Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-2 chain) (N-alpha 2)

 ACHB4_RAT               Reviewed;         495 AA.
P12392; Q63361;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
25-OCT-2017, entry version 158.
RecName: Full=Neuronal acetylcholine receptor subunit beta-4;
AltName: Full=Neuronal acetylcholine receptor non-alpha-2 chain;
Short=N-alpha 2;
Flags: Precursor;
Name=Chrnb4; Synonyms=Acrb4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
PubMed=2642007; DOI=10.1016/0896-6273(89)90207-9;
Duvoisin R.M., Deneris E.S., Patrick J., Heinemann S.F.;
"The functional diversity of the neuronal nicotinic acetylcholine
receptors is increased by a novel subunit: beta 4.";
Neuron 3:487-496(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT).
PubMed=1689727;
Boulter J., O'Shea-Greenfield A., Duvoisin R.M., Connolly J.G.,
Wada E., Jensen A., Gardner P.D., Ballivet M., Deneris E.S.,
McKinnon D., Heinemann S.F., Patrick J.;
"Alpha 3, alpha 5, and beta 4: three members of the rat neuronal
nicotinic acetylcholine receptor-related gene family form a gene
cluster.";
J. Biol. Chem. 265:4472-4482(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
TISSUE=Superior cervical ganglion;
PubMed=2918319; DOI=10.1111/j.1471-4159.1989.tb02553.x;
Isenberg K.E., Meyer G.E.;
"Cloning of a putative neuronal nicotinic acetylcholine receptor
subunit.";
J. Neurochem. 52:988-991(1989).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
STRAIN=Sprague-Dawley; TISSUE=Brain;
Groot-Kormelink P.J.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[5]
SUBUNIT, AND SITES LYS-81; ILE-133 AND GLN-141.
PubMed=16964981; DOI=10.1021/bi0611715;
Shiembob D.L., Roberts R.L., Luetje C.W., McIntosh J.M.;
"Determinants of alpha-conotoxin BuIA selectivity on the nicotinic
acetylcholine receptor beta subunit.";
Biochemistry 45:11200-11207(2006).
-!- FUNCTION: After binding acetylcholine, the AChR responds by an
extensive change in conformation that affects all subunits and
leads to opening of an ion-conducting channel across the plasma
membrane.
-!- SUBUNIT: Neuronal AChR is composed of two different types of
subunits: alpha and beta. Beta-4 subunit can be combined to alpha-
2, alpha-3 or alpha-4 to give rise to functional receptors.
Interacts with RIC3; which is required for proper folding and
assembly (By similarity). Interacts with LYPD6 (By similarity).
The pentamer alpha3-beta-4 interacts with the conotoxin BuIA
(PubMed:16964981). The heteropentamer composed of alpha-3 and
beta-4 subunits interacts with the alpha-conotoxin ImI (By
similarity). {ECO:0000250|UniProtKB:P30926,
ECO:0000269|PubMed:16964981}.
-!- INTERACTION:
P09483:Chrna4; NbExp=4; IntAct=EBI-9008856, EBI-7842410;
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Short;
IsoId=P12392-1; Sequence=Displayed;
Name=Long;
IsoId=P12392-2; Sequence=VSP_000076;
-!- TISSUE SPECIFICITY: In the brain, it is detected in the medial
habenula. In the peripheral nervous system, it is found at least
in the adrenal gland.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-
4/CHRNB4 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U42976; AAA85212.1; -; mRNA.
EMBL; M33953; AAA41668.1; -; Genomic_DNA.
EMBL; J05232; AAA41668.1; JOINED; Genomic_DNA.
EMBL; M89971; AAA41668.1; JOINED; Genomic_DNA.
EMBL; M33951; AAA41668.1; JOINED; Genomic_DNA.
EMBL; M89989; AAA41668.1; JOINED; Genomic_DNA.
EMBL; M33952; AAA41668.1; JOINED; Genomic_DNA.
EMBL; X15834; CAA33839.1; -; mRNA.
EMBL; AY574260; AAS90356.1; -; mRNA.
PIR; A30992; A30992.
PIR; B35721; B35721.
RefSeq; NP_434693.1; NM_052806.2. [P12392-1]
UniGene; Rn.9695; -.
PDB; 1OLJ; Model; -; B/D/E=25-231.
PDBsum; 1OLJ; -.
ProteinModelPortal; P12392; -.
SMR; P12392; -.
IntAct; P12392; 4.
STRING; 10116.ENSRNOP00000051052; -.
BindingDB; P12392; -.
ChEMBL; CHEMBL2658; -.
PhosphoSitePlus; P12392; -.
PaxDb; P12392; -.
Ensembl; ENSRNOT00000019458; ENSRNOP00000019458; ENSRNOG00000014427. [P12392-1]
GeneID; 25103; -.
KEGG; rno:25103; -.
UCSC; RGD:2351; rat. [P12392-1]
CTD; 1143; -.
RGD; 2351; Chrnb4.
eggNOG; KOG3645; Eukaryota.
eggNOG; ENOG410XQGR; LUCA.
GeneTree; ENSGT00760000118930; -.
HOGENOM; HOG000006757; -.
HOVERGEN; HBG003756; -.
InParanoid; P12392; -.
KO; K04815; -.
OMA; TFLFMKR; -.
OrthoDB; EOG091G0R20; -.
Reactome; R-RNO-629587; Highly sodium permeable acetylcholine nicotinic receptors.
Reactome; R-RNO-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
Reactome; R-RNO-629597; Highly calcium permeable nicotinic acetylcholine receptors.
Reactome; R-RNO-6798695; Neutrophil degranulation.
PRO; PR:P12392; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000014427; -.
Genevisible; P12392; RN.
GO; GO:0005892; C:acetylcholine-gated channel complex; IDA:RGD.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0042166; F:acetylcholine binding; IDA:RGD.
GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IC:RGD.
GO; GO:0008144; F:drug binding; IDA:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
GO; GO:0001508; P:action potential; IEA:Ensembl.
GO; GO:0035095; P:behavioral response to nicotine; IEA:Ensembl.
GO; GO:0098655; P:cation transmembrane transport; IBA:GO_Central.
GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO; GO:0007274; P:neuromuscular synaptic transmission; IBA:GO_Central.
GO; GO:0051971; P:positive regulation of transmission of nerve impulse; IEA:Ensembl.
GO; GO:0051291; P:protein heterooligomerization; IDA:RGD.
GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0035094; P:response to nicotine; IBA:GO_Central.
GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
GO; GO:0060084; P:synaptic transmission involved in micturition; IEA:Ensembl.
GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
Gene3D; 1.20.58.390; -; 1.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR036734; Neur_chan_lig-bd_sf.
InterPro; IPR006201; Neur_channel.
InterPro; IPR036719; Neuro-gated_channel_TM_sf.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR00254; NICOTINICR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell junction; Cell membrane;
Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
Ion transport; Ligand-gated ion channel; Membrane;
Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 495 Neuronal acetylcholine receptor subunit
beta-4.
/FTId=PRO_0000000391.
TOPO_DOM 21 235 Extracellular. {ECO:0000255}.
TRANSMEM 236 256 Helical. {ECO:0000255}.
TOPO_DOM 257 264 Cytoplasmic. {ECO:0000255}.
TRANSMEM 265 285 Helical. {ECO:0000255}.
TOPO_DOM 286 297 Extracellular. {ECO:0000255}.
TRANSMEM 298 318 Helical. {ECO:0000255}.
TOPO_DOM 319 463 Cytoplasmic. {ECO:0000255}.
TRANSMEM 464 484 Helical. {ECO:0000255}.
TOPO_DOM 485 495 Extracellular. {ECO:0000255}.
SITE 81 81 Key residue that facilitates effective
access of the conotoxin BuIA to the
channel binding site.
{ECO:0000305|PubMed:16964981}.
SITE 133 133 Key residue for a low dissociation
(K(off)) from the conotoxin BuIA.
{ECO:0000305|PubMed:16964981}.
SITE 141 141 Key residue for a low dissociation
(K(off)) from the conotoxin BuIA.
{ECO:0000305|PubMed:16964981}.
CARBOHYD 35 35 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 137 137 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 152 166 {ECO:0000250}.
VAR_SEQ 17 17 D -> DARLFDCSGVLPDKGPAGLTVRFP (in isoform
Long). {ECO:0000303|PubMed:2918319}.
/FTId=VSP_000076.
CONFLICT 9 9 V -> VV (in Ref. 3; CAA33839).
{ECO:0000305}.
CONFLICT 164 164 Missing (in Ref. 2; AAA41668).
{ECO:0000305}.
CONFLICT 230 231 KP -> NA (in Ref. 2; AAA41668 and 3;
CAA33839). {ECO:0000305}.
CONFLICT 287 288 Missing (in Ref. 3; CAA33839).
{ECO:0000305}.
CONFLICT 290 290 D -> N (in Ref. 3; CAA33839).
{ECO:0000305}.
SEQUENCE 495 AA; 55861 MW; 688F37AB80448F7F CRC64;
MRGTPLLLVS LFSLLQDGDC RLANAEEKLM DDLLNKTRYN NLIRPATSSS QLISIRLELS
LSQLISVNER EQIMTTSIWL KQEWTDYRLA WNSSCYEGVN ILRIPAKRVW LPDIVLYNNA
DGTYEVSVYT NVIVRSNGSI QWLPPAIYKS ACKIEVKHFP FDQQNCTLKF RSWTYDHTEI
DMVLKSPTAI MDDFTPSGEW DIVALPGRRT VNPQDPSYVD VTYDFIIKRK PLFYTINLII
PCVLITSLAI LVFYLPSDCG EKMTLCISVL LALTFFLLLI SKIVPPTSLD IPLIGKYLLF
TMVLVTFSIV TTVCVLNVHH RSPSTHTMAS WVKECFLHKL PTFLFMKRPG LEVSLVRVPH
PSQLHLATAD TAATSALGPT SPSNLYGSSM YFVNPVPAAP KSAVSSHTAG LPRDARLRSS
GRFREDLQEA LEGVSFIAQH LESDDRDQSV IEDWKFVAMV VDRLFLWVFV FVCILGTMGL
FLPPLFQIHA PSKDS


Related products :

Catalog number Product name Quantity
18-003-43294 Neuronal acetylcholine receptor protein subunit alpha-9 - Nicotinic acetylcholine receptor subunit alpha 9; NACHR alpha 9 Polyclonal 0.05 mg Aff Pur
AP10164PU-N Neuronal acetylcholine receptor subunit alpha-7 (exon 4, alpha 7-2 variant) Rabbit antibody Ab Aff - Purified 0.1 mg
'AP10164PU-N Neuronal acetylcholine receptor subunit alpha-7 (exon 4, alpha 7-2 variant) antibody Ab host: Rabbit 0.1 mg
E14765m Rat ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-9 96T
ACH10_RAT Rat ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-10 96T
'AP10164PU-N Neuronal acetylcholine receptor subunit alpha-7 (exon 4, alpha 7-2 variant) antibody Isotype Host Rabbit 0.1 mg
18-003-42940 Neuronal acetylcholine receptor protein subunit alpha-7 - N_A Polyclonal 0.1 mg Protein A
18-003-42656 Neuronal acetylcholine receptor protein subunit alpha-7 - N_A Polyclonal 0.1 mg Protein A
ACHA6_MOUSE Mouse ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-6 96T
E1492r Human ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-7 96T
CSB-EL005390RA Rat Neuronal acetylcholine receptor subunit alpha-4(CHRNA4) ELISA kit 96T
CSB-EL005389RA Rat Neuronal acetylcholine receptor subunit alpha-3(CHRNA3) ELISA kit 96T
CSB-EL005387RA Rat Neuronal acetylcholine receptor subunit alpha-10(CHRNA10) ELISA kit 96T
CSB-EL005391RA Rat Neuronal acetylcholine receptor subunit alpha-5(CHRNA5) ELISA kit 96T
CSB-EL005388RA Rat Neuronal acetylcholine receptor subunit alpha-2(CHRNA2) ELISA kit 96T
18-003-42612 Neuronal acetylcholine receptor protein subunit alpha-5 - N_A Polyclonal 0.1 mg Protein A
CSB-EL005392RA Rat Neuronal acetylcholine receptor subunit alpha-6(CHRNA6) ELISA kit 96T
CSB-EL005393RA Rat Neuronal acetylcholine receptor subunit alpha-7(CHRNA7) ELISA kit 96T
18-003-42939 Neuronal acetylcholine receptor protein subunit alpha-3 - N_A Polyclonal 0.05 mg Aff Pur
CSB-EL005394RA Rat Neuronal acetylcholine receptor subunit alpha-9(CHRNA9) ELISA kit 96T
E1324c Human ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-5 96T
18-003-42969 Neuronal acetylcholine receptor protein subunit alpha-2 - N_A Polyclonal 0.1 mg Protein A
E11168r Human ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-10 96T
ACHA7_MOUSE Mouse ELISA Kit FOR Neuronal acetylcholine receptor subunit alpha-7 96T
'AVARP13018_T100 Neuronal acetylcholine receptor subunit alpha-7 antibody Host rabbit 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur