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Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog)

 LIS1_YEAST              Reviewed;         494 AA.
P39946; D6W2W9;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 2.
18-JUL-2018, entry version 169.
RecName: Full=Nuclear distribution protein PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
AltName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
Short=LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141};
AltName: Full=nudF homolog {ECO:0000255|HAMAP-Rule:MF_03141};
Name=PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
Synonyms=LIS1 {ECO:0000255|HAMAP-Rule:MF_03141};
OrderedLocusNames=YOR269W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9201714; DOI=10.1091/mbc.8.6.1035;
Geiser J.R., Schott E.J., Kingsbury T.J., Cole N.B., Totis L.J.,
Bhattacharyya G., He L., Hoyt M.A.;
"Saccharomyces cerevisiae genes required in the absence of the CIN8-
encoded spindle motor act in functionally diverse mitotic pathways.";
Mol. Biol. Cell 8:1035-1050(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=8896271;
DOI=10.1002/(SICI)1097-0061(199609)12:10B<1059::AID-YEA994>3.0.CO;2-7;
Cheret G., Bernardi A., Sor F.J.;
"DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of
Saccharomyces cerevisiae.";
Yeast 12:1059-1064(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9153759;
DOI=10.1002/(SICI)1097-0061(199704)13:5<483::AID-YEA105>3.0.CO;2-U;
Poirey R., Jauniaux J.-C.;
"Sequencing analysis of a 36.8 kb fragment of yeast chromosome XV
reveals 26 open reading frames including SEC63, CDC31, SUG2, GCD1,
RBL2, PNT1, PAC1 and VPH1.";
Yeast 13:483-487(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169874;
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W.,
Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R.,
Boyer J., Camasses A., Casamayor A., Casas C., Cheret G.,
Cziepluch C., Daignan-Fornier B., Dang V.-D., de Haan M., Delius H.,
Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F.,
Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A.,
Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J.,
Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P.,
Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M.,
Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R.,
Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S.,
Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A.,
Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M.,
Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C.,
Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S.,
Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
Nature 387:98-102(1997).
[5]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12566428; DOI=10.1083/jcb.200209022;
Lee W.-L., Oberle J.R., Cooper J.A.;
"The role of the lissencephaly protein Pac1 during nuclear migration
in budding yeast.";
J. Cell Biol. 160:355-364(2003).
[7]
FUNCTION, SELF-ASSOCIATION, INTERACTION WITH NDL1, AND SUBCELLULAR
LOCATION.
PubMed=15965467; DOI=10.1038/ncb1273;
Li J., Lee W.-L., Cooper J.A.;
"NudEL targets dynein to microtubule ends through LIS1.";
Nat. Cell Biol. 7:686-690(2005).
[8]
FUNCTION.
PubMed=19185494; DOI=10.1016/j.cub.2008.12.047;
Markus S.M., Punch J.J., Lee W.L.;
"Motor- and tail-dependent targeting of dynein to microtubule plus
ends and the cell cortex.";
Curr. Biol. 19:196-205(2009).
-!- FUNCTION: Positively regulates the activity of the minus-end
directed microtubule motor protein dynein. Plays a central role in
positioning the mitotic spindle at the bud neck during cell
division. Targets cytoplasmic dynein to microtubule plus ends,
thereby promoting dynein-mediated microtubule sliding along the
bud cortex and consequently the movement of the mitotic spindle to
the bud neck. Following plus end binding, dynein may be offloaded
to the cortex by NUM1. Required for viability in the absence of
the kinesin-related microtubule-dependent motor protein CIN8.
{ECO:0000255|HAMAP-Rule:MF_03141, ECO:0000269|PubMed:12566428,
ECO:0000269|PubMed:15965467, ECO:0000269|PubMed:19185494}.
-!- SUBUNIT: Self-associates. Interacts with NDL1. May form a complex
with dynein. {ECO:0000269|PubMed:15965467}.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-12838, EBI-12838;
Q96HB5:CCDC120 (xeno); NbExp=3; IntAct=EBI-12838, EBI-744556;
P38853:KEL1; NbExp=3; IntAct=EBI-12838, EBI-9619;
Q14566:MCM6 (xeno); NbExp=3; IntAct=EBI-12838, EBI-374900;
Q9UJV3-2:MID2 (xeno); NbExp=3; IntAct=EBI-12838, EBI-10172526;
Q5JR59-3:MTUS2 (xeno); NbExp=3; IntAct=EBI-12838, EBI-11522433;
P47149:NNF1; NbExp=3; IntAct=EBI-12838, EBI-12098;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm,
cytoskeleton, spindle pole. Nucleus. Note=Localizes to the plus
ends of cytoplasmic microtubules.
-!- DOMAIN: Dimerization mediated by the LisH domain may be required
to activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
-!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
{ECO:0000255|HAMAP-Rule:MF_03141}.
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EMBL; U16827; AAB00685.1; -; Genomic_DNA.
EMBL; X89633; CAA61775.1; -; Genomic_DNA.
EMBL; Z75177; CAA99493.1; -; Genomic_DNA.
EMBL; BK006948; DAA11035.1; -; Genomic_DNA.
PIR; S67166; S67166.
RefSeq; NP_014912.1; NM_001183688.1.
PDB; 5VH9; EM; 7.70 A; B=140-493.
PDB; 5VLJ; EM; 10.50 A; B/C=140-493.
PDBsum; 5VH9; -.
PDBsum; 5VLJ; -.
ProteinModelPortal; P39946; -.
SMR; P39946; -.
BioGrid; 34658; 366.
DIP; DIP-1485N; -.
IntAct; P39946; 20.
MINT; P39946; -.
STRING; 4932.YOR269W; -.
MaxQB; P39946; -.
PaxDb; P39946; -.
PRIDE; P39946; -.
EnsemblFungi; YOR269W; YOR269W; YOR269W.
GeneID; 854443; -.
KEGG; sce:YOR269W; -.
EuPathDB; FungiDB:YOR269W; -.
SGD; S000005795; PAC1.
GeneTree; ENSGT00900000142520; -.
InParanoid; P39946; -.
KO; K16794; -.
OMA; DVSIGIC; -.
OrthoDB; EOG092C10HM; -.
BioCyc; YEAST:G3O-33759-MONOMER; -.
PRO; PR:P39946; -.
Proteomes; UP000002311; Chromosome XV.
GO; GO:0005881; C:cytoplasmic microtubule; IDA:SGD.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0051010; F:microtubule plus-end binding; IDA:SGD.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0030473; P:nuclear migration along microtubule; IMP:SGD.
GO; GO:2000582; P:positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; IMP:SGD.
GO; GO:1903033; P:positive regulation of microtubule plus-end binding; IDA:SGD.
Gene3D; 2.130.10.10; -; 1.
HAMAP; MF_03141; lis1; 1.
InterPro; IPR017252; Dynein_regulator_LIS1.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR037190; LIS1_N.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF00400; WD40; 4.
PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 7.
SUPFAM; SSF109925; SSF109925; 2.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 2.
PROSITE; PS50082; WD_REPEATS_2; 2.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
3D-structure; Cell cycle; Cell division; Coiled coil;
Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
Nucleus; Reference proteome; Repeat; Transport; WD repeat.
CHAIN 1 494 Nuclear distribution protein PAC1.
/FTId=PRO_0000051113.
DOMAIN 14 46 LisH. {ECO:0000255|HAMAP-Rule:MF_03141}.
REPEAT 153 192 WD 1.
REPEAT 196 244 WD 2.
REPEAT 251 292 WD 3.
REPEAT 295 334 WD 4.
REPEAT 347 395 WD 5.
REPEAT 415 454 WD 6.
REPEAT 457 492 WD 7.
COILED 90 123 {ECO:0000255|HAMAP-Rule:MF_03141}.
SEQUENCE 494 AA; 56901 MW; E667E4BA7602FB3B CRC64;
MTNWQQQLPL TDTQKNELDK SVLRYLNWNY KQTVRHEHAQ DYESVRHAIV TLSGFLLQES
VDRQEFISNN DTSNESMVDI DELLLPKKWN SIVRLQKKII ELEQNTETLV SQIKDLNTQV
SELAQFKPTT SNGTSAHNVL KWIPRNLPSC LINVESSVTS VKLHPNLPIV FVATDHGKLY
AFDLFNYTIP LASLQSHTKA ITSMDVLFTN YTNSSKKNYL VIVTASKDLQ IHVFKWVSEE
CKFQQIRSLL GHEHIVSAVK IWQKNNDVHI ASCSRDQTVK IWDFHNGWSL KTFQPHSQWV
RSIDVLGDYI ISGSHDTTLR LTHWPSGNGL SVGTGHEFPI EKVKFIHFIE DSPEIRFRTP
STDRYKNWGM QYCVSASRDR TIKIWEIPLP TLMAHRAPIP NPTDSNFRCV LTLKGHLSWV
RDISIRGQYL FSCADDKSVR CWDLNTGQCL HVWEKLHTGF VNCLDLDVDF DSNVTPRQMM
VTGGLDCKSN VFMR


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