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Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor)

 NPY5R_HUMAN             Reviewed;         445 AA.
Q15761; Q6GTR7; Q92916;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 2.
20-DEC-2017, entry version 150.
RecName: Full=Neuropeptide Y receptor type 5;
Short=NPY5-R;
AltName: Full=NPY-Y5 receptor;
Short=NPYY5-R;
Short=Y5 receptor;
Name=NPY5R; Synonyms=NPYR5;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8824284; DOI=10.1074/jbc.271.42.26044;
Hu Y., Bloomquist B.T., Cornfield L.J., Decarr L.B.,
Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L.,
Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L.;
"Identification of a novel hypothalamic neuropeptide Y receptor
associated with feeding behavior.";
J. Biol. Chem. 271:26315-26319(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hippocampus;
PubMed=8700207; DOI=10.1038/382168a0;
Gerald C., Walker M.W., Criscione L., Gustafson E.L.,
Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M.,
Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G.,
Taber R.I., Branchek T.A., Weinshank R.L.;
"A receptor subtype involved in neuropeptide-Y-induced food intake.";
Nature 382:168-171(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9169127; DOI=10.1006/geno.1997.4684;
Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J.;
"Overlapping gene structure of the human neuropeptide Y receptor
subtypes Y1 and Y5 suggests coordinate transcriptional regulation.";
Genomics 41:315-319(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"Isolation of complete coding sequence for neuropeptide Y receptor Y5
(NPY5R).";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity
of this receptor is mediated by G proteins that inhibit adenylate
cyclase activity. Seems to be associated with food intake. Could
be involved in feeding disorders.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Brain; hypothalamus.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=AAC50623.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U66275; AAC50741.1; -; mRNA.
EMBL; U56079; AAC50623.1; ALT_INIT; mRNA.
EMBL; U94320; AAC51295.1; -; mRNA.
EMBL; AY322538; AAP84351.1; -; Genomic_DNA.
EMBL; AC079238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471056; EAX04839.1; -; Genomic_DNA.
EMBL; BC042416; AAH42416.1; -; mRNA.
CCDS; CCDS3804.1; -.
RefSeq; NP_001304020.1; NM_001317091.1.
RefSeq; NP_001304021.1; NM_001317092.1.
RefSeq; NP_006165.1; NM_006174.3.
RefSeq; XP_005263095.1; XM_005263038.3.
RefSeq; XP_011530319.1; XM_011532017.2.
UniGene; Hs.519058; -.
UniGene; Hs.598503; -.
PDB; 2HE6; Model; -; @=1-445.
PDBsum; 2HE6; -.
ProteinModelPortal; Q15761; -.
BioGrid; 110949; 2.
IntAct; Q15761; 3.
STRING; 9606.ENSP00000339377; -.
BindingDB; Q15761; -.
ChEMBL; CHEMBL4561; -.
DrugBank; DB05004; AC162352.
GuidetoPHARMACOLOGY; 308; -.
iPTMnet; Q15761; -.
PhosphoSitePlus; Q15761; -.
BioMuta; NPY5R; -.
DMDM; 215274093; -.
PaxDb; Q15761; -.
PRIDE; Q15761; -.
DNASU; 4889; -.
Ensembl; ENST00000338566; ENSP00000339377; ENSG00000164129.
Ensembl; ENST00000506953; ENSP00000423474; ENSG00000164129.
Ensembl; ENST00000515560; ENSP00000423917; ENSG00000164129.
GeneID; 4889; -.
KEGG; hsa:4889; -.
UCSC; uc003iqn.3; human.
CTD; 4889; -.
DisGeNET; 4889; -.
EuPathDB; HostDB:ENSG00000164129.11; -.
GeneCards; NPY5R; -.
HGNC; HGNC:7958; NPY5R.
MIM; 602001; gene.
neXtProt; NX_Q15761; -.
OpenTargets; ENSG00000164129; -.
PharmGKB; PA31742; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00900000140797; -.
HOGENOM; HOG000294210; -.
HOVERGEN; HBG052662; -.
InParanoid; Q15761; -.
KO; K04207; -.
OMA; IKADLMS; -.
OrthoDB; EOG091G0ZDG; -.
PhylomeDB; Q15761; -.
TreeFam; TF315303; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-418594; G alpha (i) signalling events.
SIGNOR; Q15761; -.
GeneWiki; Neuropeptide_Y_receptor_Y5; -.
GenomeRNAi; 4889; -.
PRO; PR:Q15761; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000164129; -.
CleanEx; HS_NPY5R; -.
Genevisible; Q15761; HS.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0043005; C:neuron projection; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004983; F:neuropeptide Y receptor activity; TAS:ProtInc.
GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0008015; P:blood circulation; IBA:GO_Central.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0042755; P:eating behavior; IEA:Ensembl.
GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0060112; P:generation of ovulation cycle rhythm; IEA:Ensembl.
GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0014050; P:negative regulation of glutamate secretion; IEA:Ensembl.
GO; GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0002675; P:positive regulation of acute inflammatory response; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
CDD; cd15398; 7tmA_NPY5R; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000393; NPY5_rcpt.
InterPro; IPR000611; NPY_rcpt.
PANTHER; PTHR45422; PTHR45422; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01016; NRPEPTIDEY5R.
PRINTS; PR01012; NRPEPTIDEYR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 445 Neuropeptide Y receptor type 5.
/FTId=PRO_0000069939.
TOPO_DOM 1 42 Extracellular. {ECO:0000255}.
TRANSMEM 43 63 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 64 77 Cytoplasmic. {ECO:0000255}.
TRANSMEM 78 98 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 99 117 Extracellular. {ECO:0000255}.
TRANSMEM 118 138 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 139 156 Cytoplasmic. {ECO:0000255}.
TRANSMEM 157 177 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 178 208 Extracellular. {ECO:0000255}.
TRANSMEM 209 229 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 230 369 Cytoplasmic. {ECO:0000255}.
TRANSMEM 370 390 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 391 407 Extracellular. {ECO:0000255}.
TRANSMEM 408 428 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 429 445 Cytoplasmic. {ECO:0000255}.
LIPID 442 442 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 10 10 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 17 17 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 114 198 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 445 AA; 50727 MW; A2B0F3169DBA66BE CRC64;
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL
LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL
QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL
VELQETFGSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC
GLSNKENRLE ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL RVKRSVTRIK
KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL
NPILYGFLNN GIKADLVSLI HCLHM


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