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Neuronal immunoglobulin domain-containing protein rig-3

 RIG3_CAEEL              Reviewed;         487 AA.
Q18806;
07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 129.
RecName: Full=Neuronal immunoglobulin domain-containing protein rig-3 {ECO:0000305};
Flags: Precursor;
Name=rig-3 {ECO:0000312|WormBase:C53B7.1};
ORFNames=C53B7.1 {ECO:0000312|WormBase:C53B7.1};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION
PHENOTYPE, GPI-ANCHOR AT ASP-466, AND MUTAGENESIS OF 465-MET--ILE-487.
PubMed=21745641; DOI=10.1016/j.neuron.2011.05.034;
Babu K., Hu Z., Chien S.C., Garriga G., Kaplan J.M.;
"The immunoglobulin super family protein RIG-3 prevents synaptic
potentiation and regulates Wnt signaling.";
Neuron 71:103-116(2011).
-!- FUNCTION: Cell surface protein which plays a role in the
plasticity of cholinergic synapses at neuromuscular junctions and
in the polarity of the mechanosensory neuron ALM, possibly by
antagonizing Wnt signaling. {ECO:0000269|PubMed:21745641}.
-!- SUBCELLULAR LOCATION: Cell projection, axon
{ECO:0000269|PubMed:21745641}. Cell junction, synapse
{ECO:0000269|PubMed:21745641}. Cell membrane
{ECO:0000269|PubMed:21745641}; Lipid-anchor, GPI-anchor
{ECO:0000269|PubMed:21745641}. Note=Membrane association is
important for synaptic function. {ECO:0000269|PubMed:21745641}.
-!- TISSUE SPECIFICITY: Expressed in the cholinergic motor neurons AS,
VA and DA in the ventral nerve cord and in the mechanosensory ALM
neurons in the midbody. {ECO:0000269|PubMed:21745641}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in
hypersensitivity to the acetylcholinesterase inhibitor aldicarb,
indicating increased cholinergic transmission in mutant animals.
{ECO:0000269|PubMed:21745641}.
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EMBL; BX284606; CCD67885.1; -; Genomic_DNA.
PIR; T28804; T28804.
RefSeq; NP_509155.1; NM_076754.4.
UniGene; Cel.6793; -.
ProteinModelPortal; Q18806; -.
STRING; 6239.C53B7.1; -.
EPD; Q18806; -.
PaxDb; Q18806; -.
PeptideAtlas; Q18806; -.
EnsemblMetazoa; C53B7.1; C53B7.1; WBGene00004370.
GeneID; 180958; -.
KEGG; cel:CELE_C53B7.1; -.
UCSC; C53B7.1.2; c. elegans.
CTD; 180958; -.
WormBase; C53B7.1; CE06971; WBGene00004370; rig-3.
eggNOG; KOG3510; Eukaryota.
eggNOG; ENOG410XPX0; LUCA.
HOGENOM; HOG000019345; -.
InParanoid; Q18806; -.
OMA; CITIEMH; -.
OrthoDB; EOG091G06QT; -.
PhylomeDB; Q18806; -.
PRO; PR:Q18806; -.
Proteomes; UP000001940; Chromosome X.
Bgee; WBGene00004370; -.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0030424; C:axon; IDA:WormBase.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0045202; C:synapse; IDA:WormBase.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013151; Immunoglobulin.
Pfam; PF00047; ig; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 2.
1: Evidence at protein level;
Cell junction; Cell membrane; Cell projection; Complete proteome;
Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain;
Lipoprotein; Membrane; Reference proteome; Repeat; Signal; Synapse.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 466 Neuronal immunoglobulin domain-containing
protein rig-3. {ECO:0000255}.
/FTId=PRO_5004186920.
PROPEP 467 487 Removed in mature form.
{ECO:0000305|PubMed:21745641}.
/FTId=PRO_0000440240.
DOMAIN 34 139 Ig-like 1. {ECO:0000255|PROSITE-
ProRule:PRU00114}.
DOMAIN 247 354 Ig-like 2. {ECO:0000255|PROSITE-
ProRule:PRU00114}.
LIPID 466 466 GPI-anchor amidated aspartate.
{ECO:0000305|PubMed:21745641}.
DISULFID 61 124 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 271 327 {ECO:0000255|PROSITE-ProRule:PRU00114}.
MUTAGEN 465 487 Missing: Reduced axonal localization and
increased coelomocyte expression,
indicating shedding into the body cavity.
{ECO:0000269|PubMed:21745641}.
SEQUENCE 487 AA; 54615 MW; C6B8F2DF0705664F CRC64;
MGRLLAKMLF PLAMCLFVSA VSASDSPSSN EANPIVISSE AMDYDTNTIT VREGKKLMVS
CVFESDEQIH KSDLLWKQAN GNNIDGESNP SLFSVILNEK GSKHRKTSLH FSSVHTRDTG
LYTCTGRTAG GENFEKTIKL VVLPAIEWND KDTVKGALLG EPITIDCGVK GPSGKEPMIQ
MTNGNGEPLD EEIWTIAGNE ATIDSLKKEH AELTVSCITI EMHQETSKEE FPVVDRKDVN
IEVYTLPEFE TEESVQYTVI DNHVRDAIIY CNVTHSFPPV RHYTFYHGDE EIKMSDKFNI
FVNVGVSQGA HLKIHNVNEN DLGTYKCEAN NIKAKSYHTI HLREANAPAE PKVTLIEDKR
HSIIWKVESI DRDPDLPMTA VEIRHLRAGT AEASGVSDED ISDAYWKSHS IFMQRNIKDD
GIYEINGLRH GHEYVWRFRQ INEAGFGDSV VLRAKTLDDH DLEMMDSASD SKFPLALATL
FFVCLFI


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