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Non-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)

 NS3B_CVHSA              Reviewed;         154 AA.
P59633; Q7TFA9; Q80BV4;
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
23-APR-2003, sequence version 1.
23-MAY-2018, entry version 66.
RecName: Full=Non-structural protein 3b;
Short=ns3b;
AltName: Full=Accessory protein 3b;
AltName: Full=Protein X2;
ORFNames=3b;
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome
coronavirus).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=227859;
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Urbani;
PubMed=12730500; DOI=10.1126/science.1085952;
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H.,
Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D.,
Erdman D.D., Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E.,
Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K.,
Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E.,
Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.;
"Characterization of a novel coronavirus associated with severe acute
respiratory syndrome.";
Science 300:1394-1399(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Tor2;
PubMed=12730501; DOI=10.1126/science.1085953;
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L.,
Leach S.R., Mayo M., McDonald H., Montgomery S.B., Pandoh P.K.,
Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E.,
Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N.,
Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L.,
Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H.,
Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A.,
Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M.,
Petric M., Skowronski D.M., Upton C., Roper R.L.;
"The genome sequence of the SARS-associated coronavirus.";
Science 300:1399-1404(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate CUHK-Su10, and Isolate CUHK-W1;
PubMed=12853594; DOI=10.1056/NEJM200307103490216;
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.;
"Coronavirus genomic-sequence variations and the epidemiology of the
severe acute respiratory syndrome.";
N. Engl. J. Med. 349:187-188(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HKU-39849;
PubMed=12876307; DOI=10.1177/15353702-0322807-13;
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C.,
Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B.,
Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.;
"The complete genome sequence of severe acute respiratory syndrome
coronavirus strain HKU-39849 (HK-39).";
Exp. Biol. Med. 228:866-873(2003).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, and
Isolate GD01;
Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W.,
Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y.,
Li X., Lu F., Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L.,
Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H.,
Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P.,
Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y.,
Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X.,
Zhou J., Yang H.;
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TW1;
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.;
"The complete genome of SARS coronavirus clone TW1.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate FRA;
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K.,
Censini S., Guidotti S., Masignani V., Scarselli M., Mora M.,
Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.;
"SARS virus is a close relative of type II coronaviruses.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Frankfurt 1;
Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S.,
Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Shanghai QXC1;
Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.;
"Analysis of SARS coronavirus genome in Shanghai isolates.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Taiwan TC1, Isolate Taiwan TC2, and Isolate Taiwan TC3;
Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L.,
Shih M.-C.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, and
Isolate TWY;
Shu H.Y., Wu K.M., Tsai S.F.;
"The complete genome of SARS coronavirus TWH.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HSR 1;
Canducci F., Clementi M., Poli G., Vicenzi E.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate AS;
Balotta C., Corvasce S., Violin M., Galli M., Moroni M.,
Vigevani G.M., Ruan Y.J., Salemi M.;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[14]
FUNCTION.
PubMed=16107218; DOI=10.1186/1743-422X-2-66;
Yuan X., Shan Y., Zhao Z., Chen J., Cong Y.;
"G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in
transfected cells.";
Virol. J. 2:66-66(2005).
[15]
SUBCELLULAR LOCATION.
PubMed=16046244; DOI=10.1016/j.virusres.2005.06.001;
Yuan X., Yao Z., Shan Y., Chen B., Yang Z., Wu J., Zhao Z., Chen J.,
Cong Y.;
"Nucleolar localization of non-structural protein 3b, a protein
specifically encoded by the severe acute respiratory syndrome
coronavirus.";
Virus Res. 114:70-79(2005).
[16]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=16682811;
Yuan X., Shan Y., Yao Z., Li J., Zhao Z., Chen J., Cong Y.;
"Mitochondrial location of severe acute respiratory syndrome
coronavirus 3b protein.";
Mol. Cells 21:186-191(2006).
[17]
INTERACTION WITH HOST RUNX1.
PubMed=22253733; DOI=10.1371/journal.pone.0029542;
Varshney B., Agnihothram S., Agnihotram S., Tan Y.J., Baric R.,
Lal S.K.;
"SARS coronavirus 3b accessory protein modulates transcriptional
activity of RUNX1b.";
PLoS ONE 7:E29542-E29542(2012).
