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Neurosecretory protein VGF [Cleaved into: Peptide V (AQEE-30) (VGF-derived peptide); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2)]

 VGF_BOVIN               Reviewed;         618 AA.
P86435;
02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
11-JAN-2011, sequence version 2.
28-FEB-2018, entry version 33.
RecName: Full=Neurosecretory protein VGF {ECO:0000250|UniProtKB:P20156};
Contains:
RecName: Full=Peptide V {ECO:0000303|PubMed:7988466};
AltName: Full=AQEE-30;
AltName: Full=VGF-derived peptide {ECO:0000303|PubMed:7988466};
Contains:
RecName: Full=Neuroendocrine regulatory peptide-1;
Short=NERP-1;
Contains:
RecName: Full=Neuroendocrine regulatory peptide-2;
Short=NERP-2;
Flags: Precursor;
Name=VGF {ECO:0000250|UniProtKB:P20156};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000269|PubMed:19390049};
PubMed=19390049; DOI=10.1126/science.1169588;
The bovine genome sequencing and analysis consortium;
"The genome sequence of taurine cattle: a window to ruminant biology
and evolution.";
Science 324:522-528(2009).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-502.
STRAIN=Hereford; TISSUE=Brain cortex;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 481-618.
STRAIN=Hereford; TISSUE=Brain;
PubMed=17087818; DOI=10.1186/1471-2164-7-283;
Jann O.C., Aerts J., Jones M., Hastings N., Law A., McKay S.,
Marques E., Prasad A., Yu J., Moore S.S., Floriot S., Mahe M.F.,
Eggen A., Silveri L., Negrini R., Milanesi E., Ajmone-Marsan P.,
Valentini A., Marchitelli C., Savarese M.C., Janitz M., Herwig R.,
Hennig S., Gorni C., Connor E.E., Sonstegard T.S., Smith T.,
Drogemuller C., Williams J.L.;
"A second generation radiation hybrid map to aid the assembly of the
bovine genome sequence.";
BMC Genomics 7:283-283(2006).
[4] {ECO:0000305}
PROTEIN SEQUENCE OF 589-618, AND MASS SPECTROMETRY.
TISSUE=Pituitary {ECO:0000269|PubMed:7988466};
PubMed=7988466; DOI=10.1210/endo.135.6.7988466;
Liu J.W., Andrews P.C., Mershon J.L., Yan C., Allen D.L.,
Ben-Jonathan N.;
"Peptide V: a VGF-derived neuropeptide purified from bovine posterior
pituitary.";
Endocrinology 135:2742-2748(1994).
[5] {ECO:0000305}
IDENTIFICATION BY MASS SPECTROMETRY.
Colgrave M.L., Xi L., Lehnert S., Wijffels G.;
"Neuropeptidomics of the bovine hypothalamus.";
Submitted (DEC-2009) to UniProtKB.
-!- FUNCTION: May be involved in the regulation of cell-cell
interactions or in synatogenesis during the maturation of the
nervous system. {ECO:0000250|UniProtKB:P20156}.
-!- FUNCTION: NERP peptides are involved in the control of body fluid
homeostasis by regulating vasopressin release. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P20156}.
Cytoplasmic vesicle, secretory vesicle
{ECO:0000250|UniProtKB:P20156}. Note=Stored in secretory vesicles
and then secreted. {ECO:0000250|UniProtKB:P20156}.
-!- PTM: Multiple peptides are derived from VGF, with activities in
synaptic plasticity, antidepression, penile erection, autonomic
activation, and increases in energy expenditure. {ECO:0000250}.
-!- MASS SPECTROMETRY: Mass=3706.5; Method=Electrospray; Range=589-
618; Evidence={ECO:0000269|PubMed:7988466};
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EMBL; AAFC03118060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAFC03131609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DV909837; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; CO873651; -; NOT_ANNOTATED_CDS; mRNA.
STRING; 9913.ENSBTAP00000013014; -.
PaxDb; P86435; -.
PeptideAtlas; P86435; -.
PRIDE; P86435; -.
eggNOG; ENOG410IKTZ; Eukaryota.
eggNOG; ENOG410YR85; LUCA.
HOGENOM; HOG000120127; -.
InParanoid; P86435; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
GO; GO:0033500; P:carbohydrate homeostasis; IBA:GO_Central.
GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
InterPro; IPR026128; VGF.
PANTHER; PTHR15159; PTHR15159; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Coiled coil; Complete proteome;
Cytoplasmic vesicle; Direct protein sequencing; Growth factor;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 618 Neurosecretory protein VGF.
/FTId=PRO_0000391696.
PEPTIDE 282 306 Neuroendocrine regulatory peptide-1.
{ECO:0000250}.
/FTId=PRO_0000403375.
PEPTIDE 310 347 Neuroendocrine regulatory peptide-2.
{ECO:0000250}.
/FTId=PRO_0000403376.
PEPTIDE 589 618 Peptide V.
/FTId=PRO_0000391697.
COILED 301 332 {ECO:0000255}.
COMPBIAS 353 444 Glu-rich.
MOD_RES 421 421 Phosphoserine.
{ECO:0000250|UniProtKB:O15240}.
MOD_RES 425 425 Phosphothreonine.
{ECO:0000250|UniProtKB:O15240}.
CONFLICT 422 422 R -> Q (in Ref. 2; DV909837).
{ECO:0000305}.
CONFLICT 494 494 V -> E (in Ref. 3; CO873651).
{ECO:0000305}.
CONFLICT 586 586 A -> K (in Ref. 3; CO873651).
{ECO:0000305}.
CONFLICT 613 613 V -> G (in Ref. 3; CO873651).
{ECO:0000305}.
CONFLICT 617 617 R -> G (in Ref. 3; CO873651).
{ECO:0000305}.
SEQUENCE 618 AA; 67620 MW; 02B75828423DFCD3 CRC64;
MKSLRLPATV LFCLLLLIKG LGAAPPGHPE AQPPPPSSEH KEPVAGDAVL GSKDVSALEV
RAARNSEPQD EGELFQGVDP RALAAVLLQA LDRPASPPAP GGSQQRPEEE TAESLLTETV
RSQTHSLPVP ETQAPAAPPR PQTQENGAEA PDPSEELEAL ASLLQELRDF SPSSAKRQQE
TAAAETETRT HTLTRVNLES PGPERVWRAS WGEFQARVPE RAPLPPPAPP QFQARVPESG
PLPEAHQFGG GSSPKTHLGE ALAPLSKAYQ GLAAPFPKAR RPETSLLGGT EAGERLLQQG
LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG LQEEEGGGRE
TARQQEEAEQ ERRGGEERVG EEDEEAAEAE AEAEEAERAR QNALLFAEEE EGEAGAEDKR
SREETPGHRR KEAEGAEEGG AEDEDDDEEM DPQTIDSLIE LSTKLHLPAD DVVSIIEEVE
EKRKRKKNAP PEPVPPPRAA PAPTHARSPK TPPPAPAPDR EELPDGNEEL PPRDRXENEV
FSPVPYHPFP NYIRARTVQP PPASRRRHYH HALPPSRHYP DREAQARRAQ EEAEAEERRL
QEQEELENYI EHVLLRRP


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