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Non-classical export protein 102

 NCE2_CANAL              Reviewed;         170 AA.
Q5ANE3; A0A1D8PK31;
01-APR-2015, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 1.
23-MAY-2018, entry version 66.
RecName: Full=Non-classical export protein 102 {ECO:0000305};
Name=NCE102 {ECO:0000303|PubMed:24281718};
OrderedLocusNames=CAALFM_C304910CA; ORFNames=CaO19.13381, CaO19.5960;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
PubMed=19824013; DOI=10.1002/pmic.200800988;
Cabezon V., Llama-Palacios A., Nombela C., Monteoliva L., Gil C.;
"Analysis of Candida albicans plasma membrane proteome.";
Proteomics 9:4770-4786(2009).
[5]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=24281718; DOI=10.1128/mBio.00723-13;
Douglas L.M., Wang H.X., Konopka J.B.;
"The MARVEL domain protein Nce102 regulates actin organization and
invasive growth of Candida albicans.";
MBio 4:E00723-E00723(2013).
-!- FUNCTION: Involved in membrane organization. Involved in a novel
pathway of export of proteins that lack a cleavable signal
sequence. Non-classical export pathway functions also as an
alternative clearance/detoxification pathway to eliminate damaged
material, when the basic repair pathway is not sufficient (By
similarity). Regulates actin organization and subsequent
morphogenesis and pathogenesis. {ECO:0000250|UniProtKB:Q12207,
ECO:0000269|PubMed:24281718}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19824013};
Multi-pass membrane protein {ECO:0000255}. Note=Accumulates in
membrane domains at eisosomes. {ECO:0000250|UniProtKB:Q12207}.
-!- DISRUPTION PHENOTYPE: Leads to decreased virulence and forms
abnormal hyphae in mice. Shows defects in forming hyphae and
invading low concentrations of agar but can invade well in higher
agar concentrations. {ECO:0000269|PubMed:24281718}.
-!- SIMILARITY: Belongs to the NCE102 family. {ECO:0000305}.
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EMBL; CP017625; AOW28507.1; -; Genomic_DNA.
RefSeq; XP_723171.1; XM_718078.1.
EnsemblFungi; AOW28507; AOW28507; CAALFM_C304910CA.
GeneID; 3635267; -.
KEGG; cal:CAALFM_C304910CA; -.
CGD; CAL0000190917; NCE102.
HOGENOM; HOG000185206; -.
OMA; QASTAFM; -.
OrthoDB; EOG092C5IH3; -.
PRO; PR:Q5ANE3; -.
Proteomes; UP000000559; Chromosome 3.
GO; GO:0032126; C:eisosome; IDA:CGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:CGD.
GO; GO:0030036; P:actin cytoskeleton organization; IMP:CGD.
GO; GO:0007015; P:actin filament organization; IMP:CACAO.
GO; GO:0009405; P:pathogenesis; IMP:CGD.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
InterPro; IPR008253; Marvel.
Pfam; PF01284; MARVEL; 1.
PROSITE; PS51225; MARVEL; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Protein transport;
Reference proteome; Transmembrane; Transmembrane helix; Transport;
Virulence.
CHAIN 1 170 Non-classical export protein 102.
/FTId=PRO_0000431765.
TOPO_DOM 1 11 Cytoplasmic. {ECO:0000305}.
TRANSMEM 12 32 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 33 38 Extracellular. {ECO:0000305}.
TRANSMEM 39 61 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 62 76 Cytoplasmic. {ECO:0000305}.
TRANSMEM 77 97 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 98 125 Extracellular. {ECO:0000305}.
TRANSMEM 126 146 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 147 170 Cytoplasmic. {ECO:0000305}.
DOMAIN 6 141 MARVEL. {ECO:0000255|PROSITE-
ProRule:PRU00581}.
SEQUENCE 170 AA; 18123 MW; CB8AC9D732D08858 CRC64;
MLAIGDVILR AFNFVFLVIA LGLTGSLAAT TITQHNPQIN FAVFAAAFGL LTSSFYGVFA
YFVAAFAWPV ILFVFDFLNF VFTFAAATAI AAGIRAHSCS NQDYLDDNNI AQGSSGRCRK
AQASTAFLYF STFIFIASAI FSAISLSKGG LFGHSSRPAP RTGVPTMSQV


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