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Neuronal acetylcholine receptor subunit alpha-4

 ACHA4_MOUSE             Reviewed;         629 AA.
O70174; Q8BHE9; Q8VI10; Q9ET51;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
19-SEP-2003, sequence version 2.
25-OCT-2017, entry version 154.
RecName: Full=Neuronal acetylcholine receptor subunit alpha-4;
Flags: Precursor;
Name=Chrna4; Synonyms=Acra4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-529.
STRAIN=Long sleep selected line;
PubMed=11434511; DOI=10.1097/00008571-200106000-00008;
Stitzel J.A., Dobelis P., Jimenez M., Collins A.C.;
"Long sleep and short sleep mice differ in nicotine-stimulated 86Rb+
efflux and alpha4 nicotinic receptor subunit cDNA sequence.";
Pharmacogenetics 11:331-339(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Diencephalon, and Hippocampus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
PubMed=9749753; DOI=10.1046/j.1460-9568.1998.00235.x;
Watanabe H., Zoli M., Changeux J.-P.;
"Promoter analysis of the neuronal nicotinic acetylcholine receptor
alpha4 gene: methylation and expression of the transgene.";
Eur. J. Neurosci. 10:2244-2253(1998).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 118-357.
STRAIN=C57BL/6J;
Kuo Y.-P., Lukas R.J.;
"Expression of mouse nicotinic acetylcholine receptor genes in the
developing thymus.";
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540 AND SER-543, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: After binding acetylcholine, the AChR responds by an
extensive change in conformation that affects all subunits and
leads to opening of an ion-conducting channel across the plasma
membrane permeable to sodium ions.
-!- SUBUNIT: Neuronal AChR is composed of two different types of
subunits: alpha and beta. Alpha-4 subunit can be combined to beta-
2 or beta-4 to give rise to functional receptors, complexes with
beta-2 may be heteropentamers. Interacts with RIC3; which is
required for proper folding and assembly. Interacts with LYPD6.
The heteropentamer alpha-4-beta-2 interacts with alpha-conotoxins
PnIA, GID and MII (By similarity). {ECO:0000250|UniProtKB:P09483,
ECO:0000250|UniProtKB:P43681}.
-!- INTERACTION:
Q8BLC3:Lypd1; NbExp=3; IntAct=EBI-10916203, EBI-14035010;
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor
{ECO:0000250}.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-
4/CHRNA4 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF225912; AAF34716.2; -; mRNA.
EMBL; AK034228; BAC28638.1; -; mRNA.
EMBL; AK083157; BAC38788.1; -; mRNA.
EMBL; BC053013; AAH53013.1; -; mRNA.
EMBL; AB010002; BAA25752.1; -; Genomic_DNA.
EMBL; AF325347; AAL37363.1; -; mRNA.
CCDS; CCDS17192.1; -.
RefSeq; NP_056545.3; NM_015730.5.
UniGene; Mm.252369; -.
ProteinModelPortal; O70174; -.
SMR; O70174; -.
BioGrid; 197932; 2.
DIP; DIP-48731N; -.
IntAct; O70174; 6.
STRING; 10090.ENSMUSP00000066338; -.
ChEMBL; CHEMBL4457; -.
iPTMnet; O70174; -.
PhosphoSitePlus; O70174; -.
PaxDb; O70174; -.
PRIDE; O70174; -.
Ensembl; ENSMUST00000067120; ENSMUSP00000066338; ENSMUSG00000027577.
GeneID; 11438; -.
KEGG; mmu:11438; -.
UCSC; uc008okq.1; mouse.
CTD; 1137; -.
MGI; MGI:87888; Chrna4.
eggNOG; KOG3645; Eukaryota.
eggNOG; ENOG410XQGR; LUCA.
GeneTree; ENSGT00760000118930; -.
HOGENOM; HOG000006756; -.
HOVERGEN; HBG003756; -.
InParanoid; O70174; -.
KO; K04806; -.
PhylomeDB; O70174; -.
TreeFam; TF315605; -.
Reactome; R-MMU-629587; Highly sodium permeable acetylcholine nicotinic receptors.
Reactome; R-MMU-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
Reactome; R-MMU-629597; Highly calcium permeable nicotinic acetylcholine receptors.
PRO; PR:O70174; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027577; -.
ExpressionAtlas; O70174; baseline and differential.
Genevisible; O70174; MM.
GO; GO:0005892; C:acetylcholine-gated channel complex; IDA:MGI.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0015464; F:acetylcholine receptor activity; ISO:MGI.
GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IMP:MGI.
GO; GO:0005216; F:ion channel activity; IDA:MGI.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IDA:MGI.
GO; GO:0001508; P:action potential; IMP:MGI.
GO; GO:0042113; P:B cell activation; IMP:MGI.
GO; GO:0035095; P:behavioral response to nicotine; IMP:MGI.
GO; GO:0006816; P:calcium ion transport; IGI:MGI.
GO; GO:0050890; P:cognition; ISO:MGI.
GO; GO:0006281; P:DNA repair; ISO:MGI.
GO; GO:0035640; P:exploration behavior; IMP:MGI.
GO; GO:0060080; P:inhibitory postsynaptic potential; IMP:MGI.
GO; GO:0007626; P:locomotory behavior; IMP:MGI.
GO; GO:0051899; P:membrane depolarization; IMP:MGI.
GO; GO:0050877; P:nervous system process; IMP:MGI.
GO; GO:0007274; P:neuromuscular synaptic transmission; IBA:GO_Central.
GO; GO:0014059; P:regulation of dopamine secretion; IMP:MGI.
GO; GO:0042391; P:regulation of membrane potential; IGI:MGI.
GO; GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
GO; GO:0001666; P:response to hypoxia; ISO:MGI.
GO; GO:0035094; P:response to nicotine; IDA:MGI.
GO; GO:0006979; P:response to oxidative stress; ISO:MGI.
GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
GO; GO:0007165; P:signal transduction; ISO:MGI.
GO; GO:0007271; P:synaptic transmission, cholinergic; IDA:MGI.
Gene3D; 1.20.58.390; -; 1.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR036734; Neur_chan_lig-bd_sf.
InterPro; IPR006201; Neur_channel.
InterPro; IPR036719; Neuro-gated_channel_TM_sf.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR00254; NICOTINICR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 2.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism;
Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 30 {ECO:0000255}.
CHAIN 31 629 Neuronal acetylcholine receptor subunit
alpha-4.
/FTId=PRO_0000000352.
TOPO_DOM 32 249 Extracellular. {ECO:0000255}.
TRANSMEM 250 270 Helical. {ECO:0000255}.
TRANSMEM 279 299 Helical. {ECO:0000255}.
TRANSMEM 312 332 Helical. {ECO:0000255}.
TOPO_DOM 333 603 Cytoplasmic. {ECO:0000255}.
TRANSMEM 604 624 Helical. {ECO:0000255}.
MOD_RES 427 427 Phosphoserine.
{ECO:0000250|UniProtKB:P09483}.
MOD_RES 540 540 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 543 543 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
LIPID 273 273 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 59 59 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 109 109 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 163 177 {ECO:0000250}.
DISULFID 227 228 Associated with receptor activation.
{ECO:0000250}.
VARIANT 529 529 T -> A. {ECO:0000269|PubMed:11434511}.
CONFLICT 16 16 P -> L (in Ref. 1; AAF34716).
{ECO:0000305}.
CONFLICT 24 24 G -> A (in Ref. 4; BAA25752).
{ECO:0000305}.
CONFLICT 134 134 D -> N (in Ref. 1; AAF34716).
{ECO:0000305}.
SEQUENCE 629 AA; 70305 MW; 261455B6ED50B41C CRC64;
MEIGGSGAPP PLLLLPLLLL LGTGLLPASS HIETRAHAEE RLLKRLFSGY NKWSRPVANI
SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL RWDPGDYENV TSIRIPSELI
WRPDIVLYNN ADGDFAVTHL TKAHLFYDGR VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK
FGSWTYDKAK IDLVSMHSRV DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFI
IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SECGEKVTLC ISVLLSLTVF LLLITEIIPS
TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPRTH TMPAWVRRVF LDIVPRLLFM
KRPSVVKDNC RRLIESMHKM ANAPRFWPEP ESEPGILGDI CNQGLSPAPT FCNRMDTAVE
TQPTCRSPSH KVPDLKTSEV EKASPCPSPG SCHPPNSSGA PVLIKARSLS VQHVPSSQEA
AEGSIRCRSR SIQYCVSQDG AASLTESKPT GSPASLKTRP SQLPVSDQTS PCKCTCKEPS
PVSPITVLKA GGTKAPPQHL PLSPALTRAV EGVQYIADHL KAEDTDFSVK EDWKYVAMVI
DRIFLWMFII VCLLGTVGLF LPPWLAGMI


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