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Neuronal acetylcholine receptor subunit alpha-7

 ACHA7_MOUSE             Reviewed;         502 AA.
P49582;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
27-SEP-2017, entry version 157.
RecName: Full=Neuronal acetylcholine receptor subunit alpha-7;
Flags: Precursor;
Name=Chrna7; Synonyms=Acra7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=7601470; DOI=10.1016/0888-7543(95)80228-E;
Orr-Urtreger A., Seldin M.F., Baldini A., Beaudet A.L.;
"Cloning and mapping of the mouse alpha 7-neuronal nicotinic
acetylcholine receptor.";
Genomics 26:399-402(1995).
-!- FUNCTION: After binding acetylcholine, the AChR responds by an
extensive change in conformation that affects all subunits and
leads to opening of an ion-conducting channel across the plasma
membrane. The channel is blocked by alpha-bungarotoxin.
-!- SUBUNIT: Homopentamer. Interacts with RIC3; which is required for
proper folding and assembly. Interacts with LYPD6. Interacts with
the alpha-conotoxin RgIA (By similarity). Interacts with alpha-
conotoxins ImI and ImII (By similarity).
{ECO:0000250|UniProtKB:P36544, ECO:0000250|UniProtKB:P54131,
ECO:0000250|UniProtKB:Q05941}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
membrane protein.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-
7/CHRNA7 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L37663; AAC42053.1; -; mRNA.
CCDS; CCDS21329.1; -.
PIR; A57175; A57175.
RefSeq; NP_031416.3; NM_007390.3.
UniGene; Mm.113464; -.
ProteinModelPortal; P49582; -.
SMR; P49582; -.
BioGrid; 197934; 2.
DIP; DIP-48732N; -.
IntAct; P49582; 2.
STRING; 10090.ENSMUSP00000032738; -.
BindingDB; P49582; -.
ChEMBL; CHEMBL3365; -.
iPTMnet; P49582; -.
PhosphoSitePlus; P49582; -.
PaxDb; P49582; -.
PRIDE; P49582; -.
Ensembl; ENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525.
GeneID; 11441; -.
KEGG; mmu:11441; -.
UCSC; uc009vel.1; mouse.
CTD; 1139; -.
MGI; MGI:99779; Chrna7.
eggNOG; KOG3645; Eukaryota.
eggNOG; ENOG410XQGR; LUCA.
GeneTree; ENSGT00790000122957; -.
HOGENOM; HOG000006756; -.
HOVERGEN; HBG003756; -.
InParanoid; P49582; -.
KO; K04809; -.
OMA; EAICNEW; -.
OrthoDB; EOG091G0R20; -.
PhylomeDB; P49582; -.
TreeFam; TF315605; -.
Reactome; R-MMU-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
PRO; PR:P49582; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000030525; -.
ExpressionAtlas; P49582; baseline and differential.
Genevisible; P49582; MM.
GO; GO:0005892; C:acetylcholine-gated channel complex; ISO:MGI.
GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
GO; GO:0030673; C:axolemma; IDA:MGI.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0098793; C:presynapse; TAS:ARUK-UCL.
GO; GO:0042166; F:acetylcholine binding; ISO:MGI.
GO; GO:0015464; F:acetylcholine receptor activity; ISO:MGI.
GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IDA:MGI.
GO; GO:0001540; F:amyloid-beta binding; ISO:MGI.
GO; GO:0017081; F:chloride channel regulator activity; ISO:MGI.
GO; GO:0005216; F:ion channel activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0015643; F:toxic substance binding; ISO:MGI.
GO; GO:0000187; P:activation of MAPK activity; ISO:MGI.
GO; GO:0008306; P:associative learning; IMP:MGI.
GO; GO:0042113; P:B cell activation; IMP:MGI.
GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI.
GO; GO:0035095; P:behavioral response to nicotine; IGI:MGI.
GO; GO:0006816; P:calcium ion transport; ISO:MGI.
GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:MGI.
GO; GO:0050890; P:cognition; ISO:MGI.
GO; GO:0048813; P:dendrite morphogenesis; IMP:ARUK-UCL.
GO; GO:0097061; P:dendritic spine organization; IMP:ARUK-UCL.
GO; GO:0006897; P:endocytosis; IMP:MGI.
GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
GO; GO:0060112; P:generation of ovulation cycle rhythm; IMP:MGI.
GO; GO:0034220; P:ion transmembrane transport; ISO:MGI.
