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Notch 1

 F6TZ18_HORSE            Unreviewed;      2524 AA.
F6TZ18;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
27-SEP-2017, entry version 52.
SubName: Full=Notch 1 {ECO:0000313|Ensembl:ENSECAP00000020734};
Name=NOTCH1 {ECO:0000313|Ensembl:ENSECAP00000020734};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020734, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000020734, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020734,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000020734}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020734};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000020734}.
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STRING; 9796.ENSECAP00000020734; -.
PaxDb; F6TZ18; -.
Ensembl; ENSECAT00000024936; ENSECAP00000020734; ENSECAG00000022405.
eggNOG; ENOG410IR7G; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00810000125346; -.
InParanoid; F6TZ18; -.
OMA; QYVNSYT; -.
OrthoDB; EOG091G01NU; -.
TreeFam; TF351641; -.
Proteomes; UP000002281; Chromosome 25.
Bgee; ENSECAG00000022405; -.
ExpressionAtlas; F6TZ18; baseline.
GO; GO:0005912; C:adherens junction; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
GO; GO:0002193; C:MAML1-RBP-Jkappa- ICN1 complex; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0001047; F:core promoter binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0004857; F:enzyme inhibitor activity; IEA:Ensembl.
GO; GO:0005112; F:Notch binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0004872; F:receptor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060842; P:arterial endothelial cell differentiation; IEA:Ensembl.
GO; GO:0003162; P:atrioventricular node development; IEA:Ensembl.
GO; GO:0009912; P:auditory receptor cell fate commitment; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0003213; P:cardiac right atrium morphogenesis; IEA:Ensembl.
GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
GO; GO:0060948; P:cardiac vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
GO; GO:0072044; P:collecting duct development; IEA:Ensembl.
GO; GO:0007386; P:compartment pattern specification; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0003169; P:coronary vein morphogenesis; IEA:Ensembl.
GO; GO:0072017; P:distal tubule development; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
GO; GO:0003160; P:endocardium morphogenesis; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0007440; P:foregut morphogenesis; IEA:Ensembl.
GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl.
GO; GO:0072144; P:glomerular mesangial cell development; IEA:Ensembl.
GO; GO:0003241; P:growth involved in heart morphogenesis; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
GO; GO:0003192; P:mitral valve formation; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0045608; P:negative regulation of auditory receptor cell differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
GO; GO:2001027; P:negative regulation of endothelial cell chemotaxis; IEA:Ensembl.
GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
GO; GO:2000974; P:negative regulation of pro-B cell differentiation; IEA:Ensembl.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
GO; GO:0021915; P:neural tube development; IEA:Ensembl.
GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
GO; GO:0003270; P:Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
GO; GO:1903849; P:positive regulation of aorta morphogenesis; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; IEA:Ensembl.
GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0061419; P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; IEA:Ensembl.
GO; GO:0007221; P:positive regulation of transcription of Notch receptor target; IEA:Ensembl.
GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
GO; GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Ensembl.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0060768; P:regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:1901201; P:regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:0014807; P:regulation of somitogenesis; IEA:Ensembl.
GO; GO:0003256; P:regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IEA:Ensembl.
GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
GO; GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0048103; P:somatic stem cell division; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0035148; P:tube formation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
GO; GO:0060843; P:venous endothelial cell differentiation; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR024600; DUF3454_notch.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_.
InterPro; IPR008297; Notch.
InterPro; IPR022362; Notch_1.
InterPro; IPR000800; Notch_dom.
InterPro; IPR010660; Notch_NOD_dom.
InterPro; IPR011656; Notch_NODP_dom.
Pfam; PF12796; Ank_2; 2.
Pfam; PF11936; DUF3454; 1.
Pfam; PF00008; EGF; 23.
Pfam; PF07645; EGF_CA; 4.
Pfam; PF12661; hEGF; 3.
Pfam; PF06816; NOD; 1.
Pfam; PF07684; NODP; 1.
Pfam; PF00066; Notch; 3.
PIRSF; PIRSF002279; Notch; 1.
PRINTS; PR01452; LNOTCHREPEAT.
PRINTS; PR01984; NOTCH1.
SMART; SM00248; ANK; 6.
SMART; SM01334; DUF3454; 1.
SMART; SM00181; EGF; 35.
SMART; SM00179; EGF_CA; 31.
SMART; SM00004; NL; 3.
SMART; SM01338; NOD; 1.
SMART; SM01339; NODP; 1.
SUPFAM; SSF48403; SSF48403; 1.
SUPFAM; SSF57184; SSF57184; 5.
SUPFAM; SSF90193; SSF90193; 3.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 4.
PROSITE; PS00010; ASX_HYDROXYL; 20.
PROSITE; PS00022; EGF_1; 33.
PROSITE; PS01186; EGF_2; 26.
PROSITE; PS50026; EGF_3; 35.
PROSITE; PS01187; EGF_CA; 9.
PROSITE; PS50258; LNR; 3.
4: Predicted;
ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE-
ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Repeat {ECO:0000256|SAAS:SAAS00594563}.
DOMAIN 1 36 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 37 77 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 80 117 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 118 154 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 156 194 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 196 233 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 235 271 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 273 311 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 313 349 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 350 388 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 390 428 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 430 466 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 468 504 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 523 570 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 572 608 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 610 645 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 647 683 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 685 720 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 722 758 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 760 796 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 798 836 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 838 874 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 876 912 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 914 950 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 952 988 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 990 1026 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1028 1064 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1075 1112 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1114 1150 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1152 1188 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1197 1234 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1236 1274 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1276 1315 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1317 1353 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1356 1395 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 1418 1458 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1459 1500 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1501 1540 LNR. {ECO:0000259|PROSITE:PS50258}.
DOMAIN 1841 2081 ANK_REP_REGION.
{ECO:0000259|PROSITE:PS50297}.
REPEAT 1895 1927 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 1962 1994 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 1995 2027 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
REPEAT 2028 2060 ANK. {ECO:0000256|PROSITE-
ProRule:PRU00023}.
METAL 410 410 Calcium 1; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 413 413 Calcium 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 430 430 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 431 431 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 433 433 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 447 447 Calcium 2.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 448 448 Calcium 2; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 468 468 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 469 469 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 471 471 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 485 485 Calcium 3.
{ECO:0000256|PIRSR:PIRSR002279-1}.
METAL 486 486 Calcium 3; via carbonyl oxygen.
{ECO:0000256|PIRSR:PIRSR002279-1}.
DISULFID 26 35 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 67 76 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 107 116 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 144 153 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 184 193 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 223 232 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 261 270 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 301 310 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 339 348 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 359 376 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 378 387 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 394 407 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 401 416 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 418 427 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 434 445 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 439 454 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 456 465 {ECO:0000256|PIRSR:PIRSR002279-2,
ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 472 483 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 477 492 {ECO:0000256|PIRSR:PIRSR002279-2}.
DISULFID 560 569 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 598 607 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 614 624 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 635 644 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 673 682 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 689 699 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 710 719 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 748 757 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 786 795 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 807 824 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 826 835 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 864 873 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 902 911 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 940 949 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 978 987 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1016 1025 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1054 1063 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1102 1111 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1140 1149 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1178 1187 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1224 1233 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1245 1262 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1264 1273 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1305 1314 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1343 1352 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1366 1383 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 1385 1394 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 2524 AA; 269260 MW; B14C180F6F7ED3B3 CRC64;
CSQPGESCLN GGKCEVLANG TEACICSGAF AGQRCQVPNP CLSAPCKNGG TCHMVDRGGL
VDYACSCSLG FSGPLCLTPQ DNACLANPCR NGGTCDLLTL TDYKCRCPPG WSGKTCQQAD
PCASNPCANG GQCLPFEASY ICGCPPGFHG PTCKQDINEC SQSPGLCRNG GTCHNEVGSY
RCACRATHTG PHCELPYVPC SPSPCQNGGT CRPTGDTTHE CACLPGFTGQ NCEENIDDCP
GNSCKNGGAC VDGVNTYNCR CPPEWTGMYC TEDVDECQLM PNACQNGGTC HNSHGGYNCV
CVNGWTGEDC SENIDDCASA SCFHGATCHD RVASFYCECP HGRTGLLCHL NDACISNPCN
EGSNCDTNPV NGKAICTCPS GYTGPACSQD VDECSLGANP CEHAGKCINT LGSFECQCLQ
GYTGPRCEID VNECVSNPCQ NDATCLDQIG EFQCICMPGY EGVHCEVNTD ECASSPCLQN
GRCLDKINEF LCECPTGQAG HLAAYAHWGC PSLPCPPGLS LRGGPVCHRG GPGAHQAHRH
CRSEPWASRD DGVATFTCLC RPGYTGHHCE TNINECHSQP CRHGGTCQDR DNAYLCFCLK
GTTGPNCEIN LDDCASNPCD SGTCLDKIDG YECACEPGYT GSMCNINIDE CAGNPCHNGG
TCEDGINGFT CRCPEGYHDP TCLSEVNECN SDPCIHGACR DSLNGYKCDC DPGWSGANCD
INNNECESNP CVNGGTCKDM TSGYVCTCRE GFSGPNCQTN INECASNPCL NQGTCIDDVA
GYKCNCLLPY TGATCEVVLA PCAPGPCRNG GECRESEDFE SFSCVCPVGW QGQTCEIDIN
ECVKSPCRHG ASCQNTNGGY RCHCQAGYTG RNCETDIDDC RPNPCHNGGS CTDGINAAFC
DCLPGFQGAF CEEDINECAS SPCRNGANCT DCVDSYTCTC PPGFGGIHCE NNTPDCTESS
CFNGGTCVDG INSFTCLCPP GFTGSYCQHD VNECDSRPCL HGGTCQDSYG TYKCTCPQGY
TGLNCQSLVR WCDSSPCKNG GKCWQTNALY RCECHSGWTG LYCDVPSVSC EVAARLQDVN
VSRLCRNGGL CENEGSTHHC HCQAGYTGSY CEDQVDECSP SPCQNGATCT DYPGGYSCEC
VAGYHGVNCS EEINECLSHP CQNGGTCIDL TNSYKCSCPR GTQGVHCEIN MDDCTPPVDP
VSRGPKCFNN GTCVDQVGGY SCTCPPGFVG ERCEGDVNEC LSNPCDARGT QNCVQRVNDF
HCECRAGHTG RRCESVINGC KGKPCKNGGT CAVASNTARG FICRCPAGYE GATCENDARA
CGSLRCLNGG TCISGPRSPT CLCLGPFTGP ECQFPASSPC VGGNPCYNQG TCEPTSESPF
YRCLCPAKFN GLLCHILDYS FGGGVGLDIP PPQIEEACEL PACREEAGNK VCSVRCNNHA
CGWDGGDCSL NFNDPWQNCT QSLQCWKYFS NGHCDSQCNS AGCLFDGFDC QRAEGQCNPL
YDQYCKDHFS DGHCDQGCNS AECEWDGLDC AEHVPERLAA GTLVVVVLMP PEQLRNNSFH
FLRELSRLLH TNVVFKRDAS GQQMIFPYYG REEELRKHPI RRSVDGWATP GSLLGHMKAS
LLPGSGGGRQ RRELDPMDIR GSIVYLEIDN RQCVQSSSQC FQSTTDVAAF LGALASLGSL
NIPYKIEAVQ SESVEPPPPP PLHFMYVAVA AFVLLFFVGC GVLLSRKRRR QHGQLWFPEG
FKVSEASKKK RREPLGEDSV GLKPLKNASD GALMDDNQNE WGDEDLETKK FRFEESVVLP
DLDDQTDHRQ WTQQHLDAAD LRVSAMAPTP PQGEADTDCM DVNVRGPDGF TPLMIASCSG
GGLETGNSEE EEDAPAVISD FIYQGASLHN QTDRTGETAL HLAARYSRSD AAKRLLEASA
DANIQDNMGR TPLHAAVSAD AQGVFQILIR NRATDLDARM HDGTTPLILA ARLAVEGMLE
DLINSHADVN AVDDLGKSAL HWAAAVNNVE AAIVLLKNGA NKDMQNNKEE TPLFLAAREG
SYETAKVLLD HFANRDITDH MDRLPRDIAQ ERMHHDIVRL LDEYSLVRSP QLHGATLGGT
PTLSPPLCSP NGYLGNLKPT VQGKKARKPS TKGLACGGKE AKDLKARRKK SQDGKGCLLD
SSSVLSPVDS LESPHGYLSD VASPPLLPSP FQQSPSVPLN HLPGMPDTHL GVSHLSVAAK
PEMATLGGGG RLAFEAGPPR LSHLPVASST STVLGPGGGS GVMNFTVGGA TGLNSQCEWL
SRLQNGLVPN QYNPLRGSVA PSTLSTQAPA LQHGMMGPMH GGLSASALSQ MMSYQALPNT
RLATQPHLVQ TQQLQQQQQQ QQPQQNLQPP NIQPQQNLQP QPPPPHLGVS SAANGHMGRS
FLGGEPSQAD VQPLGPSSLA VHTILPQDSQ VLPTSLPSSL APPMTTAQFL TPPSQHSYSS
SPVDNTPSHQ LQVPEHPFLT PSPESPDQWS SSSPHSNISD WSEGISSPPT SMQSQIAHIP
EAFK


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