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Non-structural protein V

 V_MEASC                 Reviewed;         299 AA.
P0C774;
15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
15-JUN-2010, sequence version 1.
25-OCT-2017, entry version 29.
RecName: Full=Non-structural protein V;
Name=P/V;
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose
panencephalitis virus).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Mononegavirales; Paramyxoviridae; Morbillivirus.
NCBI_TaxID=645098;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=10949953; DOI=10.1023/A:1008196729676;
Takeuchi K., Miyajima N., Kobune F., Tashiro M.;
"Comparative nucleotide sequence analyses of the entire genomes of
B95a cell-isolated and vero cell-isolated measles viruses from the
same patient.";
Virus Genes 20:253-257(2000).
[2]
FUNCTION.
PubMed=12804771; DOI=10.1016/S0014-5793(03)00528-3;
Takeuchi K., Kadota S.I., Takeda M., Miyajima N., Nagata K.;
"Measles virus V protein blocks interferon (IFN)-alpha/beta but not
IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.";
FEBS Lett. 545:177-182(2003).
[3]
FUNCTION, AND INTERACTION WITH HOST STAT2.
PubMed=18579593; DOI=10.1128/JVI.00831-08;
Ramachandran A., Parisien J.P., Horvath C.M.;
"STAT2 is a primary target for measles virus V protein-mediated
alpha/beta interferon signaling inhibition.";
J. Virol. 82:8330-8338(2008).
[4]
FUNCTION, AND INTERACTION WITH HOST IRF7 AND CHUK.
STRAIN=Schwarz vaccine;
PubMed=18922877; DOI=10.1128/JVI.01321-08;
Pfaller C.K., Conzelmann K.K.;
"Measles virus V protein is a decoy substrate for IkappaB kinase alpha
and prevents Toll-like receptor 7/9-mediated interferon induction.";
J. Virol. 82:12365-12373(2008).
[5]
FUNCTION, AND INTERACTION WITH HOST IFIH1 AND DHX58.
PubMed=19403670; DOI=10.1128/JVI.00153-09;
Parisien J.P., Bamming D., Komuro A., Ramachandran A., Rodriguez J.J.,
Barber G., Wojahn R.D., Horvath C.M.;
"A shared interface mediates paramyxovirus interference with antiviral
RNA helicases MDA5 and LGP2.";
J. Virol. 83:7252-7260(2009).
[6]
FUNCTION, AND INTERACTION WITH HOST RELA.
STRAIN=Schwarz vaccine;
PubMed=21270162; DOI=10.1128/JVI.02342-10;
Schuhmann K.M., Pfaller C.K., Conzelmann K.K.;
"The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB
activity.";
J. Virol. 85:3162-3171(2011).
[7]
FUNCTION, AND INTERACTION WITH HOST JAK1 AND TYK2.
STRAIN=Dublin;
PubMed=23431397; DOI=10.1371/journal.pone.0057063;
Chinnakannan S.K., Nanda S.K., Baron M.D.;
"Morbillivirus v proteins exhibit multiple mechanisms to block type 1
and type 2 interferon signalling pathways.";
PLoS ONE 8:E57063-E57063(2013).
-!- FUNCTION: Plays an essential role in the inhibition of host immune
response. Prevents the establishment of cellular antiviral state
by blocking interferon-alpha/beta (IFN-alpha/beta) production and
signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2
to inhibit the transduction pathway involved in the activation of
IFN-beta promoter, thus protecting the virus against cell
antiviral state. Blocks the type I interferon signaling pathway by
interacting with host TYK2 and thereby inhibiting downstream STAT1
and STAT2 phosphorylation. Moderately affects the type II
interferon signaling. {ECO:0000269|PubMed:12804771,
ECO:0000269|PubMed:18579593, ECO:0000269|PubMed:18922877,
ECO:0000269|PubMed:19403670, ECO:0000269|PubMed:21270162,
ECO:0000269|PubMed:23431397}.
-!- SUBUNIT: Interacts with host IFIH1/MDA5 and DHX58/LGP2. Interacts
with host TYK2; this interaction inhibits the type I interferon
signaling pathway whithout affecting the type II pathway.
