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Neuropilin

 G3HZ57_CRIGR            Unreviewed;       923 AA.
G3HZ57;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
20-DEC-2017, entry version 43.
RecName: Full=Neuropilin {ECO:0000256|PIRNR:PIRNR036960};
ORFNames=I79_016352 {ECO:0000313|EMBL:EGW13111.1};
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13111.1, ECO:0000313|Proteomes:UP000001075};
[1] {ECO:0000313|Proteomes:UP000001075}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
PubMed=21804562; DOI=10.1038/nbt.1932;
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
line.";
Nat. Biotechnol. 29:735-741(2011).
-!- SIMILARITY: Belongs to the neuropilin family.
{ECO:0000256|PIRNR:PIRNR036960}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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EMBL; JH000960; EGW13111.1; -; Genomic_DNA.
RefSeq; XP_003508459.1; XM_003508411.3.
RefSeq; XP_007647231.1; XM_007649041.2.
RefSeq; XP_007647232.1; XM_007649042.2.
Ensembl; ENSCGRT00000019457; ENSCGRP00000019184; ENSCGRG00000013969.
Ensembl; ENSCGRT00001013564; ENSCGRP00001009360; ENSCGRG00001011493.
GeneID; 100763324; -.
KEGG; cge:100763324; -.
CTD; 8829; -.
InParanoid; G3HZ57; -.
KO; K06724; -.
Proteomes; UP000001075; Unassembled WGS sequence.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005883; C:neurofilament; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0097443; C:sorting endosome; IEA:Ensembl.
GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
GO; GO:0038085; F:vascular endothelial growth factor binding; IEA:Ensembl.
GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:Ensembl.
GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
GO; GO:0048846; P:axon extension involved in axon guidance; IEA:Ensembl.
GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
GO; GO:0060385; P:axonogenesis involved in innervation; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0021785; P:branchiomotor neuron axon guidance; IEA:Ensembl.
GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO; GO:0071679; P:commissural neuron axon guidance; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Ensembl.
GO; GO:1904835; P:dorsal root ganglion morphogenesis; IEA:Ensembl.
GO; GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO; GO:0021612; P:facial nerve structural organization; IEA:Ensembl.
GO; GO:1903375; P:facioacoustic ganglion development; IEA:Ensembl.
GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IEA:Ensembl.
GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0097475; P:motor neuron migration; IEA:Ensembl.
GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IEA:Ensembl.
GO; GO:1905040; P:otic placode development; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0050918; P:positive chemotaxis; IEA:Ensembl.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0048842; P:positive regulation of axon extension involved in axon guidance; IEA:Ensembl.
GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:1902336; P:positive regulation of retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:1902946; P:protein localization to early endosome; IEA:Ensembl.
GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl.
GO; GO:0061441; P:renal artery morphogenesis; IEA:Ensembl.
GO; GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Ensembl.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl.
GO; GO:0097374; P:sensory neuron axon guidance; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0006930; P:substrate-dependent cell migration, cell extension; IEA:Ensembl.
GO; GO:0061549; P:sympathetic ganglion development; IEA:Ensembl.
GO; GO:0097490; P:sympathetic neuron projection extension; IEA:Ensembl.
GO; GO:0097491; P:sympathetic neuron projection guidance; IEA:Ensembl.
GO; GO:1901998; P:toxin transport; IEA:Ensembl.
GO; GO:0061551; P:trigeminal ganglion development; IEA:Ensembl.
GO; GO:0021637; P:trigeminal nerve structural organization; IEA:Ensembl.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:1902378; P:VEGF-activated neuropilin signaling pathway involved in axon guidance; IEA:Ensembl.
GO; GO:0036486; P:ventral trunk neural crest cell migration; IEA:Ensembl.
GO; GO:0021649; P:vestibulocochlear nerve structural organization; IEA:Ensembl.
CDD; cd00041; CUB; 2.
CDD; cd06263; MAM; 1.
Gene3D; 2.60.120.260; -; 2.
Gene3D; 2.60.120.290; -; 2.
InterPro; IPR013320; ConA-like_dom_sf.
InterPro; IPR000859; CUB_dom.
InterPro; IPR000421; FA58C.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR000998; MAM_dom.
InterPro; IPR014648; Neuropilin.
InterPro; IPR022579; Neuropilin_C.
InterPro; IPR027146; NRP1.
InterPro; IPR035914; Sperma_CUB_dom_sf.
