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Notch homolog 2 N-terminal-like protein

 NT2NL_HUMAN             Reviewed;         236 AA.
Q7Z3S9; Q5BKT8; Q5VTG9; Q5XG84; Q6P192; Q8NC23; Q8WUQ9; Q96FY1;
20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
27-SEP-2017, entry version 144.
RecName: Full=Notch homolog 2 N-terminal-like protein;
Name=NOTCH2NL; Synonyms=N2N;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Retina;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
ILE-158.
TISSUE=Brain, Eye, Liver, Ovary, and Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, INTERACTION WITH ELANE, SUBCELLULAR LOCATION, PROTEOLYTIC
PROCESSING BY ELANE, AND TISSUE SPECIFICITY.
PubMed=14673143; DOI=10.1128/MCB.24.1.58-70.2004;
Duan Z., Li F.-Q., Wechsler J., Meade-White K., Williams K.,
Benson K.F., Horwitz M.;
"A novel notch protein, N2N, targeted by neutrophil elastase and
implicated in hereditary neutropenia.";
Mol. Cell. Biol. 24:58-70(2004).
-!- FUNCTION: May function in the Notch signaling pathway and regulate
neutrophil differentiation. {ECO:0000269|PubMed:14673143}.
-!- SUBUNIT: Interacts with ELANE. {ECO:0000269|PubMed:14673143}.
-!- INTERACTION:
Q5BKY6:-; NbExp=3; IntAct=EBI-945833, EBI-10243533;
Q9NWL9:-; NbExp=3; IntAct=EBI-945833, EBI-10315054;
Q96HD9:ACY3; NbExp=3; IntAct=EBI-945833, EBI-3916242;
P82987:ADAMTSL3; NbExp=3; IntAct=EBI-945833, EBI-10221726;
Q6ZMM2-2:ADAMTSL5; NbExp=3; IntAct=EBI-945833, EBI-10254938;
Q3MIX3:ADCK5; NbExp=3; IntAct=EBI-945833, EBI-3923548;
Q08117:AES; NbExp=3; IntAct=EBI-945833, EBI-717810;
P43353:ALDH3B1; NbExp=3; IntAct=EBI-945833, EBI-2558314;
P09923:ALPI; NbExp=3; IntAct=EBI-945833, EBI-1052631;
Q49AR9:ANKS1A; NbExp=4; IntAct=EBI-945833, EBI-11954519;
P29972:AQP1; NbExp=5; IntAct=EBI-945833, EBI-745213;
P55064:AQP5; NbExp=3; IntAct=EBI-945833, EBI-746103;
Q99856:ARID3A; NbExp=3; IntAct=EBI-945833, EBI-5458244;
Q9BZE9:ASPSCR1; NbExp=3; IntAct=EBI-945833, EBI-1993677;
Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-945833, EBI-727146;
A8KA13:BCL6B; NbExp=3; IntAct=EBI-945833, EBI-10174813;
P62952:BLCAP; NbExp=3; IntAct=EBI-945833, EBI-3895726;
A8K571:BMP7; NbExp=3; IntAct=EBI-945833, EBI-10174327;
Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-945833, EBI-6660291;
Q7L2K0:C16orf59; NbExp=3; IntAct=EBI-945833, EBI-8465456;
A6NFR6-4:C5orf60; NbExp=3; IntAct=EBI-945833, EBI-10173955;
Q8N4G4:CA6; NbExp=3; IntAct=EBI-945833, EBI-10265475;
Q9Y2V2:CARHSP1; NbExp=7; IntAct=EBI-945833, EBI-718719;
