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Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); TLQP-11; TLQP-21; TLQP-30; TLQP-62; HFHH-10; AQEE-30; LQEQ-19]

 VGF_RAT                 Reviewed;         617 AA.
P20156;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
26-MAY-2009, sequence version 3.
23-MAY-2018, entry version 105.
RecName: Full=Neurosecretory protein VGF;
AltName: Full=VGF8a protein;
Contains:
RecName: Full=VGF(24-63);
Contains:
RecName: Full=VGF(180-194);
Contains:
RecName: Full=VGF(375-407);
Contains:
RecName: Full=Neuroendocrine regulatory peptide-1;
Short=NERP-1;
Contains:
RecName: Full=Neuroendocrine regulatory peptide-2;
Short=NERP-2;
Contains:
RecName: Full=TLQP-11;
Contains:
RecName: Full=TLQP-21;
Contains:
RecName: Full=TLQP-30;
Contains:
RecName: Full=TLQP-62;
Contains:
RecName: Full=HFHH-10;
Contains:
RecName: Full=AQEE-30;
Contains:
RecName: Full=LQEQ-19;
Flags: Precursor;
Name=Vgf;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2676516;
Possenti R., Eldridge J.D., Paterson B.M., Grasso A., Levi A.;
"A protein induced by NGF in PC12 cells is stored in secretory
vesicles and released through the regulated pathway.";
EMBO J. 8:2217-2223(1989).
[2]
SEQUENCE REVISION.
Possenti R.;
Submitted (OCT-1995) to UniProtKB.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=2017159; DOI=10.1128/MCB.11.5.2335;
Salton S.R.J., Fischberg D.J., Dong K.-W.;
"Structure of the gene encoding VGF, a nervous system-specific mRNA
that is rapidly and selectively induced by nerve growth factor in PC12
cells.";
Mol. Cell. Biol. 11:2335-2349(1991).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1377233;
Hawley R.J., Scheibe R.J., Wagner J.A.;
"NGF induces the expression of the VGF gene through a cAMP response
element.";
J. Neurosci. 12:2573-2581(1992).
[5]
PROTEIN SEQUENCE OF 24-63; 180-194 AND 375-407, MASS SPECTROMETRY, AND
PYROGLUTAMATE FORMATION AT GLN-180.
STRAIN=Wistar; TISSUE=Corpus striatum;
PubMed=19164277; DOI=10.1074/mcp.M800501-MCP200;
Bernay B., Gaillard M.-C., Guryca V., Emadali A., Kuhn L.,
Bertrand A., Detraz I., Carcenac C., Savasta M., Brouillet E.,
Garin J., Elalouf J.-M.;
"Discovering new bioactive neuropeptides in the striatum secretome
using in vivo microdialysis and versatile proteomics.";
Mol. Cell. Proteomics 8:946-958(2009).
[6]
PEPTIDES, AND FUNCTION OF PEPTIDE TLQP-21.
PubMed=19466987; DOI=10.1111/j.1476-5381.2009.00192.x;
Severini C., La Corte G., Improta G., Broccardo M., Agostini S.,
Petrella C., Sibilia V., Pagani F., Guidobono F., Bulgarelli I.,
Ferri G.L., Brancia C., Rinaldi A.M., Levi A., Possenti R.;
"In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived
peptide, in the regulation of rat gastric motor functions.";
Br. J. Pharmacol. 157:984-993(2009).
[7]
FUNCTION OF PEPTIDES NERP-1 AND NERP-2, PYROGLUTAMATE FORMATION AT
GLN-313, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=19194657; DOI=10.1007/s00018-009-8796-0;
Toshinai K., Nakazato M.;
"Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides
processed from VGF.";
Cell. Mol. Life Sci. 66:1939-1945(2009).
-!- FUNCTION: May be involved in the regulation of cell-cell
interactions or in synatogenesis during the maturation of the
nervous system.
-!- FUNCTION: NERP peptides are involved in the control of body fluid
homeostasis by regulating vasopressin release. NERP-2 stimulates
feeding behavior in an orexin-dependent manner.
{ECO:0000269|PubMed:19194657}.
-!- FUNCTION: TLQP-21 peptide plays a central and local role in the
regulation of rat gastric motor functions.
{ECO:0000269|PubMed:19466987}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19194657}.
Cytoplasmic vesicle, secretory vesicle
{ECO:0000269|PubMed:19194657}. Note=Stored in secretory vesicles
and then secreted, NERP peptides colocalize with vasopressin in
the storage granules of hypothalamus.
-!- TISSUE SPECIFICITY: Central and peripheral nervous systems,
synthesized exclusively in neuronal and neuroendocrine cells.
{ECO:0000269|PubMed:19194657}.
-!- INDUCTION: By nerve growth factor.
-!- PTM: Multiple peptides are derived from VGF, with activities in
synaptic plasticity, antidepression, penile erection, autonomic
activation, and increases in energy expenditure.
-!- MASS SPECTROMETRY: Mass=4164.694; Method=Electrospray; Range=24-
63; Evidence={ECO:0000269|PubMed:19164277};
-!- MASS SPECTROMETRY: Mass=1655.730; Method=Electrospray; Range=180-
194; Evidence={ECO:0000269|PubMed:19164277};
-!- MASS SPECTROMETRY: Mass=3470.868; Method=Electrospray; Range=375-
407; Evidence={ECO:0000269|PubMed:19164277};
-----------------------------------------------------------------------
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EMBL; M60522; AAA41700.1; -; Genomic_DNA.
EMBL; M60525; AAA86428.1; -; mRNA.
EMBL; M74223; AAA42336.1; -; mRNA.
PIR; I56530; I56530.
PIR; S05381; S05381.
RefSeq; NP_112259.1; NM_030997.1.
UniGene; Rn.9704; -.
ProteinModelPortal; P20156; -.
SMR; P20156; -.
BioGrid; 248104; 1.
IntAct; P20156; 1.
MINT; P20156; -.
STRING; 10116.ENSRNOP00000050024; -.
CarbonylDB; P20156; -.
iPTMnet; P20156; -.
PhosphoSitePlus; P20156; -.
PaxDb; P20156; -.
PRIDE; P20156; -.
GeneID; 29461; -.
KEGG; rno:29461; -.
UCSC; RGD:69399; rat.
CTD; 7425; -.
RGD; 69399; Vgf.
eggNOG; ENOG410IKTZ; Eukaryota.
eggNOG; ENOG410YR85; LUCA.
HOGENOM; HOG000120127; -.
HOVERGEN; HBG006806; -.
InParanoid; P20156; -.
PhylomeDB; P20156; -.
PRO; PR:P20156; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0030667; C:secretory granule membrane; IDA:RGD.
GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
GO; GO:0033500; P:carbohydrate homeostasis; IBA:GO_Central.
GO; GO:0030182; P:neuron differentiation; TAS:RGD.
GO; GO:0043084; P:penile erection; IDA:RGD.
GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IDA:RGD.
InterPro; IPR026128; VGF.
PANTHER; PTHR15159; PTHR15159; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complete proteome;
Cytoplasmic vesicle; Direct protein sequencing; Growth factor;
Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 617 Neurosecretory protein VGF.
/FTId=PRO_0000022656.
PEPTIDE 24 63 VGF(24-63).
/FTId=PRO_0000375995.
PEPTIDE 180 194 VGF(180-194).
/FTId=PRO_0000375996.
PEPTIDE 285 309 Neuroendocrine regulatory peptide-1.
/FTId=PRO_0000403366.
PEPTIDE 313 350 Neuroendocrine regulatory peptide-2.
/FTId=PRO_0000403367.
PEPTIDE 375 407 VGF(375-407).
/FTId=PRO_0000375997.
PEPTIDE 556 617 TLQP-62.
/FTId=PRO_0000403368.
PEPTIDE 556 587 TLQP-30.
/FTId=PRO_0000403369.
PEPTIDE 556 576 TLQP-21.
/FTId=PRO_0000403370.
PEPTIDE 556 566 TLQP-11.
/FTId=PRO_0000403371.
PEPTIDE 567 576 HFHH-10.
/FTId=PRO_0000403372.
PEPTIDE 588 617 AQEE-30.
/FTId=PRO_0000403373.
PEPTIDE 599 617 LQEQ-19.
/FTId=PRO_0000403374.
COMPBIAS 360 452 Asp/Glu-rich (acidic).
MOD_RES 180 180 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:19164277}.
MOD_RES 313 313 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:19194657}.
MOD_RES 423 423 Phosphoserine.
{ECO:0000250|UniProtKB:O15240}.
CONFLICT 342 342 G -> A (in Ref. 1). {ECO:0000305}.
SEQUENCE 617 AA; 68179 MW; 5E23E47DF460C7B4 CRC64;
MKTFTLPASV LFCFLLLIRG LGAAPPGRSD VYPPPLGSEH NGQVAEDAVS RPKDDSVPEV
RAARNSEPQD QGELFQGVDP RALAAVLLQA LDRPASPPAV PAGSQQGTPE EAAEALLTES
VRSQTHSLPA SEIQASAVAP PRPQTQDNDP EADDRSEELE ALASLLQELR DFSPSNAKRQ
QETAAAETET RTHTLTRVNL ESPGPERVWR ASWGEFQARV PERAPLPPSV PSQFQARMSE
NVPLPETHQF GEGVSSPKTH LGETLTPLSK AYQSLSAPFP KVRRLEGSFL GGSEAGERLL
QQGLAQVEAG RRQAEATRQA AAQEERLADL ASDLLLQYLL QGGARQRDLG GRGLQETQQE
RENEREEEAE QERRGGGEDE VGEEDEEAAE AEAEAEEAER ARQNALLFAE EEDGEAGAED
KRSQEEAPGH RRKDAEGTEE GGEEDDDDEE MDPQTIDSLI ELSTKLHLPA DDVVSIIEEV
EEKRKRKKNA PPEPVPPPRA APAPTHVRSP QPPPPAPARD ELPDWNEVLP PWDREEDEVF
PPGPYHPFPN YIRPRTLQPP ASSRRRHFHH ALPPARHHPD LEAQARRAQE EADAEERRLQ
EQEELENYIE HVLLHRP


Related products :

Catalog number Product name Quantity
N-0504 Neuroendocrine Regulatory Peptide-2 (rat) NERP-2 (rat) 98 percent C175H290N56O59 CAS: 5mg
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N-0503 Neuroendocrine Regulatory Peptide-2 (human) NERP-2 (human) 98 percent C173H288N56O57 CAS: 5mg
N-0501 Neuroendocrine Regulatory Peptide-1 (human) NERP-1 (human) 98 percent C113H192N36O39 CAS: 954420-50-9 5mg
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