Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Notch 1

 F1PDC7_CANLF            Unreviewed;      2555 AA.
F1PDC7;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
31-OCT-2012, sequence version 2.
27-SEP-2017, entry version 56.
SubName: Full=Notch 1 {ECO:0000313|Ensembl:ENSCAFP00000029073};
Name=NOTCH1 {ECO:0000313|Ensembl:ENSCAFP00000029073};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000029073, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000029073, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000029073,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000029073}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000029073};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000029073}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AAEX03006746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03006755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9615.ENSCAFP00000029073; -.
PaxDb; F1PDC7; -.
Ensembl; ENSCAFT00000031242; ENSCAFP00000029073; ENSCAFG00000019633.
eggNOG; ENOG410IR7G; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00810000125346; -.
InParanoid; F1PDC7; -.
OMA; QYVNSYT; -.
OrthoDB; EOG091G01NU; -.
TreeFam; TF351641; -.
Reactome; R-CFA-1912420; Pre-NOTCH Processing in Golgi.
Reactome; R-CFA-2122947; NOTCH1 Intracellular Domain Regulates Transcription.
Reactome; R-CFA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus.
Reactome; R-CFA-350054; Notch-HLH transcription pathway.
Reactome; R-CFA-8941856; RUNX3 regulates NOTCH signaling.
Proteomes; UP000002254; Chromosome 9.
Bgee; ENSCAFG00000019633; -.
GO; GO:0005912; C:adherens junction; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
GO; GO:0002193; C:MAML1-RBP-Jkappa- ICN1 complex; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0001047; F:core promoter binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0004857; F:enzyme inhibitor activity; IEA:Ensembl.
GO; GO:0005112; F:Notch binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060842; P:arterial endothelial cell differentiation; IEA:Ensembl.
GO; GO:0003162; P:atrioventricular node development; IEA:Ensembl.
GO; GO:0009912; P:auditory receptor cell fate commitment; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0003213; P:cardiac right atrium morphogenesis; IEA:Ensembl.
GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
GO; GO:0060948; P:cardiac vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
GO; GO:0072044; P:collecting duct development; IEA:Ensembl.
GO; GO:0007386; P:compartment pattern specification; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0003169; P:coronary vein morphogenesis; IEA:Ensembl.
GO; GO:0072017; P:distal tubule development; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
GO; GO:0003160; P:endocardium morphogenesis; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0007440; P:foregut morphogenesis; IEA:Ensembl.
GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl.
GO; GO:0072144; P:glomerular mesangial cell development; IEA:Ensembl.
GO; GO:0003241; P:growth involved in heart morphogenesis; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
GO; GO:0003192; P:mitral valve formation; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0045608; P:negative regulation of auditory receptor cell differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
GO; GO:2001027; P:negative regulation of endothelial cell chemotaxis; IEA:Ensembl.
GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
GO; GO:2000974; P:negative regulation of pro-B cell differentiation; IEA:Ensembl.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
GO; GO:0021915; P:neural tube development; IEA:Ensembl.
GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
GO; GO:0003270; P:Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
GO; GO:1903849; P:positive regulation of aorta morphogenesis; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; IEA:Ensembl.
GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0061419; P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; IEA:Ensembl.
GO; GO:0007221; P:positive regulation of transcription of Notch receptor target; IEA:Ensembl.
GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
GO; GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Ensembl.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0060768; P:regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:1901201; P:regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:0014807; P:regulation of somitogenesis; IEA:Ensembl.
GO; GO:0003256; P:regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IEA:Ensembl.
GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
GO; GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0048103; P:somatic stem cell division; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0035148; P:tube formation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
GO; GO:0060843; P:venous endothelial cell differentiation; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR024600; DUF3454_notch.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_.
InterPro; IPR008297; Notch.
InterPro; IPR022362; Notch_1.
InterPro; IPR000800; Notch_dom.
InterPro; IPR010660; Notch_NOD_dom.
InterPro; IPR011656; Notch_NODP_dom.
Pfam; PF12796; Ank_2; 2.
Pfam; PF11936; DUF3454; 1.
Pfam; PF00008; EGF; 23.
Pfam; PF07645; EGF_CA; 5.
Pfam; PF12661; hEGF; 3.
Pfam; PF06816; NOD; 1.
Pfam; PF07684; NODP; 1.
Pfam; PF00066; Notch; 3.
PIRSF; PIRSF002279; Notch; 1.