Q8NEC5:CATSPER1; NbExp=5; IntAct=EBI-945833, EBI-744545;
Q8TAB7:CCDC26; NbExp=3; IntAct=EBI-945833, EBI-10271580;
Q8TC90:CCER1; NbExp=5; IntAct=EBI-945833, EBI-746041;
Q04900:CD164; NbExp=5; IntAct=EBI-945833, EBI-2115896;
Q8N619:CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10266998;
Q8TAM4:CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10271838;
Q8TCT0:CERK; NbExp=5; IntAct=EBI-945833, EBI-10274247;
Q9NX63:CHCHD3; NbExp=5; IntAct=EBI-945833, EBI-743375;
Q8NE62:CHDH; NbExp=3; IntAct=EBI-945833, EBI-7127986;
Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-945833, EBI-741528;
Q9H2X0:CHRD; NbExp=5; IntAct=EBI-945833, EBI-947551;
P07510:CHRNG; NbExp=3; IntAct=EBI-945833, EBI-9008836;
P07510-2:CHRNG; NbExp=7; IntAct=EBI-945833, EBI-11979451;
P57739:CLDN2; NbExp=3; IntAct=EBI-945833, EBI-751440;
A5D8T8:CLEC18A; NbExp=3; IntAct=EBI-945833, EBI-10173491;
P27658:COL8A1; NbExp=7; IntAct=EBI-945833, EBI-747133;
Q9BSW2:CRACR2A; NbExp=5; IntAct=EBI-945833, EBI-739773;
Q9UGL9:CRCT1; NbExp=3; IntAct=EBI-945833, EBI-713677;
Q02930-3:CREB5; NbExp=5; IntAct=EBI-945833, EBI-10192698;
P09603:CSF1; NbExp=3; IntAct=EBI-945833, EBI-2872294;
P09228:CST2; NbExp=5; IntAct=EBI-945833, EBI-8832659;
Q9H4G1:CST9L; NbExp=5; IntAct=EBI-945833, EBI-3923092;
P08311:CTSG; NbExp=3; IntAct=EBI-945833, EBI-5462635;
Q9UBR2:CTSZ; NbExp=5; IntAct=EBI-945833, EBI-8636823;
Q6I9S7:CXCL5; NbExp=3; IntAct=EBI-945833, EBI-10249885;
Q6ZMK1-3:CYHR1; NbExp=4; IntAct=EBI-945833, EBI-11997340;
Q08AG9:CYP21A2; NbExp=4; IntAct=EBI-945833, EBI-14156412;
Q96LJ7:DHRS1; NbExp=5; IntAct=EBI-945833, EBI-746300;
Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-945833, EBI-9679045;
O96015:DNAL4; NbExp=3; IntAct=EBI-945833, EBI-742362;
Q92608:DOCK2; NbExp=5; IntAct=EBI-945833, EBI-448771;
P52797:EFNA3; NbExp=3; IntAct=EBI-945833, EBI-722730;
O60573:EIF4E2; NbExp=3; IntAct=EBI-945833, EBI-398610;
O15197-2:EPHB6; NbExp=3; IntAct=EBI-945833, EBI-10182490;
O00519:FAAH; NbExp=3; IntAct=EBI-945833, EBI-1389829;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-945833, EBI-741626;
Q8NEG0:FAM71C; NbExp=5; IntAct=EBI-945833, EBI-752049;
Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-945833, EBI-10247271;
O95363:FARS2; NbExp=3; IntAct=EBI-945833, EBI-2513774;
P48023:FASLG; NbExp=3; IntAct=EBI-945833, EBI-495538;
Q96D16:FBXL18; NbExp=3; IntAct=EBI-945833, EBI-744419;
Q969U6:FBXW5; NbExp=7; IntAct=EBI-945833, EBI-741068;
Q99853:FOXB1; NbExp=3; IntAct=EBI-945833, EBI-3916225;
O43559:FRS3; NbExp=5; IntAct=EBI-945833, EBI-725515;
O14764:GABRD; NbExp=3; IntAct=EBI-945833, EBI-744352;
P23769:GATA2; NbExp=3; IntAct=EBI-945833, EBI-2806671;
P55040:GEM; NbExp=3; IntAct=EBI-945833, EBI-744104;
Q9NXC2:GFOD1; NbExp=3; IntAct=EBI-945833, EBI-8799578;
P09681:GIP; NbExp=3; IntAct=EBI-945833, EBI-8588553;
P43220:GLP1R; NbExp=5; IntAct=EBI-945833, EBI-7466542;
O76003:GLRX3; NbExp=3; IntAct=EBI-945833, EBI-374781;
Q6IB77:GLYAT; NbExp=3; IntAct=EBI-945833, EBI-715463;
P04899:GNAI2; NbExp=3; IntAct=EBI-945833, EBI-353997;
Q9Y223:GNE; NbExp=3; IntAct=EBI-945833, EBI-4291090;
P09211:GSTP1; NbExp=5; IntAct=EBI-945833, EBI-353467;
Q9Y5Q8:GTF3C5; NbExp=3; IntAct=EBI-945833, EBI-1045409;
P02008:HBZ; NbExp=5; IntAct=EBI-945833, EBI-719843;
P08631:HCK; NbExp=3; IntAct=EBI-945833, EBI-346340;
V9HW60:HEL-S-182mP; NbExp=3; IntAct=EBI-945833, EBI-10180762;
V9HWJ5:HEL-S-90n; NbExp=3; IntAct=EBI-945833, EBI-10330335;
Q03014:HHEX; NbExp=4; IntAct=EBI-945833, EBI-747421;
A4FTV9:HIST1H2AK; NbExp=3; IntAct=EBI-945833, EBI-10173457;
P49639:HOXA1; NbExp=5; IntAct=EBI-945833, EBI-740785;
P37235:HPCAL1; NbExp=7; IntAct=EBI-945833, EBI-749311;
O75506:HSBP1; NbExp=3; IntAct=EBI-945833, EBI-748664;
Q9H2F3:HSD3B7; NbExp=3; IntAct=EBI-945833, EBI-3918847;
Q96MM6:HSPA12B; NbExp=7; IntAct=EBI-945833, EBI-10291310;
Q9NZL4:HSPBP1; NbExp=3; IntAct=EBI-945833, EBI-356763;
P10809:HSPD1; NbExp=3; IntAct=EBI-945833, EBI-352528;
Q14773-3:ICAM4; NbExp=5; IntAct=EBI-945833, EBI-10233928;
P13284:IFI30; NbExp=3; IntAct=EBI-945833, EBI-2868897;
P31785:IL2RG; NbExp=3; IntAct=EBI-945833, EBI-80475;
Q92835:INPP5D; NbExp=3; IntAct=EBI-945833, EBI-1380477;
P05107:ITGB2; NbExp=8; IntAct=EBI-945833, EBI-300173;
L7RT22:ITGB5; NbExp=3; IntAct=EBI-945833, EBI-10178729;
Q15040:JOSD1; NbExp=5; IntAct=EBI-945833, EBI-2510602;
Q9ULS6:KCNS2; NbExp=4; IntAct=EBI-945833, EBI-10323864;
Q96SI1:KCTD15; NbExp=3; IntAct=EBI-945833, EBI-715783;
Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-945833, EBI-6426443;
O60259:KLK8; NbExp=5; IntAct=EBI-945833, EBI-3915857;
P35900:KRT20; NbExp=3; IntAct=EBI-945833, EBI-742094;
P78385:KRT83; NbExp=5; IntAct=EBI-945833, EBI-10221390;
P60412:KRTAP10-11; NbExp=3; IntAct=EBI-945833, EBI-10217483;
P60370:KRTAP10-5; NbExp=7; IntAct=EBI-945833, EBI-10172150;
P60409:KRTAP10-7; NbExp=3; IntAct=EBI-945833, EBI-10172290;
P60410:KRTAP10-8; NbExp=5; IntAct=EBI-945833, EBI-10171774;
P60411:KRTAP10-9; NbExp=5; IntAct=EBI-945833, EBI-10172052;
P59991:KRTAP12-2; NbExp=5; IntAct=EBI-945833, EBI-10176379;
P60329:KRTAP12-4; NbExp=5; IntAct=EBI-945833, EBI-10176396;
Q3SY46:KRTAP13-3; NbExp=5; IntAct=EBI-945833, EBI-10241252;
Q6PEX3:KRTAP26-1; NbExp=5; IntAct=EBI-945833, EBI-3957672;
Q9BYR8:KRTAP3-1; NbExp=3; IntAct=EBI-945833, EBI-9996449;
Q9BYQ6:KRTAP4-11; NbExp=7; IntAct=EBI-945833, EBI-10302392;
Q9BQ66:KRTAP4-12; NbExp=3; IntAct=EBI-945833, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=5; IntAct=EBI-945833, EBI-10172511;
Q9BYR0:KRTAP4-7; NbExp=3; IntAct=EBI-945833, EBI-10302547;
Q6L8H1:KRTAP5-4; NbExp=4; IntAct=EBI-945833, EBI-11963072;
Q6L8G9:KRTAP5-6; NbExp=5; IntAct=EBI-945833, EBI-10250562;
P26371:KRTAP5-9; NbExp=5; IntAct=EBI-945833, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=7; IntAct=EBI-945833, EBI-1044640;
Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-945833, EBI-10185730;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-945833, EBI-11958364;
Q5T7P2:LCE1A; NbExp=4; IntAct=EBI-945833, EBI-11962058;
Q5T7P3:LCE1B; NbExp=5; IntAct=EBI-945833, EBI-10245913;
Q5TA82:LCE2D; NbExp=5; IntAct=EBI-945833, EBI-10246750;
Q5T5A8:LCE3C; NbExp=5; IntAct=EBI-945833, EBI-10245291;
Q5T5B0:LCE3E; NbExp=5; IntAct=EBI-945833, EBI-10245456;
Q5TCM9:LCE5A; NbExp=4; IntAct=EBI-945833, EBI-11955689;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-945833, EBI-10257651;
O14910:LIN7A; NbExp=3; IntAct=EBI-945833, EBI-2513988;
Q96FQ7:LINC00526; NbExp=5; IntAct=EBI-945833, EBI-10286106;
P25791:LMO2; NbExp=3; IntAct=EBI-945833, EBI-739696;
Q8TBB1:LNX1; NbExp=5; IntAct=EBI-945833, EBI-739832;
Q17RD9:LOC200261; NbExp=3; IntAct=EBI-945833, EBI-10239007;
Q496Y0:LONRF3; NbExp=3; IntAct=EBI-945833, EBI-2690768;
O75427:LRCH4; NbExp=3; IntAct=EBI-945833, EBI-718707;
Q6PJG9:LRFN4; NbExp=5; IntAct=EBI-945833, EBI-7910762;
O60336:MAPKBP1; NbExp=5; IntAct=EBI-945833, EBI-947402;
Q6IPE9:MARK4; NbExp=3; IntAct=EBI-945833, EBI-10250211;
O15232:MATN3; NbExp=3; IntAct=EBI-945833, EBI-6262458;
P08582-2:MELTF; NbExp=5; IntAct=EBI-945833, EBI-10195914;
Q4ZG74:MGC13033; NbExp=3; IntAct=EBI-945833, EBI-10241963;
Q9NV56:MRGBP; NbExp=5; IntAct=EBI-945833, EBI-399076;
Q9NQ50:MRPL40; NbExp=5; IntAct=EBI-945833, EBI-1053902;
Q13330:MTA1; NbExp=5; IntAct=EBI-945833, EBI-714236;
Q9BW11:MXD3; NbExp=5; IntAct=EBI-945833, EBI-741574;
P50539-3:MXI1; NbExp=5; IntAct=EBI-945833, EBI-10211940;
Q15742:NAB2; NbExp=3; IntAct=EBI-945833, EBI-8641936;
Q8IW45:NAXD; NbExp=3; IntAct=EBI-945833, EBI-8650724;
Q92692:NECTIN2; NbExp=3; IntAct=EBI-945833, EBI-718419;
Q9NQS3:NECTIN3; NbExp=3; IntAct=EBI-945833, EBI-2826725;
Q9Y3R4:NEU2; NbExp=6; IntAct=EBI-945833, EBI-10327976;
P48645:NMU; NbExp=5; IntAct=EBI-945833, EBI-10210351;
P48146:NPBWR2; NbExp=3; IntAct=EBI-945833, EBI-10210114;
Q9NQX5:NPDC1; NbExp=5; IntAct=EBI-945833, EBI-748927;
P16860:NPPB; NbExp=3; IntAct=EBI-945833, EBI-747044;
Q6NSM0:NR1D2; NbExp=5; IntAct=EBI-945833, EBI-10250949;
Q9Y5Y2:NUBP2; NbExp=3; IntAct=EBI-945833, EBI-1048886;
P32242:OTX1; NbExp=4; IntAct=EBI-945833, EBI-740446;
Q99571:P2RX4; NbExp=5; IntAct=EBI-945833, EBI-2828248;
Q9H1Q7:PCED1A; NbExp=3; IntAct=EBI-945833, EBI-748452;
Q96HM7:PCED1B; NbExp=3; IntAct=EBI-945833, EBI-1222622;
Q92824:PCSK5; NbExp=3; IntAct=EBI-945833, EBI-751290;
O76083:PDE9A; NbExp=3; IntAct=EBI-945833, EBI-742764;
Q7Z2X4:PID1; NbExp=3; IntAct=EBI-945833, EBI-10256685;
Q96S52:PIGS; NbExp=5; IntAct=EBI-945833, EBI-2908273;
O43688:PLPP2; NbExp=3; IntAct=EBI-945833, EBI-722017;
Q9NRQ2:PLSCR4; NbExp=3; IntAct=EBI-945833, EBI-769257;
Q8NAT1:POMGNT2; NbExp=3; IntAct=EBI-945833, EBI-10269044;
P54646:PRKAA2; NbExp=3; IntAct=EBI-945833, EBI-1383852;
Q8WWY3:PRPF31; NbExp=6; IntAct=EBI-945833, EBI-1567797;
P11908:PRPS2; NbExp=3; IntAct=EBI-945833, EBI-4290895;
P25786:PSMA1; NbExp=5; IntAct=EBI-945833, EBI-359352;
Q969U7:PSMG2; NbExp=3; IntAct=EBI-945833, EBI-723276;
P43115-12:PTGER3; NbExp=3; IntAct=EBI-945833, EBI-10234038;
Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-945833, EBI-7199479;
Q9H3S7:PTPN23; NbExp=3; IntAct=EBI-945833, EBI-724478;
P15151:PVR; NbExp=5; IntAct=EBI-945833, EBI-3919694;
Q9Y2K5-2:R3HDM2; NbExp=3; IntAct=EBI-945833, EBI-10326419;
Q8TBN0:RAB3IL1; NbExp=5; IntAct=EBI-945833, EBI-743796;
O60896:RAMP3; NbExp=7; IntAct=EBI-945833, EBI-720447;
Q96PM5:RCHY1; NbExp=3; IntAct=EBI-945833, EBI-947779;
Q6P9E2:RECK; NbExp=5; IntAct=EBI-945833, EBI-10253121;
P07949:RET; NbExp=3; IntAct=EBI-945833, EBI-2480756;
P07949-2:RET; NbExp=3; IntAct=EBI-945833, EBI-4423689;
O15211:RGL2; NbExp=3; IntAct=EBI-945833, EBI-712355;
P62857:RPS28; NbExp=3; IntAct=EBI-945833, EBI-353027;
Q86UN2:RTN4RL1; NbExp=5; IntAct=EBI-945833, EBI-10258951;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-945833, EBI-10313866;
Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-945833, EBI-748391;
O00560:SDCBP; NbExp=3; IntAct=EBI-945833, EBI-727004;
Q8WWX9:SELENOM; NbExp=3; IntAct=EBI-945833, EBI-10277687;
Q9C0C4:SEMA4C; NbExp=5; IntAct=EBI-945833, EBI-10303490;
A1A5C7:SLC22A23; NbExp=3; IntAct=EBI-945833, EBI-10171756;
Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-945833, EBI-1759386;
Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-945833, EBI-750394;
P12236:SLC25A6; NbExp=3; IntAct=EBI-945833, EBI-356254;
Q92911:SLC5A5; NbExp=4; IntAct=EBI-945833, EBI-12313867;
Q9NP91:SLC6A20; NbExp=5; IntAct=EBI-945833, EBI-10311198;
Q969G3:SMARCE1; NbExp=3; IntAct=EBI-945833, EBI-455078;
P49901:SMCP; NbExp=5; IntAct=EBI-945833, EBI-750494;
Q9H4F8:SMOC1; NbExp=3; IntAct=EBI-945833, EBI-2801103;
O95863:SNAI1; NbExp=3; IntAct=EBI-945833, EBI-1045459;
Q6RVD6:SPATA8; NbExp=5; IntAct=EBI-945833, EBI-8635958;
Q9UQ90:SPG7; NbExp=5; IntAct=EBI-945833, EBI-717201;
P20155:SPINK2; NbExp=3; IntAct=EBI-945833, EBI-10200479;
O43609:SPRY1; NbExp=5; IntAct=EBI-945833, EBI-3866665;
O75716:STK16; NbExp=5; IntAct=EBI-945833, EBI-749295;
Q8IV04:TBC1D10C; NbExp=3; IntAct=EBI-945833, EBI-10261452;
Q9BT49:THAP7; NbExp=5; IntAct=EBI-945833, EBI-741350;
Q5TEJ8:THEMIS2; NbExp=3; IntAct=EBI-945833, EBI-2806032;
Q9GZM7-3:TINAGL1; NbExp=3; IntAct=EBI-945833, EBI-10303636;
Q86TG1:TMEM150A; NbExp=5; IntAct=EBI-945833, EBI-2799342;
Q9H6L2:TMEM231; NbExp=3; IntAct=EBI-945833, EBI-10307654;
Q96HV5:TMEM41A; NbExp=3; IntAct=EBI-945833, EBI-10288884;
Q96KP6:TNIP3; NbExp=5; IntAct=EBI-945833, EBI-2509913;
Q07912:TNK2; NbExp=3; IntAct=EBI-945833, EBI-603457;
Q4VB56:TNP2; NbExp=3; IntAct=EBI-945833, EBI-10241829;
P14373:TRIM27; NbExp=3; IntAct=EBI-945833, EBI-719493;
Q8IWZ5:TRIM42; NbExp=8; IntAct=EBI-945833, EBI-5235829;
Q9Y260:TRPV6; NbExp=3; IntAct=EBI-945833, EBI-750052;
O14817:TSPAN4; NbExp=5; IntAct=EBI-945833, EBI-8652667;
Q86UY0:TXNDC5; NbExp=5; IntAct=EBI-945833, EBI-2825190;
Q9BRU9:UTP23; NbExp=5; IntAct=EBI-945833, EBI-5457544;
Q9UBK9:UXT; NbExp=5; IntAct=EBI-945833, EBI-357355;
Q64LD2:WDR25; NbExp=3; IntAct=EBI-945833, EBI-744560;
Q06250:WT1-AS; NbExp=5; IntAct=EBI-945833, EBI-10223946;
Q9UBD3:XCL2; NbExp=3; IntAct=EBI-945833, EBI-10319095;
Q9GZM5:YIPF3; NbExp=3; IntAct=EBI-945833, EBI-743787;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-945833, EBI-2849569;
Q15973:ZNF124; NbExp=4; IntAct=EBI-945833, EBI-2555767;
P17041:ZNF32; NbExp=3; IntAct=EBI-945833, EBI-1965483;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-945833, EBI-740727;
Q8NDP4:ZNF439; NbExp=3; IntAct=EBI-945833, EBI-747580;
Q8IYI8:ZNF440; NbExp=5; IntAct=EBI-945833, EBI-726439;
Q9NWS9-2:ZNF446; NbExp=5; IntAct=EBI-945833, EBI-740232;
Q9P0T4:ZNF581; NbExp=5; IntAct=EBI-945833, EBI-745520;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-945833, EBI-6427977;
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14673143}.
Cytoplasm {ECO:0000269|PubMed:14673143}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q7Z3S9-1; Sequence=Displayed;
Name=2;
IsoId=Q7Z3S9-2; Sequence=VSP_033896;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q7Z3S9-3; Sequence=VSP_033895;
-!- TISSUE SPECIFICITY: Widely expressed with higher levels in
leukocytes and lymph nodes. {ECO:0000269|PubMed:14673143}.
-!- PTM: Cleaved by ELANE.
-!- SIMILARITY: Belongs to the NOTCH family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH84572.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAC11381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AK075065; BAC11381.1; ALT_INIT; mRNA.
EMBL; BX537434; CAD97676.1; -; mRNA.
EMBL; AL592307; CAH73993.1; -; Genomic_DNA.
EMBL; AL592307; CAH73994.1; -; Genomic_DNA.
EMBL; BC010154; AAH10154.3; -; mRNA.
EMBL; BC019835; AAH19835.1; -; mRNA.
EMBL; BC065219; AAH65219.2; -; mRNA.
EMBL; BC084572; AAH84572.1; ALT_INIT; mRNA.
EMBL; BC090943; AAH90943.1; -; mRNA.
CCDS; CCDS72880.1; -. [Q7Z3S9-1]
RefSeq; NP_982283.2; NM_203458.4. [Q7Z3S9-1]
RefSeq; XP_006711766.1; XM_006711703.3.
RefSeq; XP_006726418.1; XM_006726355.3.
RefSeq; XP_016855384.1; XM_016999895.1. [Q7Z3S9-1]
RefSeq; XP_016855385.1; XM_016999896.1. [Q7Z3S9-1]
RefSeq; XP_016855386.1; XM_016999897.1. [Q7Z3S9-1]
RefSeq; XP_016855387.1; XM_016999898.1. [Q7Z3S9-1]
RefSeq; XP_016858537.1; XM_017003048.1. [Q7Z3S9-1]
RefSeq; XP_016858538.1; XM_017003049.1. [Q7Z3S9-1]
RefSeq; XP_016858539.1; XM_017003050.1. [Q7Z3S9-1]
RefSeq; XP_016858540.1; XM_017003051.1. [Q7Z3S9-1]
UniGene; Hs.655156; -.
UniGene; Hs.683989; -.
UniGene; Hs.728902; -.
ProteinModelPortal; Q7Z3S9; -.
SMR; Q7Z3S9; -.
BioGrid; 132802; 244.
DIP; DIP-47315N; -.
IntAct; Q7Z3S9; 355.
MINT; MINT-2879553; -.
STRING; 9606.ENSP00000354929; -.
DMDM; 74750065; -.
MaxQB; Q7Z3S9; -.
PaxDb; Q7Z3S9; -.
PeptideAtlas; Q7Z3S9; -.
PRIDE; Q7Z3S9; -.
TopDownProteomics; Q7Z3S9-3; -. [Q7Z3S9-3]
DNASU; 388677; -.
Ensembl; ENST00000362074; ENSP00000354929; ENSG00000264343. [Q7Z3S9-1]
Ensembl; ENST00000578207; ENSP00000464060; ENSG00000264343. [Q7Z3S9-1]
Ensembl; ENST00000579793; ENSP00000476330; ENSG00000264343. [Q7Z3S9-2]
GeneID; 100996717; -.
GeneID; 100996763; -.
GeneID; 388677; -.
KEGG; hsa:100996717; -.
KEGG; hsa:100996763; -.
KEGG; hsa:388677; -.
UCSC; uc031utx.2; human. [Q7Z3S9-1]
CTD; 388677; -.
DisGeNET; 100996717; -.
DisGeNET; 100996763; -.
DisGeNET; 388677; -.
EuPathDB; HostDB:ENSG00000264343.5; -.
GeneCards; NOTCH2NL; -.
HGNC; HGNC:31862; NOTCH2NL.
HPA; CAB004669; -.
HPA; HPA046392; -.
neXtProt; NX_Q7Z3S9; -.
OpenTargets; ENSG00000264343; -.
OpenTargets; ENSG00000271383; -.
PharmGKB; PA134983899; -.
eggNOG; KOG1217; Eukaryota.
eggNOG; ENOG410XP6K; LUCA.
GeneTree; ENSGT00420000029746; -.
GeneTree; ENSGT00810000125346; -.
HOVERGEN; HBG104750; -.
InParanoid; Q7Z3S9; -.
OMA; GINAYYC; -.
OrthoDB; EOG091G0F6Z; -.
PhylomeDB; Q7Z3S9; -.
PMAP-CutDB; Q7Z3S9; -.
PRO; PR:Q7Z3S9; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000264343; -.
CleanEx; HS_NOTCH2NL; -.
Genevisible; Q7Z3S9; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
Pfam; PF00008; EGF; 3.
Pfam; PF07645; EGF_CA; 1.
SMART; SM00181; EGF; 5.
SMART; SM00179; EGF_CA; 4.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS00022; EGF_1; 5.
PROSITE; PS01186; EGF_2; 5.
PROSITE; PS50026; EGF_3; 6.
PROSITE; PS01187; EGF_CA; 1.
1: Evidence at protein level;
Alternative splicing; Calcium; Complete proteome; Cytoplasm;
Developmental protein; Differentiation; Disulfide bond;
EGF-like domain; Glycoprotein; Notch signaling pathway; Polymorphism;
Reference proteome; Repeat; Secreted.
CHAIN 1 236 Notch homolog 2 N-terminal-like protein.
/FTId=PRO_0000337103.
DOMAIN 1 24 EGF-like 1. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 25 63 EGF-like 2. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 66 104 EGF-like 3. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 105 141 EGF-like 4. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 143 180 EGF-like 5; calcium-binding.
{ECO:0000255|PROSITE-ProRule:PRU00076}.
DOMAIN 182 219 EGF-like 6. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
CARBOHYD 7 7 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 14 23 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 29 40 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 34 51 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 53 62 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 70 82 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 76 92 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 94 103 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 109 120 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 114 129 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 131 140 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 147 159 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 153 168 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 170 179 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 186 197 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 191 207 {ECO:0000255|PROSITE-ProRule:PRU00076}.
VAR_SEQ 1 1 M -> MCRDGYEPCVNEGM (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_033895.
VAR_SEQ 212 236 ETVRRGTELWERDREVWNGKEHDEN -> ATWPIFPKLLSL
QEKESYC (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_033896.
VARIANT 67 67 S -> P (in dbSNP:rs10910779).
/FTId=VAR_043601.
VARIANT 158 158 T -> I (in dbSNP:rs8002).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_043602.
VARIANT 196 196 T -> S (in dbSNP:rs4649852).
/FTId=VAR_043603.
VARIANT 226 226 E -> Q (in dbSNP:rs1053710).
/FTId=VAR_043604.
CONFLICT 19 19 L -> S (in Ref. 1; BAC11381).
{ECO:0000305}.
SEQUENCE 236 AA; 25835 MW; 2DF01880A22814C9 CRC64;
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE
DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC
TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD
SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN


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