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Notch 1

 A0A0D9RTL0_CHLSB        Unreviewed;      2555 AA.
A0A0D9RTL0;
27-MAY-2015, integrated into UniProtKB/TrEMBL.
27-MAY-2015, sequence version 1.
22-NOV-2017, entry version 26.
SubName: Full=Notch 1 {ECO:0000313|Ensembl:ENSCSAP00000011949};
Name=NOTCH1 {ECO:0000313|Ensembl:ENSCSAP00000011949};
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011949, ECO:0000313|Proteomes:UP000029965};
[1] {ECO:0000313|Ensembl:ENSCSAP00000011949, ECO:0000313|Proteomes:UP000029965}
NUCLEOTIDE SEQUENCE.
Warren W., Wilson R.K.;
Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCSAP00000011949}
IDENTIFICATION.
Ensembl;
Submitted (APR-2015) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000011949}.
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EMBL; AQIB01148135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIB01148136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIB01148137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_008003799.1; XM_008005608.1.
Ensembl; ENSCSAT00000013968; ENSCSAP00000011949; ENSCSAG00000015874.
GeneID; 103239621; -.
KEGG; csab:103239621; -.
CTD; 4851; -.
GeneTree; ENSGT00810000125346; -.
KO; K02599; -.
OMA; QYVNSYT; -.
Proteomes; UP000029965; Chromosome 12.
GO; GO:0005912; C:adherens junction; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
GO; GO:0002193; C:MAML1-RBP-Jkappa- ICN1 complex; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0001047; F:core promoter binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0004857; F:enzyme inhibitor activity; IEA:Ensembl.
GO; GO:0005112; F:Notch binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060842; P:arterial endothelial cell differentiation; IEA:Ensembl.
GO; GO:0003162; P:atrioventricular node development; IEA:Ensembl.
GO; GO:0009912; P:auditory receptor cell fate commitment; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0003213; P:cardiac right atrium morphogenesis; IEA:Ensembl.
GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
GO; GO:0060948; P:cardiac vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
GO; GO:0072044; P:collecting duct development; IEA:Ensembl.
GO; GO:0007386; P:compartment pattern specification; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0003169; P:coronary vein morphogenesis; IEA:Ensembl.
GO; GO:0072017; P:distal tubule development; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
GO; GO:0003160; P:endocardium morphogenesis; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0007440; P:foregut morphogenesis; IEA:Ensembl.
GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl.
GO; GO:0072144; P:glomerular mesangial cell development; IEA:Ensembl.
GO; GO:0003241; P:growth involved in heart morphogenesis; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
GO; GO:0003192; P:mitral valve formation; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0045608; P:negative regulation of auditory receptor cell differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
GO; GO:2001027; P:negative regulation of endothelial cell chemotaxis; IEA:Ensembl.
GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
GO; GO:2000974; P:negative regulation of pro-B cell differentiation; IEA:Ensembl.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
GO; GO:0021915; P:neural tube development; IEA:Ensembl.
GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
GO; GO:0003270; P:Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
GO; GO:1903849; P:positive regulation of aorta morphogenesis; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; IEA:Ensembl.
GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0061419; P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; IEA:Ensembl.
GO; GO:0007221; P:positive regulation of transcription of Notch receptor target; IEA:Ensembl.
GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
GO; GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Ensembl.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0060768; P:regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:1901201; P:regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:0014807; P:regulation of somitogenesis; IEA:Ensembl.
GO; GO:0003256; P:regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IEA:Ensembl.
GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
GO; GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0048103; P:somatic stem cell division; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0035148; P:tube formation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
GO; GO:0060843; P:venous endothelial cell differentiation; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR024600; DUF3454_notch.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR008297; Notch.
InterPro; IPR035993; Notch-like_dom_sf.
InterPro; IPR022362; Notch_1.
InterPro; IPR000800; Notch_dom.
InterPro; IPR010660; Notch_NOD_dom.
InterPro; IPR011656; Notch_NODP_dom.
Pfam; PF12796; Ank_2; 2.
Pfam; PF11936; DUF3454; 1.
Pfam; PF00008; EGF; 25.
Pfam; PF07645; EGF_CA; 4.
Pfam; PF12661; hEGF; 2.
Pfam; PF06816; NOD; 1.
Pfam; PF07684; NODP; 1.
Pfam; PF00066; Notch; 3.
PIRSF; PIRSF002279; Notch; 1.
PRINTS; PR01452; LNOTCHREPEAT.
PRINTS; PR01984; NOTCH1.
SMART; SM00248; ANK; 6.
SMART; SM01334; DUF3454; 1.
SMART; SM00181; EGF; 36.
SMART; SM00179; EGF_CA; 33.
SMART; SM00004; NL; 3.
SMART; SM01338; NOD; 1.
SMART; SM01339; NODP; 1.
SUPFAM; SSF48403; SSF48403; 1.
SUPFAM; SSF57184; SSF57184; 5.
SUPFAM; SSF90193; SSF90193; 3.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 4.
PROSITE; PS00010; ASX_HYDROXYL; 22.
PROSITE; PS00022; EGF_1; 35.
PROSITE; PS01186; EGF_2; 27.
PROSITE; PS50026; EGF_3; 36.
PROSITE; PS01187; EGF_CA; 8.
PROSITE; PS50258; LNR; 3.
4: Predicted;
ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
Complete proteome {ECO:0000313|Proteomes:UP000029965};
Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE-
ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
Reference proteome {ECO:0000313|Proteomes:UP000029965};
Repeat {ECO:0000256|SAAS:SAAS00594563};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 2555 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5002346008.
DOMAIN 20 58 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 59 99 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 102 139 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 140 176 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 178 216 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 218 255 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 257 293 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 295 333 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 335 371 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 372 410 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 412 450 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 452 488 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 490 526 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 528 564 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 566 601 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 603 639 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 641 676 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 678 714 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 716 751 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 753 789 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 791 827 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 829 867 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 869 905 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 907 943 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 945 981 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 983 1019 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1021 1057 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1059 1095 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1108 1143 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1145 1181 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1183 1219 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1228 1265 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1267 1305 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1307 1346 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1348 1384 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1387 1426 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1449 1489 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1490 1531 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1532 1571 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1872 2112 ANK_REP_REGION.
{ECO:0000259|PROSITE:PS50297}.
REPEAT 1926 1958 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 1993 2025 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 2026 2058 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 2059 2091 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
METAL 432 432 Calcium 1; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 435 435 Calcium 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 452 452 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 453 453 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 455 455 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 469 469 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 470 470 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 490 490 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 491 491 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 493 493 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 507 507 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 508 508 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
DISULFID 48 57 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 89 98 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 129 138 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 166 175 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 206 215 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 245 254 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 283 292 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 323 332 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 361 370 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 381 398 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 400 409 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 416 429 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 423 438 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 440 449 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 456 467 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 461 476 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 478 487 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 494 505 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 499 514 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 516 525 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 554 563 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 570 580 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 591 600 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 629 638 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 645 655 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 666 675 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 704 713 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 720 730 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 741 750 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 779 788 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 817 826 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 838 855 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 857 866 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 895 904 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 933 942 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 971 980 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1009 1018 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1047 1056 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1085 1094 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1112 1122 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1133 1142 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1171 1180 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1209 1218 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1255 1264 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1276 1293 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1295 1304 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1336 1345 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1374 1383 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1397 1414 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1416 1425 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 2555 AA; 272675 MW; F65F61EB28F219E1 CRC64;
MPPLLAPLLC LAFFPALAAR GPRCSQPGET CLNGGKCEAA NGTEACVCGG AFVGPRCQDP
NPCLSNPCKN TGTCHVVDRG GVADYACSCP LGFSGPLCLT PLDNACLTNP CRNGGTCDLL
TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFEA SYICHCPPSF HGPTCRQDVN
ECGQNPGLCR HGGTCHNEVG SYRCVCRATH TGPNCERPYV PCSPSPCQNG GTCRPTGDVT
HECTCLPGFT GQNCEENIDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ
LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFHGATC HDRVASFYCE
CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECSLGA
NPCEHAGKCI NTLGSFECQC LQGYTGPRCE IDVNECVSNP CQNDATCLDQ IGEFQCICMP
GYEGVHCEVN TDECASSPCL HNGHCLDKIN EFQCECPTGF TGHLCQYDVD ECASTPCKNG
AKCLDGPNTY TCVCTEGYTG MHCEVDIDEC DPDPCHYGSC KDGVATFTCL CRPGYTGHHC
ETNINECSSQ PCRHGGTCQD RDNAYLCFCL KGTTGPNCEI NLDDCASSPC DSGTCLDKID
GYECACEPGY TGSMCNVNID ECAGNPCHNG GTCQDGINGF TCRCPEGYHD PTCLSEVNEC
NSNPCVHGAC RDSLNGYKCD CDPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGATCEVVL APCAPSPCRN
GGECRESEDY ESFSCVCPTG WQGQTCEVDI NECVMSPCRH GASCRNTHGG YRCHCQAGYS
GRNCETDIDD CRPNPCHNGG SCTDGINTAF CDCLPGFQGT FCEEDINECA SDPCRNGANC
TDCVDSYTCT CPAGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQH
DVNECDSQPC LHGGTCQDGC GSYRCTCPQG YTGPNCQNLV HWCDSSPCKN GGKCWQTHTQ
YRCECPSGWT GLYCDVPSVS CEVAAQRQGV DVARLCQHGG LCVDAGNTHH CRCQAGYTGS
YCEDLVDECL PSPCQNGATC TDYLGGYSCK CVAGYHGVNC SEEIDECLSH PCQNGGTCLD
LPNTYKCSCP RGTQGVHCEI NVDDCNPPVD PVSRSPKCFN NGTCVDQVGG YSCTCPPGFV
GERCEGDVNE CLSNPCDARG TQNCVQRVND FHCECRAGHT GRRCESVING CKGKPCKNGG
TCAVASNTAR GFICKCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGPFTG
PECQFPASSP CLGGNPCYNQ GTCEPTSESP FYRCLCPAKF NGLLCHILDY SFGGGAGRDI
PPPQIEEACE LPECQEDAGN KVCSLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF
SDGHCDSQCN SAGCLFDGFD CQRAEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD
CAEHVPERLA AGTLVVVVLM PPEQLRNSSF HFLRELSRVL HTNVVFKRDA HGQQMIFPYY
GHEEELRKHP IKRAAEGWAT PEALLGQVKA SLLPGGSGGR RRRELDPMDV RGSIVYLEID
NRQCVQASSQ CFQSATDVAA FLGALASLGS LNIPYKIEAV QSETVEPPPP AQLHFMYVAA
AAFVLLFFVG CGVLLSRKRR RQHGQLWFPE GFKVSEASKK KRREPLGEDS VGLKPLKNAS
DGALMDDNQN EWGDEDLETK KFRFEEPVVL PDLDDQTDHR QWTQQHLDAA DLRMSAMAPT
PPQGEVDADC MDVNVRGPDG FTPLMIASCS GGGLETGNSE EEEDAPAVIS DFIYQGASLH
NQTDRTGETA LHLAARYSRS DAAKRLLEAS ADANIQDNMG RTPLHAAVSA DAQGVFQILI
RNRATDLDAR MHDGTTPLIL AARLAVEGML EDLINSHADV NAVDDLGKSA LHWAAAVNNV
DAAVVLLKNG ANKDMQNNKE ETPLFLAARE GSYETAKVLL DHFANRDITD HMDRLPRDIA
QERMHHDIVR LLDEYNLVRS PQLHGATLGG TPTLSPPLCS PNGYLGSLKP GVQGKKVRKP
SSKGLACGSK EAKDLKARRK KSQDGKGCLL DSSGMLSPVD SLESPHGYLS DVASPPLLPS
PFQQSPSVPL NHLPGMPDTH LGIGHLNVAA KPEMATLGGG GRLAFEAGPP RLSHLPVASS
TSTILGCSSG GAMNFTVGGS TSLNGQCEWL SRLQSGMVPN QYNPLRGSVA PGPLSTQAPS
LQHGMVGPLH SSLAASALSQ MMSYQGLPST RLATQPHLVQ TQQVQPQNLQ MQQQNLQPPN
IQQQQNLQPP PPPPQPHLGV SSAASGHLGR SFLGGEPSQA DVQPLGPSSL AVHTILPQES
PALPTSLPSS LVPPVTAAQF LTPPSQHSYS SSPVDNTPSH QLQVPEHPFL TPSPESPDQW
SSSSPHSNVS DWSEGVSSPP TSMQSQIARI PEAFK


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