PRINTS; PR01452; LNOTCHREPEAT.
PRINTS; PR01984; NOTCH1.
SMART; SM00248; ANK; 6.
SMART; SM01334; DUF3454; 1.
SMART; SM00181; EGF; 36.
SMART; SM00179; EGF_CA; 32.
SMART; SM00004; NL; 3.
SMART; SM01338; NOD; 1.
SMART; SM01339; NODP; 1.
SUPFAM; SSF48403; SSF48403; 1.
SUPFAM; SSF57184; SSF57184; 5.
SUPFAM; SSF90193; SSF90193; 3.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 4.
PROSITE; PS00010; ASX_HYDROXYL; 22.
PROSITE; PS00022; EGF_1; 36.
PROSITE; PS01186; EGF_2; 28.
PROSITE; PS50026; EGF_3; 36.
PROSITE; PS01187; EGF_CA; 10.
PROSITE; PS50258; LNR; 3.
4: Predicted;
ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE-
ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Repeat {ECO:0000256|SAAS:SAAS00594563}.
DOMAIN 14 53 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 54 94 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 97 134 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 135 171 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 173 211 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 213 250 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 252 288 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 290 328 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 330 366 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 367 405 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 407 445 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 447 483 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 485 521 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 523 559 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 561 596 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 598 634 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 636 671 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 673 709 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 711 746 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 748 784 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 786 822 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 824 862 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 864 900 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 902 938 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 940 976 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 978 1014 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1016 1052 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1054 1090 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1102 1138 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1140 1176 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1178 1214 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1223 1260 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1262 1300 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1302 1341 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1343 1379 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1382 1421 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1444 1484 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1485 1526 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1527 1566 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1866 2106 ANK_REP_REGION.
{ECO:0000259|PROSITE:PS50297}.
REPEAT 1920 1952 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 1987 2019 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 2020 2052 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 2053 2085 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
METAL 427 427 Calcium 1; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 430 430 Calcium 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 447 447 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 448 448 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 450 450 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 464 464 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 465 465 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 485 485 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 486 486 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 488 488 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 502 502 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 503 503 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
