GENTAUR Molecular Products.

 U3FU84_CALJA            Unreviewed;       232 AA.
 U3FU84;
 13-NOV-2013, integrated into UniProtKB/TrEMBL.
 13-NOV-2013, sequence version 1.
 13-FEB-2019, entry version 35.
 RecName: Full=Noggin {ECO:0000256|PIRNR:PIRNR008129};
 Name=NOG {ECO:0000313|EMBL:JAB51746.1,
 ECO:0000313|Ensembl:ENSCJAP00000053661};
 Callithrix jacchus (White-tufted-ear marmoset).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
 NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB51746.1};
 [1] {ECO:0000313|Ensembl:ENSCJAP00000053661}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 Keerthi T., Ganesan G., Rao M.;
 Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000313|EMBL:JAB51746.1}
 NUCLEOTIDE SEQUENCE.
 TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51746.1},
 Cerebral cortex {ECO:0000313|EMBL:JAB24031.1}, and
 Hippocampus {ECO:0000313|EMBL:JAB13845.1};
 PubMed=25243066; DOI=10.1186/2047-217X-3-14;
 Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
 Moriyama E.N., French J.A., Norgren R.B.Jr.;
 "De novo assembly of the common marmoset transcriptome from NextGen
 mRNA sequences.";
 Gigascience 3:14-14(2014).
 [3] {ECO:0000313|Ensembl:ENSCJAP00000053661}
 IDENTIFICATION.
 Ensembl;
 Submitted (APR-2018) to UniProtKB.
 -!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling
     which is required for growth and patterning of the neural tube and
     somite. {ECO:0000256|PIRNR:PIRNR008129}.
 -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR008129}.
 -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR008129}.
 -!- SIMILARITY: Belongs to the noggin family.
     {ECO:0000256|PIRNR:PIRNR008129}.
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 EMBL; GAMS01009291; JAB13845.1; -; mRNA.
 EMBL; GAMR01009901; JAB24031.1; -; mRNA.
 EMBL; GAMP01001010; JAB51745.1; -; mRNA.
 EMBL; GAMP01001009; JAB51746.1; -; mRNA.
 RefSeq; XP_002748445.1; XM_002748399.3.
 SMR; U3FU84; -.
 Ensembl; ENSCJAT00000026991; ENSCJAP00000053661; ENSCJAG00000013903.
 GeneID; 100395820; -.
 KEGG; cjc:100395820; -.
 CTD; 9241; -.
 GeneTree; ENSGT00390000006009; -.
 KO; K04658; -.
 OrthoDB; 1391421at2759; -.
 Proteomes; UP000008225; Unplaced.
 GO; GO:0005615; C:extracellular space; IEA:Ensembl.
 GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
 GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
 GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
 GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
 GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
 GO; GO:0051216; P:cartilage development; IEA:UniProtKB-UniRule.
 GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
 GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
 GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
 GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
 GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
 GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
 GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
 GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
 GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
 GO; GO:0061384; P:heart trabecula morphogenesis; IEA:Ensembl.
 GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
 GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
 GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
 GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
 GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
 GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
 GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
 GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
 GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:UniProtKB-UniRule.
 GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
 GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
 GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
 GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
 GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
 GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
 GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
 GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
 GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
 GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
 GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
 GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
 GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
 GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
 GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
 GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
 GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
 GO; GO:0090193; P:positive regulation of glomerulus development; IEA:Ensembl.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
 GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
 GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
 GO; GO:0061053; P:somite development; IEA:Ensembl.
 GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
 GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
 GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
 GO; GO:0042060; P:wound healing; IEA:Ensembl.
 Gene3D; 2.10.90.10; -; 1.
 InterPro; IPR029034; Cystine-knot_cytokine.
 InterPro; IPR008717; Noggin.
 PANTHER; PTHR10494; PTHR10494; 1.
 PIRSF; PIRSF008129; Noggin; 1.
 SUPFAM; SSF57501; SSF57501; 1.
 2: Evidence at transcript level;
 Chondrogenesis {ECO:0000256|PIRNR:PIRNR008129};
 Complete proteome {ECO:0000313|Proteomes:UP000008225};
 Developmental protein {ECO:0000256|PIRNR:PIRNR008129};
 Differentiation {ECO:0000256|PIRNR:PIRNR008129};
 Disulfide bond {ECO:0000256|PIRSR:PIRSR008129-1};
 Reference proteome {ECO:0000313|Proteomes:UP000008225};
 Secreted {ECO:0000256|PIRNR:PIRNR008129};
 Signal {ECO:0000256|SAM:SignalP}.
 SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
 CHAIN        28    232       Noggin. {ECO:0000256|SAM:SignalP}.
                              /FTId=PRO_5015101563.
 CARBOHYD     62     62       N-linked (GlcNAc...) asparagine.
                              {ECO:0000256|PIRSR:PIRSR008129-2}.
 DISULFID    155    192       {ECO:0000256|PIRSR:PIRSR008129-1}.
 DISULFID    178    228       {ECO:0000256|PIRSR:PIRSR008129-1}.
 DISULFID    184    230       {ECO:0000256|PIRSR:PIRSR008129-1}.
 DISULFID    207    215       {ECO:0000256|PIRSR:PIRSR008129-1}.
 SEQUENCE   232 AA;  25774 MW;  FCA0D8E1E2098580 CRC64;
 MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
 LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI
 KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS
 KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC

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