSMUST00000058475; ENSMUSP00000050484; ENSMUSG00000048904.
GeneID; 18014; -.
KEGG; mmu:18014; -.
UCSC; uc007qsl.2; mouse.
CTD; 4762; -.
MGI; MGI:107754; Neurog1.
eggNOG; KOG3898; Eukaryota.
eggNOG; ENOG4111U26; LUCA.
GeneTree; ENSGT00680000099860; -.
HOGENOM; HOG000063655; -.
HOVERGEN; HBG101129; -.
InParanoid; P70660; -.
KO; K09081; -.
OMA; YIWALAE; -.
OrthoDB; EOG091G0PNH; -.
PhylomeDB; P70660; -.
TreeFam; TF315153; -.
PRO; PR:P70660; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000048904; Expressed in 90 organ(s), highest expression level in cerebral cortex ventricular layer.
CleanEx; MM_NEUROG1; -.
Genevisible; P70660; MM.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043204; C:perikaryon; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO; GO:0070888; F:E-box binding; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
GO; GO:0031223; P:auditory behavior; ISO:MGI.
GO; GO:0045165; P:cell fate commitment; IGI:MGI.
GO; GO:0090102; P:cochlea development; ISO:MGI.
GO; GO:0090103; P:cochlea morphogenesis; ISO:MGI.
GO; GO:0097094; P:craniofacial suture morphogenesis; ISO:MGI.
GO; GO:0048806; P:genitalia development; ISO:MGI.
GO; GO:0035112; P:genitalia morphogenesis; ISO:MGI.
GO; GO:1905748; P:hard palate morphogenesis; ISO:MGI.
GO; GO:0048839; P:inner ear development; ISO:MGI.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0098583; P:learned vocalization behavior; ISO:MGI.
GO; GO:0071626; P:mastication; ISO:MGI.
GO; GO:1901078; P:negative regulation of relaxation of muscle; ISO:MGI.
GO; GO:1905747; P:negative regulation of saliva secretion; ISO:MGI.
GO; GO:0022008; P:neurogenesis; IDA:MGI.
GO; GO:0050885; P:neuromuscular process controlling balance; ISO:MGI.
GO; GO:0030182; P:neuron differentiation; IDA:MGI.
GO; GO:0030432; P:peristalsis; ISO:MGI.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0031536; P:positive regulation of exit from mitosis; IMP:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0048634; P:regulation of muscle organ development; ISO:MGI.
GO; GO:0045664; P:regulation of neuron differentiation; IGI:MGI.
GO; GO:0007356; P:thorax and anterior abdomen determination; ISO:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0021559; P:trigeminal nerve development; ISO:MGI.
GO; GO:0021650; P:vestibulocochlear nerve formation; ISO:MGI.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR032653; Ngn1.
PANTHER; PTHR19290:SF130; PTHR19290:SF130; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; Differentiation;
DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 244 Neurogenin-1.
/FTId=PRO_0000127397.
DOMAIN 93 145 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
SEQUENCE 244 AA; 26300 MW; 3C9C0E1A08AB074B CRC64;
MPAPLETCIS DLDCSSSNSS SDLSSFLTDE EDCARLQPLA STSGLSVPAR RSAPALSGAS
NVPGAQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND RERNRMHNLN AALDALRSVL
PSFPDDTKLT KIETLRFAYN YIWALAETLR LADQGLPGGS ARERLLPPQC VPCLPGPPSP
ASDTESWGSG AAASPCATVA SPLSDPSSPS ASEDFTYGPG DPLFSFPGLP KDLLHTTPCF
IPYH


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