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Noggin

 NOGG_MOUSE              Reviewed;         232 AA.
P97466;
14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
10-MAY-2017, entry version 137.
RecName: Full=Noggin {ECO:0000303|PubMed:9585504, ECO:0000303|PubMed:9603738};
Flags: Precursor;
Name=Nog;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, FUNCTION, AND
DISRUPTION PHENOTYPE.
STRAIN=129/Sv;
PubMed=9585504; DOI=10.1101/gad.12.10.1438;
McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M.,
McMahon A.P.;
"Noggin-mediated antagonism of BMP signaling is required for growth
and patterning of the neural tube and somite.";
Genes Dev. 12:1438-1452(1998).
[2]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=9603738; DOI=10.1126/science.280.5368.1455;
Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.;
"Noggin, cartilage morphogenesis, and joint formation in the mammalian
skeleton.";
Science 280:1455-1457(1998).
-!- FUNCTION: Essential for cartilage morphogenesis and joint
formation. Inhibitor of bone morphogenetic proteins (BMP)
signaling which is required for growth and patterning of the
neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits
chondrocyte differentiation through its interaction with GDF5 and,
probably, GDF6 (By similarity). {ECO:0000250|UniProtKB:Q13253,
ECO:0000269|PubMed:9585504, ECO:0000269|PubMed:9603738}.
-!- SUBUNIT: Homodimer. Interacts with GDF5; inhibits chondrocyte
differentiation. {ECO:0000250|UniProtKB:Q13253}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed in condensing cartilage and immature
chondrocytes. {ECO:0000269|PubMed:9603738}.
-!- DEVELOPMENTAL STAGE: Embryonic expression was first detected in
the node at 7.5 dpc. By early somite stages, expression extends
anteriorly along the entire length of the notochord and is
expressed in the dorsal neural tube from the caudal hindbrain to
the posterior-most region of the embryo. By the time cranial tube
closure is completed expression is continuous along most of the
dorsal midline of the neural tube, to its rostral termination at
the base of the forebrain. Expression in the neural tube and
caudal notochord remains unchanged during early organogenesis from
9.5 dpc to 10.5 dpc. {ECO:0000269|PubMed:9585504}.
-!- DISRUPTION PHENOTYPE: Defects in Nog are the cause of a recessive
lethal phenotype at birth. Multiple defects include a failure of
neural tube closure, broad club-shaped limbs, loss of caudal
vertebrae, a shortened body axis, and retention of a small
vestigial tail. {ECO:0000269|PubMed:9585504}.
-!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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EMBL; U79163; AAB38281.1; -; Genomic_DNA.
CCDS; CCDS25236.1; -.
RefSeq; NP_032737.1; NM_008711.2.
UniGene; Mm.135266; -.
ProteinModelPortal; P97466; -.
SMR; P97466; -.
MINT; MINT-346913; -.
STRING; 10090.ENSMUSP00000061427; -.
iPTMnet; P97466; -.
PhosphoSitePlus; P97466; -.
PaxDb; P97466; -.
PRIDE; P97466; -.
Ensembl; ENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneID; 18121; -.
KEGG; mmu:18121; -.
UCSC; uc007kwh.2; mouse.
CTD; 9241; -.
MGI; MGI:104327; Nog.
eggNOG; ENOG410IIR6; Eukaryota.
eggNOG; ENOG410Z62S; LUCA.
GeneTree; ENSGT00390000006009; -.
HOGENOM; HOG000089944; -.
HOVERGEN; HBG006514; -.
InParanoid; P97466; -.
KO; K04658; -.
OMA; RCTWIPI; -.
OrthoDB; EOG091G0HWR; -.
PhylomeDB; P97466; -.
TreeFam; TF353745; -.
Reactome; R-MMU-201451; Signaling by BMP.
PRO; PR:P97466; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000048616; -.
CleanEx; MM_NOG; -.
ExpressionAtlas; P97466; baseline and differential.
Genevisible; P97466; MM.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0019955; F:cytokine binding; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
GO; GO:0048318; P:axial mesoderm development; IMP:MGI.
GO; GO:0007411; P:axon guidance; IMP:MGI.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:BHF-UCL.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
GO; GO:0021533; P:cell differentiation in hindbrain; ISO:MGI.
GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
GO; GO:0007417; P:central nervous system development; IMP:MGI.
GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; ISO:MGI.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:MGI.
GO; GO:0048706; P:embryonic skeletal system development; ISO:MGI.
GO; GO:0003203; P:endocardial cushion morphogenesis; IMP:BHF-UCL.
GO; GO:0007492; P:endoderm development; IDA:MGI.
GO; GO:0001706; P:endoderm formation; IDA:MGI.
GO; GO:0001837; P:epithelial to mesenchymal transition; IMP:BHF-UCL.
GO; GO:0060325; P:face morphogenesis; IMP:MGI.
GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; ISO:MGI.
GO; GO:0061384; P:heart trabecula morphogenesis; IMP:BHF-UCL.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0060173; P:limb development; ISO:MGI.
GO; GO:0060425; P:lung morphogenesis; IMP:MGI.
GO; GO:0003149; P:membranous septum morphogenesis; IMP:BHF-UCL.
GO; GO:0048762; P:mesenchymal cell differentiation; IMP:MGI.
GO; GO:0001707; P:mesoderm formation; IDA:MGI.
GO; GO:0042474; P:middle ear morphogenesis; ISO:MGI.
GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IMP:BHF-UCL.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IDA:HGNC.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:MGI.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:BHF-UCL.
GO; GO:0061037; P:negative regulation of cartilage development; IDA:MGI.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
GO; GO:0060302; P:negative regulation of cytokine activity; ISO:MGI.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0010629; P:negative regulation of gene expression; IDA:MGI.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:MGI.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0001839; P:neural plate morphogenesis; IMP:MGI.
GO; GO:0001843; P:neural tube closure; IMP:MGI.
GO; GO:0021915; P:neural tube development; IMP:MGI.
GO; GO:0048570; P:notochord morphogenesis; IMP:MGI.
GO; GO:0001649; P:osteoblast differentiation; IMP:BHF-UCL.
GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0007389; P:pattern specification process; IMP:MGI.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IMP:BHF-UCL.
GO; GO:0021983; P:pituitary gland development; IMP:MGI.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.
GO; GO:0090193; P:positive regulation of glomerulus development; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0060513; P:prostatic bud formation; IMP:MGI.
GO; GO:0030510; P:regulation of BMP signaling pathway; IMP:MGI.
GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; ISO:MGI.
GO; GO:0001501; P:skeletal system development; IMP:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; ISO:MGI.
GO; GO:0061053; P:somite development; IMP:MGI.
GO; GO:0021510; P:spinal cord development; IMP:MGI.
GO; GO:0001657; P:ureteric bud development; IDA:MGI.
GO; GO:0060676; P:ureteric bud formation; IDA:UniProtKB.
GO; GO:0001655; P:urogenital system development; IMP:MGI.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IMP:BHF-UCL.
GO; GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL.
GO; GO:0042060; P:wound healing; IMP:BHF-UCL.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR008717; Noggin.
PANTHER; PTHR10494; PTHR10494; 1.
PIRSF; PIRSF008129; Noggin; 1.
SUPFAM; SSF57501; SSF57501; 1.
2: Evidence at transcript level;
Chondrogenesis; Complete proteome; Developmental protein;
Differentiation; Disulfide bond; Glycoprotein; Reference proteome;
Secreted; Signal.
SIGNAL 1 27 {ECO:0000255}.
CHAIN 28 232 Noggin.
/FTId=PRO_0000019814.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 155 192 {ECO:0000250}.
DISULFID 178 228 {ECO:0000250}.
DISULFID 184 230 {ECO:0000250}.
DISULFID 207 215 {ECO:0000250}.
SEQUENCE 232 AA; 25770 MW; 0192AF6373B78B74 CRC64;
MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED LAELDQLLRQ RPSGAMPSEI
KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS
KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC


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