-!- FUNCTION: Induces host cell G0/G1 arrest and apoptosis.
{ECO:0000269|PubMed:16107218, ECO:0000269|PubMed:16682811}.
-!- SUBUNIT: Interacts with host RUNX1 isoform b.
{ECO:0000269|PubMed:22253733}.
-!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
{ECO:0000269|PubMed:16046244}. Host mitochondrion
{ECO:0000269|PubMed:16682811}.
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EMBL; AY278741; AAP13447.1; -; Genomic_RNA.
EMBL; AY274119; AAP41039.1; -; Genomic_RNA.
EMBL; AY282752; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278554; AAP13569.1; -; Genomic_RNA.
EMBL; AY278491; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278487; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278488; AAP30032.1; -; Genomic_RNA.
EMBL; AY278489; AAP51229.1; -; Genomic_RNA.
EMBL; AY278490; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY279354; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY291451; AAP37019.1; -; Genomic_RNA.
EMBL; AY310120; AAP50487.1; -; Genomic_RNA.
EMBL; AY291315; AAP33699.1; -; Genomic_RNA.
EMBL; AY463059; AAR86789.1; -; Genomic_RNA.
EMBL; AY338174; AAQ01599.1; -; Genomic_RNA.
EMBL; AY338175; AAQ01611.1; -; Genomic_RNA.
EMBL; AY348314; AAP97884.1; -; Genomic_RNA.
EMBL; AP006557; BAC81350.1; -; Genomic_RNA.
EMBL; AP006558; BAC81364.1; -; Genomic_RNA.
EMBL; AP006559; BAC81378.1; -; Genomic_RNA.
EMBL; AP006560; BAC81392.1; -; Genomic_RNA.
EMBL; AP006561; BAC81406.1; -; Genomic_RNA.
EMBL; AY323977; AAP72976.1; -; Genomic_RNA.
EMBL; AY427439; AAQ94062.1; -; Genomic_RNA.
RefSeq; NP_828853.1; NC_004718.3.
SMR; P59633; -.
PRIDE; P59633; -.
GeneID; 1489670; -.
KEGG; vg:1489670; -.
Proteomes; UP000000354; Genome.
Proteomes; UP000103670; Genome.
Proteomes; UP000109640; Genome.
Proteomes; UP000116947; Genome.
Proteomes; UP000121636; Genome.
Proteomes; UP000131569; Genome.
Proteomes; UP000131955; Genome.
Proteomes; UP000137377; Genome.
Proteomes; UP000138690; Genome.
Proteomes; UP000143093; Genome.
Proteomes; UP000145651; Genome.
Proteomes; UP000146108; Genome.
Proteomes; UP000146181; Genome.
Proteomes; UP000146296; Genome.
Proteomes; UP000148194; Genome.
Proteomes; UP000153467; Genome.
Proteomes; UP000160648; Genome.
Proteomes; UP000164441; Genome.
Proteomes; UP000172416; Genome.
GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
GO; GO:0001817; P:regulation of cytokine production; IEP:CACAO.
InterPro; IPR022117; SARS_3b.
Pfam; PF12383; SARS_3b; 1.
1: Evidence at protein level;
Apoptosis; Complete proteome;
G0/G1 host cell cycle checkpoint dysregulation by virus;
Host mitochondrion; Host nucleus; Host-virus interaction;
Modulation of host cell apoptosis by virus;
Modulation of host cell cycle by virus; Reference proteome.
CHAIN 1 154 Non-structural protein 3b.
/FTId=PRO_0000106132.
REGION 80 138 Mitochondrial targeting signal.
REGION 134 154 Nucleolar targeting.
MOTIF 135 153 Bipartite nuclear localization signal.
{ECO:0000255}.
VARIANT 31 31 K -> Q (in strain: Isolate GD01).
VARIANT 99 99 T -> I (in strain: Isolate BJ02).
VARIANT 115 115 L -> Q (in strain: Isolate GD01).
VARIANT 121 121 Q -> P (in strain: Isolate BJ01 and
Isolate BJ04).
SEQUENCE 154 AA; 17750 MW; 82AB0B68F11060A8 CRC64;
MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL RIGTQVLKTM
SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH RMCKYTQSTA LQELLIQQWI
QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK KQVR


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