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Noggin

 H2QDH3_PANTR            Unreviewed;       232 AA.
H2QDH3; A0A2J8MFG6;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
12-SEP-2018, entry version 43.
RecName: Full=Noggin {ECO:0000256|PIRNR:PIRNR008129};
Name=NOG {ECO:0000313|EMBL:JAA00517.1,
ECO:0000313|Ensembl:ENSPTRP00000016018, ECO:0000313|VGNC:VGNC:9602};
ORFNames=CK820_G0020947 {ECO:0000313|EMBL:PNI58264.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016018, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000016018, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000016018}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA00517.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00517.1},
Skeletal muscle {ECO:0000313|EMBL:JAA37618.1}, and
Skin {ECO:0000313|EMBL:JAA23392.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI58264.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI58264.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI58264.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling
which is required for growth and patterning of the neural tube and
somite. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR008129}.
-!- SIMILARITY: Belongs to the noggin family.
{ECO:0000256|PIRNR:PIRNR008129}.
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EMBL; AACZ04026982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABC01010821; JAA00517.1; -; mRNA.
EMBL; GABD01009708; JAA23392.1; -; mRNA.
EMBL; GABE01007121; JAA37618.1; -; mRNA.
EMBL; NBAG03000258; PNI58264.1; -; Genomic_DNA.
RefSeq; XP_523802.2; XM_523802.5.
STRING; 9598.ENSPTRP00000016018; -.
Ensembl; ENSPTRT00000017301; ENSPTRP00000016018; ENSPTRG00000009430.
GeneID; 468413; -.
KEGG; ptr:468413; -.
CTD; 9241; -.
VGNC; VGNC:9602; NOG.
eggNOG; ENOG410IIR6; Eukaryota.
eggNOG; ENOG410Z62S; LUCA.
GeneTree; ENSGT00390000006009; -.
KO; K04658; -.
OMA; RCTWIPI; -.
OrthoDB; EOG091G0HWR; -.
TreeFam; TF353745; -.
Proteomes; UP000002277; Chromosome 17.
Bgee; ENSPTRG00000009430; Expressed in 4 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-UniRule.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0061384; P:heart trabecula morphogenesis; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0090193; P:positive regulation of glomerulus development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 2.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR008717; Noggin.
PANTHER; PTHR10494; PTHR10494; 1.
PIRSF; PIRSF008129; Noggin; 1.
SUPFAM; SSF57501; SSF57501; 1.
2: Evidence at transcript level;
Chondrogenesis {ECO:0000256|PIRNR:PIRNR008129};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Developmental protein {ECO:0000256|PIRNR:PIRNR008129};
Differentiation {ECO:0000256|PIRNR:PIRNR008129};
Disulfide bond {ECO:0000256|PIRSR:PIRSR008129-1};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Secreted {ECO:0000256|PIRNR:PIRNR008129};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 232 Noggin. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015092631.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000256|PIRSR:PIRSR008129-2}.
DISULFID 155 192 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 178 228 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 184 230 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 207 215 {ECO:0000256|PIRSR:PIRSR008129-1}.
SEQUENCE 232 AA; 25788 MW; F87BF8E1E2098580 CRC64;
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI
KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS
KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCAWIPI QYPIISECKC SC


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