Interacts with host IRF7; this interaction inhibits IRF7
translocation to the nucleus. Interacts with host CHUK and RELA.
Interacts (via C-terminus) with host STAT2.
{ECO:0000269|PubMed:18579593, ECO:0000269|PubMed:18922877,
ECO:0000269|PubMed:19403670, ECO:0000269|PubMed:21270162,
ECO:0000269|PubMed:23431397}.
-!- INTERACTION:
Q9BYX4:IFIH1 (xeno); NbExp=2; IntAct=EBI-3650423, EBI-6115771;
Q04206:RELA (xeno); NbExp=3; IntAct=EBI-3650423, EBI-73886;
P52630:STAT2 (xeno); NbExp=4; IntAct=EBI-3650423, EBI-1546963;
-!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
-!- RNA EDITING: Modified_positions=231; Note=Partially edited. RNA
editing at this position consists of an insertion of one guanine
nucleotide. The sequence displayed here is the V protein, derived
from the edited RNA. The unedited RNA gives rise to the P protein
(AC Q9WMB4).;
-!- SIMILARITY: Belongs to the paramyxoviruses V protein family.
{ECO:0000305}.
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EMBL; AB016162; -; NOT_ANNOTATED_CDS; Genomic_RNA.
ProteinModelPortal; P0C774; -.
SMR; P0C774; -.
DIP; DIP-61740N; -.
IntAct; P0C774; 5.
OrthoDB; VOG090000AV; -.
Proteomes; UP000008699; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0039557; P:suppression by virus of host IRF7 activity; IEA:UniProtKB-KW.
GO; GO:0039554; P:suppression by virus of host MDA-5 activity; IEA:UniProtKB-KW.
GO; GO:0039564; P:suppression by virus of host STAT2 activity; IEA:UniProtKB-KW.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR024279; Paramyx_V_Zn-bd.
InterPro; IPR028243; Paramyxo_P/V_N.
Pfam; PF13825; Paramyxo_PNT; 1.
Pfam; PF13008; zf-Paramyx-P; 1.
1: Evidence at protein level;
Complete proteome; Host cytoplasm; Host-virus interaction;
Inhibition of host innate immune response by virus;
Inhibition of host interferon signaling pathway by virus;
Inhibition of host IRF7 by virus; Inhibition of host MDA5 by virus;
Inhibition of host RLR pathway by virus;
Inhibition of host STAT2 by virus;
Interferon antiviral system evasion; Metal-binding;
Reference proteome; RNA editing; Viral immunoevasion; Zinc.
CHAIN 1 299 Non-structural protein V.
/FTId=PRO_0000394721.
COMPBIAS 213 218 Poly-Pro.
METAL 232 232 Zinc 1. {ECO:0000250}.
METAL 251 251 Zinc 1. {ECO:0000250}.
METAL 255 255 Zinc 2. {ECO:0000250}.
METAL 267 267 Zinc 2. {ECO:0000250}.
METAL 269 269 Zinc 2. {ECO:0000250}.
METAL 272 272 Zinc 2. {ECO:0000250}.
METAL 276 276 Zinc 1. {ECO:0000250}.
METAL 279 279 Zinc 1. {ECO:0000250}.
SEQUENCE 299 AA; 32016 MW; FEDBD36B65E382D0 CRC64;
MAEEQARHVK NGLECIRALK AEPIGSLAVE EAMAAWSEIS DNPGQDRATC KEEEAGSSGL
SKPCLSAIGS TEGGAPRIRG QGSGESDDDA ETLGIPSRNL QASSTGLQCY HVYDHSGEAV
KGIQDADSIM VQSGLDGDST LSGGDDESEN SDVDIGEPDT EGYAITDRGS APISMGFRAS
DVETAEGGEI HELLKLQSRG NNFPKLGKTL NVPPPPNPSR ASTSETPIKK GHRREIGLIW
NGDRVFIDRW CNPMCSKVTL GTIRARCTCG ECPRVCEQCR TDTGVDTRIW YHNLPEIPE


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