GO; GO:0006811; P:ion transport; IMP:MGI.
GO; GO:0007611; P:learning or memory; IGI:ARUK-UCL.
GO; GO:0007613; P:memory; IMP:MGI.
GO; GO:0050804; P:modulation of chemical synaptic transmission; IGI:ARUK-UCL.
GO; GO:0098815; P:modulation of excitatory postsynaptic potential; IDA:ARUK-UCL.
GO; GO:1902430; P:negative regulation of amyloid-beta formation; ISO:MGI.
GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IMP:MGI.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IMP:MGI.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IDA:ARUK-UCL.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:MGI.
GO; GO:0042698; P:ovulation cycle; IMP:MGI.
GO; GO:1905923; P:positive regulation of acetylcholine biosynthetic process; IC:ARUK-UCL.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IGI:ARUK-UCL.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:1905920; P:positive regulation of CoA-transferase activity; IGI:ARUK-UCL.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:ARUK-UCL.
GO; GO:2000463; P:positive regulation of excitatory postsynaptic potential; IGI:ARUK-UCL.
GO; GO:0001988; P:positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure; IMP:MGI.
GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; IDA:ARUK-UCL.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ARUK-UCL.
GO; GO:0051247; P:positive regulation of protein metabolic process; IGI:ARUK-UCL.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:ARUK-UCL.
GO; GO:1905906; P:regulation of amyloid fibril formation; IGI:ARUK-UCL.
GO; GO:1902991; P:regulation of amyloid precursor protein catabolic process; ISO:MGI.
GO; GO:0050727; P:regulation of inflammatory response; IMP:MGI.
GO; GO:0042391; P:regulation of membrane potential; IMP:MGI.
GO; GO:1901214; P:regulation of neuron death; IGI:ARUK-UCL.
GO; GO:0014061; P:regulation of norepinephrine secretion; IMP:MGI.
GO; GO:0051823; P:regulation of synapse structural plasticity; IC:ARUK-UCL.
GO; GO:0032222; P:regulation of synaptic transmission, cholinergic; IC:ARUK-UCL.
GO; GO:0032225; P:regulation of synaptic transmission, dopaminergic; IMP:MGI.
GO; GO:1905144; P:response to acetylcholine; ISO:MGI.
GO; GO:1904645; P:response to amyloid-beta; IMP:ARUK-UCL.
GO; GO:0009409; P:response to cold; IDA:ARUK-UCL.
GO; GO:0045471; P:response to ethanol; IMP:MGI.
GO; GO:0032094; P:response to food; IMP:MGI.
GO; GO:0001666; P:response to hypoxia; ISO:MGI.
GO; GO:0035094; P:response to nicotine; IMP:MGI.
GO; GO:0050893; P:sensory processing; IDA:ARUK-UCL.
GO; GO:0007165; P:signal transduction; ISO:MGI.
GO; GO:0050808; P:synapse organization; IGI:ARUK-UCL.
GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:MGI.
GO; GO:0042110; P:T cell activation; IMP:MGI.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR006201; Neur_channel.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR00254; NICOTINICR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
2: Evidence at transcript level;
Cell junction; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
Membrane; Postsynaptic cell membrane; Receptor; Reference proteome;
Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 502 Neuronal acetylcholine receptor subunit
alpha-7.
/FTId=PRO_0000000368.
TOPO_DOM 23 230 Extracellular. {ECO:0000255}.
TRANSMEM 231 255 Helical. {ECO:0000255}.
TRANSMEM 262 280 Helical. {ECO:0000255}.
TRANSMEM 296 317 Helical. {ECO:0000255}.
TOPO_DOM 318 469 Cytoplasmic. {ECO:0000255}.
TRANSMEM 470 490 Helical. {ECO:0000255}.
CARBOHYD 46 46 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 133 133 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 150 164 {ECO:0000250}.
DISULFID 212 213 Associated with receptor activation.
{ECO:0000250}.
SEQUENCE 502 AA; 56632 MW; C9312E5226D120E3 CRC64;
MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV RFPDGQIWKP DILLYNSADE
RFDATFHTNV LVNASGHCQY LPPGIFKSSC YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL
QMQEADISSY IPNGEWDLMG IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE DKVRPACQHK
PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT PDSGVVCGRL ACSPTHDEHL
MHGTHPSDGD PDLAKILEEV RYIANRFRCQ DESEVICSEW KFAACVVDRL CLMAFSVFTI
ICTIGILMSA PNFVEAVSKD FA


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