DISULFID 43 52 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 84 93 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 124 133 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 161 170 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 201 210 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 240 249 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 278 287 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 318 327 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 356 365 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 376 393 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 395 404 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 411 424 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 418 433 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 435 444 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 451 462 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 456 471 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 473 482 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 489 500 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 494 509 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 511 520 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 549 558 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 565 575 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 586 595 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 624 633 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 640 650 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 661 670 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 699 708 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 715 725 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 736 745 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 774 783 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 812 821 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 833 850 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 852 861 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 890 899 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 928 937 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 966 975 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1004 1013 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1042 1051 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1080 1089 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1128 1137 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1166 1175 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1204 1213 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1250 1259 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1271 1288 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1290 1299 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1331 1340 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1369 1378 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1392 1409 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1411 1420 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 2555 AA; 272134 MW; 0936823139EC41FA CRC64;
SPLLCLILRV PASTGLRCSQ PSESCLNGGK CEVFLNGTEA CVCSGAFVGQ RCQAPNPCLS
APCKNAGTCH TVDRGGLVDY ACTCRLGFSG PLCLTPRDNA CLSTPCRNGG TCDLLTLTEY
KCRCPPGWSG KTCQQADPCA SNPCANGGQC LPFEASYICG CPPGFHGPTC RQDVNECSQS
PGLCQNGGTC HNEVGSYRCT CRATHTGPHC ELPYVPCSPS PCQNGGTCRP TGDTTHECAC
LPGFTGQNCE ENIDDCPGNN CKNGGACVDG VNTYNCRCPP EWTGQYCTED VDECQLMPNA
CQNGGTCHNT HGGYNCVCVN GWTGEDCSEN IDDCASAACF HGATCHDRVA SFYCECPHGR
TGLLCHLNDA CISNPCNEGS NCDTNPVNGK AICTCPSGYT GPACSQDVDE CSLGANPCEH
AGKCINTLGS FECQCLQGYT GPRCEIDVNE CISNPCQNDA TCLDQIGEFQ CICMPGYEGV
HCEVNTDECA SSPCLQNGRC LDKINEFLCE CPTGFTGHLC QYDVDECAST PCKNGAKCLD
GPNTYSCMCT EGYTGLHCEV DIDECDPDPC HYGVCKDGVA TFTCLCQPGY TGHHCESNIN
ECHSQPCRHG GTCQDRDNAY LCSCLKGTTG PNCETNLDDC ASSPCESGTC LDRIDGYECA
CEPGYTGSMC NVNIDECAGN PCHHGGTCED GINSFMCRCP EGYHGPTCLS EVNECSSNPC
IHGACRDSLN GYKCDCDPGW SGANCDVNNN ECESNPCANG GACRDMTSGY VCTCREGFSG
PNCQTNINEC ASNPCLNQGS CIDDVAGYKC NCPLPYTGAT CEVVLAPCAP SPCRNGGACK
ESEDYESFSC ICPTGWQGQT CEVDINECVK TPCRNGASCQ NTNGGYRCHC RAGYTGRNCE
TDVDDCRPNP CHNGGSCTDG VNTAFCDCLP GFQGPFCEED INECASNPCR HGANCTDCVD
SYTCTCPTGF SGIHCENNTP DCTESSCFNG GTCVDGINSF TCLCPPGFTG SYCQHDINEC
DSRPCLHGGT CQDSYGTYRC TCPQGYTGLN CQNLVRWCDS SPCKNGGKCW QSNTLYRCEC
HSGWTGLYCD VPNVSCEVAA QRQDVNVTHL CRNGGLCMDA GNTHHCRCQA GYTGSYCEDQ
VDECSPSPCQ NGATCTDYPG GYSCECVAGY HGVNCSEEMN ECLSHPCQNG GTCIDLINTY
KCSCPRGTQG VHCEVNVDDC SPPIDPVSRG PKCFNNGTCV DQVGGYSCTC PPGFVGERCE
GDVNECLSNP CDIRGTQNCV QRVNDFYCEC RAGHTGRRCE SIINGCKGRP CQNGGTCAVA
SNTARGFICK CPAGFEGATC ENDARACGSR RCLNGGTCIS GPRSPTCLCL GPFTGPECQF
PAGSPCVGGN PCYNQGSCEP TTESPFYRCL CPANFNGLLC HILDYSFGGG LGLDIPPPQI
EEACELPECH EEAGNKVCSL ACNNHACGWD GGDCSLNFND PWQNCSQSLQ CWKYFSNGHC
DSQCNSAGCL FDGFDCQRAE GQCNPLYDQY CKDHFGDGHC DQGCNSAECE WDGLDCAEHV
PERLAAGALV LVVLTPPAQL RNNSLHFLRE LSRLLHTNVV FKRDAHGQPM IFPYYGREEE
LRKHPIKRAV DSWAVPGALL NRVEAALLPG GAGRRRRELD PMDIRGSIVY LEIDNRQCVQ
SSSQCFQSAT DVAAFLGALA SLGSLNIPYK IEAVQSETVE LPPPPQLHFM YVAVAAFVLL
FFVGCGVLLS RKRRRQHGQL WFPEGFKVSE ASKKKRREPL GEDSVGLKPL KNVSDGALMD
DNQNEWGDED LEAKKFRFEE PVVLPDLDDQ TDHRQWTQQH LDAADLRVSA MAPTPPQGEA
DADCMDVNVR GPDGFTPLMI ASCSGGGLET GNSEEEEDAP AVISDFIYQG ASLHNQTDRT
GETALHLAAR YSRSDAAKRL LEASADANIQ DNMGRTPLHA AVSADAQGVF QILIRNRATD
LDARMHDGTT PLILAARLAV EGMLEDLINS HADVNAVDDL GKSALHWAAA VNNVEAAVVL
LKNGANKDMQ NNKEETPLFL AAREGSYETA KVLLDHFANR DITDHMDRLP RDIAQERMHH
DIVRLLDEYS LVRSPQLHGP ALGGTPTLSP PLCSPNGYLG NLKPSVPGKK ARKPSTKGLA
CGGKETKDLK ARRKKSQDGK ACLLDSSSVL SPVDSLESPH GYLSDVASPP LLSSPFQPSP
SVPLGHLPGM PDAHLGVSHL SVAAKPEMAT LAGGGRLAFE AGPPRLSHLP VASSTGTVLG
TGSGSTSGSG GGAVNFTMGG ATALNGQCEW LSRLQNGLVP NQYNPLRGNV APGPLSSQAP
GLQHSLMGPL HAGLPTTAAL SHMMSYQALP NTRLASQPHL VQTQPLQQVP QQQQNLQPPT
IQQPQSLPPP PQPPQPHLGV SSAASGHVGR SFLGGEPSQA DVQPLGASGL AVHTILPQDS
QALPTALPAA LAPAMTTAQF LTPPSQHSYS SSPADNTPSH QLQVPEHPFL TPSPESPDQW
SSSSPHSHVS DWSEGISSPP TSTQSHIAHI PETLK


Related products :

Catalog number Product name Quantity
20-783-74777 HAMSTER ANTI NOTCH 1 - Notch 1; hN1; Translocation-associated notch protein TAN-1 Monoclonal 0.1 ml
EIAAB27544 hN1,Homo sapiens,Human,Neurogenic locus notch homolog protein 1,Notch 1,NOTCH1,TAN1,Translocation-associated notch protein TAN-1
25-493 NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily co 0.05 mg
EIAAB27545 Neurogenic locus notch homolog protein 1,Notch 1,Notch1,Rat,Rattus norvegicus
EIAAB27550 Neurogenic locus notch homolog protein 3,Notch 3,Notch3,Rat,Rattus norvegicus
EIAAB27551 Mouse,Mus musculus,Neurogenic locus notch homolog protein 3,Notch 3,Notch3
EIAAB27547 Neurogenic locus notch homolog protein 2,Notch 2,Notch2,Rat,Rattus norvegicus
EIAAB27552 Homo sapiens,Human,Neurogenic locus notch homolog protein 3,Notch 3,NOTCH3
EIAAB27554 Int3,Int-3,Mouse,Mus musculus,Neurogenic locus notch homolog protein 4,Notch 4,Notch4
EIAAB27549 hN2,Homo sapiens,Human,Neurogenic locus notch homolog protein 2,Notch 2,NOTCH2
EIAAB27548 Motch B,Mouse,Mus musculus,Neurogenic locus notch homolog protein 2,Notch 2,Notch2
EIAAB27553 hNotch4,Homo sapiens,Human,INT3,Neurogenic locus notch homolog protein 4,Notch 4,NOTCH4
3881BP-50 Notch 1 Blocking Peptide target: Notch 1 50 μg
EIAAB27546 Motch,Motch A,Mouse,mT14,Mus musculus,Neurogenic locus notch homolog protein 1,Notch 1,Notch1,p300
26-040 The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch protein family are transmembrane receptors that are critica 0.05 mg
27-489 NOTCH3 encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establ 0.05 mg
OBT2045 HAMSTER ANTI NOTCH 1, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Hamster, Format S_N, Isotypes IgG1, Applications C, F, WB, Clone 8G10 0.1 ml
SCH-OBT2045 HAMSTER ANTI NOTCH 1, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Hamster, Format S_N, Isotypes IgG1, Applications C, F, WB, Clone 8G10 0.1 ml
MCA2410PE MOUSE ANTI MOUSE NOTCH 1 RPE, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Mouse, Format RPE, Isotypes IgG1, Applications F*, Clone mN1A 100 TESTS
SCH-MCA2410PET MOUSE ANTI MOUSE NOTCH 1 RPE, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Mouse, Format RPE, Isotypes IgG1, Applications F*, Clone mN1A 25 TESTS
SCH-MCA2410PE MOUSE ANTI MOUSE NOTCH 1 RPE, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Mouse, Format RPE, Isotypes IgG1, Applications F*, Clone mN1A 100 TESTS
MCA2410PET MOUSE ANTI MOUSE NOTCH 1 RPE, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Mouse, Format RPE, Isotypes IgG1, Applications F*, Clone mN1A 25 TESTS
MCA5704 HAMSTER ANTI MOUSE NOTCH 4, Product Type Monoclonal Antibody, Specificity NOTCH 4, Target Species Mouse, Host Hamster, Format Purified, Isotypes IgG, Applications F, Clone HMN4_14 0.25 mg
MCA5704GA HAMSTER ANTI MOUSE NOTCH 4, Product Type Monoclonal Antibody, Specificity NOTCH 4, Target Species Mouse, Host Hamster, Format Purified, Isotypes IgG, Applications F, Clone HMN4_14 0.1 mg
MCA2410 MOUSE ANTI MOUSE NOTCH 1, Product Type Monoclonal Antibody, Specificity NOTCH 1, Target Species Mouse, Host Mouse, Format Purified, Isotypes IgG1, Applications C, F*, WB, Clone mN1A 0.25 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur