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Novel protein similar to vertebrate urocortin 3 (Stresscopin) (UCN3) (Urocortin 3,-like)

 Q1LYP1_DANRE            Unreviewed;       147 AA.
Q1LYP1;
30-MAY-2006, integrated into UniProtKB/TrEMBL.
30-MAY-2006, sequence version 1.
25-OCT-2017, entry version 87.
SubName: Full=Novel protein similar to vertebrate urocortin 3 (Stresscopin) (UCN3) {ECO:0000313|EMBL:AAI54483.1};
SubName: Full=Urocortin 3,-like {ECO:0000313|Ensembl:ENSDARP00000107038};
Name=ucn3l {ECO:0000313|Ensembl:ENSDARP00000107038,
ECO:0000313|ZFIN:ZDB-GENE-060130-250};
Synonyms=LOC100003848 {ECO:0000313|EMBL:AAI54483.1},
si:dkey-117n7.5 {ECO:0000313|ZFIN:ZDB-GENE-060130-250};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000107038, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|EMBL:AAI54483.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Whole body {ECO:0000313|EMBL:AAI54483.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AAI63836.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSDARP00000107038, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107038,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[4] {ECO:0000313|Ensembl:ENSDARP00000107038}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107038};
Ensembl;
Submitted (AUG-2013) to UniProtKB.
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EMBL; BX004864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC154482; AAI54483.1; -; mRNA.
EMBL; BC163836; AAI63836.1; -; mRNA.
EMBL; BC163845; AAI63845.1; -; mRNA.
RefSeq; NP_001076423.1; NM_001082954.2.
UniGene; Dr.114681; -.
STRING; 7955.ENSDARP00000107038; -.
Ensembl; ENSDART00000122493; ENSDARP00000107038; ENSDARG00000087241.
GeneID; 100003848; -.
KEGG; dre:100003848; -.
CTD; 100003848; -.
ZFIN; ZDB-GENE-060130-250; ucn3l.
eggNOG; ENOG410IZ00; Eukaryota.
eggNOG; ENOG410YJR9; LUCA.
GeneTree; ENSGT00390000001251; -.
HOGENOM; HOG000230495; -.
HOVERGEN; HBG036243; -.
KO; K05257; -.
OMA; TKLRGQM; -.
OrthoDB; EOG091G10Y0; -.
TreeFam; TF330723; -.
Reactome; R-DRE-373080; Class B/2 (Secretin family receptors).
Proteomes; UP000000437; Chromosome 4.
Bgee; ENSDARG00000087241; -.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
GO; GO:0001664; F:G-protein coupled receptor binding; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
GO; GO:0007586; P:digestion; IEA:InterPro.
GO; GO:0006950; P:response to stress; IEA:InterPro.
InterPro; IPR000187; CRF.
InterPro; IPR024270; Urocortin_II/III.
PANTHER; PTHR17575; PTHR17575; 1.
Pfam; PF00473; CRF; 1.
ProDom; PD455741; PD455741; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 19 {ECO:0000256|SAM:SignalP}.
CHAIN 20 147 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011097981.
DOMAIN 107 143 CRF. {ECO:0000259|Pfam:PF00473}.
SEQUENCE 147 AA; 16623 MW; CEA96AEB1B50F623 CRC64;
MWLARTLLAL ALLCAPVSSL CLPTYDPEPN FLCNNEVFSE ANDKRQPTNS LLDSVNLLFK
SAHALSSEEP RERRTTPASK YRYLSQTQLR SKLYRNSAKS DRRSQVTLSL DVPTNIMNIL
FNIAKAKNLR AKADDNARLL AQIGKRK


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