PANTHER; PTHR44185; PTHR44185; 1.
PANTHER; PTHR44185:SF1; PTHR44185:SF1; 1.
Pfam; PF00431; CUB; 2.
Pfam; PF11980; DUF3481; 1.
Pfam; PF00754; F5_F8_type_C; 2.
Pfam; PF00629; MAM; 1.
PIRSF; PIRSF036960; Neuropilin; 1.
PRINTS; PR00020; MAMDOMAIN.
SMART; SM00042; CUB; 2.
SMART; SM00231; FA58C; 2.
SMART; SM00137; MAM; 1.
SUPFAM; SSF49785; SSF49785; 2.
SUPFAM; SSF49854; SSF49854; 2.
SUPFAM; SSF49899; SSF49899; 1.
PROSITE; PS01180; CUB; 2.
PROSITE; PS01285; FA58C_1; 2.
PROSITE; PS01286; FA58C_2; 2.
PROSITE; PS50022; FA58C_3; 2.
PROSITE; PS00740; MAM_1; 1.
PROSITE; PS50060; MAM_2; 1.
3: Inferred from homology;
Calcium {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|PIRSR:PIRSR036960-
1}; Complete proteome {ECO:0000313|Proteomes:UP000001075};
Developmental protein {ECO:0000256|PIRNR:PIRNR036960};
Differentiation {ECO:0000256|PIRNR:PIRNR036960};
Disulfide bond {ECO:0000256|PIRSR:PIRSR036960-2, ECO:0000256|PROSITE-
ProRule:PRU00059, ECO:0000256|SAAS:SAAS00934412};
Membrane {ECO:0000256|SAM:Phobius};
Metal-binding {ECO:0000256|PIRSR:PIRSR036960-1};
Neurogenesis {ECO:0000256|PIRNR:PIRNR036960};
Receptor {ECO:0000256|PIRNR:PIRNR036960};
Reference proteome {ECO:0000313|Proteomes:UP000001075};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 21 {ECO:0000256|SAM:SignalP}.
CHAIN 22 923 Neuropilin. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003444723.
TRANSMEM 857 882 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 27 141 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 147 265 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 275 424 F5/8 type C.
{ECO:0000259|PROSITE:PS50022}.
DOMAIN 431 583 F5/8 type C.
{ECO:0000259|PROSITE:PS50022}.
DOMAIN 648 811 MAM. {ECO:0000259|PROSITE:PS50060}.
METAL 195 195 Calcium. {ECO:0000256|PIRSR:PIRSR036960-
1}.
METAL 209 209 Calcium. {ECO:0000256|PIRSR:PIRSR036960-
1}.
METAL 250 250 Calcium. {ECO:0000256|PIRSR:PIRSR036960-
1}.
DISULFID 27 54 {ECO:0000256|PIRSR:PIRSR036960-2,
ECO:0000256|PROSITE-ProRule:PRU00059}.
DISULFID 82 104 {ECO:0000256|PIRSR:PIRSR036960-2}.
DISULFID 147 173 {ECO:0000256|PIRSR:PIRSR036960-2}.
DISULFID 206 228 {ECO:0000256|PIRSR:PIRSR036960-2}.
DISULFID 275 424 {ECO:0000256|PIRSR:PIRSR036960-2}.
DISULFID 431 583 {ECO:0000256|PIRSR:PIRSR036960-2}.
SEQUENCE 923 AA; 103023 MW; 8725F23BF25FAA81 CRC64;
MERGLPLLCA ALALALALAS AFRSEKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA
PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENENGRLW GKFCGKIAPS PVVSSGPFLF
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPSGVIKS PGFPEKYPNS LECTYIIFAP
KMSEIILEFE SFDLEQDSNP PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS
GILSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN
WSVERSRLNY PENGWTPGQD SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV
DISSNGEDWI TLKEGNKAII FQGNTNPTDV VLGVFPKPLI TRFVRIKPAS WETGISMRFE
VYGCKITDYP CSGMLGMVSG LISDSQITAS NQGDRNWMPE NIRLVTSRSG WALPPSSHPY
VNEWLQVDLG DEKIVRGVII QGGKHRENKV FMKKFKIAYS NNGSDWKMIM DDSKHKAKTF
EGNNNYDTPE LRTFSPLSTR FVRIFPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF
CHWEHDSHAQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGESD
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN
FELVDGVKLK KDKLNPQSNY SEA


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